Diethylethanolamine

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

H290 (40.2%): May be corrosive to metals [Warning Corrosive to Metals]

H302+H312+H332 (40.2%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (22.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H312 (77.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (63.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (23.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (76.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (46.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P234, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P362+P364, P363, P370+P378, P390, P403+P233, P403+P235, P405, P406, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1097 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Wear goggles, self-contained breathing apparatus and rubber overclothing (including gloves).

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

Overspread sufficient sodium bisulfate and sprinkle water. Drain into the sewer with abundant water.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Diethylaminoethanol should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude the formation of explosive concentrations of diethylaminoethanol vapors are permitted.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Drain into the sewer with abundant water. (a) Dissolve in a combustible solvent such as alcohols, etc. Burn in an open furnace by igniting from a safe distance with the utmost care or sprinkle into the fire chamber of the furnace with afterburner and scrubber. (b) Pour into sodium bisulfate in a large evaporating dish. Sprinkle water and neutralize. Drain into the sewer with sufficient water.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet or significantly contaminated should be removed or replaced.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.

For more Preventive Measures (Complete) data for DIETHYLAMINOETHANOL (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants and strong acids. Cool. Dry.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

2.0 [ppm] (Ceiling = 5 ppm)[German Research Foundation (DFG)]

6.0 [ppm]

83 [ppm]

500 [ppm]

10 ppm (50 mg/m³)

TWA 10 ppm (50 mg/m3) [skin]

10.0 [ppm]

100 ppm (NIOSH, 2024)

100.0 [ppm]

Excerpts from Documentation for IDLHs: Human data: A very short exposure (<30 seconds) to a concentration estimated to be less than 100 ppm has resulted in nausea and vomiting within 5 minutes; other persons in the same room also complained of the nauseating odor but did not become ill [Cornish 1965].

See: 100378

2.0 [ppm]

8 hr Time Weighted Avg (TWA): 2 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

2 ppm as TWA; (skin).

2 ppm [1991]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes. The substance is severely irritating to the skin and respiratory tract. The substance may cause effects on the nervous system.

Excerpt from NIOSH Pocket Guide for 2-Diethylaminoethanol:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

2-diethylaminoethanol appears as a colorless liquid. Flash point 103-140 °F. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Causes burns to the skin, eyes and mucous membranes.

Colorless liquid with a nauseating, ammonia-like odor; [NIOSH]

COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a nauseating, ammonia-like odor.

COLORLESS LIQUID

Colorless liquid.

NAUSEATING ODOR

Nauseating, ammonia-like odor.

325 °F at 760 mmHg (NTP, 1992)

163 °C @ 760 MM HG

163.00 °C. @ 760.00 mm Hg

162 °C @760 [mm Hg]

-94 °F (NTP, 1992)

FREEZING POINT: -70 °C

140 °F (NTP, 1992)

140 °F (OPEN CUP)

125 °F (closed cup)

52 °C c.c.

Very soluble (NTP, 1992)

SOL IN ALL PROPORTIONS IN WATER; SOL IN ALC, ETHER, ACETONE, BENZENE, PETROLEUM ETHER

1000000 mg/L @ 25 °C (exp)

Solubility in water: miscible

Miscible

0.8921 at 77 °F (USCG, 1999) - Less dense than water; will float

0.8921 @ 20 °C/4 °C

Relative density (water = 1): 0.88

0.8851 @ 20°C

4.03 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.03 (Air= 1)

21 mmHg at 68 °F (NTP, 1992)

21.0 [mmHg]

21 MM HG @ 20 °C

Vapor pressure, kPa at 20 °C: 2.8

1.4 [mm Hg] @20 °C

Stability During Transport: Stable.

608 °F (320 °C)

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

5 mPa-s at 20 °C

383.9 kJ/kg

29.2 mN/m at 20 °C

Flammable. Soluble in water. This chemical is sensitive to moisture. Slowly hydrolyzes.

Alcohols and Polyols

Amines, Phosphines, and Pyridines

2-DIETHYLAMINOETHANOL is an organic compound with both amine and alcohol substituents. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. This compound can react with strong oxidizers and acids. (NTP, 1992)

Strong oxidizers, strong acids.

