Tributylamine

H302 (99.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H310 (79.8%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H311 (16.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H315 (85.6%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (14.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H330 (84.2%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H412 (14.4%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3068 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H227: Combustible liquid [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P210, P260, P262, P264, P270, P271, P280, P284, P301+P317, P302+P352, P304+P340, P308+P316, P316, P319, P320, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P273, P391, and P501 (click each P-code to see the statement)

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

P210, P260, P262, P264, P270, P271, P273, P280, P284, P301+P317, P302+P352, P304+P340, P316, P320, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use water spray, powder, foam, carbon dioxide.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

To fight fire, use foam, CO2, dry chemical.

Use water spray, dry chemical, foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for ammonia and organic ammonia derivatives adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Cover the spilled material with inert absorbent.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

Use water spray to cool and disperse vapors and protect personnel. Approach release from upwind. Sand, clay, earth, or other absorbent material may be used to contain liquid.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

For more Preventive Measures (Complete) data for TRIBUTYLAMINE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Dry. Separated from strong oxidants, strong acids and food and feedstuffs.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.

Outside or detached storage is preferred. Separate from oxidizing materials, acids, and sources of halogen. Store in a cool, dry, well-ventilated location.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

0.049 [ppm]

0.54 [ppm]

3.2 [ppm]

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the skin. The substance is mildly irritating to the eyes.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

For more Personal Protective Equipment (PPE) (Complete) data for TRIBUTYLAMINE (6 total), please visit the HSDB record page.

NO open flames. Above 63 °C use a closed system and ventilation.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Tributylamine appears as a pale yellow liquid with an ammonia-like odor. Less dense than water. Very irritating to skin, mucous membranes, and eyes. May be toxic by skin absorption. Low toxicity. Used as an inhibitor in hydraulic fluids.

Colorless to yellow hygroscopic liquid; [ICSC] Ammoniacal odor; [HSDB] Colorless liquid; [MSDSonline]

COLOURLESS-TO-YELLOW HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR.

Pale yellow liquid

Odor of ammonia

415 °F at 760 mmHg (NTP, 1992)

216-217 °C

216.5 °C @760 [mm Hg]

-94 °F (NTP, 1992)

185 °F (NTP, 1992)

63 °C (145 °F) - closed cup

145 °F (63 °C)

187 °F (open cup)

63 °C c.c.

Slightly soluble (NTP, 1992)

In water, 142 mg/L at 25 °C

In water, 40 ppm at 18 °C

Sparingly soluble in water

Soluble in acetone; very soluble in ethanol, ethyl ether

Soublel in most org solvents

Solubility in water, g/100ml at 20 °C: 0.3

0.7771 at 68 °F (NTP, 1992) - Less dense than water; will float

0.7782 at 20 °C/20 °C

Bulk density: 6.5 lb/gal

Relative density (water = 1): 0.78

0.78 @25 °C

6.38 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

6.39 (Air = 1)

Relative vapor density (air = 1): 6.4

20 mmHg at 212 °F (NTP, 1992)

0.09 [mmHg]

9.34X10-2 mm Hg at 25 °C

Vapor pressure, Pa at 20 °C: 40-93

0.0934 [mm Hg] @25 °C

log Kow = 4.46

Stable under recommended storage conditions.

When heated to decomp, emits toxic fumes of /nitrogen oxides/.

1.35 cP at 25 °C; 0.73 cP at 60 °C

12,390.6 gcal/gmole

24.9 dynes/cm at 20 °C

Hygroscopic. Slightly soluble in water.

Amines, Phosphines, and Pyridines

TRIBUTYLAMINE can react with oxidizing materials (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Incompatible materials: Strong oxidizing agents.

Can react with oxidizing materials.

Reacts with acids, oxidizing materials, chlorine, hypochlorite, halogenated compounds, and reactive organic compounds.

