1-nitropropane

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P321, P330, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

H302+H312 (11.7%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (75.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H331 (39.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (60.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P316, P317, P321, P330, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 326 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P319, P321, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H351: Suspected of causing cancer [Warning Carcinogenicity]

P203, P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P318, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P321, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Use water spray, dry chemical, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. / Nitropropanes/

To fight fire, use alcohol foam, CO2, dry chemical, water spray.

Alcohol foam. Water may be ineffective.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. Further information: Use water spray to cool unopened containers.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

After covering the spills with soda ash, mix and spray with water. Scoop into a bucket of water and leave it stand for 2 hr. Neutralize with 6 M HCl ...

If liquid ... is spilled or leaked ... 1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels and burn in a suitable combustion chamber which allows burning in an unconfined condition and is equipped with appropriate effluent gas cleaning device. Large quantities can be collected, diluted in fuel oil, and atomized in suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Liquid 1-nitropropane should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Liquid ... may be disposed of by diluting in fuel oil and atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

For more Preventive Measures (Complete) data for 1-Nitropropane (12 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants and strong bases.

Store in a cool, dry, well-ventilated location. Separate from amines, acids, alkalies, oxidizing materials, metal oxides, and combustibles. Outside or detached storage is preferred. /Nitropropanes/

Store in containers tightly closed. Outdoor or isolated storage is preferable. Indoor storage needs standard combustible liquid storage.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): 3: Flammable liquids.

2.0 [ppm]

16 [ppm]

170 [ppm]

1000 [ppm]

25 ppm (90 mg/m³)

TWA 25 ppm (90 mg/m3)

25.0 [ppm]

1000 ppm (NIOSH, 2024)

1000.0 [ppm]

Excerpts from Documentation for IDLHs: Other animal data: It has been reported that rabbits survived a 1­hour exposure to 10,000 ppm [Machle et al. 1940]. Human data: Volunteers found brief exposures to concentrations exceeding 100 ppm to cause eye irritation [Silverman et al. 1946].

1000 ppm

See: 108032

8 hr Time Weighted Avg (TWA): 25 ppm.

Peak Exposure Recommendation: Transient increases in workers' exposure levels may exceed 3 times the value of the TLV-TWA level for no more than 15 minutes at a time, on no more than 4 occasions spaced 1 hour apart during a workday, and under no circumstances should they exceed 5 times the value of the TLV-TWA level. In addition, the 8-hour TWA is not to be exceeded for an 8-hour work period.

A4; Not classifiable as a human carcinogen.

25 ppm as TWA; A4 (not classifiable as a human carcinogen).

25 ppm [1992]

7.4 mg/m

Denmark TWA 15 ppm (54 mg/cu m)

Finland TWA 25 ppm (90 mg/cu m); STEL 40 ppm (150 mg/cu m)

France TWA 25 ppm (90 mg/cu m)

Germany (DFG MAK) TWA 25 ppm (90 mg/cu m)

For more Other Standards Regulations and Guidelines (Complete) data for 1-Nitropropane (11 total), please visit the HSDB record page.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes and respiratory tract.

Excerpt from NIOSH Pocket Guide for 1-Nitropropane:

Skin: No recommendation is made specifying the need for personal protective equipment for the body.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift).

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)

Wear neoprene rubber gloves, plastic working clothes, and self-contained breathing apparatus.

Clothing wet with liquid 1-nitropropane should be placed in closed containers for storage until it can be discarded or until provision is made for removal of 1-nitropropane from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the 1-nitropropane, the person performing the operation should be informed of 1-nitropropane's hazardous properties.

Employees should be provided with and required to use splash-proof safety goggles where liquid 1-nitropropane may contact the eyes.

Respirator Recommendations: Up to 250 ppm: [Table#3958]

For more Personal Protective Equipment (PPE) (Complete) data for 1-Nitropropane (13 total), please visit the HSDB record page.

NIOSH/OSHA

Up to 250 ppm:

(APF = 10) Any supplied-air respirator*

Up to 625 ppm:

1-nitropropane appears as a colorless oily flammable liquid. Density about the same as water. Vapors much heavier than air. Vapors may irritate skin, eyes and mucous membranes. Toxic oxides of nitrogen are released during combustion. Used as a propellant and as a solvent.

