Sec-Butyl acetate

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 4.9% (16 of 325) of reports.

H225 (94.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]

Aggregated GHS information provided per 325 reports by companies from 10 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria per 16 of 325 reports by companies.

There are 9 notifications provided by 309 of 325 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P319, P332+P317, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

Excerpt from NIOSH Pocket Guide for sec-Butyl acetate:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: WATER FLUSH PROMPTLY - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Fire Extinguishing Agents Not to Be Used: Water may be ineffective

Fire Extinguishing Agents: Foam, carbon dioxide, or dry chemical (USCG, 1999)

Use foam, alcohol-resistant foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

To fight fire, use alcohol foam, CO2, dry chemical.

If material on fire or involved in a fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Butyl acetates/

Water may be ineffective on fire. Cool exposed containers with water.

Fire fighting: Use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

Flashback along vapor trail may occur.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

1) Remove all ignition sources. 2) Ventilate area of spill or leak. 3) For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper towel in suitable location away from combustible materials. Large quantities may be collected & atomized in suitable combustion chamber. sec-Butyl acetate should not be allowed to enter a confined space, such as sewer, because of possibility of explosion.

/Absorb/ it in vermiculite, dry sand, earth or a similar material.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Apply appropriate foam to diminish vapor and fire hazard. /Butyl acetates/

Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Use surface active agent (eg detergent, soaps, alcohols), if approved by EPA. Inject "universal" gelling agent to solidify encircled spill and increased effectiveness of booms. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Butyl acetates/

Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Butyl acetates/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

THE BASIC VENTILATION METHODS ARE LOCAL EXHAUST VENTILATION AND DILUTION OR GENERAL VENTILATION.

Employees should wash promptly when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard.

... A complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation. ... Clothing wet with liquid sec-butyl acetate should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of sec-butyl acetate from the clothing. If the clothing is to be laundered, or otherwise cleaned to remove the sec-butyl acetate, the person performing the operation should be informed of sec-butyl acetate's hazardous properties.

For more Preventive Measures (Complete) data for SEC-BUTYL ACETATE (10 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS DUE TO CONTACT WITH HEAT, MOISTURE, ACIDS OR ACID FUMES, SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & ... PERIODICALLY INSPECTED & MONITORED.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

124 [ppm]

1700 [ppm]

10000 [ppm]

200 ppm (950 mg/m³)

TWA 200 ppm (950 mg/m3)

200.0 [ppm]

1700 ppm ; Based on 10% of the lower explosive limit. (NIOSH, 2024)

1700.0 [ppm]

1700 ppm [IDLH based on 10% of the lower explosive limit for safety consideration even though the relevent toxicological data indicated that irreversible health effects or impairment of escape existed only at higher concentrations.

1700 ppm

1700 ppm [10%LEL]

See: 105464

50.0 [ppm]

150.0 [ppm]

8 hr Time Weighted Avg (TWA): 200 ppm

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

50 ppm as TWA; 150 ppm as STEL.

241 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

· Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The vapour is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

Excerpt from NIOSH Pocket Guide for sec-Butyl acetate:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Watery colorless liquid with a pleasant, fruity odor. Floats on water. Produces irritating vapor. (USCG, 1999)

Colorless liquid with a pleasant, fruity odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a pleasant, fruity odor.

Colorless liquid

HAS FRUITY ODOR CHARACTERISTIC OF ACETATE ESTERS

Pleasant fruity odor

234 °F at 760 mmHg (USCG, 1999)

112 °C @760 [mm Hg]

-100 °F (USCG, 1999)

-98.9 °C

62 °F (USCG, 1999)

31 °C (88 °F) (open cup)

62 °F (closed cup)

17 °C c.c.

0.8 % (NIOSH, 2024)

Miscible with alcohol and ether

Soluble ethanol, ethyl ether; slightly soluble in carbon tetrachloride

In water, 6200 mg/L at 20 °C

Solubility in water, g/100ml at 20 °C: 0.8

0.872 at 68 °F (USCG, 1999) - Less dense than water; will float

0.8748 g/cu cm at 20 °C

Relative density (water = 1): 0.87

0.862-0.866 @ 20°C

4.0 (Air = 1)

Relative vapor density (air = 1): 4.0

51.7 mmHg (USCG, 1999)

17.0 [mmHg]

17 mm Hg at 20 °C /ext/

Vapor pressure, kPa at 20 °C: 1.33

17 [mm Hg] @20 °C

log Kow = 1.72

Heat /contributes to instability/.