IDENTIFICATION AND USE: Tributylamine is a pale yellow liquid. It is used as a solvent; inhibitor in hydraulic fluids; chemical intermediate. HUMAN EXPOSURE AND TOXICITY: A corrosive irritant to skin, eyes, and mucous membranes. 8 female and 8 male volunteers were exposed to tributylamine in varying concentrations. An odor threshold of 0.07 +/- 0.03 ppm (approx. 0.54 mg/cu m) was identified in this study. ANIMAL STUDIES: 6 albino rabbits, tested on 2 sites (1 site abraded, 1 site intact skin), 4 hr exposure, observation after 4, 24, 72 hr, Draize method used for scoring, erythema/eschar formation and for edema formation. Some thickening of the skin after 24 hr, exfoliation of epidermis after 5 d, skin appeared normal after 10 d. Six albino rabbits were subjected to test irritation of the eye. They were exposed to tributylamine into their conjunctival sac. After the exposure all animals showed slight conjuctival congestion, which was reversible within 2 to 3 hours. Exposure of four male and four female rats to 120 ppm for nineteen 6 hr exposures caused nose irritation, restlessness, incoordination, and tremors, organs appeared normal at autopsy. When rats were treated orally with 0.45 or 4.5 mg/kg bw/day daily for 6 months, there were no effects with respect to general constitution, behavior or histology. Pregnant rats were orally treated by gavage on gestation days 6 -15 with doses of 15, 45 and 135 mg/kg/day. Three dams died prematurely on days 7 and 8. The other animals of this group showed transient reductions in food consumption and body weight gain. There were no embryo- or fetotoxic effects except a slight and dose-related increase in fetal body weight gain, which was significant at the highest dose. The treatment did not produce malformations. Tributylamine did not induce micronuclei in vivo in mice.

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Redness. Pain.

LCLo (rat) = 75 ppm/4h

LC50 Rat, inhalation 500 mg/cu m air/4 hr

LD50 Rabbit, dermal 195 mg/kg bw

LD50 Rats, i.p. 107 mg/kg bw

LD50 Mice, i.p. 107 mg/kg bw

For more Non-Human Toxicity Values (Complete) data for TRIBUTYLAMINE (9 total), please visit the HSDB record page.

Synergistic interactions between 2,4-D (94757) & environmental chemicals on in-vitro 2,4-D cytotoxicity & the influence of lipophilicity of the cmpds were investigated. GM-05757 cells were incubated with 2,4-D (used as its dimethylammonium salt) in binary combinations with /12 chemicals including/ ... tributylamine (102829), ... for 1 hr. All cmpds were used at concns previously determined not to have induced any growth inhibition (NOECs), measured as the ratio of cells counted immediately after exposure ended to those counted 48 hr after exposure ended. The concns of 2,4-D & the other chemicals alone & in combination causing a 20% decr in cell growth (EC20) were determined. Associations between the EC20s of the combinations & their lipophilicity, as indicated by the logarithm of the octanol/water partition coefficient, were examined by logistic regression techniques. All cmpds enhanced the toxicity of 2,4-D, as evidenced by decreases in the EC20. Except in the case of nitriloacetic-acid, the decreases in the EC20 were similar, varying from 43.3 to 60.7% over that of 2,4-D alone. ... Except for tributylamine, the decreases in EC20 produced by the combined exposures were strongly correlated with their lipophilicity. The correlation coefficient was reduced if tributylamine was included in the analysis. ... All chemicals may exhibit synergistic toxic effects when combined at nontoxic doses with dissimilar cmpds. The strength of the correlation appears to be related to lipophilicity. This correlation may reflect the ability of lipophilic cmpds to damage the cell membrane which then facilitates & enhances uptake of hydrophilic agents.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/amines and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

/HUMAN EXPOSURE STUDIES/ 8 female and 8 male volunteers were exposed to the test substance (> 99.5% pure) in varying concentrations. An odor threshold of 0.07 +/- 0.03 ppm (approx. 0.54 mg/cu m) was identified in this study (lowest value: 0.01 ppm)

/SIGNS AND SYMPTOMS/ A corrosive irritant to skin, eyes, and mucous membranes.

/LABORATORY ANIMALS: Acute Exposure/ Rated 1 on rabbit eyes. ... tested externally on eyes of rabbits and numerically on scale of 1-10 according to degree of injury observed after 24 hr, paying particular attention to condition of cornea. Most severe injuries ... rated 10.

/LABORATORY ANIMALS: Acute Exposure/ /Cats, oral administration/ 780 mg/kg bw: After 20 min salivation, tonic-clonic convulsions and subsequent convulsive tremors, panting, lateral position; 390 mg/kg bw: tremor of the whole body, convulsions, lateral position; the surviving animal showed vomiting and loud screaming. 156 mg/kg bw: After 20 min salivation, accellerated respiration, restlessness, loud screaming, panting, tonic-clonic convulsions, tremor of the whole body, vomiting. 78 mg/kg bw: restlessness, tonic-clonic convulsions, lateral position, ataxia, accellerated respiration, loud screaming, vomiting 39 mg/kg bw: 3 hr after aplication salivation and slight staggering, ataxia, screaming, convulsive tremors, imbalance. /Gross pathology/ 780 mg/kg bw: slight lung edema of otherwise hyperventilated lungs.

