Ethylmorpholine

This chemical does not meet GHS hazard criteria for 1% (5 of 484) of reports.

H226 (99%): Flammable liquid and vapor [Warning Flammable liquids]

H302+H312+H332 (21.5%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H302 (99%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (34.5%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H312 (49.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (84.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (14.7%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (47.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (14.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (37.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (14.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 484 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 5 of 484 reports by companies.

There are 15 notifications provided by 479 of 484 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P330, P332+P317, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For mixtures containing alcohol or polar solvent, alcohol-resistant foam may be more effective.

SMALL FIRE: Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

LARGE FIRE: Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. For petroleum crude oil, do not spray water directly into a breached tank car. This can lead to a dangerous boil over. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, alcohol-resistant foam. In case of fire: keep drums, etc., cool by spraying with water.

ALCOHOL FOAM, FOAM, CARBON DIOXIDE, DRY CHEMICAL.

WATER MAY BE INEFFECTIVE.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

1) REMOVE ALL IGNITION SOURCES. 2) VENTILATE AREA OF SPILL OR LEAK. 3) FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS.

Cover with the 9:1 mixture of sand and soda ash. After mixing, transfer into a paper carton, stuffed with ruffled paper. Burn in an open furnace with the utmost care or in the furnace with afterburner and scrubber.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

...GOOD VENTILATION IS VERY IMPORTANT. /MORPHOLINE/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet should be immediately removed due to its flammability hazard.

Take off the clothing followed by drying and washing or disposing. Dispose shoes by incineration.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants.

Store in a detached storehouse without any ignition source.

TWA 5 ppm (23 mg/m3) [skin]

20.0 [ppm]

TWA 20 ppm (94 mg/m3) [skin] See Appendix G

100 ppm (NIOSH, 2024)

100.0 [ppm]

Excerpts from Documentation for IDLHs: Exposures to 100 ppm for 2.5 minutes have resulted in olfactory fatigue and irritation of the eyes, nose, and throat; irritation was slight after 25 minutes at 50 ppm and absent at 25 ppm [Smyth 1964]. Corneal edema has been noted in workers exposed to concentrations greater than 40 ppm for several hours [Dernehl 1966]. In another study, workers exposed to concentrations as high as 11 ppm but averaging about 3 to 4 ppm complained of drowsiness, optical halos, and foggy vision [Woewicki 1968].

See: 100743

5.0 [ppm]

8 hr Time Weighted Avg (TWA): 5 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

5 ppm as TWA; (skin)

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the eyes. This may result in distortion of vision.

Excerpt from NIOSH Pocket Guide for N-Ethylmorpholine:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point 15%) - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection. (>15%)

• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)

Recommendations for respirator selection. Max concn for use: 50 ppm. Respirator Class(es): Any chemical cartridge respirator with organic vapor cartridge(s). May require eye protection. Any supplied-air respirator. May require eye protection.

Recommendations for respirator selection. Max concn for use: 100 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. May require eye protection. Any powered, air-purifying respirator with organic vapor cartridge(s). May require eye protection. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s). Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.

Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator with a full facepiece and operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode.

Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.

For more Personal Protective Equipment (PPE) (Complete) data for N-ETHYLMORPHOLINE (8 total), please visit the HSDB record page.

Up to 50 ppm:

(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*

(APF = 10) Any supplied-air respirator*

Up to 100 ppm:

(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*

(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)*

(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)

(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister

(APF = 50) Any self-contained breathing apparatus with a full facepiece

(APF = 50) Any supplied-air respirator with a full facepiece

Emergency or planned entry into unknown concentrations or IDLH conditions:

(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode

(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus

Any appropriate escape-type, self-contained breathing apparatus

Important additional information about respirator selection

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Above 32 °C use a closed system, ventilation and explosion-proof electrical equipment.

N-ethyl morpholine appears as a colorless liquid with a strong ammonia-like odor. Severely irritates skin, eyes, and mucous membranes. Moderately soluble in water and less dense than water. Flash point 83 °F.

Colorless liquid with an ammonia-like odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with an ammonia-like odor.

COLORLESS LIQUID

Colorless liquid.