Colorless liquid with a somewhat disagreeable odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless oily liquid with a somewhat disagreeable odor.

Colorless liquid with a somewhat disagreeable odor.

Colorless liquid

Somewhat disagreeable odor

Mild, fruity odor

270 °F at 760 mmHg (NTP, 1992)

131.2 °C

131.1 °C @760 [mm Hg]

-162 °F (NTP, 1992)

-104.3 °C

93 °F (NTP, 1992)

36 °C, 96 °F (closed cup)

93 °F (34 °C) - open cup

120 °F open cup (commercial grade)

Slightly soluble (NTP, 1992)

In water, 1.50X10+4 mg/L at 25 °C

Slightly soluble in water (1.4 mL/100 mL)

Slightly soluble in water

Miscible with ethanol, ethyl ether; soluble in chloroform

Solubility in water, g/100ml: 1.4

0.9934 at 77 °F (USCG, 1999) - Less dense than water; will float

0.9961 g/cu cm at 25 °C

Relative density (water = 1): 0.99

0.9961 @25 °C

3.06 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

3.06 (Air = 1)

Relative vapor density (air = 1): 3.1

8 mmHg (NIOSH, 2024)

10.1 [mmHg]

1.01X10+1 mm Hg at 25 °C /Extrapolated/

Vapor pressure, kPa at 20 °C: 1.0

7.5 [mm Hg] @20 °C

log Kow = 0.87

Henry's Law constant = 8.70X10-5 atm-cu m/mol at 25 °C

Stable under recommended storage conditions.

789 °F (USCG, 1999)

789 °F, 421 °C

Highly flammable. Water soluble.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Highly Flammable

Strong Oxidizing Agent

1-NITROPROPANE forms salts with inorganic bases such as calcium hydroxide. The dry salts are explosive [Chem. Eng. news 30:2344. 1952].

Incompatible materials: Strong oxidizing agents, Strong bases.

Metal oxides increase its sensitivity to thermal ignition.

Even though no detonation of 1-nitropropane has been reported, contact with amines, strong acids, and alkalies may cause 1-nitropropane to become unstable. Contact with strong oxidizers may cause fires and explosions. Mixtures of 1-nitropropane and hydrocarbons (or other combustible materials) are highly flammable. Contact with metal oxides may cause decomp and development of pressure.

The nitroalkanes are mild oxidants under ordinary conditions, but precautions should be taken when they are subjected to high temperatures and pressures, since violent reactions may occur.

For more Hazardous Reactivities and Incompatibilities (Complete) data for 1-Nitropropane (8 total), please visit the HSDB record page.

Amines; strong acids, alkalis & oxidizers; hydrocarbons & other combustible materials; metal oxides

IDENTIFICATION AND USE: 1-Nitropropane (1-NP) is a colorless liquid. 1-NP is used as a rocket propellant, gasoline additive, and in chemical syntheses. HUMAN STUDIES: Anorexia, nausea, vomiting, and intermittent diarrhea and headaches occurred in men exposed at 20 to 45 ppm of 1-NP during a dipping processes. Additionally, human exposure to 1-NP concentrations exceeding 100 ppm reportedly causes eye irritation in humans. ANIMAL STUDIES: Exposures at 5,000 ppm of 1-NP for 3 hr killed rabbits and guinea pigs. However, concentration of 10,000 ppm for 1 hr was not lethal. Signs of 1-NP exposure included conjunctival irritation, lacrimation, slow respiration with some rales, incoordination, ataxia, and weakness. Rats treated with 1-NP at 1 mmol/kg bw three times per week for 16 weeks had only slightly reduced body weight, and after 26 weeks (termination of treatment), they regained their body weight. One benign liver tumor was observed in these rats. Hepatotoxic symptoms were also observed. There have been numerous studies on the mutagenic activity of 1-NP in Salmonella typhimurium (Ames test). 1-NP was not mutagenic in multiple strains of S. typhimurium with or without the addition of various microsomal metabolic activating systems. The effects of DNA repair synthesis were also studied in numerous mammalian cell lines derived from humans, mice, hamsters, and rats, but 1-NP was not active. An additional study examined liver cell lines that possess cytochrome P450 metabolic capability versus V79 cells that lack this capability. 1-NP was completely inactive in the liver cell lines but did induce mutations and micronuclei in V79 cells.

