allylglycidylether

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (39.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (60.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H361 (99.7%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H412 (96.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 375 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P320, P321, P330, P332+P317, P333+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P320, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H361f: Suspected of damaging fertility [Warning Reproductive toxicity]

Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use powder, foam, carbon dioxide, water. In case of fire: keep drums, etc., cool by spraying with water.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in inert absorbent. Wash away remainder with plenty of water. Store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Clothing which becomes contaminated with allyl glycidyl ether should removed immediately and placed in closed containers for storage until it can be discarded or until provision is made for removal of alllyl glycidyl ether from clothing. If the clothing is to be laundered or cleaned, the person performing the operation should be informed of allyl glycidyl ether's hazardous properties.

Where there is any possibility of a worker's eyes being exposed to AGE, an eye-wash fountain should be provided within the immediate work area for emergency use. ...

Where there is any possibility of a worker's body being exposed to AGE, facilities for quick drenching of the body should be provided within the immediate work area for emergency use. ...

For more Preventive Measures (Complete) data for ALLYL GLYCIDYL ETHER (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids. Cool. Keep in the dark.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

5 ppm (22 mg/m³)

10 ppm (44 mg/m³)

TWA 5 ppm (22 mg/m3) ST 10 ppm (44 mg/m3) [skin]

10 ppm (45 mg/m³)

C 10 ppm (45 mg/m3) See Appendix G

50 ppm (NIOSH, 2024)

50.0 [ppm]

Excerpts from Documentation for IDLHs: Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 270 ppm [Hine et al. 1956] cited in ACGIH [1971], AIHA [1965], and Patty [1963]. . . . Basis for revised IDLH: The revised IDLH for allyl glycidyl ether is 50 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

See: 106923

1.0 [ppm]

8 hr Time Weighted Avg (TWA): 1 ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

A4; Not classifiable as a human carcinogen.

1 ppm as TWA; A4 (not classifiable as a human carcinogen).

carcinogen category: 2; skin absorption (H); sensitization of skin (SH)

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

· Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

Corrosive. The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Exposure could cause central nervous system depression. Exposure could cause lowering of consciousness. Medical observation is indicated.

Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. May cause genetic damage in humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. This substance is possibly carcinogenic to humans.

Excerpt from NIOSH Pocket Guide for Allyl glycidyl ether:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.

Allyl glycidyl ether appears as a colorless liquid with a pleasant odor. Slightly less dense than water and insoluble in water. Hence floats on water. Poisonous by ingestion and mildly toxic by inhalation and skin contact. Very irritating to skin and eyes. Used to make other chemicals.

Colorless liquid with a pleasant odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a pleasant odor.

COLORLESS LIQUID

Colorless liquid ...

CHARACTERISTIC, NOT UNPLEASANT ODOR

... Pleasant odor.

309 °F at 760 mmHg (NTP, 1992)

153.9 °C AT 760 MM HG

-148 °F (NTP, 1992)

FREEZING POINT: FORMS GLASS @ -100 °C

-148 °F [forms glass]

135 °F (NTP, 1992)

135 °F (OPEN CUP)

45 °C c.c.

greater than or equal to 100 mg/mL at 65.3 °F (NTP, 1992)

14.1% IN WATER; MISCIBLE WITH ACETONE, TOLUENE, & OCTANE

Solubility in water, g/100ml: 14 (freely soluble)

0.969 at 68 °F (NTP, 1992) - Less dense than water; will float

SP GR: 0.9698 AT 20 °C/40 °C

Relative density (water = 1): 0.97

3.94 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

3.32 @ 25 °C (AIR= 1)

Relative vapor density (air = 1): 3.9

3.6 mmHg at 68 °F ; 5.8 mmHg at 86 °F (NTP, 1992)

4.7 [mmHg]

4.7 MM HG AT 25 °C

Vapor pressure, kPa at 25 °C: 0.63

0.46 (estimated)

Odor Threshold Low: 9.4 [ppm]

Odor threshold from HSDB

44 mg/cu m odor low; 44 mg/cu m odor high.

INDEX OF REFRACTION: 1.4348 @ 20 °C

Flammable agents - 2nd degree

Reactive agents - 1st degree

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Plastics & Rubber -> Glycidyl Ethers

Flammable. Insoluble in water.

Hydrocarbons, Aliphatic Unsaturated

Epoxides

Polymerizable Compounds

Polymerizable

Peroxidizable Compound

ALLYL GLYCIDYL ETHER reacts violently with oxidizing agents. Can form peroxides. Polymerizes readily [Handling Chemicals Safely 1980. p.128].

