dicyclohexylamine

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P264, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P391, P405, and P501 (click each P-code to see the statement)

H302 (91.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (98.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (21.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H400 (98.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (98.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3087 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P273, P391, and P501 (click each P-code to see the statement)

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P361+P364, P363, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

TO FIGHT FIRE, USE ALCOHOL FOAM, CO2, AND DRY CHEMICAL.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize remainder. Then wash away with plenty of water.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

PROPHYLACTIC HEALTH MEASURES INCL MECHANIZATION & AUTOMATION OF TECHNOLOGICAL PROCESSES IN MFR & USE OF INHIBITORS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Separated from strong oxidants, strong acids and food and feedstuffs.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

NO open flames.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield.

Do not eat, drink, or smoke during work.

Dicyclohexylamine appears as a colorless liquid with a faint fishlike odor. Less dense than water. May be toxic by ingestion. Severely irritates skin, eyes and mucous membranes. Used to make paints, varnishes and detergents.

Colorless liquid with a faint fishy odor; [HSDB]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

COLORLESS LIQUID

FAINT FISHY ODOR

Amine odor.

492.4 °F at 760 mmHg (NTP, 1992)

255.8 °C @ 760 MM HG

68 °F (NTP, 1992)

greater than 210 °F (NTP, 1992)

105 °C o.c.

Slightly soluble (NTP, 1992)

SPARINGLY SOL IN WATER; SOL IN USUAL ORGANIC SOLVENTS; MISCIBLE WITH CYCLOHEXYLAMINE

Soluble in ethanol, ether, benzene.

Soluble in oxygenated solvents.

Solubility in water, g/100ml at 25 °C: 0.08

0.913 to 0.919 at 59 °F (NTP, 1992)

0.9104 at 25 °C/25 °C

Relative density (water = 1): 0.9

6.25 at 68 °F mmHg (NTP, 1992) - Heavier than air; will sink (Relative to Air)

6.25 (AIR= 1)

Relative vapor density (air = 1): 6.25

0.03 [mmHg]

3.38X10-2 at 25 °C

Vapor pressure, kPa at 37.7 °C: 1.6

When heated to decomposition it emits toxic fumes of /nitrogen oxide/.

STRONG BASE

INDEX OF REFRACTION: 1.4823 @ 25 °C/D

pKa = 10.4

147.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID6025018]

146.9 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6025018]

READILY FORMS ADDUCTS WITH SOLVENTS

Boiling point

Heat of sublimation

Optical coefficient

Refractive index

Sound absorption

Sound propagation

Sound velocity

Surface tension

Slightly soluble in water. May be sensitive to air.

Amines, Phosphines, and Pyridines

DICYCLOHEXYLAMINE reacts with oxidizing agents. Forms crystalline salts with many N-protected amino acids (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing. Symptoms may be delayed.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Severe deep burns.

Burning sensation. Abdominal pain. Shock or collapse.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Dicyclohexylamine

PDF Document

LD50 Rat oral is 373 mg/kg

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. /Dinitrophenol and related compounds/

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... Monitor for pulmonary edema and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... Cover skin burns with dry sterile dressings after decontamination ... Rapid body cooling may be necessary in case of hyperthermia. Salicylates are contraindicated. /Dinitrophenol and related compounds/

SKIN IRRITANT & POSSIBLE SENSITIZER.

SYSTEMIC EFFECTS IN MAN INCL NAUSEA & VOMITING, ANXIETY, RESTLESSNESS & DROWSINESS. /CYCLOHEXYLAMINE/

HUMAN LYMPHOCYTE CULTURES EXPOSED TO 4 COMPD @ 3 CONCN (10-3, 10-4 & 10-5 MOLAR) DURING FINAL 5 & 25 HR OF CULTURE. RESULTS CONFIRM THAT CYCLAMATE & CYCLOHEXYLAMINE @ HIGH CONCN CAN INDUCE CHROMOSOME ABERRATIONS. N-HYDROXYCYCLOHEXYLAMINE & DICYCLOHEXYLAMINE HAVE SIMILAR EFFECTS.