A4; Not classifiable as a human carcinogen.

The substance can be absorbed into the body by inhalation and by ingestion.

inhalation, ingestion, skin and/or eye contact

Headache. Nausea. Vomiting.

Redness.

Further see Inhalation.

irritation eyes; headache, nausea, vomiting, diarrhea; In Animals: liver, kidney damage

Eyes, central nervous system, liver, kidneys

Neurotoxin - Other CNS neurotoxin

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

ACGIH Carcinogen - Not Classifiable.

LC50 (rat) = 3,100 ppm/8H

LD50 Rat oral 455 mg/kg

LC50 Rat inhalation 3100 ppm/8 hr

LD50 Mouse oral 800 mg/kg

LD50 Mouse ip 250 mg/kg

Immediate First Aid: Ensure that adequate decontamination has been carried out. if patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nitrates, Nitrites, and Related Compounds/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat as necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 dL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Nitrates, nitrites, and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Monitor cardiac rhythm and treat arrhythmias if necessary. Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present For hypotension with signs of hypovolemia, administer fluid cautiously. If unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Nitrates, nitrites, and related compounds/

/SIGNS AND SYMPTOMS/ ... Industrial experience with 1-nitropropane has been virtually without incident; a few field reports of warning symptoms such as headache and nausea resulting from prolonged exposure to excessive amounts have been made, but these appear well in advance of systemic injury ... .

/SIGNS AND SYMPTOMS/ Potential symptoms of overexposure are eye irritation, headache, nausea, vomiting and diarrhea.

/SIGNS AND SYMPTOMS/ The chemical may produce... injury to the liver and kidneys in exposed humans. High concentrations of the chemical also may produce methemoglobinemia with cyanosis. 1-Nitropropane vapors also are damaging to the lungs. 1-Nitropropane is, however, more acutely irritating to mucous membranes than 2-nitropropane.

/SIGNS AND SYMPTOMS/ Anorexia, nausea, vomiting, and intermittent diarrhea and headaches occurred in men exposed at 20 to 45 ppm of nitropropane during a dipping processes. These symptoms ceased when methyl ethyl ketone was substituted. Additionally, human exposure to 1-NP concentrations exceeding 100 ppm reportedly causes eye irritation in humans.

/GENOTOXICITY/ The effects of DNA repair synthesis were also studied in numerous mammalian cell lines derived from humans, mice, hamsters, and rats, but 1-NP was not active. An additional study examined liver cell lines that possess cytochrome P450 metabolic capability versus V79 cells that lack this capability. 1-NP was completely inactive in the liver cell lines but did induce mutations and micronuclei in V79 cells.

/LABORATORY ANIMALS: Acute Exposure/ Rabbits died from exposure to 5000 ppm for 3 hr ... effects were conjunctiva irritation, lacrimation, slow respiration with some rales, muscular incoordination, ataxia and weakness. Autopsy of animals ... revealed severe fatty infiltration of liver and moderate kidney damage.

/LABORATORY ANIMALS: Acute Exposure/ The acute inhalation toxicity of 1-nitropropane is not greatly different from that of 2-nitropropane ... exposures at 5,000 ppm of 1-nitropropane for 3 hr killed rabbits and guinea pigs, whereas the lowest lethal concentration of 2-nitropropane for these animals after a 2.25 hr exposure were 4313 and 9607 ppm, respectively. The symptoms and gross pathological changes observed in the exposed animals were similar to those exposed to nitroethane.

/LABORATORY ANIMALS: Acute Exposure/ In a study of the physiologic response of animals to some simple mononitroparaffins, ... /investigators/ administered 1-NP and 2-nitropropane by stomach tube to rabbits. In the case of 1-NP, the lethal dose was between 0.25 and 0.50 g/kg; for 2-nitropropane, the range was between 0.50 and 0.75 g/kg bw.

