N-methylaniline

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (88.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H319 (38.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H373 (99.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (99.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (88.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P337+P317, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 443 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H227: Combustible liquid [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P260, P264, P270, P273, P280, P301+P317, P308+P316, P319, P321, P330, P370+P378, P391, P403, P405, and P501 (click each P-code to see the statement)

P273, P391, and P501 (click each P-code to see the statement)

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P308+P316, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use water spray, powder, foam, carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Separated from strong oxidants, strong acids and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

0.5 [ppm]

1.5 [ppm]

17 [ppm]

100 [ppm]

0.5 ppm (2 mg/m³)

TWA 0.5 ppm (2 mg/m3) [skin]

2.0 [ppm]

2 ppm (9 mg/m³)

TWA 2 ppm (9 mg/m3) [skin] See Appendix G

100 ppm (NIOSH, 2024)

100.0 [ppm]

Excerpts from Documentation for IDLHs: Other animal data: It has been reported that a dog survived 50 seven­hour exposures to 86 ppm [Treon et al. 1949].

See: 100618

8 hr Time Weighted Avg (TWA): 0.5 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

Biological Exposure Index (BEI): Determinant: methemoglobin in blood; Sampling Time: during or end of shift; BEI: 1.5% of hemoglobin. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. The determinant is nonspecific, since it is also observed after exposure to other chemicals. The biological determinant is an indicator of exposure to the chemical, but the quantitative interpretation of the measurement is ambiguous. These determinants should be used as a screening test if a quantitative test is not practical or as a confirmatory test if the quantitative test is not specific and the origin of the determinant is in question. /Methemoglobin inducers/

0.5 ppm as TWA; (skin); BEI issued.

0.5 ppm [1992]

2.2 mg/m

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

Excerpt from NIOSH Pocket Guide for Monomethyl aniline:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

N-methylaniline appears as a colorless to brown viscous liquid. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

Yellow to light-brown liquid with a weak, ammonia-like odor; [NIOSH]

COLOURLESS OR SLIGHTLY YELLOW OILY LIQUID. TURNS BROWN ON EXPOSURE TO AIR.

Yellow to light-brown liquid with a weak, ammonia-like odor.

COLORLESS OR SLIGHTLY YELLOW LIQ

Yellow to light brown liquid.

Weak, ammonia-like odor.

385.3 °F at 760 mmHg (NTP, 1992)

196.25 °C

194-196 °C

385.3 °F

196.2 °C @760 [mm Hg]

-71 °F (NTP, 1992)

175 °F (NTP, 1992)

175 °F CC

79.5 °C c.c.

1 to 5 mg/mL at 70.7 °F (NTP, 1992)

SOL IN ETHANOL, ETHER, CARBON TETRACHLORIDE

5624 mg/l @ 25 °C

Solubility in water: none

Insoluble

0.989 at 68 °F (USCG, 1999) - Less dense than water; will float

0.989 @ 20 °C/4 °C

Relative density (water = 1): 0.99

0.99 @ 20°C

3.9 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

3.70 (AIR= 1)

Relative vapor density (air = 1): 3.7

1 mmHg at 106 °F (NTP, 1992)

0.45 [mmHg]

0.453 mm Hg @ 25 °C, calculated from experimentally derived coefficients

Vapor pressure, Pa at 20 °C: 39.9

1 mmHg at 106 °F

0.453 [mm Hg] @25 °C

0.3 mmHg

Log kow = 1.66

... TURNS REDDISH BROWN ON STANDING.

BECOMES BROWN ON EXPOSURE TO AIR

WHEN HEATED TO DECOMP, IT EMITS HIGHLY TOXIC FUMES OF /NITROGEN OXIDES/.

2.568 cP @ 15 °C; 1.766 cP @ 30 °C

Becomes brown on exposure to air (NTP, 1992). Slightly soluble in water.

Amines, Aromatic

N-METHYLANILINE is an aryl an amine. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

CAN REACT WITH OXIDIZING MATERIALS

Strong acids, strong oxidizers.

