1,2-epoxybutane

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H351: Suspected of causing cancer [Warning Carcinogenicity]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1001) of reports.

H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (> 99.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (99.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (> 99.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H351 (> 99.9%): Suspected of causing cancer [Warning Carcinogenicity]

H412 (47.1%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1001 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 1001 reports by companies.

There are 17 notifications provided by 1000 of 1001 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

P273, and P501 (click each P-code to see the statement)

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Fire Extinguishing Agents Not to Be Used: Water may be ineffective.

Fire Extinguishing Agents: Dry chemical, alcohol foam, carbon dioxide (USCG, 1999)

Use foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

... May travel to a source of ignition and flash back.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible); polymerization hazard]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Evacuate danger area! Remove all ignition sources. Personal protection: self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources or ifnition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas...

Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up: contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations...

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for 1-BUTENE OXIDE (6 total), please visit the HSDB record page.

SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge...

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... Clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/

For more Preventive Measures (Complete) data for 1-BUTENE OXIDE (11 total), please visit the HSDB record page.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store it in an explosion-proof refrigerator. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)

Fireproof. Separated from incompatible materials. See Chemical Dangers. Cool. Store only if stabilized. Store in an area without drain or sewer access.

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carfully resealed and kept upright to prevent leakage.

Chemical stability: stable under recommended storage conditions.

Store in a cool, dry, well-ventilated location. Store away from heat, oxidizing materials, and sunlight.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

Level of Distinct Odor Awareness (LOA) = 0.15 ppm

AEGLs Status: Interim

72 [ppm]

140 [ppm]

330 [ppm]

skin absorption (H); carcinogen category: 2

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used.

CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Workplace Environmental Exposure Level (WEEL): 8-hr Time-weighted Average (TWA) 2 ppm. Last Revised: 2003.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes, respiratory tract and skin. Exposure at high levels could cause lowering of consciousness.

This substance is possibly carcinogenic to humans.

Clean protective clothing; rubber gloves; chemical worker's goggles; self-contained breathing apparatus (USCG, 1999)

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).

Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practicies. Wash and dry hands.

Body Protection: Complete suit protecting against chemicals, flame retardant antistatic protective clothing. The type of protective equiment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Repiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate governemtn standards such as NIOSH (US) or CEN (EU).

PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... Gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting.

AVOID ALL CONTACT!

Use closed system or ventilation.

Protective gloves. Protective clothing.

1,2-butylene oxide appears as a clear colorless volatile liquid with an ethereal odor. Flash point near 0 °F. Density about 6.9 lb / gal. Soluble in water. Boiling point near 140 °F. Flammable over a wide range of vapor-air concentrations. May polymerize with the evolution of heat and possible rupture of container if contaminated. Vapors irritate eyes, skin and respiratory system. Prolonged contact with skin may cause in delayed burns. Vapors are heavier than air. Used as an intermediate to make various polymers. Chemicals that polymerize are often stabilized by refrigeration.

Colorless liquid with a characteristic odor; [ICSC] Colorless liquid with an unpleasant odor; May decompose on exposure to moisture; [MSDSonline]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid

Disagreeable odor

Sweetish, somewhat like butyric acid, and disagreeable

145 °F at 760 mmHg (NTP, 1992)

63.3 °C @760 [mm Hg]

-76 °F (NTP, 1992)

10 °F (NTP, 1992)

-7 °F (-22 °C) (closed cup)

-22 °C c.c.

greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)

In water, 95.5 g/L at 25 °C (OECD Method 105)

In water, 8.68 g/100 g water at 25 °C

In water, 59 g/L at 20 °C

Very soluble in ethanol, acetone; miscible with ether

Miscible with common aliphatic and aromatic solvents

Solubility in water, g/100ml at 20 °C: 5.9 (moderate)

0.826 at 77 °F (USCG, 1999) - Less dense than water; will float

0.8297 g/cu cm at 20 °C

0.83 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.3

0.8312 @ 20°C

2.49 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

2.49 (Air = 1)

Relative vapor density (air = 1): 2.2

160 mmHg at 55 °F ; 215 mmHg at 70.0 °F (NTP, 1992)

180.0 [mmHg]

170 mm Hg at 24 °C

Vapor pressure, kPa at 20 °C: 18.8

180 [mm Hg] @25 °C

log Kow = 0.68 (OECD Method 107)

959 °F (USCG, 1999)

822 °F (439 °C)

When heated to decomposition it emits acrid smoke and fumes.