/LABORATORY ANIMALS: Acute Exposure/ The results of early inhalation experiments with 1-NP, nitroethane, and nitromethane showed that 1-NP was more toxic than either nitroethane or nitromethane. Rabbits died after exposure to 1-NP at 5000 ppm for 3 hr, but a concn of 10,000 ppm for 1 hr was not lethal. Signs of 1-NP exposure included conjunctival irritation, lacrimation, slow respiration with some rales, incoordination, ataxia, and weakness.

For more Non-Human Toxicity Excerpts (Complete) data for 1-Nitropropane (24 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for 1-nitropropane is available.[Available from, as of February 1, 2019: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of February 4, 2019: http://actor.epa.gov/dashboard/]

1-Nitropropane was evaluated for repeat-dose toxicity when orally administered to male and female Sprague-Dawley rats (5/sex/group) at dose levels of 0, 10, 30, and 100 mg/kg/day for 28 consecutive days. Two additional groups (5/sex/group) received the vehicle alone or 100 mg/kg/day of 1-nitropropane and were maintained for observation an additional 14 days post-treatment. One mortality was reported among the high-dose males on day 27, after developing severe clinical signs of hunched posture, lethargy, and ataxis. Animals receiving 100 mg/kg/day were seen to have increased salivation with red/brown staining around the mouth after treatment on day 15, and two females from this group developed a hunched posture on day 28 (prior to final dosing). Decreased bodyweight gain and food intake were noted for high-dose males, but these parameters were comparable to controls in females from this group and animals from other treatment groups. Necropsy performed on the early mortality revealed dark kidneys, thickening of the forestomach, and sloughing of the glandular epithelium. The organ weight data revealed that 100 mg/kg animals had statistically significant increases in absolute and relative brain weights with no corresponding microscopic changes. No effects were seen in animals from the 10 or 30 mg/kg groups, nor from the additional 100 mg/kg/day group, held for observation and recovery. The NOEL for the conditions of this study was determined to be 30 mg/kg/day.

Radio-labeled ((14)C) 1-Nitropropane was evaluated for skin absorption when applied to the shaved, intact dorsal skin of 2 female rhesus monkeys (weight and age not stated). The test material was applied as a solution (15.28 mg (14)C-1-nitropropane in 300 uL alcohol) then covered with an occlusive patch. The patch was removed after 12 hours and the skin was wiped with soap/acetone swabs. Swabs and patches were extracted with acetone and alcohol, then the swabs combusted to (14)CO2 and water. Both the extracts and combustion products were assayed for radioactivity. Blood samples, urine, and feces were collected at various time intervals for 72 hours following treatment, while the test site and 2 small areas of adjacent untreated skin (approximately 1.13 sq cm) were excised after 72 hours and examined histologically. All samples were analyzed for radioactivity. The 2 monkeys (PH0140 and PH0142) showed no signs of toxicity, and food and water consumption were normal. Within 72 hours, 0.204% and 0.405% (PH0140 and PH0142, respectively) of the applied dose was recovered from urine and feces, with an average of 94.8% of that for both animals being excreted in the urine. The skin from the application sites as well as adjacent skin samples contained 0.043% and 0.102% of the total dose. The swabs and patches accounted for 0.115% and 0.064% of the total dose while negligible amounts of radioactivity were detected in blood samples from either monkey. It was reported that 99.583% and 99.389% (PH0140 and PH0142, respectively) of the dose remained unrecovered due to the high volatility of the test material as well as the carrier.

