Ethylenediamine

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2078) of reports.

H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]

H302+H332 (11.5%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]

H302 (99.8%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (28.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H312 (73.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (> 99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (38.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332 (27.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H334 (> 99.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H412 (49.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2078 reports by companies from 35 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 2078 reports by companies.

There are 34 notifications provided by 2077 of 2078 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.

Signs and Symptoms of Acute Ethylenediamine Exposure: Acute exposure to ethylenediamine may result in cough, difficulty in breathing, irritation of the lungs, and pneumonia. Nausea, vomiting, and diarrhea are often seen. Contact with ethylenediamine may result in redness, pain, irritation, and burns.

Emergency Life-Support Procedures: Acute exposure to ethylenediamine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to ethylenediamine.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. Transport to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to ethylenediamine.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Thoroughly wash exposed skin areas with water for at least 15 minutes.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. Transport to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. DO NOT induce vomiting.

4. Activated charcoal is of no value.

5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.

6. Transport to a health care facility. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

Wear full protective clothing including gloves and boots. If necessary to enter closed area, wear full-faced gas masks with self-contained breathing apparatus. Use water spray, dry chemical, alcohol foam, or carbon dioxide. Do not use water in case of drum or tank fires. If a leak or spill has not ignited, use water spray to reduce the vapors and dilute spills to nonflammable mixtures. Use water to keep fire-exposed containers cool. (EPA, 1998)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Use water spray, dry chem, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams may be ineffective and spread material.

Do not use water in case of drum or tank fires.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Collect the spilled substance into containers. The container should be made of the same material as the original container.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in the liq form, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. ... 4. If in the solid form, collect, allow to melt, and dispose of the liq as above.

Overspread /spill with/ sufficient sodium bisulfate and sprinkle water.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Ethylenediamine may be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Catalytic /destruction/ of waste gases from ethylenediamine production is described.

Removal of ethylenediamine from wastewater using ion exchange is described.

CARE MUST BE TAKEN IN HANDLING BECAUSE OF CAUSTIC NATURE OF ETHYLENEDIAMINE & IRRITATING PROPERTIES OF ITS VAPOR.

Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. Respirators may also be used for operations which require entry into tanks or closed vessels, and in emergency situations. ... If employees' clothing has had any possibility of being contaminated with solid ethylenediamine, employees should change into uncontaminated clothing before leaving the work premises. Clothing which has had any possibility of being contaminated with solid or liquid ethylenediamine should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of ethylenediamine from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the ethylenediamine the person performing the operation should be informed of ethylenediamine's hazardous properties. Where there is any possibility of exposure of an employee's body to solid or liquid ethylenediamine, facilities for quick drenching of the body should be provided within the immediate work area for emergency use. Any clothing which becomes wet with liquid ethylenediamine or non-impervious clothing which becomes contaminated with ethylenediamine should be removed immediately and not reworn until the ethylenediamine is removed from the clothing. ... Skin that becomes contaminated with ethylenediamine should be immediately washed or showered to remove any ethylenediamine. Workers subject to skin contact with solid or liquid ethylenediamine should wash any areas of the body which may have contacted ethylenediamine at the end of each work day. Eating and smoking sould not be permitted in areas where solid or liquid ethylenediamine are handled, processed, or stored. Employees who handle solid or liquid ethylenediamine should wash their hands thoroughly before eating, smoking, or using toilet facilities.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

For more Preventive Measures (Complete) data for ETHYLENEDIAMINE (9 total), please visit the HSDB record page.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, acids, chlorinated organic compounds and food and feedstuffs. Cool. Well closed. Store only in original container.

Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

NR = Not recommended due to insufficient data.

AEGLs Status: Final

0.88 [ppm]

9.7 [ppm]

20 [ppm]

10 ppm (25 mg/m³)

TWA 10 ppm (25 mg/m3)

10.0 [ppm]

1000 ppm (NIOSH, 2024)

1000.0 [ppm]

Excerpts from Documentation for IDLHs: Other animal data: It has been reported that rats have survived an 8­hour exposure to 2,000 ppm [Smyth et al. 1951]. \\ Human data: It has been reported that workers will not stay in concentrations of 2,000 ppm [UCC 1971].