Strong acids, strong oxidizers

The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Blue lips, fingernails and skin. Cough. Dizziness. Headache. Laboured breathing. Sore throat.

MAY BE ABSORBED! Further see Inhalation.

Abdominal pain. Blue lips, fingernails and skin. Dizziness. Headache. Laboured breathing. Nausea.

lassitude (weakness, exhaustion), dizziness, headache; dyspnea (breathing difficulty), cyanosis; methemoglobinemia; pulmonary edema; liver, kidney damage

respiratory system, liver, kidneys, blood, central nervous system

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as primary toxic effect.

n-Methylaniline

2 x 10^-3 mg/kg-day

2 x 10^-2 mg/kg-day

PDF Document

Inadequate information to assess carcinogenic potential

PPRTV Current

MONOMETHYL ANILINE (1.95 G/KG OF FOOD) & SODIUM NITRITE (1.0 G/L WATER) FED TO MICE CAUSED LUNG ADENOMAS & MALIGNANT LYMPHOMAS.

SYMPTOMATOLOGY: 1. GRAYISH BLUE CYANOSIS... 2. ...HEADACHE, NAUSEA, SOMETIMES VOMITING, DRYNESS OF THROAT. 3. CENTRAL NERVOUS SYMPTOMS: CONFUSION, ATAXIA, VERTIGO, TINNITUS, WEAKNESS, DISORIENTATION, LETHARGY, DROWSINESS, &...COMA. CONVULSIONS MAY OCCUR... /ANILINE/

SYMPTOMATOLOGY: 4. CARDIAC EFFECTS: HEART BLOCKS, ARRHYTHMIAS & SHOCK. 5. DEATH, ALTHOUGH UNCOMMON, IS USUALLY DUE TO CARDIOVASCULAR COLLAPSE & RESP PARALYSIS. 6. URINARY SIGNS...INCL PAINFUL MICTURITION, HEMATURIA, HEMOGLOBINURIA (& METHEMOGLOBINURIA), OLIGURIA, & RENAL INSUFFICIENCY... /ANILINE/

HAZARD: TOXIC BY INGESTION, INHALATION & SKIN ABSORPTION.

There are no reports of human intoxication from exposure to N-methyl aniline; however, the clinical toxicology of N-methyl aniline is expected to resemble that seen in cases of aniline poisoning. Overexposure would be expected to induce methemoglobinemia with signs of cyanosis (especially in the lips, nose, and earlobes) weakness, dizziness, and severe headache. Further, based on the fact that aniline can cross the placenta and induce fetal methemoglobinemia, a similar property can be expected in the case of N-methyl aniline.

ANOXIA VIA METHEMOGLOBIN FORMATION. RABBITS & CATS EXPOSED TO 7.6 PPM SHOWED DYSPNEA & CYANOSIS WITH METHEMOGLOBIN FORMATION. CENTROLOBULAR LIVER NECROSIS, PULMONARY INVOLVEMENT, EDEMA PROGRESSING TO INTERSTITIAL PNEUMONITIS.

N-Methyl aniline ... caused poisoning readily by percutaneous absorption. The application of 3 grams or more per kg of body weight upon the intact skin of a rabbit for 1 hour or more always produced death.

... The minimum lethal dose of N-methyl aniline /was found/ to be 280 mg/kg in rabbits when administered orally and 24 mg/kg for both rabbits and cats when administered by intravenous injection. The signs of intoxication included weight loss, dyspnea, prostration, albuminuria, cyanosis, and occasional terminal convulsions.

... Deaths /were reported/ among rabbits, guinea pigs, and rats after 130 or fewer 7-hour inhalation exposures at 7.6 ppm N-methyl aniline and among cats after 58 or fewer similar exposures at 27 ppm. A dog, however, survived 50 such exposures at 86 ppm. One monkey survived 130 seven-hour inhalation exposures at 2.4 ppm, and one rabbit survived 130 seven-hour exposures at 2.3 ppm. Safe limits of exposure for the most susceptible animals were said to range from 2.3 to 7.6 ppm. Various blood changes, including methemoglobinemia (at 7.6 ppm) and the formation of Heinz bodies (at 2.4 ppm), were observed in rats. Animals that died had pulmonary involvement ranging from edema to interstitial pneumonia, as well as occasional centrolobular hepatic necrosis and moderate kidney damage.

