Mercury amide chloride (Hg(NH2)Cl)

This chemical does not meet GHS hazard criteria for 2.3% (1 of 44) of reports.

H300 (97.7%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (97.7%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H330 (97.7%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H373 (95.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (97.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (95.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 44 reports by companies.

There are 5 notifications provided by 43 of 44 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Have physician treat for mercury poisoning.

EYES or SKIN: flush with water.

INGESTION: call a physician; give milk or white of egg beaten with water, then a table- spoon of salt in glass of water; repeat until vomit fluid is clear; repeat milk or white of egg. (USCG, 1999)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (material itself does not burn or burns with difficulty). Use water in flooding quantites as fog. Use "alcohol" foam, dry chemical, or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Cover with plastic sheet to prevent spreading.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

· For solids, prevent dust cloud and avoid inhalation of dust.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Mercury spills should be cleaned up immediately by use of a special vacuum cleaner. Then the area should be washed with a dilute calcium sulfide solution. Small quantities of mercury can be picked up by mixing with copper metal granules. ... /Mercury/

Mercury removal from waste water can be accomplished by these processes: BMS process; Chlorine is added to the waste water, oxidizing any mercury present to the ionic state. The BMS adsorbent (an activated carbon concentrate of sulfur cmpd on its surface) is used to collect ionic mercury. The spent adsorbent is then distilled to recover the mercury, leaving a carbon residue for reuse or disposal. TMR IMAC Process; Waste water is fed into a reactor, whereby a slight excess of chlorine is maintained, oxidizing any mercury present to ionic mercury. The liquid is then passed through the TMR IMAC ion-exchange resin where mercury ions are adsorbed. The mercury is then stripped from the spent resin with hydrochloric acid solution. /Mercury cmpds/

SPILLED MERCURY CMPD OR SOLN CAN BE CLEANED UP BY ANY METHOD THAT DOES NOT CAUSE EXCESSIVE AIRBORNE CONTAMINATION OR SKIN CONTACT. /MERCURY COMPOUNDS/

1) Ventilate area of spill. 2) Collect spilled material for reclamation using commercially available mercury vapor depressants or specialized vacuum cleaners. /Inorganic mercury/

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D009, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

If material not involved in fire: Keep material out of water sources and sewers.

Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.

Preventative measure: adequate ventilation; careful attention to good housekeeping, e.g., avoidance of spills, and prompt and proper cleaning if a spill occurs; all containers of mercury and its compounds should be kept tightly closed; should be washed on a regular basis with dilute calcium sulfide solution or other suitable reactant; floors should be nonporous; all workers directly involved in the plant operation should shower thoroughly each day before leaving. /Mercury compounds/

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

10 mg Hg/m3 (NIOSH, 2024)

10 mg/cu m (as Hg) /Mercury cmpd (except (organo) alkyl compounds (as Hg)/

8 hr Time Weighted Avg (TWA): 0.025 mg/cu m, skin /Mercury, elemental and inorganic forms, as Hg/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Mercury, elemental and inorganic forms, as Hg/

A4: Not classifiable as a human carcinogen. /Mercury, inorganic forms, including metallic mercury, as Hg/

Biological Exposure Index (BEI): Determinant: total inorganic mercury in urine; Sampling Time: prior to shift; BEI: 35 ug/g creatine. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. /Mercury/

Biological Exposure Index (BEI): Determinant: total inorganic mercury in blood; Sampling Time: end of shift at end of workweek; BEI: 15 ug/L. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. /Mercury/

Chronic Inhalation: 0.0002 mg/m3 (L134)

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Gloves, goggles, respirator (USCG, 1999)

GLOVES, GOGGLES, RESPIRATOR.

Personnel protection: ... Wear appropriate chemical protective gloves, boots, and goggles. ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

Mercury ammonium chloride appears as a white crystalline solid. Corrosive to the mucous membranes. Very toxic by inhalation and ingestion.

