Mercuric nitrate

H272 (49.4%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

H300+H310+H330 (49.4%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H300 (98.7%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (98.7%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H330 (98.7%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (98.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (98.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P210, P220, P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P370+P378, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 77 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P261, P262, P264, P264+P265, P270, P272, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P333+P317, P361+P364, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

INHALATION: remove to fresh air; get medical attention.

INGESTION: alimentary absorption is very rapid; action during first 10-15 min. determines prognosis. Give egg whites, milk, or activated charcoal and induce vomiting; consult physician.

EYES or SKIN: flush with water. (USCG, 1999)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Contaminated clothing may be a fire risk when dry.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

SMALL FIRE: Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.

LARGE FIRE: Flood fire area with water from a distance. Do not move cargo or vehicle if cargo has been exposed to heat. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media.

If material on fire or involved in fire: Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

Small Dry Spill

· With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.

Large Spill

· Dike far ahead of spill for later disposal.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· Consider initial downwind evacuation for at least 100 meters (330 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.

Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Water spill: Add dilute caustic soda (NaOH). IF dissolved, apply sodium sulfide (Na2S) solutuion to precipate heavy metals. If dissolved in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amt. Use mechanical dredges or lifts to remove immobolized masses of pollutants and precipitates. Allow to aerate.

Mercury spills should be cleaned up immediately by use of a special vacuum cleaner. Then the area should be washed with a dilute calcium sulfide solution. Small quantities of mercury can be picked up by mixing with copper metal granules. ... /Mercury/

Mercury removal from waste water can be accomplished by these processes: BMS process; Chlorine is added to the waste water, oxidizing any mercury present to the ionic state. The BMS adsorbent (an activated carbon concentrate of sulfur cmpd on its surface) is used to collect ionic mercury. The spent adsorbent is then distilled to recover the mercury, leaving a carbon residue for reuse or disposal. TMR IMAC Process; Waste water is fed into a reactor, whereby a slight excess of chlorine is maintained, oxidizing any mercury present to ionic mercury. The liquid is then passed through the TMR IMAC ion-exchange resin where mercury ions are adsorbed. The mercury is then stripped from the spent resin with hydrochloric acid solution. /Mercury cmpds/

For more Cleanup Methods (Complete) data for MERCURIC NITRATE (6 total), please visit the HSDB record page.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D009, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.

Personnel protection: ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amount of water or soap and water.

If fire becomes uncontrollable - consider evacuation of one-half (1/2) mile radius.

Preventative measure: adequate ventilation; careful attention to good housekeeping, e.g., avoidance of spills, and prompt and proper cleaning if a spill occurs; all containers of mercury and its compounds should be kept tightly closed; should be washed on a regular basis with dilute calcium sulfide solution or other suitable reactant; floors should be nonporous; all workers directly involved in the plant operation should shower thoroughly each day before leaving. /Mercury compounds/

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk.

SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.

LARGE SPILL: Dike far ahead of spill for later disposal. (ERG, 2024)

Separated from combustible substances, reducing agents and food and feedstuffs. See Chemical Dangers. Keep in the dark. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Well closed. Store only in original container.

Storage temperature: Ambient; Venting: Open

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

0.02 [mg/m3], as Hg, inhalable fraction[German Research Foundation (DFG)]

0.1 [mg/m3], as Hg

10 mg Hg/m3 (NIOSH, 2024)

10.0 [mg/m3], as Hg

10 mg/cu m (as Hg) /Mercury cmpd (except (organo) alkyl compounds (as Hg)/

0.02 [mg/m3], as Hg

8 hr Time Weighted Avg (TWA): 0.025 mg/cu m, skin /Mercury, elemental and inorganic forms, as Hg/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Mercury, elemental and inorganic forms, as Hg/

A4: Not classifiable as a human carcinogen./Mercury, elemental and inorganic forms, as Hg/

Biological Exposure Index (BEI): Determinant: total inorganic mercury in urine; Sampling Time: prior to shift; BEI: 35 ug/g creatine. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. /Mercury/

Biological Exposure Index (BEI): Determinant: total inorganic mercury in blood; Sampling Time: end of shift at end of workweek; BEI: 15 ug/L. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. /Mercury/

(as Hg): 0.025 mg/m

(as Hg): 0,02 mg/m

(as Hg, inhalable fraction): 0.02 mg/m

Chronic Inhalation: 0.0002 mg/m3 (L134)

Small Fire

· Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.

Large Fire

· Flood fire area with water from a distance.

· Do not move cargo or vehicle if cargo has been exposed to heat.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

On the basis of toxicity expts on lab animals with exposure to mercuric nitrate, a value of 0.05 mg/cu m was obtained as the max permissible Hg concn in the workplace air. For very short and occasional exposures, the 0.2 mg/cu m value is acceptable.

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the gastrointestinal tract and kidneys. This may result in tissue lesions and kidney failure. Medical observation is indicated.

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the central nervous system, kidneys and peripheral nervous system. This may result in ataxia, sensory and memory disturbances, tremors, muscle weakness and kidney impairment. The substance may have effects on male fertility. May cause heritable genetic damage to human germ cells.