Strong oxidizers, strong acids

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough. Nausea. Sore throat. Vomiting. Dizziness.

MAY BE ABSORBED! Redness. Pain.

Redness. Pain. Blurred vision.

Abdominal pain. Diarrhoea.

irritation eyes, skin, respiratory system; nausea, vomiting

Eyes, skin, respiratory system

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

LCLo (rat) = 4,500 mg/m3/4H

LD50 Rabbit skin 1,260 mg/kg

LD50 Guinea pig skin 1,000 mg/kg

LD50 Rat oral 1,300 mg/kg

LD50 Rat ip 1,220 mg/kg

For more Non-Human Toxicity Values (Complete) data for DIETHYLAMINOETHANOL (7 total), please visit the HSDB record page.

Employees should be screened for history of certain medical conditions which might place the employee at increased risk from diethylaminoethanol exposure. /These are/ chronic respiratory disease ... skin disease ... /and/ eye disease. ... Any employee developing the above-listed conditions should be referred for further medical examination.

/Diethylaminoethanol/ can also produce nausea and vomiting.

An attempt by a laboratory worker to remove animals from an inhalation chamber containing approx 100 ppm resulted in nausea and vomiting within 5 min after a fleeting exposure; no irritation of the eyes or throat was noted during this brief exposure. Other persons in the same room also complained of a nauseating odor but showed no ill effects.

Environmental samples were analyzed for diethylaminoethanol at the Johnson Museum, Cornell University, Ithaca, New York in January 1983. The survey was requested by the 40 employees because of eye irritation and dermatitis. Diethylaminoethanol was used to humidify the air in the museum. Air samples and bulk samples were analyzed for diethylaminoethanol. Medical interviews were conducted. Of the 14 samples taken, only 2 had detectable amounts of diethylaminoethanol. The two concentrations were 0.05 and 0.04 mg/cu m. This was below the OSHA standard of 50 mg/cu m. The two bulk samples contained about 30 mg per square meter of exposed area. A total of 46% of the employees complained of eye irritation, 37% complained of skin irritation, and 17% complained of headache, nose and throat irritation, or dizziness. Six females reported gynecological problems. /It was/ concluded that contact with surfaces coated with condensed diethylaminoethanol may be responsible for some of the irritant effects. It is recommended that diethylaminoethanol be wiped from surfaces, or the use of diethylaminoethanol be discontinued.

In response to a request from a management representative an evaluation was made of an outbreak of illness at a /electronics manufacturing plant/ located in Cincinnati, Ohio. The company manufactured electrical circuit boards and electrical equipment for the commercial and defense industries. In September of 1988 two boilers were prepared for operation by adding corrosion inhibitinq chemicals, diethylaminoethanol and cyclohexylamine. Steam produced by the boilers was used for humidity in the work area. Symptoms consistent with acute toxic effects of diethylaminoethanol and cyclohexylamine were noted in 65 of the employees. These included nausea, dizziness, vomiting, and eye, nose, and throat irritation. A significantly higher risk of having several symptoms was noted among the employees in the areas humidified with boiler steam than among employees in the nonboiler steam humidified areas. Employee exposures to metals from solder fumes and methyl-ethyl-ketone were all below established-limits. There was friable asbestos insulation exposed on one boiler. /It was/ concluded that the exposures to the two corrosion inhibiting chemica1s were responsible for the workers' symptoms.

On March 23, 1981, the National Institute for Occupational Safety and Health (NIOSH) received a request for a Health Hazard Evaluation from Boehring Ingelheim, Ltd, Ridgefield, Connecticut. The request stated that approximately 15 employees in the office support area of a production building had been experiencing rashes since the beginning of March 1981. Environmental samplinq did not reveal any diethylaminoethanol in air samples. However, results of sampling suggested the presence of a conjugated amine which possesses acidic properties. The specific agent could not be identified. Skin examinations revealed an irritant-type rash on the exposed areas of the face neck and hands. The distribution of the rash was consistent with and suggestive of a phototoxic skin reaction. Both the environmental and medical evaluations indicated the source of the dermatitis to be the air-handling system. However, no specific etiologic agent has been identified. The information in the body of the fu11 report suggests that a condensation or reaction product of diethylaminoethanol was likely responsible for the reported symptoms.