WHITE, PULVERULENT PIECES, OR A WHITE AMORPHOUS POWDER

SMALL PRISMS

White crystalline powder

Odorless

Earthy metallic taste

Sublimes

SOLUBILITY IN COLD WATER: 0.14 G/100 CC; SOLUBILITY IN HOT WATER: 100 G/100 CC (DECOMPOSES)

Sol in warm hydrochloric, nitric, and acetic acids; dissolves in sodium thiosulfate

Sol in ammonium carbonate, insol in alcohol

Soluble in water

5.7 at 68 °F (USCG, 1999) - Denser than water; will sink

5.70 @ 20 °C

STABLE IN AIR, BUT DARKENS ON EXPOSURE TO LIGHT

When heated to decomposition ... emits very toxic fumes of /hydrogen chloride, nitrogen oxides, and mercury/.

Volatile without melting at dull red heat

Slightly water soluble. Decomposes in hot water.

Metals, Less Reactive

Non-Redox-Active Inorganic Compounds

SEVERAL MINUTES AFTER ADDN OF ETHANOL TO MIXTURE OF MERCURY(II) AMIDE CHLORIDE AND IODINE, AN EXPLOSION OCCURS. ADDN OF THE COMPOUND TO CHLORINE GAS OR BROMINE VAPOR LEADS TO A DELAYED VIOLENT OR EXPLOSIVE REACTION.

INFUSIBLE, DECOMP BY ACIDS

High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26)

A4: Not classifiable as a human carcinogen. /Mercury, elemental and inorganic forms, as Hg/

3, not classifiable as to its carcinogenicity to humans. (L135)

Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)

Oral (L7) ; inhalation (L7) ; dermal (L7)

Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)

Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)

PREPARATIONS CONTAINING IODINE ENHANCE ABSORPTION OF THE MERCURIAL, SO THAT THEY SHOULD NOT BE APPLIED SHORTLY BEFORE OR CONCOMITANTLY WITH AMMONIATED MERCURY.

Mercuric ammonium chloride, 0.075 mg/kg doses calculated as mercury, increased blood acid phosphatase and decreased cerebral and gonadial lactate dehydrogenase.

Among mercuric iodide (HgI2), mercuric chloride (HgCl2) and mercuric ammonium chloride, the acute toxic concn to monolayer cell cultures (Hepl-2, Vero and amnion) was the lowest for HgI2 (cell degeneration), followed by that of HgCl2. The Hg(II) cmpds belonged to class II type materials (highly toxic). The sensitivity of the cell lines to the mercury (Hg) was practically similar; only human amnion cells were somewhat more sensitive than the remaining ones. The Hg inhibited the cell growth and multiplication and the max effect was observed by 48 hr. The investigated cmpd inhibited monoamine oxidase activity in the hepatic mitochondria at 10-2M.

A toxicological study of poorly soluble mercury compounds, including mercuric iodide, mercuric ammonium chloride and mercuric oxide indicated that mercuric iodide was the most toxic compound. Acute toxicity study following administration via stomach and single inhalation exposure to rats showed they have approx similar toxicity.

Acute toxicity studies with several mono and divalent mercury cmpd in rats and mice by different admin routes (oral, cutaneous, ip) indicated that mercuric ammonium chloride was the least toxic Hg2+ cmpd. Mercuric chloride (via stomach in mice) and mercuric nitrate (ip in mice) were most toxic among Hg+ cmpd. Hg2+ cmpd were more toxic than the Hg+ cmpd. The effect of anion on the toxicity of the cmpd was more evident in the Hg2+ subgroup.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D009, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for MERCURIC AMMONIUM CHLORIDE (8 total), please visit the HSDB record page.

UN 1630; Mercuric ammonium chloride, solid

IMO 6.1; Mercury ammonium chloride

49 232 42; Mercuric ammonium chloride, solid

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.