1-Nitropropane's production and use as a solvent for cellulose acetate, vinyl resins, lacquers, synthetic rubbers, fats, oils, and dyes, as a gasoline additive, and an ingredient in rocket propellant may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 10.1 mm Hg at 25 °C indicates 1-nitropropane will exist solely as a vapor in the atmosphere. Vapor-phase 1-nitropropane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 37 days. 1-Nitropropane does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, 1-nitropropane is expected to have high mobility based upon an estimated Koc of 37. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 8.70X10-5 atm-cu m/mole. The pKa of 1-nitropropane is 8.98, indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to organic carbon and clay than their neutral counterparts. 1-Nitropropane may volatilize from dry soil surfaces based upon its vapor pressure. Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum suggests that biodegradation may be an important environmental fate process in soil and water. If released into water, 1-nitropropane is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization of the neutral species from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 12 hours and 7 days, respectively. A BCF of 1.3 suggests bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 1-nitropropane may occur through inhalation and dermal contact with this compound at workplaces where 1-nitropropane is produced or used. The general population is exposed to 1-nitropropane via inhalation from smoking cigarettes. (SRC)

1-Nitropropane's production and use as a solvent for cellulose acetate, vinyl resins, lacquers, synthetic rubbers, fats, oils, and dyes and other organic materials, an intermediate(1), as a gasoline additive(2) and an ingredient in rocket propellant(1,2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 36(SRC), determined from a structure estimation method(2), indicates that 1-nitropropane is expected to have very high mobility(SRC). The pKa of 1-nitropropane is 8.98(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of 1-nitropropane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 8.7X10-5 atm-cu m/mole(3). 1-Nitropropane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 10.1 mm Hg at 25 °C(5). Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum(6) suggests that biodegradation may be an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 36(SRC), determined from a structure estimation method(2), indicates that 1-nitropropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces is expected(3) based upon a Henry's Law constant of 8.70X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 12 hrs and 7 days, respectively(SRC). A pKa of 8.98(5) indicates 1-nitropropane will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process for the ionized species(SRC). According to a classification scheme(6), a BCF of 1.3(7) indicates that bioconcentration in aquatic organisms is low(SRC). Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum(7) suggests that biodegradation may be an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-nitropropane, which has a vapor pressure of 10.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-nitropropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 37 days(SRC), calculated from its rate constant of 4.40X10-13 cu cm/molecule-sec at 25 °C(3). 1-Nitropropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

1-Nitropropane's production and use as a solvent for cellulose acetate, vinyl resins, lacquers, synthetic rubbers, fats, oils, and dyes, as a gasoline additive, and an ingredient in rocket propellant may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 10.1 mm Hg at 25 °C indicates 1-nitropropane will exist solely as a vapor in the atmosphere. Vapor-phase 1-nitropropane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 37 days. 1-Nitropropane does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, 1-nitropropane is expected to have high mobility based upon an estimated Koc of 37. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 8.70X10-5 atm-cu m/mole. The pKa of 1-nitropropane is 8.98, indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to organic carbon and clay than their neutral counterparts. 1-Nitropropane may volatilize from dry soil surfaces based upon its vapor pressure. Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum suggests that biodegradation may be an important environmental fate process in soil and water. If released into water, 1-nitropropane is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization of the neutral species from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 12 hours and 7 days, respectively. A BCF of 1.3 suggests bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 1-nitropropane may occur through inhalation and dermal contact with this compound at workplaces where 1-nitropropane is produced or used. The general population is exposed to 1-nitropropane via inhalation from smoking cigarettes. (SRC)

1-Nitropropane's production and use as a solvent for cellulose acetate, vinyl resins, lacquers, synthetic rubbers, fats, oils, and dyes and other organic materials, an intermediate(1), as a gasoline additive(2) and an ingredient in rocket propellant(1,2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 36(SRC), determined from a structure estimation method(2), indicates that 1-nitropropane is expected to have very high mobility(SRC). The pKa of 1-nitropropane is 8.98(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of 1-nitropropane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 8.7X10-5 atm-cu m/mole(3). 1-Nitropropane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 10.1 mm Hg at 25 °C(5). Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum(6) suggests that biodegradation may be an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 36(SRC), determined from a structure estimation method(2), indicates that 1-nitropropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces is expected(3) based upon a Henry's Law constant of 8.70X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 12 hrs and 7 days, respectively(SRC). A pKa of 8.98(5) indicates 1-nitropropane will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process for the ionized species(SRC). According to a classification scheme(6), a BCF of 1.3(7) indicates that bioconcentration in aquatic organisms is low(SRC). Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum(7) suggests that biodegradation may be an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-nitropropane, which has a vapor pressure of 10.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-nitropropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 37 days(SRC), calculated from its rate constant of 4.40X10-13 cu cm/molecule-sec at 25 °C(3). 1-Nitropropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: When 1-nitropropane was incubated with activated sludge, 23.3% mineralization occurred in 5 days(1). During a closed bottle biodegradability test, using a municipal sewage plant effluent innoculum, 45% degradation of 1-nitropropane occurred within 28 days(1). Aerobic C14 studies performed with soil microorganisms resulted in 4.6% conversion to CO2 in 35 days(1). During this time 21.2% was lost as volatile products(1).