1000 ppm

See: 107153

8 hr Time Weighted Avg (TWA): 10 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

A4: Not classifiable as a human carcinogen.

10 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen).

10 ppm [1990]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Table: AEGLs for ETHYLENE DIAMINE (ppm) [Table#1533]

Max allowable concn (USSR) 2 mg/cu m

Ethylenediamine appears as a clear colorless liquid with an ammonia-like odor. Flash point of 91 °F and a melting point of 47 °F. Corrosive to tissue. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Density 7.5 lb / gal. Used to make other chemicals and as a fungicide.

CBI; Liquid; Other Solid; Liquid

Colorless, viscous liquid with an ammonia-like odor; [NIOSH]

COLOURLESS-TO-YELLOW HYGROSCOPIC LIQUID WITH PUNGENT ODOUR.

Colorless, viscous liquid with an ammonia-like odor.

Colorless, viscous liquid with an ammonia-like odor. [fungicide] [Note: A solid below 47 °F.]

Water-white liquid

Colorless, viscous liquid ... [Note: A solid below 47 degrees F].

Ammonia-like

241 °F at 760 mmHg (EPA, 1998)

116-117 °C

117.00 to 118.00 °C. @ 760.00 mm Hg

117.2 °C @760 [mm Hg]

46 °F (EPA, 1998)

11.14 °C

93 °F (EPA, 1998)

104 °F (40 °C) CLOSED CUP, 150 °F (66 °C) OPEN CUP /ANHYDROUS 76%/

110 °F (closed cup)

33.9 °C (open cup), 43.3 °C (closed cup)

34 °C c.c.

greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)

Crystals; sublimes without melting; freely sol in water; practically insol in alc /Dihydrochloride/

Sol in benzene unless insufficiently dried; slightly sol in ether

SOL IN ALL PROPORTIONS IN ETHYL ALCOHOL; VERY SOL IN WATER

Water solubility = 1X10+6 mg/l

Miscible with water, oxygenated and aromatic solvents

1000 mg/mL

Solubility in water: miscible

Miscible

0.898 at 77 °F (EPA, 1998) - Less dense than water; will float

0.898 @ 25 °C/4 °C

Saturated liquid density: 56.650 lb/cu ft; liquid heat capacity: 0.694 Btu/lb-F; saturated vapor pressure: 0.216 lb/sq in; saturated vapor density: 0.00228 lb/cu ft (all at 70 °F)

Relative density (water = 1): 0.9

1.46 @ 20°C

2.07 (EPA, 1998) - Heavier than air; will sink (Relative to Air)

2.07 (AIR= 1)

Relative vapor density (air = 1): 2.1

10.7 mmHg at 68 °F (EPA, 1998)

12.1 [mmHg]

12.1 mm Hg @ 25 °C

Highly flammable. Hygroscopic. Fumes in the air. Water soluble. Biodegrades readily.

Amines, Phosphines, and Pyridines

Highly Flammable

Air-Reactive

A base. Highly reactive with many compounds. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, carbon disulfide, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, hydrogen chloride, mesityl oxide, nitric acid, oleum, AgClO4, sulfuric acid, beta-propiolactone and vinyl acetate. Incompatible with strong acids, strong oxidizers (perchlorate salts), and chlorinated organic compounds. It is also incompatible with halogenated organic compounds and metal halides. May react with nitromethane and diisopropyl peroxydicarbonate. May ignite on contact with cellulose nitrate. Readily absorbs carbon dioxide from the air to give crusty solid deposits. (NTP, 1992). Ethylenediamine reacts violently with ethylene chlorohydrin. (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1554.).

Carbon disulfide reacts violently with ... ethylenediamine.

Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, carbon disulfide, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO3, oleum, AgClO4, sulfuric acid, beta-propiolactone, vinyl acetate.

A flask exploded while a chemist was adding ethylenediamine drop-wise to silver perchlorate.