Strong oxidizers.

Strong oxidizers

1-Allyloxy-2,3-epoxypropane

B*: Compounds that form peroxides on concentration (distillation/evaporation)

Bretherick's

Detonation during distillation despite negative peroxide test result (some chemicals may require multiple testing methods). See Bretherick's.

A4; Not classifiable as a human carcinogen.

Allyl Glycidyl Ether

TR-376: Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies) (1990 )

06/27/89

Equivocal Evidence

No Evidence

Some Evidence

Under the conditions of these 2-year inhalation studies, there was equivocal evidence of carcinogenic activity of allyl glycidyl ether for male Osborne-Mendel rats, based on the presence of one papillary adenoma of respiratory epithelial origin, one squamous cell carcinoma of respiratory epithelial origin, and one poorly differentiated adenocarcinoma of olfactory epithelial origin, all occurring in the nasal passage of males exposed to 10 ppm. There was no evidence of carcinogenic activity of allyl glycidyl ether for female rats. One papillary adenoma of the respiratory epithelium was present in a female rat exposed to 5 ppm. There was some evidence of carcinogenic activity of allyl glycidyl ether for male B6C3F1 mice, based on the presence of three adenomas of the respiratory epithelium, dysplasia in four males, and focal basal cell hyperplasia of the respiratory epithelium in seven males in the nasal passage of mice exposed to 10 ppm. There was equivocal evidence of carcinogenic activity of allyl glycidyl ether for female mice, based on the presence of one adenoma of the respiratory epithelium and focal basal cell hyperplasia of the respiratory epithelium in seven females exposed to 10 ppm. The sensitivity of the assay to detect potential carcinogenicity may have been reduced in male rats because of poor survival in all groups.

In exposed mice, body weights were decreased 10% or more, mortality was decreased, and there were lower incidences of liver neoplasms (males) and pituitary gland adenomas (females) compared with controls.

Significant exposure-related nonneoplastic lesions were restricted to the nasal passage in both rats and mice and induced inflammation, metaplasia, respiratory epithelial hyperplasia, and olfactory epithelial degeneration. Basal cell hyperplasia and dysplasia of the respiratory epithelium of the nasal passage were found only in the mice.

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough. Sore throat. Burning sensation. Drowsiness. Lethargy.

MAY BE ABSORBED! Dry skin. Redness. Pain. Blisters.

Redness. Pain. Blurred vision. Severe deep burns.

Burning sensation. Headache. Dullness. Drowsiness. Nausea. Vomiting.

irritation eyes, skin, nose, respiratory system; dermatitis; pulmonary edema; narcosis; possible hematopoietic, reproductive effects

Eyes, skin, respiratory system, blood, reproductive system

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

ACGIH Carcinogen - Not Classifiable.

LC50 (rat) = 670 ppm/8H

LD50 Rabbit percutaneous 2.55 g/kg

LC50 Mouse inhalation 270 ppm/4 hours

LC50 Rat inhalation 670 ppm/8 hr

LD50 Mouse intragastric 0.39 g/kg

LD50 Rat intragastric 1.60 g/kg

SEVERAL CASES OF DERMATITIS AND 1 CASE OF EYE IRRITATION CONSTITUTE THE HUMAN DATA.

Allyl glycidyl ether is a CNS depressant and also causes acute pulmonary edema. It is classified as slightly toxic after oral administration and percutaneous application, appreciably irritating and injurious to the eyes and skin, capable of causing skin sensitization in human subjects ... .

Short-term (acute): Exposure to AGE can cause moderate irritation of the skin and severe irritation of the eyes and respiratory tract. Long-term (chronic): Exposure to AGE can cause dermatitis with itching, swelling, and blisters. Skin sensitization to AGE and cross sensitization with other epoxy agents can also occur.

Dermal contact is the usual mode of exposure, but droplets in mist can also attack the eyes and respiratory tract. Glycidyl & diglycidyl ethers tend to be irritants and sensitizing agents. /Glycidyl & diglycidyl ethers/

... CLASSIFIED AS A MODERATE PRIMARY SKIN IRRITANT AND SEVERE EYE IRRITANT. ... SYSTEMIC TOXICITY TO RATS WAS OBSERVED AFTER 50 DAILY, 7 HOUR EXPOSURES AT 260, 400 AND 900 PPM, MANIFESTED BY INCREASED WEIGHT GAIN AT 260 PPM, AND HIGH MORTALITY AT 600 AND 900 PPM.