AMMONIACAL ODOR

Ammonia-like odor.

280 to 282 °F at 760 mmHg (NTP, 1992)

138-139 °C @ 763 MM HG

-81 °F (NTP, 1992)

-62.78 °C

82 °F (NTP, 1992)

90 °F (32 °C) (OPEN CUP)

(oc) 90 °F

greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

SOL IN ALL PROPORTIONS IN WATER, ETHANOL & ETHER; SOL IN ACETONE

Solubility in water: miscible

Miscible

0.916 at 68 °F (USCG, 1999) - Less dense than water; will float

0.8996 @ 20 °C/4 °C

Relative density (water = 1): 0.99

4 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.0 (AIR= 1)

Relative vapor density (air = 1): 4.0

6.2 mmHg at 68 °F (NTP, 1992)

6.1 [mmHg]

6.1 MM HG @ 20 °C

Vapor pressure, kPa at 20 °C: 0.80

1.08 mPa S @ 20 °C

36.94 kJ/mole @ 101.3 kPa

Odor Threshold Low: 0.08 [ppm]

Odor Threshold High: 0.25 [ppm]

Detection odor threshold from AIHA (mean = 0.085 ppm)

INDEX OF REFRACTION: 1.4400 @ 20 °C/D; SADTLER REFERENCE NUMBER: 11309 (IR, PRISM)

pKa = 7.67 (conjugate acid)

WT/GAL: 7.6 LB @ 20 °C

MODERATELY VOLATILE

Viscosity

Nitrogen Compounds -> Morpholines

Highly flammable. Moderately soluble in water.

Amines, Phosphines, and Pyridines

Highly Flammable

N-ETHYL MORPHOLINE can react vigorously with oxidizing materials. It dissolves LiAlH4. (NTP, 1992)

...CAN REACT VIGOROUSLY WITH OXIDIZING MATERIALS.

Strong acids, strong oxidizers.

Strong acids, strong oxidizers

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough. Sore throat.

Redness.

Redness. Pain. Blurred vision.

irritation eyes, nose, throat; visual disturbance: corneal edema, blue-gray vision, colored haloes

Eyes, respiratory system

LCLo (rat) = 2,000 ppm/4H

The oral, single-dose LD50 for rats was 1.78 g/kg (1.49-2.12 g/kg) ...

... Ten humans exposed at 100 ppm N-ethylmorpholine for 2.5 min experienced irritation to the eyes, nose, and throat and olfactory fatigue. Irritation was slight with the same duration of exposure at 50 ppm and absent at 25 ppm.

Corneal edema was observed in workers exposed at 40 ppm and more N-ethylmorpholine for several hr. The lesions appeared near the end of the work shift and cleared within 3 to 4 hr after cessation of exposure. Other investigators have also reported that corneal edema caused by amine vapors is reversible. Distortion of vision is experienced at concn below those which produce eye or respiratory irritation. Another study reported that workers exposed at concn generally in the 3 to 4 ppm N-ethylmorpholine range, and never above 11 ppm, complained of drowsiness, optical halos, and foggy vision.

... An epidemic of neurogenic urinary retention from a company, employing 141 and 75 people at 2 different plants, manufacturing polyurethane foam products ... Abnormalities in vision, upper respiratory irritation, dermatitis, and pulmonary abnormalities also occurred but appeared to be related to the presence of other chemicals including N-ethylmorpholine and toluene diisocyanate.

ALL /N-SUBSTITUTED MORPHOLINES TESTED INCLUDING N-ETHYL MORPHOLINE/ EXHIBITED A LOW DEGREE OF ORAL TOXICITY ... N-ETHYL DERIVATIVES PRESENT THE HIGHEST POTENTIAL HAZARD FROM VAPOR EXPOSURE ... .