ENHANCED FREQUENCIES OF GAPS & BREAKS FOLLOWING TREATMENT OF HUMAN LEUKOCYTE CULTURES WITH DICYCLOHEXYLAMINE SULFATE. ABERRATION FREQUENCIES IN CONTROLS ABOUT 6% & 2-FOLD & 3-FOLD INCR IN CHROMATID DAMAGE WITH INT & HIGHER DOSES OF ALL TEST COMPD. EXPOSURE TIMES AS SHORT AS 5 HR.

STRONG IRRITANT TO SKIN & MUCOUS MEMBRANES.

LIQUID IS VERY IRRITATING TO SKIN, & VAPOR...IN AIR IS EXTREMELY IRRITATING & INJURIOUS, CAUSING CORNEAS OF GUINEA PIGS & WHITE MICE TO BECOME OPAQUE. /CYCLOHEXYLAMINE/

DOSES OF 0.25 G/KG /AFTER INJECTION IN RABBITS/ ARE JUST SUBLETHAL, CAUSING CONVULSIONS & TEMPORARY PARALYSIS. IT IS SKIN IRRITANT.

IN ANIMALS SOMEWHAT MORE TOXIC THAN CYCLOHEXYLAMINE, & UNLIKE LATTER IT CAN BE ABSORBED IN DANGEROUS AMT THROUGH SKIN. RABBITS WHICH INGEST IT DIE IN CONVULSIONS.

DICYCLOHEXYLAMINE ANTAGONIZES BLOOD GLUCOSE INCR IN INTACT & HEPATECTOMIZED RATS INFUSED WITH GLUCOSE & INDUCED LIVER GLYCOGEN RISE IN NORMAL FASTED RATS. IT LOWERED BLOOD TRIGLYCERIDES.

For more Non-Human Toxicity Excerpts (Complete) data for DICYCLOHEXYLAMINE (8 total), please visit the HSDB record page.

Dicyclohexylamine (CAS # 101-83-7) was evaluated for acute oral toxicity in male and female Sprague-Dawley albino rats (alternately 2 and 3/sex/treatment level) administered single undiluted doses of 158, 200, 251 and 316 mg/kg. Treatment-related mortality was consistent with an Oral LD50 (with 95% confidence limits) of 240 (205-285) mg/kg as follows: 158 mg/kg (0/2M; 0/3F), 200 mg/kg (0/3M; 1/2F), 251 mg/kg (1/2M; 2/3F), and 316 mg/kg (3/3M; 1/2F). Death occurred from several hours to 24 hours after dosing. Pharmacotoxic signs included reduction in food consumption and activity (1 day in survivors), progressive weakness, prostration and death. Upon gross necropsy of the study lethalities, treatment-related changes of visceral organs included focal hemorrhaging of the lungs, discolored liver and acute inflammation of the gastrointestinal tract. Study survivors of 14-day post-treatment observation were free of any gross treatment-related pathology at terminal sacrifice. This study was briefly summarized. No further information was reported.

Dicyclohexylamine (CAS # 101-83-7) was evaluated for acute dermal toxicity in solitary male or female New Zealand albino rabbits administered single undiluted dermal applications of 126, 316 and 501 mg/kg for 24 hours. Two male and 3 female rabbits each were administered doses of 200 mg/kg. Treatment-related mortality was consistent with a Dermal LD50 in rabbits of 200-316 mg/kg as follows: 200 mg/kg (1/2M; 0/3F), 316 mg/kg (1/1F), and 501 mg/kg (1/1M). Death occurred prior to 16th hour post-treatment observation in all cases. A solitary male of the 126 mg/kg dose and a male and 3 females of 200 mg/kg doses survived to the 14th day end of post-treatment observation and terminal sacrifice. Pharmacotoxic signs associated with treatment included reduced appetite and activity (2-3 days in survivors), progressive weakness, prostration and death. Upon terminal necropsy of study lethalities, focal hemorrhage of the lungs, discoloration of liver, enlarged gall bladder and inflammation of the gastrointestinal tract were identified. Terminal sacrifice of the study survivors found them with normal-appearing viscera and no gross treatment-related pathology. This study was briefly summarized. No further information was reported.