ANAEROBIC: Anaerobic C14 studies performed with soil microorganisms resulted in 3.0% conversion to CO2(1). During this time, 35.7% was lost as volatile products(1).

The rate constant for the vapor-phase reaction of 1-nitropropane with photochemically-produced hydroxyl radicals has been reported as 4.40X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 37 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Photodegradation of 1-nitropropane in the gas phase has been measured according to the Fujiki Test; this test uses three 360 nm and three 300 nm emitting lamps and Pyrex glass reaction tubes(3). After 24 hours, degradation of greater than 95% was reported for 1-nitropropane(3). 1-Nitropropane is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). 1-nitropropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

A BCF value of 1.3 was measured for fish (Golden ide) in a static 3-day test with 1-nitropropane present at 50 ppb(1). According to a classification scheme(2), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Bioconcentration of 1-nitropropane in algae (Chlorella fusca) was measured using (14)C-labelled 1-nitropropane at 50 ppb. The algae were irradiated for 24 hours; 92.9% of the radioactivity was present in solution, 1.7% of the radioactivity was associated with the algae(1). A bioconcentration factor of 180 for algae was calculated from this experiment(1).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-nitropropane can be estimated to be 36(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-nitropropane is expected to have very high mobility in soil. The pKa of 1-nitropropane is 8.98(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

A pKa of 8.98(1) indicates 1-nitropropane will exist partially in the anion form at pH values of 5 to 9(SRC). The Henry's Law constant for the neutral species of 1-nitropropane is 8.70X10-5 atm-cu m/mole(2). This Henry's Law constant indicates that 1-nitropropane is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 12 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 7 days(SRC). 1-Nitropropane's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1-Nitropropane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 10.1 mm Hg(3).

1-Nitropropane was detected at a concentration of 30 ug/g in fresh and 1.34 ug/g in used machine cutting-fluid emulsion(1). 1-Nitropropane was detected at unreported concentrations in gases from a landfill simulator containing municipal refuse and municipal wastewater sludges(2). The compound has been reported in tobacco smoke(3).

According to the 2016 TSCA Inventory Update Reporting data, 1 reporting facility estimated the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of 1-nitropropane in the United States is not known or reasonable ascertainable; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 21,537 workers (1,311 of these are female) are potentially exposed to 1-nitropropane in the US(1). Occupational exposure to 1-nitropropane may occur through inhalation and dermal contact with this compound at workplaces where 1-nitropropane is produced or used(SRC). The general population is exposed to 1-nitropropane via smoking cigarettes(SRC).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Liquid ... may be disposed of by diluting in fuel oil and atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

/GUIDE 129 FLAMMABLE LIQUIDS (Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Nitropropanes/

/GUIDE 129 FLAMMABLE LIQUIDS (Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Nitropropanes/

/GUIDE 129 FLAMMABLE LIQUIDS (Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind, uphill and/or upstream. Ventilate closed spaces before entering. /Nitropropanes/

/GUIDE 129 FLAMMABLE LIQUIDS (Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Nitropropanes/

For more DOT Emergency Guidelines (Complete) data for 1-Nitropropane (8 total), please visit the HSDB record page.

UN 2608; Nitropropanes

IMO 3; Nitropropanes

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Nitropropanes is included on the dangerous goods list. /Nitropropanes/

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Nitropropanes is included on the dangerous goods list. /Nitropropanes/

Flammable Liquid

Symbol: Xn; R: 10-20/21/22; S: (2)-9

UN Hazard Class: 3; UN Pack Group: III