1.30e+02

1.60e+03

3.80e+01

4.0E+03(G)

1.40e-02

2.00e-03

Volatile

3.80e+02

4.90e+03

1.10e+02

4.0E+03 (G)

The substance is harmful to aquatic organisms.

N-Methylaniline may be released to the environment as a result of its manufacture, transport, disposal and use as a chemical intermediate and solvent. It may also be released from coal gasification plants and waste incinerators. N-Methylaniline is found naturally in some vegetables and fruits. N-Methylaniline has low adsorptivity to soil and if released on soil may leach. It may photodegrade on the soil surface. N-methylaniline slowly reacts with humic material in soil. It biodegrades in screening studies with acclimated inocula and may be expected to biodegrade in soil. In one study in which high levels of N-methylaniline in sludge was incorporated to soil, N-methylaniline was almost completely degraded from the surface 6 inches of soil in 231 days. N-Methylaniline is estimated to have a relatively high Henry's Law constant and would therefore be expected to volatilize from water. Its volatilization half-life in a model river and model lake is estimated to be 3.5 and 28 days, respectively. It may also photodegrade in surface water or be oxidized by naturally-occurring oxidants in the water body. N-Methylaniline would not be expected to adsorb to sediment or bioconcentrate in fish. N-Methylaniline should exist in the atmosphere as a vapor and react with photochemically-produced hydroxyl radicals with an estimated half-life of 8.8 hr. It may also photolyze or oxidize while in the vapor phase or in aerosols. N-Methylaniline is soluble in water and therefore should be scavenged by rain. People may be occupationally exposed to N-methylaniline by dermal contact or inhalation. The general population will be exposed by ingesting vegetables in which it naturally occurs. (SRC)

N-Methylaniline is produced in nature, being found in fresh vegetables, such as spinach, red cabbage, carrots, and celery(1), and fruits, such as orange rind(2).

N-Methylaniline may be released to the environment(SRC) as a result of its manufacture, transport, disposal and use as a chemical intermediate and solvent(1). N-Methylaniline has been identified in the waste stream of incinerators and may be emitted from such facilities(2). Similarly, it is found in condensate from coal gasification plants and may released with the tar wastes or emissions from such plants(3).

TERRESTRIAL FATE: N-Methylaniline has low adsorptivity to soil(2) and if released on soil may leach, especially in sandy soil. It may photodegrade on the soil surface(3). Some N-methylaniline may also volatilize from the soil surface. When N-methylaniline was applied to land in sludge and the sludge allowed to dry and then tilled into the soil to a depth 6 inches within 5 days, N-methylaniline degraded fairly rapidly(1). The avg concn of N-methylaniline over 3 plots in 0-6 inch cores was 511, 138, and 16 ppb, 5, 122 and 241 days after sludge application, respectively. While 82 ppb of N-methylaniline was found in 9-15 inch cores, 5 days after application, none was found at later sampling dates. While N-methylaniline biodegrades in screening studies and may therefore be expected to biodegrade in soil, it is also known to slowly react with humic material in soil(4). It is easily oxidized(5) and may react with natural oxidants in soil(SRC).

1.30e+02

1.60e+03

3.80e+01

4.0E+03(G)

1.40e-02

2.00e-03

Volatile

3.80e+02

4.90e+03

1.10e+02

4.0E+03 (G)

The substance is harmful to aquatic organisms.