TESTED IN LIQUID FORM BY APPLYING A DROP FULL-STRENGTH TO RABBIT'S EYE... CAUSES THE CORNEA TO BECOME HAZY IN ABOUT FIVE MINUTES & EPITHELIUM TO SLOUGH FROM THE SURFACE. STANDARDIZED TESTING & GRADING ON RABBIT EYES GIVES A GRADE 7 INJURY ON A SCALE OF 1 TO 10. /MOST SEVERE INJURIES ARE RATED 10/

A DIRECT MUTAGENIC EFFECT WAS FOUND WITH N-ETHYLMORPHOLINE IN MUTAGENICITY TESTS WITH SALMONELLA TYPHIMURIUM STRAINS TA1535 & TA100, WITH & WITHOUT METABOLIC ACTIVATION BY LIVER PREPN FROM SPRAGUE-DAWLEY RATS. TESTS INDICATE OCCURRENCE OF AN ALKYLATING IMPURITY IN N-ETHYLMORPHOLINE.

... 1 of 6 rats died after a 4-hr inhalation exposure at 2000 ppm.

N-Ethylmorpholine's use as an intermediate for dyestuffs, pharmaceuticals, rubber accelerators, and emulsifying agents may result in its release to the environment through various waste streams. If released to water, N-ethylmorpholine will be essentially non-volatile. Insufficient data are available to predict the relative importance or rate of biodegradation in soil or water. If released to the atmosphere, N-ethylmorpholine will exist primarily in the vapor phase. Vapor-phase N-ethylmorpholine will degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of approximately 2.5 hours. Removal of atmospheric N-ethylmorpholine may occur through wet deposition. If released to soil, N-ethylmorpholine is expected to have very high mobility based on an estimated Koc value of 12. Volatilization of N-ethylmorpholine is not expected from moist soils, but will be important from dry soils. Occupational exposure to morpholines, such as N-ethylmorpholine, can occur through inhalation, dermal contact, and ingestion. (SRC)

N-Ethylmorpholine's use as an intermediate for dyestuffs, pharmaceuticals, rubber accelerators, and emulsifying agents(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Using a structure estimation method based on molecular connectivity indexes(1), the Koc for N-ethylmorpholine can be estimated to be about 12(SRC). According to a suggested classification scheme(2), this estimated Koc value suggests that N-ethylmorpholine has very high soil mobility(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC). Volatilization of N-ethylmorpholine is expected from dry soils(SRC) based on an experimental vapor pressure of 5 mm Hg(3,SRC), but not important from moist soils(SRC) based on an estimated Henry's Law constant of 2.74X10-8 atm-cu m/mole(4,SRC).

AQUATIC FATE: Based on a suggested classification scheme(2), N-Ethylmorpholine will be essentially non-volatile from water(SRC) based upon an estimated Henry's Law constant of 2.74X10-8 atm-cu m/mol(1,SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in natural waters(SRC).

ATMOSPHERIC FATE: Based on an experimental vapor pressure of approximately 5 mm Hg at 25 °C(1), and a suggested classification scheme(2), N-ethylmorpholine will exist primarily in the vapor phase in the atmosphere(SRC). It will degrade in the ambient atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 2.5 hours(3,SRC). Removal of atmospheric N-ethylmorpholine may occur through wet deposition(SRC).

The rate constant for the vapor-phase reaction of N-ethylmorpholine with photochemically produced hydroxyl radicals has been estimated to be approximately 1.49X10-10 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 2.5 hours at an atmospheric concentration of 5x10+5 hydroxyl radicals per cu cm(1,SRC).

Because it is miscible in water(2), bioconcentration in aquatic organisms is not expected to be an important fate process for N-ethylmorpholine(1,SRC).

Using a structure estimation method based on molecular connectivity indexes(1), the Koc for N-ethylmorpholine can be estimated to be about 12(SRC). According to a suggested classification scheme(2), this estimated Koc value suggests that N-ethylmorpholine has very high soil mobility(SRC).

The Henry's Law constant for N-ethylmorpholine can be estimated to be 2.47X10-8 atm-cu m/mole(SRC) using a structure estimation method(1). This value of Henry's Law constant indicates that N-ethylmorpholine will be essentially non-volatile from water(2).

...HAS PECULIARLY DISTURBING ACTION ON CORNEAL EPITHELIUM...CAUSING TRANSIENT EDEMA OF CORNEAL EPITHELIUM IN WORKERS EXPOSED TO 40 PPM OR MORE IN AIR DURING WORK DAY, CAUSING ONSET OF BLUE-GREY VISION OR COLORED HALOS AROUND LIGHTS A FEW HOURS AFTER EXPOSURE.