Dust mask; goggles or face shield; protective gloves (USCG, 1999)

Personnel protection: ... Wear appropriate chemical protective gloves, boots, and goggles. ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work. Wash hands before eating.

Mercuric nitrate appears as a white crystalline solid. Toxic by inhalation, ingestion and/or skin contact. Prolonged exposure to fire or heat may result in an explosion. Produces toxic oxides of nitrogen when heated to decomposition. Used to make other chemicals and in medicine.

White to yellow powder or crystals with a sharp odor; [HSDB]

COLOURLESS CRYSTALS OR WHITE HYGROSCOPIC POWDER.

White or slightly yellow crystal powder

Deliquescent crystalline

White granules or crystalline powder; colorless, rhombic crystals.

Sharp odor

VERY SOL IN COLD WATER; SOL IN ACETONE, NITRIC ACID, AMMONIA; INSOL IN ALCOHOL /MERCURIC NITRATE HEMIHYDRATE/

Soluble in small amount of water and in dilute acids.

Soluble in water; insoluble in ethanol

Solubility in water: good

4.3 at 68 °F (USCG, 1999) - Denser than water; will sink

4.3 at 20 °C (solid)

4.4 g/cm³

Decomposed by heat

Solution will corrode most metals.

Mercuric nitrate dissolves in water, then forms a cloudy acid solution. The reaction is not hazardous.

Solid in contact with wood or paper may cause fire.

Decomposed by hot water

Thermal decomposition leads to red mercury(II) oxide.

With much water or on boiling with water an insol basic salt is formed; deliquescent odor of nitric acid; white or slightly yellow crystalline powder; density: 4.3; sol in small amt water; sol in dilute acids /Mercuric nitrate hydrate/

Metals -> Mercury Compounds, Inorganic

Deliquescent. Soluble in a small amount of water. With much water or on boiling with water, an insoluble basic salt is formed.

Nitrate and Nitrite Compounds, Inorganic

Strong Oxidizing Agent

MERCURIC NITRATE is noncombustible, but, as an oxidizing agent, will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Light sensitive. Mixtures with alkyl esters may explode, owing to the formation of alkyl nitrates. Mixtures with phosphorus, tin(II) chloride, or other reducing agents may react explosively [Bretherick 1979. p. 108-109]. Acetylene forms a sensitive acetylide when passed into an aqueous solution of mercuric nitrate [Mellor 4:933. 1946-47]. Should not be mixed with alcohols as explosive mercury fulminates may be formed [Bahme 1961. p. 9]. Is violently reduced by hypophosphoric acid [Mellor 4:993. 1946-47]. Reacts with phosphine to give a yellow precipitate that explodes when heated or subjected to shock [Mellor 4:993. 1946-47].

ACETYLENE FORMS A SENSITIVE ACETYLIDE WHEN PASSED INTO AQ SOLN OF MERCURIC NITRATE. MERCURIC NITRATE IS VIOLENTLY REDUCED TO MERCURY BY HYPOPHOSPHORIC ACID. MERCURIC NITRATE REACTS WITH UNSATURATED & AROMATIC CMPD WITH VIOLENCE IF GIVEN TIME TO GENERATE ENOUGH HEAT.

Gas oil was stirred vigorously with the finely divided solid nitrate to complete the removal of sulfur compounds. After the mixture had congealed, preventing further stirring, a violent reaction set in, which reached incandescence, accompanied by vigorous evolution of nitrous fumes. This was attributed to the self-catalyzed nitrating action of mercury nitrate in a semi-solid environment unable to lose heat effectively. A similar occurrence was observed when crushed nitrate was just covered with cracked naphtha. ... This type of hazard was known in cracked distillates containing high proportions of unsaturated and aromatic cmpd, when allowed to stand in prolonged contact with mercury(2+) nitrate. The hazard may be avoided by using several small portions of the salt sequentially and working with 100 g portions of hydrocarbons.

ALCOHOL SHOULD NOT BE MIXED WITH MERCURIC NITRATE, AS EXPLOSIVE FULMINATE MAY BE FORMED. THE REACTION OF PHOSPHINES & MERCURIC NITRATE GIVES A YELLOW PRECIPITATE WHICH EXPLODES WHEN HEATED OR SUBJECTED TO SHOCK. AN EXPLOSION OCCURRED DURING THE USE OF MERCURIC NITRATE FOR DETERMINING SULFUR IN BALL'S REACTION.

Phosphine reacts with aqueous salt solution to give a complex nitrate phosphide, which when dry explodes on heating or impact.

Phosphinic ('hypophosphorus') acid violently reduces the salt to the metal.

High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, L7, A8, A25, A26)

A4: Not classifiable as a human carcinogen. /Mercury, elemental and inorganic forms, as Hg/

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). Inorganic mercury compounds are not classifiable as to their carcinogenicity to humans (Group 3). (L135)

Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L7)

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Oral (L7) ; inhalation (L7); dermal (L7)

Cough. Sore throat. Burning sensation. Shortness of breath.