/LABORATORY ANIMALS: Acute Exposure/ Male white New Zealand rabbits (4 animals/dose) were subjected to test acute dermal toxicity. The test item (purity not stated) was applied onto 1/10 of the body surface for 24 h under occlusive conditions. The effects were observed for further 14 days. This single application of the test item to male New Zealand rabbits resulted in a LD50 = 195 mg/kg bw.

/LABORATORY ANIMALS: Acute Exposure/ 6 albino rabbits, tested on 2 sites (1 site abraded, 1 site intact skin), 4 hr exposure, observation after 4, 24, 72 hr, Draize method used for scoring, erythema/eschar formation and for edema formation. Some thickening of the skin after 24 hr, exfoliation of epidermis after 5 d, skin appeared normal after 10 d.

For more Non-Human Toxicity Excerpts (Complete) data for TRIBUTYLAMINE (13 total), please visit the HSDB record page.

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of July 7, 2016: http://actor.epa.gov/dashboard/]

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static, pH 7.9-8.0, dissolved oxygen 97-98% saturated; Concentration: 19000 ug/L for 24 hr (95% confidence interval: 8700-40000 ug/L); Effect: intoxication, immobilization />99% purity/

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, renewal, pH 7.9-8.0, dissolved oxygen 97-100% saturated; Concentration: 8000 ug/L for 48 hr (95% confidence interval: 6100-10800 ug/L); Effect: intoxication, immobilization />99% purity/

Tributylamine's production and use as a catalyst and stabilizer may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.0934 mm Hg at 25 °C indicates tributylamine will exist solely as a vapor in the atmosphere. Vapor-phase tributylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. Tributylamine does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, tributylamine is expected to have low mobility based upon an estimated Koc of 1860. The pKa of tributylamine is 10.89, indicating that this compound will exist entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. Tributylamine is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 2% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is not an important environmental fate process in soil and water. If released into water, tributylamine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's pKa. BCFs of <0.32-47 in carp suggest bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to tributylamine may occur through inhalation and dermal contact with this compound at workplaces where tributylamine is produced or used. Use data indicate that the general population is not likely to be exposed to tributylamine. (SRC)

Tributylamine's production and use as a catalyst and stabilizer(1) may result in its release to the environment through various waste streams(SRC). Tributylamine is a stabilizer for the chemical warfare agent sarin(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1860(SRC), determined from a structure estimation method(2), indicates that tributylamine is expected to have low mobility in soil(SRC). The pKa of tributylamine is 10.89(3), indicating that this compound will exist entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Tributylamine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.0934 mm Hg at 25 °C(5). A 2% of Theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is a slow environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1860(SRC), determined from a structure estimation method(2), indicates that tributylamine is expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.89(3) indicates tributylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Tributylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(5), BCFs of <0.32-47, reported in carp(6), suggest bioconcentration in aquatic organisms is low to moderate. A 2% of Theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation may be a slow environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tributylamine, which has a vapor pressure of 0.0934 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tributylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), calculated from its rate constant of 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tributylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Tributylamine, present at 100 mg/L, reached 2% of its Theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Only slight bio-oxidation of tributylamine was observed (15-day Theoretical BOD of approximately 5%) using the JIS (Japanese Industrial Standards) BOD dilution method with an activated sludge inoculum(2).

The rate constant for the vapor-phase reaction of tributylamine with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tributylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Tributylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

BCFs of <3.2-47 and <0.32-18 were measured using carp (Cyprinus carpio) which were exposed over a 4-week period to 10 and 100 ug/L of tributylamine, respectively(1). According to a classification scheme(2), these BCFs suggest bioconcentration in aquatic organisms is low to moderate.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tributylamine can be estimated to be 1860(SRC). According to a classification scheme(2), this estimated Koc value suggests that tributylamine is expected to have low mobility in soil. The pKa of tributylamine is 10.89(3), indicating that this compound will exist entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

A pKa of 10.89(1) indicates tributylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Tributylamine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.0934 mm Hg(2).

SURFACE WATER: Tributylamine was detected, not quantified in samples of Rhine River water from several locations in The Netherlands delta(1).

Various waste effluent streams generated during the commercial production of the n-butylamines (mono-, di-, and tri-) contain the n-butylamines(1). Wastewater and atmospheric vent effluents may also be generated at the industrial sites using tributylamine as a chemical intermediate(SRC).