N-Methylaniline may be released to the environment as a result of its manufacture, transport, disposal and use as a chemical intermediate and solvent. It may also be released from coal gasification plants and waste incinerators. N-Methylaniline is found naturally in some vegetables and fruits. N-Methylaniline has low adsorptivity to soil and if released on soil may leach. It may photodegrade on the soil surface. N-methylaniline slowly reacts with humic material in soil. It biodegrades in screening studies with acclimated inocula and may be expected to biodegrade in soil. In one study in which high levels of N-methylaniline in sludge was incorporated to soil, N-methylaniline was almost completely degraded from the surface 6 inches of soil in 231 days. N-Methylaniline is estimated to have a relatively high Henry's Law constant and would therefore be expected to volatilize from water. Its volatilization half-life in a model river and model lake is estimated to be 3.5 and 28 days, respectively. It may also photodegrade in surface water or be oxidized by naturally-occurring oxidants in the water body. N-Methylaniline would not be expected to adsorb to sediment or bioconcentrate in fish. N-Methylaniline should exist in the atmosphere as a vapor and react with photochemically-produced hydroxyl radicals with an estimated half-life of 8.8 hr. It may also photolyze or oxidize while in the vapor phase or in aerosols. N-Methylaniline is soluble in water and therefore should be scavenged by rain. People may be occupationally exposed to N-methylaniline by dermal contact or inhalation. The general population will be exposed by ingesting vegetables in which it naturally occurs. (SRC)

N-Methylaniline is produced in nature, being found in fresh vegetables, such as spinach, red cabbage, carrots, and celery(1), and fruits, such as orange rind(2).

N-Methylaniline may be released to the environment(SRC) as a result of its manufacture, transport, disposal and use as a chemical intermediate and solvent(1). N-Methylaniline has been identified in the waste stream of incinerators and may be emitted from such facilities(2). Similarly, it is found in condensate from coal gasification plants and may released with the tar wastes or emissions from such plants(3).

TERRESTRIAL FATE: N-Methylaniline has low adsorptivity to soil(2) and if released on soil may leach, especially in sandy soil. It may photodegrade on the soil surface(3). Some N-methylaniline may also volatilize from the soil surface. When N-methylaniline was applied to land in sludge and the sludge allowed to dry and then tilled into the soil to a depth 6 inches within 5 days, N-methylaniline degraded fairly rapidly(1). The avg concn of N-methylaniline over 3 plots in 0-6 inch cores was 511, 138, and 16 ppb, 5, 122 and 241 days after sludge application, respectively. While 82 ppb of N-methylaniline was found in 9-15 inch cores, 5 days after application, none was found at later sampling dates. While N-methylaniline biodegrades in screening studies and may therefore be expected to biodegrade in soil, it is also known to slowly react with humic material in soil(4). It is easily oxidized(5) and may react with natural oxidants in soil(SRC).

AQUATIC FATE: The Henry's Law constant is estimated to be 1.14X10-5 atm-cu m/mol(SRC), from its vapor pressure, 0.453 mm Hg(1), and water solubility, 5624 mg/L(2). Using this Henry's Law constant, its half-life in a model river and model lake is estimated to be 3.5 and 28 days, respectively(3,SRC). N-Methylaniline is sensitive to photooxidation and may photodegrade in surface water(4). It is sensitive to oxidation(5) and may be oxidized by naturally-occurring oxidants in the water body(SRC). N-Methylaniline has a low Koc(6) and BCF(7) would not be expected to adsorb to sediment or bioconcentrate in fish(SRC).

ATMOSPHERIC FATE: According to its vapor pressure, 0.453 mm Hg at 25 °C(2), N-methylaniline should exist in the atmosphere as a vapor(4). It will react with photochemically-produced hydroxyl radicals with an estimated half-life of 8.8 hr(3,SRC). It may also photolyze or oxidize while in the vapor phase or in aerosols. The rates of vapor phase photolysis are unknown. N-Methylaniline is fairly soluble in water, 5624 mg/L(1), and therefore should be scavenged by rain(SRC).

The BOD of N-methylaniline in coarse-filtered Lake Superior harbor water over the course of 20 days was not sufficiently different from controls to calculate a degradation rate(1). Little BOD resulted when N-methylaniline was incubated at 21 °C for 20 days in ground water, river water, or Lake Superior Harbor water(1). In a continuous biological treatment simulation test, complete DOC removal was achieved(3). N-Methylaniline (100 ppm) was moderately biodegradable in an activated sludge test with 42% total organic carbon removed(2). The test solution and acclimation procedure employed attempted to simulate industrial wastewater treated at the Fukashiba treatment plant in Japan. Aberrant behavior of N-methylaniline in a semi-continuous activated sludge (SCAS) biodegradation test was found to result from inadequate acclimation of the inoculum(4). It was degraded by Alcalignes sp. and Corynebacterium sp., both isolated from the activated sludge(4).