MAY BE ABSORBED! Redness. Pain. Blisters.

Redness. Pain.

Metallic taste. Burning sensation. Nausea. Abdominal pain. Vomiting. Diarrhoea.

Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137, A5)

Neurotoxin - Sensorimotor

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

LD50: 26 mg/kg (Oral, Rat) (L443)

LD50: 75 mg/kg (Dermal, Rat) (L443)

LD50: 7 mg/kg (Intraperitoneal, Mouse) (L443)

Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613, A7)

Basic Treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and neat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with available water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Mercury and related compounds/

Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient with severe pulmonary edema or respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Mercury and related compounds/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat as necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 d of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Nitrates, nitrites, and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Monitor cardiac rhythm and treat arrhythmias if necessary. Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present For hypotension with signs of hypovolemia, administer fluid cautiously. If unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Nitrates, nitrites, and related compounds/

LETHAL DOSE FOR SINGLE IV INJECTION WAS APPROX 2.6 MG HG/KG OF MERCURIC NITRATE IN WHITE LEGHORN COCKS. WHEAT FEED TREATED WITH MERCURIC NITRATE CAUSED WT LOSS DURING 1ST 3 WK OF FEEDING. ...

Lebistes reticulatus were exposed 18 days to 25, 50 or 100 ppb (203) mercuric nitrate. Females had lower mortality and accumulated less mercury (Hg) (in 100 ppb solution, maximum body concn of mercury was approx 35 ppm on day 7 and 8) than males (maximum body concn of mercury was approx 40 ppm on day 5 and 6. After approx 14 days, Hg content in the fish decreased to a plateau of approx 20 ppm. Similar pattern was observed in fish exposed to 25 and 50 ppb mercury.

The effect of inorganic compounds on liver injury resulting from disorders of carbohydrate metabolism was investigated. Male albino-rats, 90 days old, were divided into ten groups of ten rats. Rats were acclimated to laboratory conditions before they were fed sublethal doses of mercury-nitrate ... for 30 days. Rats were fasted overnight before sacrifice. Body/liver weight ratios were recorded, and thin slices of liver were removed for determination of glycogen. Mercuric nitrate caused depletion of glycogen in the liver.

Acute toxicity studies with several mono-and divalent Mercury (Hg) in rats and mice by different administration routes (oral, cutaneous, and ip) indicated that mercuric chloride (Hg2C12) (via stomach in mice), and mercuric nitrate (Hg2(NO3)2) (ip in mice) were most toxic among Hg+ cmpd. Hg2+ cmpd were more toxic than the Hg+ cmpd. The effect of anion on the toxicity of the cmpd was more evident in Hg2+ subgroup.

... /Some/ ointments contain ... mercuric nitrate (Hg(HNO3)2.2H2O). ... Dogs & cats are particularly susceptible to toxic effects of mercury from mercurial ointments, due to both direct absorption & to licking of parts to which the ointment has been applied. Poisoning in cattle has also been recorded after use of ointments containing ... mercuric nitrate. ... The sensitivity ... /of sheep & cattle/ is so great that fatal cases of poisoning have occurred as result of treatment, with ointments containing mercury, of other animals kept in the same house.

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment because it is persistent.

Although mercuric nitrate was the material used to treat fur from which felt was made /in the fur-cutting and felt-hat industries/, the mercury was gradually released from the fur amd felt in the form of metalic mercury vapor. Thus the workers had a mixed exposure to dust of mercury compounds (esp nitrate) & to vapor of the element.

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment because it is persistent.

Although mercuric nitrate was the material used to treat fur from which felt was made /in the fur-cutting and felt-hat industries/, the mercury was gradually released from the fur amd felt in the form of metalic mercury vapor. Thus the workers had a mixed exposure to dust of mercury compounds (esp nitrate) & to vapor of the element.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D009, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

/GUIDE 141: OXIDIZERS - TOXIC/ Fire or Explosion: These substances will accelerate burning when involved in a fire. May explode from heat or contamination. Some may burn rapidly. Some will react explosively with hydrocarbons (fuels). May ignite combustibles (wood, paper, oil, clothing, etc.). Containers may explode when heated. Runoff may create fire or explosion hazard.

/GUIDE 141: OXIDIZERS - TOXIC/ Health: Toxic by ingestion. Inhalation of dust is toxic. Fire may produce irritating, corrosive and/or toxic gases. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution.

/GUIDE 141: OXIDIZERS - TOXIC/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 141: OXIDIZERS - TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for MERCURIC NITRATE (8 total), please visit the HSDB record page.

UN 1625; MERCURIC NITRATE

IMO 6.1; MERCURIC NITRATE

49 187 69; Mercuric nitrate, oxidizer

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Severe marine pollutant.

Symbol: T+, N; R: 26/27/28-33-50/53; S: (1/2)-13-28-45-60-61; Note: A, 1

UN Hazard Class: 6.1; UN Pack Group: II