When heated to decomp it emits acrid smoke and irritating fumes.

23.3 dynes/cm = 0.0233 N/m at 21 °C

Odor Threshold Low: 3.0 [ppm]

Odor Threshold High: 7.0 [ppm]

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"

Index of refraction: 1.3888 at 20 °C

2.0 (Butyl acetate = 1)

Highly flammable. Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

SEC-BUTYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Dissolves rubber and plastics (USCG, 1999).

Contact with nitrates, strong oxidizers, strong alkalies, and strong acids may cause fires and explosions.

Nitrates; strong oxidizers, alkalis and acids.

Nitrates; strong oxidizers, alkalis & acids

The substance can be absorbed into the body by inhalation of its vapour.

inhalation, ingestion, skin and/or eye contact

Cough. Sore throat. Dizziness. Headache.

Dry skin.

Redness.

irritation eyes; headache; drowsiness; dryness upper respiratory system, skin; narcosis

Eyes, skin, respiratory system, central nervous system

Neurotoxin - Acute solvent syndrome

LCLo (rat) = 24,000 ppm/4h

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Esters and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

Consider initial effects on skin and resp tract in any placement or periodical exam, as well as liver and kidney function.

/HUMAN EXPOSURE STUDIES/ A study of sensory irritation (nasal pungency) associated with a series of homologous ketones and secondary and tertiary alcohols and esters was conducted. The study group consisted of three men and one woman, 41 to 65 years old, who lacked a sense of smell (anosmics) and three men and one woman 41 to 68 years old, with normal olfaction (normosmics). The subjects were exposed to 2-propanone (67641), 2-pentanone (107879), 2-heptanone (110430), 2-nonanone (821556), 2-propanol (67630), 2-methyl-2-propanol (75650), 2-butanol (78922), 4-heptanol (589559), tert-butyl-acetate (540885), and sec-butyl-acetate (105464) vapors at concentrations of 1x10-2 to 1x10+6 ppm by sniffing bottles containing the solvents. They also sniffed bottles containing a blank (nonodoriferous solvent). The subjects were asked to estimate the concentration of each solvent at which they could first detect the odor and perceive nasal pungency. Attempts were made to correlate the thresholds with the concentration of the saturated vapor at ambient temperature (23 °C). Both the normosmics and anosmics could detect the solvent vapors; however, the normosmics detected the vapors at much lower concentrations. The nasal pungency and odor thresholds of the ketones decreased with increasing carbon chain length, but tended to plateau at 2-heptanone. The odor and pungency thresholds of the alcohols tended to increase when the hydroxy group was changed from a primary to a secondary carbon atom. The odor and pungency thresholds of the esters were similar. When plotted against the logarithm of the saturation vapor concentration, the logarithm of the pungency thresholds of the compounds conformed to a linear function that was approximately parallel to the saturation vapor concentration. No association between odor threshold and saturation vapor concentration was seen. The authors conclude that anosmics as well as normosmics can detect odors of volatile organic compounds, although at different concentrations. The pungency threshold data suggest that physical rather than chemical factors are involved in the interaction of volatile organic compounds with the nasal mucosa.

/SIGNS AND SYMPTOMS/ Overexposure to sec-butyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness. Prolonged overexposure may produce irritation of the skin.

/SIGNS AND SYMPTOMS/ Vapors cause slight smarting of the eyes or resp system if present in high concn. ... If spilled on clothing and allowed to remain may cause smarting and reddening of the skin.

/SIGNS AND SYMPTOMS/ In man, exposure to concentrations of 950 ppm for 30 min causes irritation of the nose and eyes, headaches and weakness. The principal symptoms in cases of occupational exposure are headaches and irritation of the mucous membranes of the nose and of the conjunctiva. Other symptoms mentioned include vertigo, palpitations, gastrointestinal disorders, anaemia, cutaneous lesions, dermatitis and affections of the liver.