In a 21-day biodegradation using an acclimated activated sludge inoculum, 82% mineralization and 99.9% primary degradation was obtained(6). It was found that degradation was faster when acclimation was performed in a single flask, rather than by an enrichment procedure(6). Results of standard aerobic biodegradability tests for N-methylaniline include: 92% Dissolved organic carbon (DOC) in 8 days in the Zahn-Wellens test; 29 and 67% DOC removal after 28 and 42 days, respectively in the French AFNOR test(2); 46% CO2 produced and 92% DOC removed in 28 days after 14 days acclimation (Sturm test)(1); 17% DOC removal after 19 days in the OECD Screening test(1); 38% Theoretical BOD was obtained in a 5-day test(5); 18-20% Theoretical BOD was expended after 5-8 days in a respiratory test using 500 ppm of the test substance(3); 0% Theoretical BOD in 30 days with a drop of sewage as an inoculum(1); 3% BODT in 14 days in the MITI test(1); 8% mineralization to CO2 occurred in a 21-day test using an activated sludge inoculum(4). The test results suggest that N-methylaniline will biodegrade when the degrading microorganisms are acclimated(SRC).

N-Nethylaniline showed no potential for biodegradation under anaerobic conditions using an anaerobic digesting sludge inoculum(1). A net gas production of 14% (standard error of mean of 16.5%) and a 42 day lag was obtained when it was incubated for >60 days under anaerobic conditions at 35 °C for over 60 days.

The pKa for N-methylaniline is 4.848 at 25 °C(1) indicating that some of the molecule is ionized (e.g, 10% at pH 5.8) at the acidic end of the environmental pH range. N-Methylaniline is susceptible to oxidation and photooxidation in solution(3,4) as is evidenced by its turning brown on exposure to air(3). Algae-induced phototransformations of anilines is believed to involve superoxide ions(5). In a laboratory study, the half-life of N-methylaniline in a photoreactor illuminated with 20 W fluorochemical lamps (radiation between 300 and 400 nm with a maximum at 350 nm) was 1.5 hr(2).

N-Methylaniline has a vapor pressure of 0.453 mm Hg at 25 degC(3) and therefore in the atmosphere, it will exist primarily as the vapor(2). In the atmosphere, vapor-phase N-methylaniline reacts with photochemically-produced hydroxyl radicals with an estimated rate constant of 43.9X10-12 cu cm/molecule-s(1). Assuming a hydroxyl radical concn of 5X10+5 radicals/cu cm, the half-life of N-methylaniline in the atmosphere would be 8.8 hr(SRC). The structurally similar chemical, aniline, has a strong UV absorption band at 285 nm which extends beyond 290 nm(4) and therefore N-methylaniline which would be expected to have similar UV absorption and could be subject to direct photolysis.

N-Methylaniline was found to have very low bioconcentration in fish using the procedures of the Ministry of International Trade and Industry (MITI) in Japan(1,2). Using its log Kow of 1.66(3), one would estimate a BCF of 11 for N-methylaniline using a recommended regression equation(4). This would indicate that N-methylaniline would not bioconcentrate in aquatic organisms(SRC).