According to the 2012 TSCA Inventory Update Reporting data, two reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of tributylamine in the United States may be as low as <10 workers up to the range of 25-49 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 51,214 workers (15,366 of these are female) were potentially exposed to tributylamine in the US(1). Occupational exposure to tributylamine may occur through inhalation and dermal contact with this compound at workplaces where tributylamine is produced or used(SRC). Use data indicate that the general population is not likely to be exposed to tributylamine(SRC).

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static, pH 7.9-8.0, dissolved oxygen 97-98% saturated; Concentration: 19000 ug/L for 24 hr (95% confidence interval: 8700-40000 ug/L); Effect: intoxication, immobilization />99% purity/

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, renewal, pH 7.9-8.0, dissolved oxygen 97-100% saturated; Concentration: 8000 ug/L for 48 hr (95% confidence interval: 6100-10800 ug/L); Effect: intoxication, immobilization />99% purity/

Tributylamine's production and use as a catalyst and stabilizer may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.0934 mm Hg at 25 °C indicates tributylamine will exist solely as a vapor in the atmosphere. Vapor-phase tributylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. Tributylamine does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, tributylamine is expected to have low mobility based upon an estimated Koc of 1860. The pKa of tributylamine is 10.89, indicating that this compound will exist entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. Tributylamine is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 2% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is not an important environmental fate process in soil and water. If released into water, tributylamine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's pKa. BCFs of <0.32-47 in carp suggest bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to tributylamine may occur through inhalation and dermal contact with this compound at workplaces where tributylamine is produced or used. Use data indicate that the general population is not likely to be exposed to tributylamine. (SRC)

Tributylamine's production and use as a catalyst and stabilizer(1) may result in its release to the environment through various waste streams(SRC). Tributylamine is a stabilizer for the chemical warfare agent sarin(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1860(SRC), determined from a structure estimation method(2), indicates that tributylamine is expected to have low mobility in soil(SRC). The pKa of tributylamine is 10.89(3), indicating that this compound will exist entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Tributylamine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.0934 mm Hg at 25 °C(5). A 2% of Theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is a slow environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1860(SRC), determined from a structure estimation method(2), indicates that tributylamine is expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.89(3) indicates tributylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Tributylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(5), BCFs of <0.32-47, reported in carp(6), suggest bioconcentration in aquatic organisms is low to moderate. A 2% of Theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation may be a slow environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tributylamine, which has a vapor pressure of 0.0934 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tributylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), calculated from its rate constant of 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tributylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Tributylamine, present at 100 mg/L, reached 2% of its Theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Only slight bio-oxidation of tributylamine was observed (15-day Theoretical BOD of approximately 5%) using the JIS (Japanese Industrial Standards) BOD dilution method with an activated sludge inoculum(2).

The rate constant for the vapor-phase reaction of tributylamine with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tributylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Tributylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

BCFs of <3.2-47 and <0.32-18 were measured using carp (Cyprinus carpio) which were exposed over a 4-week period to 10 and 100 ug/L of tributylamine, respectively(1). According to a classification scheme(2), these BCFs suggest bioconcentration in aquatic organisms is low to moderate.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tributylamine can be estimated to be 1860(SRC). According to a classification scheme(2), this estimated Koc value suggests that tributylamine is expected to have low mobility in soil. The pKa of tributylamine is 10.89(3), indicating that this compound will exist entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

A pKa of 10.89(1) indicates tributylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Tributylamine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.0934 mm Hg(2).

SURFACE WATER: Tributylamine was detected, not quantified in samples of Rhine River water from several locations in The Netherlands delta(1).

Various waste effluent streams generated during the commercial production of the n-butylamines (mono-, di-, and tri-) contain the n-butylamines(1). Wastewater and atmospheric vent effluents may also be generated at the industrial sites using tributylamine as a chemical intermediate(SRC).

According to the 2012 TSCA Inventory Update Reporting data, two reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of tributylamine in the United States may be as low as <10 workers up to the range of 25-49 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 51,214 workers (15,366 of these are female) were potentially exposed to tributylamine in the US(1). Occupational exposure to tributylamine may occur through inhalation and dermal contact with this compound at workplaces where tributylamine is produced or used(SRC). Use data indicate that the general population is not likely to be exposed to tributylamine(SRC).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Health: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for TRIBUTYLAMINE (8 total), please visit the HSDB record page.

UN 2542; Tributylamine

IMO 6.1; Tributylamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Tributylamine is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Tributylamine is included on the dangerous goods list.

Do not transport with food and feedstuffs.

UN Hazard Class: 6.1; UN Pack Group: II