Dicyclohexylamine (CAS # 101-83-7) was evaluated for acute inhalation toxicity in 6 male New Zealand albino rabbits administered whole-body exposures to 1.4 mg/L for 6 hours. A 2.1 g sample was vaporized and supplied to the 35L exposure chamber via an air flow rate of 4.0 L/min. There was no mortality associated with treatment. Treated rabbits exhibited slight lethargy only, which resolved immediately after termination of the exposure and no further untoward effects of toxicity were noted throughout 14-day post-exposure observation. Upon terminal necropsy, all viscera appeared normal. This study was briefly summarized. No further information was reported.

Dicyclohexylamine (CAS # 101-83-7) was evaluated for primary dermal irritation in 6 New Zealand albino rabbits each administered 0.5 ml undiluted dermal applications to both intact and abraded skin for 24 hours. The unanimous response and a 24-72 hour average primary irritation score was assigned a classification of corrosive. Continued observation found loosening at the edges of the resultant scab showing injury in depth within 17 to 21 days after treatment. This study was briefly summarized. No further information was reported.

Dicyclohexylamine (CAS # 101-83-7) was evaluated for acute eye irritation in 6 New Zealand albino rabbits administered single 0.1 ml undiluted ocular instillations for 24 hours. A 24-72 hour average irritation score of 32.6/110 reflected an overall response assigned a classification of moderately irritating. Treatment initially caused severe discomfort and rabbits pawed and tightly closed the treated eyes. At 1 hour post-treatment, severe erythema was apparent that was unresolved at 24th hour examination. The 24th hour post-instillation examination also found treated rabbits with slight corneal cloudiness and a sluggish iridic reaction to light. Gradual improvement was seen over the ensuing 48-168 hours and, at 14th day examination, all treated eyes were clear of any signs of irritation. This study was briefly summarized. No further information was reported.

The substance is harmful to aquatic organisms.

Dicyclohexylamine's production and use as a chemical intermediate; in insecticides and plasticizers; as a corrosion inhibitor; as an antioxidant in rubber, lubricating oils, and fuels; as a catalyst for paint, varnishes, and inks; as a detergent and as an extractant may result in its release to the environment. If released to the atmosphere, dicyclohexylamine is expected to exist solely in the vapor phase in the ambient atmosphere, based on an experimental vapor pressure of 3.4X10-2 mm Hg. Vapor-phase dicyclohexylamine is expected to be readily degraded by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.9 hours. If released to soil, dicyclohexylamine is expected to have moderate mobility in soil based on an estimated Koc of 260. Volatilization from moist soil surfaces may occur based on an estimated Henry's Law constant of 5.5X10-5 atm-cu m/mol. If released into water, an estimated Koc of 260 indicates that adsorption to suspended solids and sediment is expected to occur. Volatilization from water surfaces is expected based on the Henry's Law constant for this compound. Estimated volatilization half-lives for a model river and lake are 1.1 and 12 days, respectively. An estimated BCF of 1200 indicates that bioconcentration in aquatic organisms will be important. Microbial degradation of dicyclohexylamine is expected to occur. Occupational exposure to dicyclohexylamine may occur through inhalation and dermal contact with this compound at workplaces where it is produced or used. (SRC)

Dicyclohexylamine is not known to occur as a natural product; it occurs as metabolites of cyclamates