KIDNEYS OF ... /RATS/ EXPOSED TO 400 PPM /50 DAYS/ ... EXCESSIVE KIDNEY-BODY WT RATIOS. 260 PPM ... VERY SLIGHT IRRITATION OF EYES & SLIGHT RESPIRATORY DISTRESS. AT HIGHER LEVELS CORNEAL OPACITIES ... & SEVERE RESPIRATORY DIFFICULTIES. ... AUTOPSY SHOWED BRONCHOPNEUMONIA, EMPHYSEMA, BRONCHIECTASIS, PNEUMONITIS & HEMORRHAGE.

/AT LEVELS HIGHER THAN 260 PPM AUTOPSY OF RATS EXPOSED 50 DAYS REVEALED/ ... MOTTLED DISCOLORATION OF THE LIVER & ENLARGED ADRENAL GLANDS. 2 ANIMALS EXPOSED TO 900 PPM HAD NECROTIC SPLEENS. ... PREDOMINANT TOXICOLOGIC ACTIVITY WAS DEPRESSION OF CNS AFTER INTRAGASTRIC ADMINISTRATION.

ADMIN TO MICE & RATS ORALLY PRODUCED MODERATE DEPRESSION & DYSPNEA WITHIN 15-19 MIN. DEATH OCCURRED IN 4 HR TO 5 DAYS. ... @ AUTOPSY HYPOTONICITY OF ENTERIC TRACT & EXTENSIVE ADHESIONS OF STOMACH WALLS TO ADJACENT TISSUES WERE NOTED. NO CHARACTERISTIC MICROSCOPIC PATHOLOGY OCCURRED ... .

For more Non-Human Toxicity Excerpts (Complete) data for ALLYL GLYCIDYL ETHER (12 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=106-92-3]

Toxicology and carcinogenesis studies were conducted by exposing groups of 50 Osborne-Mendel rats and B6C3F1 mice of each sex to allyl glycidyl ether (greater than 97% pure) by inhalation for 6 hr/day, 5 days/wk for ... 2 yr. ... Under the conditions of these 2 yr inhalation studies, there was equivocal evidence of carcinogenic activity of allyl glycidyl ether for male Osborne-Mendel rats, based on the presence of one papillary adenoma of respiratory epithelial origin, one squamous cell carcinoma of the respiratory epithelial origin, and one poorly differentiated adenocarcinoma of olfactory epithelial origin, all occurring in the nasal passage of males exposed to 10 ppb. There was no evidence of carcinogenic activity of allyl glycidyl ether for female rats. One papillary adenoma of the respiratory epithelium was present in a female rat exposed to 5 ppm. There was some evidence of carcinogenic activity of allyl glycidyl ether for male B6C3F1 mice based on the presence of three adenomas of the respiratory epithelium, dysplasia in four males, and focal basal cell hyperplasia of the respiratory epithelium in seven males in the nasal passage of mice exposed to 10 ppm. There was equivocal evidence of carcinogenic activity of allyl glycidyl ether for female mice, based on the presence of one adenoma of the respiratory epithelium and focal basal cell hyperplasia of the respiratory epithelium in seven females exposed to 10 ppm. The sensitivity of the assay to detect potential carcinogenicity may have been reduced in male rats because of poor survival in all groups.

The mutagenicity of allyl glycidyl ether (AGE) was evaluated in Salmonella tester strains TA98 and TA1535, both in the presence and absence of added metabolic activation by either Aroclor-induced or phenobarbitol-induced rat liver S9 fraction. AGE was tested for mutagenicity at concentrations of 0.5, 1.0 and 2.0 micromoles/plate using the plate incorporation method. AGE caused a positive response in tester strain 1535 at 2.0 micromoles/plate in the presence of metabolic activation by Aroclor-induced rat liver S9 fraction.

LD50 Goldfish 78 mg/l/24 hr /Conditions of bioassay not specified/

LD50 Goldfish 30 mg/l/96 hr /Conditions of bioassay not specified/

The substance is harmful to aquatic organisms.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for ALLYL GLYCIDYL ETHER (8 total), please visit the HSDB record page.

UN 2219; Allyl glycidyl ether

IMO 3.3; Allyl glycidyl ether

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: Xn; R: 10-20/22-37/38-40-41-43-52/53-62-68; S: (2)-24/25-26-36/37/39-61

UN Hazard Class: 3; UN Pack Group: III