4-nitrosophenol

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P264, P264+P265, P270, P273, P280, P301+P317, P305+P354+P338, P317, P318, P330, P391, P405, and P501 (click each P-code to see the statement)

H242 (20.7%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

H301 (11.7%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (88.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (56.4%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (55.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H411 (88.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

H413 (11.7%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P234, P235, P240, P261, P264, P264+P265, P270, P272, P273, P280, P301+P316, P301+P317, P302+P352, P305+P354+P338, P317, P318, P321, P330, P332+P317, P333+P317, P362+P364, P370+P378, P391, P403, P405, P410, P411, P420, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 188 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 150 [Substances (Self-Reactive / Temperature Controlled)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should keep this material in a tightly-closed container under an inert atmosphere, and store it at refrigerated temperatures. (NTP, 1992)

1.1 [mg/m3]

12 [mg/m3]

71 [mg/m3]

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

P-benzoquinone monoxime is a black solid. (NTP, 1992)

Wet Solid

Pale yellow or light-brown solid; [HSDB] Black solid; [CAMEO] Yellow-brown powder; [MSDSonline]

PALE YELLOW ORTHORHOMBIC NEEDLES, BROWNS @ 126 °C

CRYSTALLIZES IN LIGHT BROWN LEAFLETS

270 to 291 °F (decomposes) (NTP, 1992)

less than 1 mg/mL at 70 °F (NTP, 1992)

MODERATELY SOL IN WATER; SOL IN DILUTE ALKALIES GIVING GREEN TO BROWNISH GREEN SOLUTIONS; SOL IN ALC, ETHER, ACETONE

SOL IN HOT BENZENE

0.15 [mmHg]

KA= 3.3X10-7 @ 25 °C

DECOMPOSES @ 144 °C

Crystal structure

Diamagnetic susceptibility

Diffusion

Electron conductivity

Formula unit

Magnetic susceptibility

Space group

Unit cell

Unit cell parameter

Viscosity

Nitrogen Compounds -> Other Aromatics (Nitrogen)

Insoluble in water.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Phenols and Cresols

Explosive

P-BENZOQUINONE MONOXIME explodes when heated. Explodes on contact with acid, alkali (NTP, 1992).

Neurotoxin - Other CNS neurotoxin

CAN CAUSE SKIN IRRITATION, SENSITIZATION.

P-NITROSOPHENOL WAS NOT MUTAGENIC TOWARDS SALMONELLA TYPHIMURIUM STRAINS TA1530 & TA1535, WHICH ARE SENSITIVE TO N-NITROSO COMPOUNDS, BUT HAD A DIRECT MUTAGENIC EFFECT ON STRAIN TA1538. THIS WAS ACCOMPANIED BY A SIGNIFICANT CYTOTOXIC EFFECT WHICH AGAIN WAS NOT SEEN IN STRAINS TA1530 & TA1535.

WHEN ADMIN ORALLY IN SINGLE DOSE OF 320 MG/KG OR AT 32 MG/KG/DAY FOR 20 DAYS, NITROSOPHENOL CAUSED ACUTE METHEMOGLOBINEMIA, ACCOMPANIED BY ANEMIA. THIS PREPN HAD NO TOXIC EFFECTS WHEN ADMIN AT 1 MG/KG/DAY FOR 6 MONTHS.

Flammable Solid