Dicyclohexylamine's production and use as a chemical intermediate; in insecticides and plasticizers; as a corrosion inhibitor; as an antioxidant in rubber, lubricating oils, and fuels; as a catalyst for paint, varnishes, and inks; as a detergent and as an extractant(1) will result in its release to the environment(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 260(SRC), determined from a structure estimation method(2), indicates that dicyclohexylamine is expected to have moderate mobility in soil(SRC). Volatilization of dicyclohexylamine from moist soil surfaces is expected given an estimated Henry's Law constant of 5.5X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Dicyclohexylamine is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 3.4X10-2 mm Hg(4).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 260(SRC), determined from a structure estimation method(2), indicates that dicyclohexylamine is expected to adsorb to suspended solids and sediment in water(SRC). Dicyclohexylamine is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.5X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 1.1 and 12 days, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 1200(3,SRC), from an estimated log Kow of 4.37(6,SRC), suggests that bioconcentration in aquatic organisms is very high(SRC). A biodegradation study based on BOD measurements, using an activated sludge seed, and an initial concentration of 100 mg/l, indicated 76.9% degradation of dicyclohexylamine after 2 weeks(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dicyclohexylamine, which has an experimental vapor pressure of 3.4X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dicyclohexylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 2.9 hours(3,SRC).

A biodegradation study based on BOD measurements, using an activated sludge seed, and an initial concentration of 100 mg/l, indicated 76.9% degradation of dicyclohexylamine after 2 weeks(1). Dicyclohexylamine was degraded under aerobic conditions by acclimated sewage enrichment cultures(2).

The rate constant for the vapor-phase reaction of dicyclohexylamine with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 2.9 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Dicyclohexylamine is not expected to undergo direct photolysis in the environment due to the lack of functional groups to absorb light in the environmental spectrum(SRC).

An estimated BCF value of 1200 was calculated for dicyclohexylamine(SRC), using an estimated log Kow of 4.37(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is very high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for dicyclohexylamine can be estimated to be about 260(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that dicyclohexylamine is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for dicyclohexylamine is estimated as 5.5X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that dicyclohexylamine will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 1.1 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 12 days(2,SRC). Dicyclohexylamine's Henry's Law constant of 5.5X10-5 atm-cu m/mole(1,SRC) indicates that volatilization from moist soil surfaces is expected to occur(SRC). Dicyclohexylamine is not expected to volatilize from dry soil surfaces based on an experimental vapor pressure of 3.4X10-2 mm Hg(3).

SURFACE WATER: Dicyclohexylamine was detected in Rhine water samples taken from Lobith and Werkendam, The Netherlands in 1989, at 0.015 and 0.025 ug/l, respectively(1).

The substance is harmful to aquatic organisms.

Dicyclohexylamine's production and use as a chemical intermediate; in insecticides and plasticizers; as a corrosion inhibitor; as an antioxidant in rubber, lubricating oils, and fuels; as a catalyst for paint, varnishes, and inks; as a detergent and as an extractant may result in its release to the environment. If released to the atmosphere, dicyclohexylamine is expected to exist solely in the vapor phase in the ambient atmosphere, based on an experimental vapor pressure of 3.4X10-2 mm Hg. Vapor-phase dicyclohexylamine is expected to be readily degraded by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.9 hours. If released to soil, dicyclohexylamine is expected to have moderate mobility in soil based on an estimated Koc of 260. Volatilization from moist soil surfaces may occur based on an estimated Henry's Law constant of 5.5X10-5 atm-cu m/mol. If released into water, an estimated Koc of 260 indicates that adsorption to suspended solids and sediment is expected to occur. Volatilization from water surfaces is expected based on the Henry's Law constant for this compound. Estimated volatilization half-lives for a model river and lake are 1.1 and 12 days, respectively. An estimated BCF of 1200 indicates that bioconcentration in aquatic organisms will be important. Microbial degradation of dicyclohexylamine is expected to occur. Occupational exposure to dicyclohexylamine may occur through inhalation and dermal contact with this compound at workplaces where it is produced or used. (SRC)