0.40 mPa.s at 25 °C

-15,200 btu/lb (-8,470 cal/g or -3.54X10+7 J/kg)

30.3 kJ/mol at 63.4 °C

Approximately 7 at 50 g/L at 20 °C

Highly flammable. Soluble in water and may decompose upon contact with water.

Epoxides

Polymerizable Compounds

Highly Flammable

Polymerizable

Epoxides, such as 1,2-BUTYLENE OXIDE, are highly reactive. They polymerize in the presence of catalysts or when heated. Contact with anhydrous metal halides; amino, hydroxyl and carboxyl functions; inorganic acids and charcoal may cause polymerization. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

Incompatible materials: Oxidizing agents.

IDENTIFICATION AND USE: 1-Butene oxide is a colorless liquid with a pungent, disagreeable, sweetish odor, somewhat like butyric acid. It is used as an intermediate, for various polymers, a stabilizer for chlorinated solvents, and a corrosion inhibitor. 1-Butene oxide is also used as an acid scavenger for chlorine-containing materials such as trichloroethylene and to react with ammonia to produce alkanolamines. HUMAN EXPOSURE AND TOXICITY: 1-Butene oxide is possibly carcinogenic to humans (Group 2B). ANIMAL STUDIES: 1-Butene oxide was irritating to the eyes. Irritating effects to the skin were severe (corrosion) if evaporation was minimized due to occlusive application, but there was no effect by semi-occlusive application. It was not sensitizing in a guinea pig maximization test. In 90-day inhalation studies with rats and mice 1-butene oxide mainly caused nasal lesions. Systemic effects occurred at higher concentrations (rat 2400 mg/cu m: decreased mean body weight gain; mice 2400 mg/cu m: e.g. renal tubular necrosis). There is clear evidence for 1-butene oxide being a locally acting carcinogen in male rats (inhalation of 600 mg/cu m caused no tumors and 1,200 mg/cu m caused neoplasms of the nasal cavity and the lung of male rats) and there is equivocal evidence for a carcinogenic activity in female rats. There was no evidence for carcinogenic activity in male or female mice. 1-Butene oxide was genotoxic in vitro. However, it did not cause chromosomal aberrations in bone marrow or dominant-lethal mutations in germ cells of rats. With respect to reproductive toxicity the 90 day studies with rat and mice did not reveal adverse effects on the reproductive organs up to 2400 mg/kg body weight. Additionally, the lack of an effect from pre-gestational exposure in the developmental toxicity study and a negative dominant-lethal test may indicate that 1,2-epoxybutane does not reach male and female germ cells in effective concentrations. No developmental toxicity or teratogenicity was detected in rats after inhalation of up to 3,000 mg/cu m throughout gestation.

1,2-Epoxybutane (EBU)

Respiratory

2 x 10 ^-2 mg/m^3

Evaluation: No epidemiological data relevant to the carcinogenicity of 1,2-epoxybutane were available. There is limited evidence in experimental animals for the carcinogenicity of 1,2-epoxybutane. Overall evaluation: 1,2-Epoxybutane is possibly carcinogenic to humans (Group 2B). In making the overall evaluation, the Working Group took into consideration that 1,2-epoxybutane is a direct acting alkylating agent which is mutagenic in a range of test systems.

1,2-Epoxybutane

Group 2B: Possibly carcinogenic to humans

Volume 47: (1989) Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting

Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

NB Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data

TR-329: Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1988 )

08/19/86

Clear Evidence

Equivocal Evidence

No Evidence

Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined). There was equivocal evidence of carcinogenic activity for female F344/N rats, as shown by the presence of papillary adenomas of the nasal cavity. There was no evidence of carcinogenic activity for male or female B6C3F1 mice exposed at 50 or 100 ppm. 1,2-Epoxybutane exposure was associated with adenomatous hyperplasia and inflammatory lesions of the nasal cavity in rats and inflammatory lesions of the nasal cavity in mice.