Contact with ... chlorinated organic cmpd may cause ... explosions.

For more Hazardous Reactivities and Incompatibilities (Complete) data for ETHYLENEDIAMINE (7 total), please visit the HSDB record page.

Strong acids & oxidizers, carbon tetrachloride & other chlorinated organic compounds, carbon disulfide [Note: Corrosive to metals.]

Ethylene diamine

Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on no human data and inadequate animal data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA:Inadequate.

A4: Not classifiable as a human carcinogen.

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough. Sore throat. Shortness of breath. Burning sensation. Wheezing. Shortness of breath.

Redness. Pain. Burning sensation. Skin burns.

Redness. Pain. Blurred vision. Severe burns.

Burns in mouth and throat. Sore throat. Burning sensation. Abdominal pain. Shock or collapse.

irritation nose, respiratory system; sensitization dermatitis; asthma; liver, kidney damage

Skin, respiratory system, liver, kidneys

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

ACGIH Carcinogen - Not Classifiable.

Ethylene Diamine

9 x 10^-2 mg/kg-day

2 x 10^-1 mg/kg-day

PDF Document

Inadequate information to assess carcinogenic potential

PPRTV Current

LCLo (rat) = 4,000 ppm/8 hr

LD50 Rat oral 500 mg/kg

LD50 Rat ip 76 mg/kg

LD50 Rat sc 300 mg/kg

LD50 Mouse ip 200 mg/kg

For more Non-Human Toxicity Values (Complete) data for ETHYLENEDIAMINE (7 total), please visit the HSDB record page.

Ethylenediamine (EDA) (31.6-1000 mg/kg, ip) inhibited the convulsive effects of pentylenetetrazol (100 mg/kg, ip) in mice. EDA (100-1000 mg/kg, ip) incr the convulsion threshold to the iv infusion of 3 convulsants in the order pentylenetetrazol > bicuculline > strychnine.

A 37-yr-old pt sensitized to ethylenediamine by topical use of a steroid cream for scaly rash, developed an itchy morbilliform rash affecting the whole body following piperazine citrate therapy for threadworms.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 l/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin bumps with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

... A complete history and physical exam /is required/ ... to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Persons with a history of asthma, allergies, or unknown sensitization to ethylenediamine would be expected to be at incr risk from exposure. Exam of the resp system, liver, and kidneys should be stressed. The skin should be examined for evidence of chronic disorders. ... Should be repeated on an annual basis.

VOLUNTARY VAPOR INHALATION FOR 5 TO 10 SECONDS PRODUCED TINGLING OF THE FACE AND IRRITATION OF THE NASAL MUCOSA AT 200 PPM AND SEVERE NASAL IRRITATION AT 400 PPM.

SIXTEEN PATCH TESTS WITH CHEM CMPD KNOWN TO BE ALLERGENIC WERE DONE. EIGHT CMPD INCL ETHYLENEDIAMINE WERE RESPONSIBLE FOR 86.5% OF THE POSITIVE REACTIONS OBSERVED. MORE THAN HALF OF THE REACTIONS WERE TO NEOMYCIN, ETHYLENEDIAMINE, AND MERCURY.

A MALE PATIENT DEVELOPED ASTHMA AFTER AN OCCUPATIONAL-TYPE EXPOSURE TEST TO ETHYLENEDIAMINE.

A STUDY POPULATION OF 1158 PAID ADULT VOLUNTEERS WAS OBTAINED. AFTER PATCH TESTING, 0.43% SHOWED POSITIVE REACTIONS TO ETHYLENEDIAMINE.

For more Human Toxicity Excerpts (Complete) data for ETHYLENEDIAMINE (14 total), please visit the HSDB record page.

