Tripropylamine

This chemical does not meet GHS hazard criteria for 0.5% (5 of 1105) of reports.

H226 (99.5%): Flammable liquid and vapor [Warning Flammable liquids]

H301 (98.3%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (92.1%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H314 (99.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (85.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332 (93.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (90.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H412 (13.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1105 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 5 of 1105 reports by companies.

There are 17 notifications provided by 1100 of 1105 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P273, and P501 (click each P-code to see the statement)

H226: Flammable liquid and vapor [Warning Flammable liquids]

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P316, P320, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Use foam, dry chemical, or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water and soap and water. Avoid bodily contact with the material.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... .

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

4.0 [mg/m3]

37 [mg/m3]

220 [mg/m3]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Full impervious protective clothing, including boots and gloves. Where splashing is possible wear full face shield or chemical safety goggles. Use approved respirator to protect against vapors. (USCG, 1999)

Tripropylamine appears as a water-white liquid. Flash point near 125 °F. Less dense than water. May be mildly toxic by ingestion and inhalation. Used as a solvent.

Colorless liquid with an odor of amines; [HSDB] Colorless to slightly yellow liquid; [NTP]

Colourless to fishy liquid; Mild fishy aroma

Water white liquid

Colorless liquid

Amine odor

313 °F at 760 mmHg (NTP, 1992)

156.00 to 158.00 °C. @ 760.00 mm Hg

156 °C @760 [mm Hg]

-136.3 °F (NTP, 1992)

-93.5 °C

98 °F (NTP, 1992)

105 °F (41 °C) OPEN CUP

less than 1 mg/mL at 66 °F (NTP, 1992)

Very soluble in ethyl ether and ethanol

In water, 748 mg/l @ 25 °C

0.748 mg/mL at 25 °C

Soluble in water

Soluble (in ethanol)

0.754 at 68 °F (USCG, 1999) - Less dense than water; will float

0.7558 @ 20 °C

0.754-0.760

0.7558 @ 20°C

4.9 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.9 (Air= 1)

less than 1 mmHg at 68 °F (NTP, 1992)

1.51 [mmHg]

1.51 mm Hg @ 25 °C

1.51 [mm Hg] @25 °C

log Kow= 2.79

356 °F (USCG, 1999)

WHEN HEATED TO DECOMPOSITION, EMITS TOXIC FUMES OF /NITROGEN OXIDES/

4.68X10-3 Pa.s @ 200 K

5.27X10+7 J/Kmol @ 179.65 K

3.32X10-2 N/m @ 179.65 K

Positive

Agilent XCT

Electrospray ionization

formic acid (5.3nM)

MeCN (80%)

Highly flammable. Slightly soluble in water.

Amines, Phosphines, and Pyridines

Highly Flammable

TRIPROPYLAMINE is incompatible with oxidizing agents (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 5,100 mg/m3/4hr

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burs with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

THE TOXIC CONCN OF TRI-N-PROPYLAMINE REQUIRED TO IMMOBILIZE 50% OF ELIMINIUS MODESTUS NAUPLIUS LARVAS IN 6 MIN WAS 3.3X10-8 MOLAR.

Rated 1 on rabbit eyes. ... Tested externally on eyes of rabbits & numerically on scale of 1-10 according to degree of injury observed after 24 hr, paying particular attention to condition of cornea. Most severe injuries ... rated 10.