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Cough. Sore throat. Laboured breathing. Headache. Drowsiness.

Redness.

Redness. Pain.

Abdominal pain. See Inhalation.

Neurotoxin - Other CNS neurotoxin

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

IRIS Current

LC50 (rat) = 6,300 mg/m3/4h

LD50 rat (oral) 900 mg/kg body weight

LC50 rat (inhalation, 4 hr) > 6,300 < 20,000 mg/cu m

LD50 rabbit (dermal) 1,757 (1,255 - 2,546) mg/kg body weight

LD50 Rat oral 1,170 mg/kg

For more Non-Human Toxicity Values (Complete) data for 1-BUTENE OXIDE (7 total), please visit the HSDB record page.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene oxide and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . Treat frostbite with rapid rewarming techniques ... . /Ethylene oxide and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary. Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethylene oxide and related compounds/

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

/LABORATORY ANIMALS: Acute Exposure/ 1,2- Epoxybutane was not sensitizing in a guinea pig maximisation test.

/LABORATORY ANIMALS: Acute Exposure/ It was irritating to the eyes. Irritating effects to the skin were severe (corrosion) if evaporation was minimized due to occlusive application, but there was no effect by semi-occlusive application.

/LABORATORY ANIMALS: Acute Exposure/ ... rated 4 on rabbit eyes. ... Tested externally on eyes of rabbits ... paying particular attention to condition of cornea. Most severe injuries have been rated 10.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In a 14-day Inhalation study rats and mice were exposed to 0, 400, 800, 1600, 3200, or 6400 ppm (0, 1200, 2400; 4800, 9600, 19000 mg/cu m 1,2-Epoxybutane (5 males and 5 females of each species). All rats at 9600 and 19000 mg/cu m and 2/5 female rats at 4800 mg/cu m died, all mice at 4800, 9600, 19000 mg/cu m and 1/5 male mice at 2400 mg/cu m died. Erratic movements and piloerection were compound-related effects in rats exposed at 4800 mg/cu m. Clinical signs observed in mice at 2400 mg/cu m included dyspnea and listlessness on the first exposure day. Final mean body mass of surviving rats exposed at 2400 or 4800 mg/m3 were 12% -33% lower than those of the controls; final mean body weights of surviving mice at 2400 mg/cu m were 10% -12% lower than those of the OECD SIDS 1,2-EPOXYBUTANE 12 UNEP PUBLICATIONS controls.Necropsy was performed on all animals, tissues for the following animals examined histologically for rats: 1 male at 9600 mg/cu m, 2 males and 2 females at 4800 mg/cu m, 1 male at 2400 mg/cu m and for mice: 2 males at 4800 mg/cu m , 2 males and 1 female at 2400 mg/cu m, 1 male at 1200 mg/cu m. Compound-related lesions included pulmonary hemorrhage and rhinitis in rats at 4800 mg/m3 and nephrosis in mice at 2400 and 4800 mg/cu m.

1.60e+02

6.70e+02

2.10e+01

8.80e+01

4.20e+01

2.00e+00

9.20e-03

2.00e-02

Volatile

1.53e+04

4.80e+02

2.00e+03

6.30e+01

2.60e+02

1.30e+02

The substance is harmful to aquatic organisms.

1-Butene oxide's production and use as an intermediate for various polymers and use as a stabilizer for chlorinated solvents may result in its release to the environment through various waste streams. Evaporation of 1-butene oxide into the atmosphere is likely to occur as stabilized chlorinated solvents evaporate with their use in metal cleaning and degreasing operations. Its use as an inert ingredient in pesticides for non-food uses may result in its direct release to the environment. 1-Butene oxide may be formed in the ambient atmosphere via reaction of alkenes with atmospheric oxidants. If released to air, a vapor pressure of 170 mm Hg at 24 °C indicates 1-butene oxide will exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-butene oxide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 8.4 days. 1-Butene oxide may react with tropospheric aerosols and water to yield 1,2-butanediol through hydrolysis, especially under acidic atmospheric conditions. If released to soil, 1-butene oxide is expected to have very high mobility based upon an estimated Koc of 10. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 1.7X10-4 atm-cu m/mole. 1-Butene oxide is expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 100% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is an important environmental fate process in soil and water. Other screening tests also indicate that 1-butene oxide is readily biodegradable. Some degradation may occur in moist soils via hydrolysis. If released into water, 1-butene oxide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Aerobic aqueous biodegradation screening studies indicate that 1-butene oxide will biodegrade readily. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 6.9 hours and 4.7 days, respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. 1-Butene oxide has an aqueous hydrolysis half-life of about 6.5 days at pH 7 and 25 °C. In seawater, the hydrolysis rate may be accelerated by at least 30% due to chloride ion reaction. Occupational exposure to 1-butene oxide may occur through inhalation and dermal contact with this compound at workplaces where 1-butene oxide is produced or used. Use data indicate that the general population may be exposed to 1-butene oxide via inhalation of ambient air. Occupational and consumer exposure are likely where chlorinated solvents are used. (SRC)