Since the pKa of N-methylaniline is 4.848(2), N-methylaniline will be partially ionized at acidic environmental pHs and its adsorption to soil would be expected to be pH-dependent(SRC). The Koc for N-methylaniline predicted from molecular structure is 65(3). According to a suggested classification scheme(5), this estimated Koc suggests that N- methylaniline will be highly mobile in soil(SRC). Batch equilibrium studies used to determine the adsorption isotherms for N-methylaniline to a Podzol (4.85% OC pH 2.8), an Alfisol (1.25% OC, pH 6.7) and a sediment (1.58% OC, pH 7.1) yielded the results (soil, Freundlich adsorption constants (Kf), Freundlich exponent (1/n), Koc): Podzol, 22.29, 0.89, 460; Alfisol, 0.59, 0.78, 47; Sediment, 1.12, 0.77, 71(1). N-Methylaniline will be almost completely ionized at the pH of the Podzol and therefore ionic interactions may be dominant(1,SRC). N-Methylaniline reacts slowly with humates possibly by adding to quinoidal structures in the humic substances(4). Covalent bond formation is inferred by the lack of extractability of the aniline from the humic material as well as reactions with model compounds(4).

The Henry's Law constant for N-methylaniline estimated from its vapor pressure, 0.453 mm Hg(1), and water solubility, 5624 mg/L(2), is 1.14X10-5 atm-cu-m/mol(SRC). Using this value for the Henry's Law constant, one can estimate a volatilization half-life of 3.5 days for N-methylaniline in a model river 1 m deep flowing at 1 m/s with a wind speed of 3 m/s(3). Similarly, the volatilization half-life for N-methylaniline from a model lake 1 m deep, with a 0.05 m/s current and a 0.5 m/s wind is estimated to be 28 days(3).

SURFACE WATER: N-Methylaniline was found in the River Elbe and River Ammersbek at 0.8 and 1.1 ppb, respectively(1). A 1989 monitoring study of five sites in the Rhine delta in The Netherlands found N-methylaniline at one site on the main stream at 0.027 ug/L(2).

In a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWs) sponsored by the Effluent Guidelines Division of the U.S. EPA, N-methylaniline was identified in discharges of the following industrial category (positive occurrences, median concn in ppb): petroleum refining (1; 161.3), printing and publishing (1; 9.8), pharmaceuticals (2; 1022), foundries (1; 2.2), aluminum (1; 6.1), organic chemicals (5; 18.5), publicly owned treatment works (2; 39.8)(1). The highest effluent concn was 1736 ppb in the pharmaceuticals industry(1). N-Methylaniline was detected in the effluent of one of three New Jersey publicly-owned treatment works (POTWs) at 13-17 ppb(2). It was detected, but not quantified, in wastewater from the Kashima petrochemical complex (includes organic chemicals factory) in Japan(3). Sludge from the Muskegon County (MI) Wastewater Treatment System contained 310 ppb of N-methylaniline which was applied to land(4).

In 1988, N-methylaniline was qualitatively identified in air at a forest site in West Germany, studied because of severe damage to spruce trees over the previous decade(1).

Samples of fresh vegetables containing N-methylaniline include (vegetable, concn): spinach, 3.4 ppm; red cabbage, 0.3 ppm; carrots, 0.8 ppm; celery, 0.5 ppm(1). No N-methylaniline was found in cabbage, cauliflower, kale, white beet, swede, red beet, large radish and red radish(1). Samples of pickled vegetables containing N-methylaniline include (vegetable, concn): paprika, 13.1 ppm; cucumber, 13.8 ppm; cucumber with mustard, 6.1 ppm; onion, 6.8 ppm; celery, 7 ppm(1). Tilsiter cheese and brown bread contained 37.9 and 0.7 ppm of N-methylaniline, but the chemical was not found in various forms of herring, cod roe and camembert and limburger cheese(1).

N-Methylaniline was detected, but not quantified in cold-pressed Valencia orange oil from Florida(1).

N-Methylaniline was not detected in cigarette smoke concentrate, although it was detected in a previous study(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 82 workers are exposed to N-methylaniline in the USA(1). Workers would be exposed to N-methylaniline by inhalation and dermal contact(SRC). The general population will be exposed to N-methylaniline primarily through the consumption of vegetables naturally containing this chemical(SRC).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for N-METHYLANILINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Do not transport with food and feedstuffs.

Symbol: T, N; R: 23/24/25-33-50/53; S: (1/2)-28-36/37-45-60-61

UN Hazard Class: 6.1; UN Pack Group: III