LC50 Pimephales promelas (fathead minnow) 115.7 mg/l/96 hr @ 22 °C (95% confidence limit 98.6-131.6 mg/l) /Static bioassay/

TLM: ORYZIAS LATIPES 1000 MG/L/24 HR /CONDITIONS OF BIOASSAY NOT SPECIFIED/

Toxicity Threshold (Cell Multiplication Inhibition Test) Uronema parduczi Chatton-Lwoff (protozoa) 52 mg/l /Conditions of bioassay not specified/

Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 0.85 mg/l /Conditions of bioassay not specified/

For more Ecotoxicity Values (Complete) data for ETHYLENEDIAMINE (9 total), please visit the HSDB record page.

7.00e+03

1.10e+05

1.80e+03

7.00e+02

4.10e-01

9.00e-02

Volatile

1.89e+05

2.10e+04

3.20e+05

5.40e+03

Ethylenediamine is produced in large quantities and large amounts of the chemical may be released, as emissions and in wastewater during its production and use as a chemical intermediate. Despite its wide use, no monitoring data or information concerning concentrations in effluents could be located. If released to air, a vapor pressure of 12.1 mm Hg at 25 °C indicates ethylenediamine will exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylenediamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 6 hours. In the atmosphere, ethylenediamine should react with photochemically-produced hydroxyl radicals and carbon dioxide to form the insoluble carbonate. It will also be scavenged by rain. If released to soil, ethylenediamine is expected to have slight mobility based upon an average Koc of 4766. Volatilization from moist soil surfaces is not expected to be an important fate process based upon a Henry's Law constant of 1.73X10-9 atm-cu m/mole. Ethylenediamine may volatilize from dry soil surfaces based upon its vapor pressure. However, adsorption to soil may attenuate volatilization. If released into water, ethylenediamine is expected to adsorb to suspended solids and sediment in water based upon the average Koc value. Based on aerobic screening studies, biodegradation is expected to be the most important degradation process for this compound in the environment but no experimental rates in water or soil are available. Biodegradation of ethylenediamine using sewage inocula ranged from 47 to 95% loss of the theoretical BOD over 2 to 3 weeks. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's Henry's Law constant. As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonated; the dissociated form will not volatilize. An estimated BCF of <1 suggests the potential for bioconcentration in aquatic organisms is low. Human exposure to ethylenediamine is primarily occupational via dermal contact and inhalation with the vapor and aerosol at workplaces where ethylenediamine is produced or used. (SRC)

Ethylenediamine is a degradation product of the agricultural fungicide maneb.

Ethylenediamine's production and use in the manufacture of carbamate fungicides and tetraacetylethylenediamine, chelating agents, lube oil and gas additives, nonreactive polyamide resins, aminoethylethanolamine-based surfactants and ethylene(bis)stearamide(1) as well as a solvent, emulsifying agent, textile lubricant and antifreeze inhibitor(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to have slight mobility in soil(SRC). Volatilization of ethylenediamine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.73X10-9 atm-cu m/mole(3). The potential for volatilization of ethylenediamine from dry soil surfaces may exist based upon a vapor pressure of 12.1 mm Hg(4). However, adsorption to soil may attenuate volatilization(SRC). Based on screening studies(5-7), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in soil are available. Ethylenediamine may also form stable complexes with metal ions(8) in soil, but again, experimental data are lacking(SRC).

AQUATIC FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.73X10-9 atm-cu m/mole(4). As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonated; the dissociated form will not volatilize. According to a classification scheme(5), an estimated BCF of less than 1(SRC), from its log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Based on screening studies(8-10), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in water are available. Complexation of ethylenediamine with transition metals(11) in the water or reaction with humic materials(12) is possible(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylenediamine, which has a vapor pressure of 12.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor. Vapor-phase ethylenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.3x10-11 cu cm/molecule-sec at 25 °C(3) using a structure estimation method(3). As ethylenediamine is miscible in water(4), washout by rain will also be an important removal process(SRC).