Epoxides, such as 1-butene oxide, can be formed in the ambient atmosphere via reaction of alkenes with various atmospheric oxidants such as atomic oxygen, ozone and nitrate radicals(1). Epoxides are the major product of the reaction of alkenes with atomic oxygen(1).

1-Butene oxide's production and use as an intermediate for various polymers and use as a stabilizer for chlorinated solvents(1) may result in its release to the environment through various waste streams(SRC). Its use as an inert ingredient in pesticides for non-food uses(2) may result in its direct release to the environment(SRC). Evaporation of 1-butene oxide into the atmosphere is likely to occur as stabilized solvents evaporate with their use in metal cleaning and degreasing operations(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 1-butene oxide is expected to have very high mobility in soil(SRC). Volatilization of 1-butene oxide from moist soil surfaces is expected to be an important fate process(SRC), given an estimated Henry's Law constant of 1.70X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 170 mm Hg(3), and its water solubility, 95,500 mg/L(4). 1-Butene oxide is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure. A 100% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC). Results of various biodegradation screening tests suggest that 1-butene oxide is readily biodegradable(3). 1-Butene oxide has an aqueous hydrolysis half-life of about 6.5 days at pH 7 and 25 °C(3,4); therefore, hydrolysis may be an important fate process in moist soils(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 1-butene oxide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a estimated Henry's Law constant of 1.7X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 170 mm Hg(4), and its water solubility, 95,500 mg/L(4). Using this Henry's Law constant and an estimation method(2), volatilization half-lives for a model river and model lake are 6.9 hours and 4.7 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.68(3) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 100% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is an important environmental fate process in water(SRC). Results of various biodegradation screening tests suggest that 1-butene oxide is readily biodegradable(3). The epoxides (such as butene oxide) degrade in water by hydrolysis and related ionic reactions to glycols(7); hydrolysis of 1-butene oxide yields 1,2-butene glycol (also known as 1,2-butanediol)(7). 1-Butene oxide has an aqueous hydrolysis half-life of about 6.5 days at pH 7 and 25 °C(3,4). In seawater, the hydrolysis rate of the similar 1-propene oxide is accelerated by at least 30% due to chloride ion reaction(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-butene oxide, which has a vapor pressure of 170 mm Hg at 24 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase 1-butene oxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is 8.4 days(SRC), calculated from its rate constant of 1.91X10-12 cu cm/molecule-sec at 25 °C(3). Epoxides, such as 1-butene oxide, may be formed in the ambient atmosphere via reaction of alkenes with various atmospheric oxidants(4). 1-Butene oxide may react with tropospheric aerosols and water to yield 1,2-butanediol through hydrolysis, especially under acidic conditions(4).

AEROBIC: 1-Butene oxide, present at 100 mg/L, reached 100% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(1); 1,2-butanediol was formed as the degradation product(1). 1-Butene oxide failed the ready biodegradability test (OECD 301D, closed bottle, sewage sludge test) with 17% degradation after 29-30 days(2,3). In a CO2-Headspace test according to ISO 14593 (activated sludge, domestic, non-adapted), 80-90% degradation of 1-butene oxide was reached within 28 days which classified the compound as readily biodegradable(3,4). Using OECD Guideline 301A (new version, Ready Biodegradability: DOC Die Away Test), 80-90% degradation was reached within 28 days(3,4). A conclusion from the available test results is that 1-butene oxide is readily biodegradable(3).