The inhibition of hydroxysteroid-sulfotransferase activity in the rat liver by alkylamines was investigated. Liver homogenates were prepared from Wistar-rats, & cytosolic fractions were obtained. Hydroxysteroid-sulfotransferase activities towards dehydroepiandrosterone, androsterone, & 2-naphthol were assayed. Cytosolic fractions were fractionated by column chromatography. Triethylamine, which was used as an elution solvent for column chromatography to purify chemically synthesized 3'-phosphoadenosine-5'-phosphosulfate inhibited androgen sulfation with androsterone & dehydroepiandrosterone, but did not affect hydroxysteroid-sulfotransferase activities with cortisol & 2-naphthol. ... Fourteen primary, secondary, & tertiary amines were examined for inhibitory actions on hydroxysteroid-sulfotransferase activities towards dehydroepiandrosterone, cortisol, & 2-naphthol. A secondary amine, di-n-butylamine, & three tertiary amines, triethylamine, tri-n-propylamine, & tri-n-butylamine, inhibited dehydroepiandrosterone hydroxysteroid-sulfotransferase activity by 40 to 60%, irrespective of sex. However, 2-naphthol & cortisol hydroxysteroid-sulfotransferase activities were not affected to any significant extent. Lineweaver Burk plots with partially purified hydroxysteroid hydroxysteroid-sulfotransferase indicated that the inhibition by triethylamine fitted a noncompetitive inhibition. ... Glucocorticoid hydroxysteroid-sulfotransferase appears to be distinct from the hydroxysteroid hydroxysteroid-sulfotransferase, & that this has implications for the inhibition of human liver hydroxysteroid-sulfotransferase activities by synthetic steroids & tertiary amines given as drugs.

Tripropylamine's production and use in chemical research may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.51 mm Hg at 25 °C indicates tripropylamine will exist solely in the vapor-phase in the ambient atmosphere. Vapor-phase tripropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hrs. If released to soil, tripropylamine is expected to have low mobility based upon an estimated Koc of 780. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 3.8X10-4 atm-cu m/mole. The pka of tripropylamine is 10.65, indicating that this compound will primarily exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process because the cation is not expected to volatilize. Tripropylamine may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, tripropylamine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected as the pKa of tripropylamine suggests that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Occupational exposure to tripropylamine may occur through inhalation and dermal contact with this compound at workplaces where tripropylamine is produced or used. (SRC)

Tripropylamine is of little commercial value in comparison to dipropylamine and monoisopropylamine(1); however, it has been employed in some specialized uses. Tripropylamine has been used to synthesize wall carbon nanotubes(2), which may result in its release to the environment through various waste streams.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 780(SRC), determined from a log Kow of 2.79(2) and a regression-derived equation(3), indicates that tripropylamine is expected to have low mobility in soil(SRC). Although the Henry's Law constant of 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(5), and water solubility, 748 mg/l(4), indicates volatilization may occur(SRC), the pKa of tripropylamine, 10.65(6), indicates tripropylamine will exist almost entirely in the ionized form at pH values of 5 to 9 and therefore volatilization from moist soil surfaces is not expected to be an important fate process. The potential for volatilization of tripropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.51 mm Hg(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 780(SRC), determined from a log Kow of 2.79(2) and a regression-derived equation(3), indicates that tripropylamine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(7), and water solubility, 748 mg/l(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 hrs and 6 days, respectively(SRC). A pKa of 10.65(8) indicates tripropylamine will exist almost entirely in the ionized form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(5), an estimated BCF of 30(SRC), from a log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tripropylamine, which has a vapor pressure of 1.51 mm Hg at 25 °C(2), is expected to exist solely in the vapor phase in the ambient atmosphere. Vapor-phase tripropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hrs(SRC), calculated from its rate constant of 1X10-10 cu cm/molecule-sec at 25 °C(3), determined using a structure estimation method(3).

The rate constant for the vapor-phase reaction of tripropylamine with photochemically-produced hydroxyl radicals has been estimated as 1X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tripropylamine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2).

An estimated BCF of 30 was calculated for tripropylamine(SRC), using a log Kow of 2.79(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of tripropylamine is estimated as 780(SRC), using a log Kow of 2.79(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that tripropylamine is expected to have low mobility in soil. The pKa of tripropylamine is 10.65(4) indicating that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. Thus mobility will be greatly reduced.