For more Human Toxicity Excerpts (Complete) data for SEC-BUTYL ACETATE (6 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ Exposure to a concentration of 10000 ppm for 5 hr caused irritation and death in guinea-pigs.

/LABORATORY ANIMALS: Acute Exposure/ Application of the liquid to rabbit eyes caused superficial reversible injury, graded 5 on a scale of 1 to 10. /Butyl acetate/

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Exposure of albino rabbits to 500 ppm for twenty days and to 1000 ppm for four days, and exposure of guinea pigs to 500 ppm for ten days, and 1000 ppm for four days caused no corneal or conjuctival injury detectable by slit- lamp biomicroscopy, and corneal sensation was not altered. /Butyl acetate/

/OTHER TOXICITY INFORMATION/ SEC-BUTYL ACETATE INHIBITED /SRP: THE EFFECT OF/ ACETYLCHOLINE IN THE GUINEA PIG ILEUM.

Environmental effects from the substance have not been investigated adequately.

sec-Butyl acetate's production and use as a solvent for nitrocellulose lacquers, thinners, nail enamels, and leather finishes may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 17 mm Hg at 25 °C indicates sec-butyl acetate will exist solely as a vapor in the atmosphere. Vapor-phase sec-butyl acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 70 hours. sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, sec-butyl acetate is expected to have very high mobility based upon an estimated Koc of 16. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole. sec-Butyl acetate may volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 86% of the theoretical BOD was reached in 2 weeks indicating that biodegradation is an important environmental fate process in soil and water. If released into water, sec-butyl acetate is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 5.4 hours and 5 days, respectively. An estimated BCF of 6 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is expected to occur slowly based upon estimated hydrolysis half-lives of 3.5 years and 128 days at pH 7 and 8, respectively. Occupational exposure to sec-butyl acetate may occur through inhalation and dermal contact with this compound at workplaces where sec-butyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to sec-butyl acetate via ingestion of food containing this compound. (SRC)

... Volatiles formed during fringe process and during a continuous process of malt vinegar manufacture /were measured/. ... sec-Butyl acetate ... was detected during the /initial/ alcoholic fermentation.

sec-Butyl acetate's production and use as a solvent for nitrocellulose lacquers, thinners and leather finishes(1) may lead to its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of sec-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 17 mm Hg(3), and water solubility, 6200 mg/L(4). sec-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 17 mm Hg(4), and water solubility, 6200 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5.4 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 6(SRC), from its log Kow of 1.72(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(9) suggests that biodegradation is an important environmental fate process in water(SRC). Hydrolysis is expected to occur slowly based upon estimated hydrolysis half-lives of 3.5 years and 128 days at pH 7 and 8, respectively(10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-butyl acetate, which has a vapor pressure of 17 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 70 hours(SRC), calculated from its rate constant of 5.5X10-12 cu cm/molecule-sec at 25 °C(3). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: sec-Butyl acetate, present at 100 mg/L, reached 86% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1).

The rate constant for the vapor-phase reaction of sec-butyl acetate with photochemically-produced hydroxyl radicals has been reported as 5.5X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 70 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.06 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 3.5 years and 128 days at pH values of 7 and 8, respectively(2). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 6 was calculated in fish for sec-butyl acetate(SRC), using a log Kow of 1.72(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of sec-butyl acetate can be estimated to be 16(SRC). According to a classification scheme(2), this estimated Koc value suggests that sec-butyl acetate is expected to have very high mobility in soil.

The Henry's Law constant for sec-butyl acetate is estimated as 4.2X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 17 mm Hg(1), and water solubility, 6200 mg/L(2). This Henry's Law constant indicates that sec-butyl acetate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 5.4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). sec-Butyl acetate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of sec-butyl acetate from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

SURFACE WATER: sec-Butyl acetate was identified, not quantified, in 1 of 8 rivers sampled in West Germany(1).

INDOOR AIR: sec-Butyl acetate was detected at an average concentration of 2 ug/cu m in West German homes(1).

sec-Butyl acetate was identified, not quantified, as a volatile flavor component of baked potatoes(1), Beaufort cheese(2), and Gruyere type cheese made in the French Alps(2).

Inhalation, ingestion, skin, and eye contact.

According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use for sec-butyl acetate is 1 to 99 persons; the data may be greatly underestimated(1).

