lead arsenite

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H350: May cause cancer [Danger Carcinogenicity]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P264, P264+P265, P270, P280, P305+P351+P338, P308+P316, P318, P319, P321, P337+P317, P405, and P501 (click each P-code to see the statement)

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P260, P261, P264, P264+P265, P270, P271, P280, P304+P340, P305+P351+P338, P308+P316, P318, P319, P332+P317, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Refer to the "General First Aid" section. (ERG, 2024)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Vacuum with specialist equipment or carefully sweep into containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Store in an area without drain or sewer access.

Biological Exposure Indices (BEI) [ACGIH] - Lead in blood = 200 ug/L (20 ug/100 ml); sampling time not critical; Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek; [ACGIH]

4.2 [mg/m3]

47 [mg/m3]

280 [mg/m3]

0.05 [mg/m3], as Pb (0.01 mg/m3, as As)

5.0 [mg/m3], as As

(inhalable fraction): 0.01 mg/m

Acute Oral: 0.005 mg/kg/day (Arsenic) (L134)

Chronic Oral: 0.0003 mg/kg/day (Arsenic) (L134)

Chronic Inhalation: 0.01 mg/m3 (Arsenic) (L134)

Chronic Inhalation: 0.05 mg/m3 (Lead) (L134)

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance is irritating to the eyes and respiratory tract. Ingestion could cause effects on the gastrointestinal tract. This may result in severe gastroenteritis, loss of fluids and electrolytes, cardiac disorders and shock. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the skin, mucous membranes, bone marrow, blood, central nervous system, peripheral nervous system and liver. This may result in pigmentation disorders, perforation of the nasal septum, anaemia, nervous system impairment and liver impairment. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

Use closed system, ventilation or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection if powder.

Do not eat, drink, or smoke during work. Wash hands before eating.

Lead(II) arsenite is a white powder. It is insoluble in water. It is toxic by inhalation and by ingestion.

White solid; Insoluble in water; [Merck Index]

WHITE POWDER.

Solubility in water: none

5.85 g/cm³

5.85 @25 °C

Metals -> Lead Compounds, Inorganic

Carcinogens

Insoluble in water.

Salts, Basic

LEAD(II) ARSENITE has weak oxidizing or reducing powers. Redox reactions can however still occur. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive.

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead has been shown to competitively inhibit calcium's binding of calmodulin, interferring with neurotransmitter release. It exhibits similar competitive inhibition at the NMDA receptor and protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Lead also affects the nervous system by impairing regulation of dopamine synthesis and blocking evoked release of acetylcholine. However, it's main mechanism of action occurs by inhibiting delta-aminolevulinic acid dehydratase, an enzyme vital in the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (T1, T4, A17, A20, A22, L136)

1, carcinogenic to humans. (L135)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. Lead is a neurotoxin and has been known to cause brain damage and reduced cognitive capacity, especially in children. Lead exposure can result in nephropathy, as well as blood disorders such as high blood pressure and anemia. Lead also exhibits reproductive toxicity and can results in miscarriages and reduced sperm production. (T1, L20, L21)

The substance can be absorbed into the body by inhalation and by ingestion.

Oral (L136) ; inhalation (L136); dermal (L136)

Cough. Sore throat.

Redness. Pain.

Abdominal pain. Burning sensation in the throat and chest. Vomiting. Headache. Diarrhoea. Weakness. Shock or collapse.

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).

Neurotoxin - Sensorimotor

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Aplastic anemia - The presence of increased methemoglobin in the blood; the compound is classified as primary toxic effect.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens.

NTP Carcinogen - Reasonably anticipated to be a human carcinogen.

ACGIH Carcinogen - Confirmed Animal.

Both arsenic and poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20, L21)

The substance is harmful to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

The substance is harmful to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

Do not transport with food and feedstuffs. Marine pollutant.

Symbol: T, N; R: 23/25-50/53; S: (1/2)-20/21-28-45-60-61; Note:

UN Hazard Class: 6.1; UN Pack Group: II