Occupational exposure to morpholines, such as N-ethylmorpholine, can occur through inhalation, dermal contact and ingestion(1).

N-Ethylmorpholine's use as an intermediate for dyestuffs, pharmaceuticals, rubber accelerators, and emulsifying agents may result in its release to the environment through various waste streams. If released to water, N-ethylmorpholine will be essentially non-volatile. Insufficient data are available to predict the relative importance or rate of biodegradation in soil or water. If released to the atmosphere, N-ethylmorpholine will exist primarily in the vapor phase. Vapor-phase N-ethylmorpholine will degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of approximately 2.5 hours. Removal of atmospheric N-ethylmorpholine may occur through wet deposition. If released to soil, N-ethylmorpholine is expected to have very high mobility based on an estimated Koc value of 12. Volatilization of N-ethylmorpholine is not expected from moist soils, but will be important from dry soils. Occupational exposure to morpholines, such as N-ethylmorpholine, can occur through inhalation, dermal contact, and ingestion. (SRC)

N-Ethylmorpholine's use as an intermediate for dyestuffs, pharmaceuticals, rubber accelerators, and emulsifying agents(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Using a structure estimation method based on molecular connectivity indexes(1), the Koc for N-ethylmorpholine can be estimated to be about 12(SRC). According to a suggested classification scheme(2), this estimated Koc value suggests that N-ethylmorpholine has very high soil mobility(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC). Volatilization of N-ethylmorpholine is expected from dry soils(SRC) based on an experimental vapor pressure of 5 mm Hg(3,SRC), but not important from moist soils(SRC) based on an estimated Henry's Law constant of 2.74X10-8 atm-cu m/mole(4,SRC).

AQUATIC FATE: Based on a suggested classification scheme(2), N-Ethylmorpholine will be essentially non-volatile from water(SRC) based upon an estimated Henry's Law constant of 2.74X10-8 atm-cu m/mol(1,SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in natural waters(SRC).

ATMOSPHERIC FATE: Based on an experimental vapor pressure of approximately 5 mm Hg at 25 °C(1), and a suggested classification scheme(2), N-ethylmorpholine will exist primarily in the vapor phase in the atmosphere(SRC). It will degrade in the ambient atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 2.5 hours(3,SRC). Removal of atmospheric N-ethylmorpholine may occur through wet deposition(SRC).

The rate constant for the vapor-phase reaction of N-ethylmorpholine with photochemically produced hydroxyl radicals has been estimated to be approximately 1.49X10-10 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 2.5 hours at an atmospheric concentration of 5x10+5 hydroxyl radicals per cu cm(1,SRC).

Because it is miscible in water(2), bioconcentration in aquatic organisms is not expected to be an important fate process for N-ethylmorpholine(1,SRC).

Using a structure estimation method based on molecular connectivity indexes(1), the Koc for N-ethylmorpholine can be estimated to be about 12(SRC). According to a suggested classification scheme(2), this estimated Koc value suggests that N-ethylmorpholine has very high soil mobility(SRC).

The Henry's Law constant for N-ethylmorpholine can be estimated to be 2.47X10-8 atm-cu m/mole(SRC) using a structure estimation method(1). This value of Henry's Law constant indicates that N-ethylmorpholine will be essentially non-volatile from water(2).

...HAS PECULIARLY DISTURBING ACTION ON CORNEAL EPITHELIUM...CAUSING TRANSIENT EDEMA OF CORNEAL EPITHELIUM IN WORKERS EXPOSED TO 40 PPM OR MORE IN AIR DURING WORK DAY, CAUSING ONSET OF BLUE-GREY VISION OR COLORED HALOS AROUND LIGHTS A FEW HOURS AFTER EXPOSURE.

Occupational exposure to morpholines, such as N-ethylmorpholine, can occur through inhalation, dermal contact and ingestion(1).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

Flammable Liquid

UN Hazard Class: 3; UN Pack Group: III