... EYE INJURY FROM THE FLUID /IS/ VERY SEVERE IN RABBIT FROM 0.005 ML UNDILUTED, SEVERE FROM 15% OR MORE IN GLYCOL & NOT SEVERE FROM 5% IN GLYCOL.

... REPEATED, DAILY INHALATION EXPOSURES OF RATS @ 500 PPM (+ OR -10%) REVEALED MARKED EYE & NASAL IRRITATION ON THE FIRST EXPOSURE DAY. MILD TREMORS OF THE HEAD & FORELEGS CONTINUED THROUGHOUT THE 5-DAY EXPOSURE PERIOD. CORNEAL OPACITY WAS OBSERVABLE IN A NUMBER OF THE RATS BY THE THIRD DAY, & BY THE FIFTH EXPOSURE 4 OF 20 ANIMALS HAD DIED. ALL ANIMALS LOST 40 TO 80 G. AUTOPSY SHOWED ACUTE PURULENT BRONCHITIS, AND BRONCHOPNEUMONIA BUT NO OTHER ORGAN INVOLVEMENT.

... EXPOSURES @ 200 PPM (+ OR - 5%) RESULTED IN WEIGHT LOSS & EVENTUAL DEATH OF 7 OF THE 50 RATS EXPOSED BY ONE MONTH. BRONCHOPNEUMONIA WAS APPARENT CAUSE OF DEATH. AT THE END OF THREE MONTHS, APPARENT ADAPTATION OCCURRED, AS NO CLINICAL VARIABLES THAT WERE MEASURED DIFFERED FROM THE CONTROLS; SIMILAR FINDINGS WERE MADE AT THE END OF SIX MONTHS. HISTOPATHOLOGIC EXAMINATION REVEALED THAT CONTROL AND EXPOSED ANIMAL TISSUES WERE NOT SIGNIFICANTLY DIFFERENT.

DIETHYLAMINOETHANOL BLOCKED IMPULSE CONDUCTION IN FROG SCIATIC NERVES, BUT HAD NO LOCAL ANESTHETIC EFFECT ON RABBIT CORNEA.

For more Non-Human Toxicity Excerpts (Complete) data for DIETHYLAMINOETHANOL (13 total), please visit the HSDB record page.

In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of diethylaminoethanol might cause exacerbation of symptoms due to its irritant properties. ... Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. ... Those with pre-existing eye problems may be at increased risk from exposure.

LC50 Pimephales promelas (fathead minnow) 1780 mg/l/96 hr (95% confidence limit 1660-1920 mg/l), flow-through bioassay with measured concentrations, 24.9 °C, dissolved oxygen 6.5 mg/l, hardness 40.8 mg/l calcium carbonate, alkalinity 40.9 mg/l calcium carbonate, and pH 7.70

LC50 Pimephales promelas (fathead minnow) 1780 mg/l/96 hr (95% confidence limit 1660-1920 mg/l), flow-through bioassay with measured concentrations, 24.9 °C, dissolved oxygen 6.5 mg/l, hardness 40.8 mg/l calcium carbonate, alkalinity 40.9 mg/l calcium carbonate, and pH 7.70

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Drain into the sewer with abundant water. (a) Dissolve in a combustible solvent such as alcohols, etc. Burn in an open furnace by igniting from a safe distance with the utmost care or sprinkle into the fire chamber of the furnace with afterburner and scrubber. (b) Pour into sodium bisulfate in a large evaporating dish. Sprinkle water and neutralize. Drain into the sewer with sufficient water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for DIETHYLAMINOETHANOL (8 total), please visit the HSDB record page.

UN 2686; Diethylaminoethanol

IMO 3.3; Diethylaminoethanol

49 131 86; Diethylaminoethanol

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive Flammable Liquid

Symbol: C; R: 10-20/21/22-34; S: (1/2)-25-26-36/37/39-45

UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II