In one standard dilution test using non-acclimated sewage seed, 24 and 47% of the theoretical BOD was removed after 5 and 20 days, respectively, in fresh water, and 2 and 16%, respectively, in salt water(1). In a second standard dilution test using non-acclimated sewage seed, 0.6 and 17% BOD was removed in 5 days using fresh and salt water, respectively(2). The concentration of the ethylenediamine was 7 to 10 ppm in both studies(1,2). Using acclimated activated sludge, 97.5% COD was removed at a rate of 9.8 mg COD/g/hr (3), 67% of the theoretical BOD was removed in 5 days in a second study(4) and 36 and 70% of the theoretical BOD was removed in 5 and 20 days, respectively, in a third study(1). Ethylenediamine, at a concentration of 100 mg/l, showed a 93 to 95% theoretical BOD loss over a 28 day period in the Japanese MITI test using an activated sludge inoculum(5).

The rate constant for the vapor-phase reaction of ethylenediamine with photochemically-produced hydroxyl radicals has been estimated as 6.3x10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Ethylenediamine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). In addition, ethylenediamine does not contain chromophores which absorb radiation >290 nm so direct photolysis will not be significant. Ethylenediamine is a strong base and undergoes the typical reactions of primary amines(4). Many of these reactions may occur in the environment, but there is little documentation as to what reactions take place in the environment and at what rates. It may readily combine with CO2 from the atmosphere to form a nonvolatile carbonate and one is cautioned to protect the chemical from undue exposure to the atmosphere(3). No experimental data could be found containing information on the rate of this reaction. The ability of ethylenediamine to form five-membered rings by coordination of the two unshared pairs of electrons on the nitrogen atoms with metallic ions leads to complexes that are much more stable than those produced with other amines(5). Metallic ions in soils or natural waters may therefore combine with ethylenediamine but no information could be found on reactions with soil components. Humic acids that occur in natural waters contain aldehyde groups which could also potentially react with the amine groups to form adducts but again data in natural systems are lacking(4,SRC).

An estimated BCF of less than 1 was calculated for ethylenediamine(SRC), using a log Kow of -2.04(1)and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

Ethylenediamine has two primary amine groups and at the pH range found in most soils it is expected to be partially protonated given a pKa1 of 10.7 and a pKa2 of 7.6(1). An average Koc of 4766 (range=2071 to 6160) was measured for ethylenediamine in six different soils; five were from the vadose zone and one from an aquifer (saturated zone)(2). pH values ranged from 6.0 to 9.6 and the fraction of organic carbon from 0.0024 to 0.0391 for this group of soils. Soils with increased cation exchange capacity and organic content had greater affinity for ethylenediamine(2).

Ethylenediamine has a Henry's Law constant of 1.73X10-9 atm-cu m/mole(1). This Henry's Law constant indicates that ethylenediamine is expected to be essentially nonvolatile from water surfaces(2). As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonated; the dissociated form will not volatilize. The Henry's Law constant of ethylenediamine(1) also indicates that volatilization from moist soil surfaces should not occur(SRC). The potential for volatilization of ethylenediamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 12.1 mm Hg(3).

... Amines from decomposing fish ... /Amines/

Skin sensitization has been observed in a number of instances because of the use of ethylenediamine as a stabilizer in pharmaceutical skin creams. Sensitization is less likely in industrial exposures because the contact is less intimate and because damaged skin is not usually involved.

Inhalation of vapor, percutaneous absorption, ingestion and skin and eye contact.

ETHYLENEDIAMINE SENSITIVITY IN METALLURGIC INDUSTRIES IS DISCUSSED.

has statistically estimated that 64,513 workers (21,469 of these are female) are potentially exposed to ethylenediamine in the US(1). Occupational exposure to ethylenediamine may occur through inhalation and dermal contact with this compound at workplaces where ethylenediamine is produced or used(SRC).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Ethylenediamine may be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Catalytic /destruction/ of waste gases from ethylenediamine production is described.

Removal of ethylenediamine from wastewater using ion exchange is described.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for ETHYLENEDIAMINE (8 total), please visit the HSDB record page.

UN 1604; Ethylenediamine

IMO 8.2; Ethylenediamine

49 356 28; Ethylenediamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive Flammable Liquid

Do not transport with food and feedstuffs.

Symbol: C; R: 10-21/22-34-42/43; S: (1/2)-23-26-36/37/39-45

UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II