Dinitrosopentamethylenetetramine

H228 (81.6%): Flammable solid [Danger Flammable solids]

H242 (28.9%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

H302 (98.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H317 (19.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H319 (63.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (64.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (63.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P234, P235, P240, P241, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P333+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, P410, P411, P420, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 76 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H242: Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P210, P234, P235, P240, P264, P270, P280, P301+P317, P330, P370+P378, P403, P410, P411, P420, and P501 (click each P-code to see the statement)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]:

Refer to the "General First Aid" section. (ERG, 2024)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]:

SMALL FIRE: Dry chemical, CO2, water spray or regular foam.

LARGE FIRE: Flood fire area with water from a distance. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: BEWARE OF POSSIBLE CONTAINER EXPLOSION. Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch or walk through spilled material. Stop leak if you can do it without risk.

SMALL SPILL: Pick up with inert, damp, non-combustible material using clean, non-sparking tools and place into loosely covered plastic containers for later disposal. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Flammable explosive solid.

Dry Powder

Cream-colored solid; [Hawley] Off-white powder; [MSDSonline]

LIGHT CREAM-COLORED POWDER

LIGHT-YELLOW NEEDLES

SOL IN DIMETHYL FORMAMIDE; SOMEWHAT SOL IN PYRIDINE

SOMEWHAT SOL IN METHYL ETHYL KETONE & ACETONITRILE

SLIGHTLY SOL IN WATER (ABOUT 1%), METHANOL, ETHANOL

SLIGHTLY SOL IN BENZENE, ETHER, ACETONE

READILY SOL DIMETHYL SULFOXIDE

HYDROLYZES IN PRESENCE OF DILUTE HYDROCHLORIC ACID @ 100 °C

Nitrogen Compounds -> Nitrosamines

No rapid reaction with air. No rapid reaction with water.

Amines, Phosphines, and Pyridines

Azo, Diazo, Azido, Hydrazine, and Azide Compounds

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Explosive

Strong Oxidizing Agent

Self-reactive. N,N'-DINITROSOPENTAMETHYLENE TETRAMINE is a blowing agent with an exothermic decomposition slightly above its melting point of 203 °C, Ellern, 161(1968). It is shock sensitive.

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Dinitrosopentamethylenetetramine

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 11: (1976) Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

N,N-Dinitrosopentamethylenetetramine

PDF Document

NO TUMORS...IN 15 MALE & 15 FEMALE 4-WK OLD FISCHER RATS GIVEN 9 MG/ANIMAL BY ORAL GAVAGE ON 5 DAYS/WK FOR 1 YR & OBSERVED FOR...6 MO.

...24 6-7-WK OLD MALE CB RATS RECEIVED WEEKLY IP INJECTIONS OF 25 MG DNPT IN POLYETHYLENE GLYCOL 400 FOR 25 WK (TOTAL DOSE, 650 MG) &...OBSERVED FOR UP TO 2 YR. AMONG 13 RATS THAT SURVIVED 16 OR MORE MO, 1 DEVELOPED HEPATOMA & 1 PITUITARY TUMOR. 1 HEPATOMA...AMONG 24 CONTROLS.

IN RATS... DOSE OF 80 MG/KG BODY WT GIVEN DAILY BY IP INJECTION FOR 30 DAYS WAS TOLERATED; HIGHER DOSES PRODUCED TOXIC EFFECTS WITHIN CNS, WHICH RANGED FROM DEPRESSION OF CONDITIONED REFLEXES TO TONIC & CLONIC SPASMS.

DIFFERENT TYPES OF CHEM CARCINOGENS (EG, NITROSAMINES) & SOME NONCARCINOGENIC ANALOGS TESTED IN VITRO FOR THEIR TRANSFORMING ACTIVITY IN AKR LEUKEMIA VIRUS INFECTED NIH SWISS MOUSE EMBRYO CELL SYSTEM. THESE TRANSFORMING ACTIVITIES IN VITRO WERE SAME AS IN IN VIVO.

STUDIES ON A RIMOSUS EXPOSED TO N-NITROSO-N-METHYLUREA, N-NITROSO-N-METHYLBIURET & N-METHYL-N-NITROSO-N'-NITROGUANIDINE SHOWED INCIDENCE OF MUTATIONS WAS GREATEST & MICROBIAL SURVIVAL RATE WAS LOWEST FOLLOWING EXPOSURE TO N-NITROSODIALLYLAMINE & 1 OF AMIDES.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Solid