triamiphos

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

P262, P264, P270, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P405, and P501 (click each P-code to see the statement)

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Note: Triamiphos is a cholinesterase inhibitor.

Signs and Symptoms of Triamiphos Exposure: Acute exposure to triamiphos may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory signs include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.

Emergency Life-Support Procedures: Acute exposure to triamiphos may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to triamiphos.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

5. Rush to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self-exposure to triamiphos.

3. Remove and isolate contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas thoroughly with water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. Rush to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of triamiphos is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step

4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of triamiphos may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step

4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.

4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. Rush to a health care facility. (EPA, 1998)

Triamiphos is listed as an organophosphorus pesticide. As for other organophosphorus pesticides, stay upwind; keep out of low areas. Move containers from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.

This material may burn, but does not ignite readily. Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam. (EPA, 1998)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Spillages of pesticides at any stage of their storage or handling should be treated with great care. Liquid formulations may be reduced to solid phase by evaporation. Dry sweeping of solids is always hazardous: these should be removed by vacuum cleaning or by dissolving them in water or other solvent in the factory environment. In the field they may be washed away with water into a suitable soak-hole. Contaminated top-soil should be removed and buried if any domestic animals or fowls are in the area. Soak-holes should be used for disposing of washing waters from cleaning application equipment, clothing or hands. These should be at least 30 cm deep and sited well away from wells or watercourses. /Pesticides/

Washing facilities should be available; and eating, drinking and smoking should be prohibited in the area. ... Where a pesticide is of moderate or higher hazard and can be readily absorbed through the skin, special precautions are necessary ... Special arrangements for cleansing clothing and overalls may be necessary; in any case, these should not be left for the worker to wash at home. ... Special care may be taken to provide washing facilites at the workplace, even though this may be in remote fields. Workers should be encouraged to use these rather than bathe themselves in canals and rivers ... /Pesticides/

Triamiphos is an organophosphorus pesticide. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.

Small spills: absorb with sand or other non-combustible absorbent material and place into containers for later disposal.

Small dry spills: with clean shovel place material into clean dry containers and cover; move containers from spill area.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

Pesticides of any degree of toxicity should be transported in containers which are clearly labelled, leak-proof and not easily damaged. They should never be transported beside or above any type of food, and all spillages should be immediately reported. Any foodstuffs transported in the same compartment as a pesticide may thus be held, pending examination to ensure that it has not been in any way contaminated. ... Pesticides of moderate or higher hazard should be stored so that only authorized persons can have access to them. It is particularly important that children should be excluded from any contact with pesticide concentrates or residues. Spillages often occur in storage and repacking rooms and must be cleaned up with care. Rooms used for storage only should be soundly constructed and fitted with secure locks. Floors should be kept clear and the pesticides clearly identified. If repacking is carried out in storage rooms, adequate light should be available; floors should be impervious and sound; washing facilities should be available ... /Pesticides/

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

0.060 [mg/m3]

0.66 [mg/m3]

4.0 [mg/m3]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Triamiphos appears as a solid. Used in the control of powdery mildew on apples and ornamentals. Product discontinued by U.S. supplier. (EPA, 1998)

Colorless or white solid; [HSDB]

White crystals

Colorless crystals

Decomposes on distillation

400 °C @760 [mm Hg]

167-169 °C

Moderately soluble in most common organic solvents except petroleum ether.

250 mg/l in water @ 20 °C

5 g/l in benzene @ 20 °C

30-35 g/l in chloroform @ 20 °C

10-15 g/l in ethanol @ 20 °C

Very low at room temperature

0.0000001 [mm Hg] @25 °C

Stable in neutral solutions and in neutral aqueous dispersions. Hydrolyzes readily in the presence of strong mineral acids; rather stable to alkali.

When heated to decomposition it emits very toxic fumes of /phosphorus oxides and nitrogen oxides/.

Non-corrosive

Pesticides -> Organophosphate Insecticides

No rapid reaction with air. No rapid reaction with water.

Amines, Phosphines, and Pyridines

Azo, Diazo, Azido, Hydrazine, and Azide Compounds

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Organophosphates, such as TRIAMIPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Other Poison - Organophosphate

LD50 Rat oral 20 mg/kg

LD50 Rat percutaneous 48 mg/kg

LD50 Mouse oral 10 mg/kg

LD50 Rabbit percutaneous 1500 mg/kg

Strict routine medical supervision of workers heavily exposed to concentrates, as in the manufacture and packing of pesticides, is essential and should include laboratory tests. /Pesticides/

Honey bees tolerate a diet containing 10 ppm.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Spillages of pesticides at any stage of their storage or handling should be treated with great care. Liquid formulations may be reduced to solid phase by evaporation. Dry sweeping of solids is always hazardous: these should be removed by vacuum cleaning or by dissolving them in water or other solvent in the factory environment. In the field they may be washed away with water into a suitable soak-hole. Contaminated top-soil should be removed and buried if any domestic animals or fowls are in the area. Soak-holes should be used for disposing of washing waters from cleaning application equipment, clothing or hands. These should be at least 30 cm deep and sited well away from wells or watercourses. /Pesticides/