Occupational exposure to sec-butyl acetate may occur through inhalation and dermal contact with this compound at workplaces where sec-butyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to sec-butyl acetate via ingestion of food containing this compound. (SRC)

Environmental effects from the substance have not been investigated adequately.

sec-Butyl acetate's production and use as a solvent for nitrocellulose lacquers, thinners, nail enamels, and leather finishes may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 17 mm Hg at 25 °C indicates sec-butyl acetate will exist solely as a vapor in the atmosphere. Vapor-phase sec-butyl acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 70 hours. sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, sec-butyl acetate is expected to have very high mobility based upon an estimated Koc of 16. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole. sec-Butyl acetate may volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 86% of the theoretical BOD was reached in 2 weeks indicating that biodegradation is an important environmental fate process in soil and water. If released into water, sec-butyl acetate is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 5.4 hours and 5 days, respectively. An estimated BCF of 6 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is expected to occur slowly based upon estimated hydrolysis half-lives of 3.5 years and 128 days at pH 7 and 8, respectively. Occupational exposure to sec-butyl acetate may occur through inhalation and dermal contact with this compound at workplaces where sec-butyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to sec-butyl acetate via ingestion of food containing this compound. (SRC)

... Volatiles formed during fringe process and during a continuous process of malt vinegar manufacture /were measured/. ... sec-Butyl acetate ... was detected during the /initial/ alcoholic fermentation.

sec-Butyl acetate's production and use as a solvent for nitrocellulose lacquers, thinners and leather finishes(1) may lead to its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of sec-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 17 mm Hg(3), and water solubility, 6200 mg/L(4). sec-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 17 mm Hg(4), and water solubility, 6200 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5.4 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 6(SRC), from its log Kow of 1.72(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(9) suggests that biodegradation is an important environmental fate process in water(SRC). Hydrolysis is expected to occur slowly based upon estimated hydrolysis half-lives of 3.5 years and 128 days at pH 7 and 8, respectively(10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-butyl acetate, which has a vapor pressure of 17 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 70 hours(SRC), calculated from its rate constant of 5.5X10-12 cu cm/molecule-sec at 25 °C(3). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: sec-Butyl acetate, present at 100 mg/L, reached 86% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1).

The rate constant for the vapor-phase reaction of sec-butyl acetate with photochemically-produced hydroxyl radicals has been reported as 5.5X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 70 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.06 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 3.5 years and 128 days at pH values of 7 and 8, respectively(2). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 6 was calculated in fish for sec-butyl acetate(SRC), using a log Kow of 1.72(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of sec-butyl acetate can be estimated to be 16(SRC). According to a classification scheme(2), this estimated Koc value suggests that sec-butyl acetate is expected to have very high mobility in soil.

The Henry's Law constant for sec-butyl acetate is estimated as 4.2X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 17 mm Hg(1), and water solubility, 6200 mg/L(2). This Henry's Law constant indicates that sec-butyl acetate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 5.4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). sec-Butyl acetate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of sec-butyl acetate from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

SURFACE WATER: sec-Butyl acetate was identified, not quantified, in 1 of 8 rivers sampled in West Germany(1).

INDOOR AIR: sec-Butyl acetate was detected at an average concentration of 2 ug/cu m in West German homes(1).

sec-Butyl acetate was identified, not quantified, as a volatile flavor component of baked potatoes(1), Beaufort cheese(2), and Gruyere type cheese made in the French Alps(2).

Inhalation, ingestion, skin, and eye contact.

According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use for sec-butyl acetate is 1 to 99 persons; the data may be greatly underestimated(1).

Occupational exposure to sec-butyl acetate may occur through inhalation and dermal contact with this compound at workplaces where sec-butyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to sec-butyl acetate via ingestion of food containing this compound. (SRC)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Butyl acetates/

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Butyl acetates/

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Butyl acetates/

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Butyl acetates/

For more DOT Emergency Guidelines (Complete) data for SEC-BUTYL ACETATE (8 total), please visit the HSDB record page.

UN 1123; Butyl acetates

IMO 3.2; Butyl acetates

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: F; R: 11-66; S: (2)-16-23-25-29-33; Note: C

UN Hazard Class: 3; UN Pack Group: II