Dicyclohexylamine is not known to occur as a natural product; it occurs as metabolites of cyclamates

Dicyclohexylamine's production and use as a chemical intermediate; in insecticides and plasticizers; as a corrosion inhibitor; as an antioxidant in rubber, lubricating oils, and fuels; as a catalyst for paint, varnishes, and inks; as a detergent and as an extractant(1) will result in its release to the environment(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 260(SRC), determined from a structure estimation method(2), indicates that dicyclohexylamine is expected to have moderate mobility in soil(SRC). Volatilization of dicyclohexylamine from moist soil surfaces is expected given an estimated Henry's Law constant of 5.5X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Dicyclohexylamine is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 3.4X10-2 mm Hg(4).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 260(SRC), determined from a structure estimation method(2), indicates that dicyclohexylamine is expected to adsorb to suspended solids and sediment in water(SRC). Dicyclohexylamine is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.5X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 1.1 and 12 days, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 1200(3,SRC), from an estimated log Kow of 4.37(6,SRC), suggests that bioconcentration in aquatic organisms is very high(SRC). A biodegradation study based on BOD measurements, using an activated sludge seed, and an initial concentration of 100 mg/l, indicated 76.9% degradation of dicyclohexylamine after 2 weeks(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dicyclohexylamine, which has an experimental vapor pressure of 3.4X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dicyclohexylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 2.9 hours(3,SRC).

A biodegradation study based on BOD measurements, using an activated sludge seed, and an initial concentration of 100 mg/l, indicated 76.9% degradation of dicyclohexylamine after 2 weeks(1). Dicyclohexylamine was degraded under aerobic conditions by acclimated sewage enrichment cultures(2).

The rate constant for the vapor-phase reaction of dicyclohexylamine with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 2.9 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Dicyclohexylamine is not expected to undergo direct photolysis in the environment due to the lack of functional groups to absorb light in the environmental spectrum(SRC).

An estimated BCF value of 1200 was calculated for dicyclohexylamine(SRC), using an estimated log Kow of 4.37(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is very high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for dicyclohexylamine can be estimated to be about 260(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that dicyclohexylamine is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for dicyclohexylamine is estimated as 5.5X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that dicyclohexylamine will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 1.1 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 12 days(2,SRC). Dicyclohexylamine's Henry's Law constant of 5.5X10-5 atm-cu m/mole(1,SRC) indicates that volatilization from moist soil surfaces is expected to occur(SRC). Dicyclohexylamine is not expected to volatilize from dry soil surfaces based on an experimental vapor pressure of 3.4X10-2 mm Hg(3).

SURFACE WATER: Dicyclohexylamine was detected in Rhine water samples taken from Lobith and Werkendam, The Netherlands in 1989, at 0.015 and 0.025 ug/l, respectively(1).

Dicyclohexylamine was detected in 2 of 9 biologically treated effluent samples from a bleached Kraft mill, at a mean concentration of 60 ug/l(1). Trench leachates from Maxey Flats, Kentucky and West Valley, NY low-level radioactive waste disposal sites, contained unspecified levels of dicyclohexylamine(2).

URBAN/SUBURBAN: Dicyclohexylamine was identified in ambient air samples from Lake Charles, LA(1).

Dicyclohexylamine was detected in fresh machine cutting-fluid emulsions at a concentration of 18.8 ug/g(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2900 workers are potentially exposed to dicyclohexylamine in the US(1). Occupational exposure to dicyclohexylamine may occur through inhalation and dermal contact with this compound at workplaces where it is produced or used(SRC).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for DICYCLOHEXYLAMINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive

Do not transport with food and feedstuffs.

Symbol: C, N; R: 22-34-50/53; S: (1/2)-26-36/37/39-45-60-61

UN Hazard Class: 8; UN Pack Group: III