The rate constant for the vapor-phase reaction of 1-butene oxide with photochemically-produced hydroxyl radicals is 1.91X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of 8.4 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). The rate constant for the reaction of hydroxyl radicals in aqueous solutions at pH 9 is 7.8X10+8 L/mol-sec(3); this corresponds to an aquatic half-life of 2.9 years at an aquatic concentration of 1X10-17 hydroxyl radicals per liter(4). The epoxides (such as butene oxide) degrade in water by hydrolysis and related ionic reactions to glycols(5); hydrolysis of 1-butene oxide yields 1,2-butene glycol (also known as 1,2-butanediol)(5). The hydrolysis rate of 1-butene oxide may be similar to the hydrolysis rate of propene oxide(SRC). Propene oxide has hydrolysis half-lives of 6.6, 11.6, and 11.6 days at respective pHs of 5, 7, and 9 at 25 °C(5); in seawater, the hydrolysis rate of propene oxide is accelerated by at least 30% due to chloride ion reaction(5). 1-Butene oxide has a reported hydrolysis half-life of 157 hours (6.54 days) at pH 7(6). 2-Butene oxide (2,3-epoxybutane) has a reported hydrolysis half-life of 15.7 days at 25 °C(7). The acid-catalyzed rate constant of 1-butene oxide was measured as 0.074/M-sec at 24 °C with 1,2-butanediol as the hydrolysis product(8); this corresponds to a half-life of about 3 years at pH 7(SRC), but it ignores the neutral hydrolysis rate constant.

An estimated BCF of 3 was calculated in fish for 1-butene oxide(SRC), using a log Kow of 0.68(1) and a regression-derived equation(2). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-butene oxide can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-butene oxide is expected to have very high mobility in soil.

The Henry's Law constant for 1-butene oxide is estimated as 1.7X10-4 atm-cu m/mole(SRC), derived upon its vapor pressure, 170 mm Hg(1), and water solubility, 95,500 mg/L(2). This Henry's Law constant indicates that 1-butene oxide is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 6.9 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 4.7 days(SRC). 1-Butene oxide's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1-Butene oxide is expected to volatilize from dry soil surfaces based upon its vapor pressure(SRC).

Trace concentrations of small soluble epoxides (such as 1-butene oxide) are suspected byproducts of drinking water ozonation(1).

According to the 2012 TSCA Inventory Update Reporting data, 2 reporting facilities estimate the number of persons reasonably likely to be reporting information on chemical production and exposed in their respective industrial use in the United States manufacturing, processing, or use of Oxirane, 2-ethyl- (CAS 106-88-7), may be as low as <10 workers up to the range of 100-499 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 261,650 workers (42,961 of these are female) are potentially exposed to 1-butene oxide in the US(1). Occupational exposure to 1-butene oxide may occur through inhalation and dermal contact with this compound at workplaces where 1-butene oxide is produced or used(SRC). Use data indicate that the general population may be exposed to 1-butene oxide via inhalation of ambient air(SRC). At the workplace at BASF AG, the measured concentrations of 1-butene oxide were 1.89 mg/cu m (95% percentile) during 1979 to 2000 and can occur in the following activities: sampling, cleaning/maintenance, filling, dispersive use in laboratories, pilot plants and workshops(2).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for 1-BUTENE OXIDE (6 total), please visit the HSDB record page.

/GUIDE 127P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /1,2-Butylene oxide, stabilized/

/GUIDE 127P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. /1,2-Butylene oxide, stabilized/

/GUIDE 127P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /1,2-Butylene oxide, stabilized/

/GUIDE 127P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /1,2-Butylene oxide, stabilized/

For more DOT Emergency Guidelines (Complete) data for 1-BUTENE OXIDE (8 total), please visit the HSDB record page.

3022 127P

UN 3022; 1,2-Butylene oxide, stabilized

IMO 3; 1,2-Butylene oxide, stabilized

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. /1,2-Butylene oxide, stabilized/

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. /1,2-Butylene oxide, stabilized/

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Flammable Liquid

Airtight.

Symbol: F, Xn; R: 11-20/21/22-36/37/38-40-52/53; S: (2)-9-16-29-36/37-61

UN Hazard Class: 3; UN Pack Group: II