The Henry's Law constant for tripropylamine is estimated as 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(1), and water solubility, 748 mg/l(2). This Henry's Law constant indicates that tripropylamine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 6 days(SRC). Tripropylamine's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). However, the pKa of tripropylamine is 10.65(4). This pKa indicates that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. Thus volatilization of tripropylamine from water surfaces or moist soil surfaces is not likely to occur. The potential for volatilization of tripropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.51 mm Hg(1).

Occupational exposure to tripropylamine may occur through inhalation and dermal contact with this compound at workplaces where tripropylamine is produced or used. (SRC)

Tripropylamine's production and use in chemical research may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.51 mm Hg at 25 °C indicates tripropylamine will exist solely in the vapor-phase in the ambient atmosphere. Vapor-phase tripropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hrs. If released to soil, tripropylamine is expected to have low mobility based upon an estimated Koc of 780. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 3.8X10-4 atm-cu m/mole. The pka of tripropylamine is 10.65, indicating that this compound will primarily exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process because the cation is not expected to volatilize. Tripropylamine may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, tripropylamine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected as the pKa of tripropylamine suggests that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Occupational exposure to tripropylamine may occur through inhalation and dermal contact with this compound at workplaces where tripropylamine is produced or used. (SRC)

Tripropylamine is of little commercial value in comparison to dipropylamine and monoisopropylamine(1); however, it has been employed in some specialized uses. Tripropylamine has been used to synthesize wall carbon nanotubes(2), which may result in its release to the environment through various waste streams.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 780(SRC), determined from a log Kow of 2.79(2) and a regression-derived equation(3), indicates that tripropylamine is expected to have low mobility in soil(SRC). Although the Henry's Law constant of 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(5), and water solubility, 748 mg/l(4), indicates volatilization may occur(SRC), the pKa of tripropylamine, 10.65(6), indicates tripropylamine will exist almost entirely in the ionized form at pH values of 5 to 9 and therefore volatilization from moist soil surfaces is not expected to be an important fate process. The potential for volatilization of tripropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.51 mm Hg(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 780(SRC), determined from a log Kow of 2.79(2) and a regression-derived equation(3), indicates that tripropylamine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(7), and water solubility, 748 mg/l(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 hrs and 6 days, respectively(SRC). A pKa of 10.65(8) indicates tripropylamine will exist almost entirely in the ionized form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(5), an estimated BCF of 30(SRC), from a log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tripropylamine, which has a vapor pressure of 1.51 mm Hg at 25 °C(2), is expected to exist solely in the vapor phase in the ambient atmosphere. Vapor-phase tripropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hrs(SRC), calculated from its rate constant of 1X10-10 cu cm/molecule-sec at 25 °C(3), determined using a structure estimation method(3).

The rate constant for the vapor-phase reaction of tripropylamine with photochemically-produced hydroxyl radicals has been estimated as 1X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tripropylamine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2).

An estimated BCF of 30 was calculated for tripropylamine(SRC), using a log Kow of 2.79(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of tripropylamine is estimated as 780(SRC), using a log Kow of 2.79(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that tripropylamine is expected to have low mobility in soil. The pKa of tripropylamine is 10.65(4) indicating that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. Thus mobility will be greatly reduced.

The Henry's Law constant for tripropylamine is estimated as 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(1), and water solubility, 748 mg/l(2). This Henry's Law constant indicates that tripropylamine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 6 days(SRC). Tripropylamine's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). However, the pKa of tripropylamine is 10.65(4). This pKa indicates that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. Thus volatilization of tripropylamine from water surfaces or moist soil surfaces is not likely to occur. The potential for volatilization of tripropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.51 mm Hg(1).

Occupational exposure to tripropylamine may occur through inhalation and dermal contact with this compound at workplaces where tripropylamine is produced or used. (SRC)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for TRIPROPYLAMINE (8 total), please visit the HSDB record page.

UN 2260; Tripropylamine

IMO 3.0; Tripropylamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid Corrosive