diisopropylamine

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (57.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (62.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (37.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (70.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 407 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P321, P330, P363, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Give nothing to drink. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use alcohol-resistant foam, water, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Use dry chemical, "alcohol resistant" foam, carbon dioxide, or water spray. Water may be ineffective. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.

Use dry chemical, alcohol foam or carbon dioxide fire fighting agents. Water may be ineffective, but effective to keep fire-exposed containers cool, to disperse the vapors, to flush spills away from exposures, to dilute spills to nonflammable mixtures and thus to prevent the spread of fires. Wear complete protective clothing.

Vapors are heavier than air and may travel to a source of ignition and flash back.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Cover the spilled material with inert absorbent or sand. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE RECLAIMED OR COLLECTED AND ATOMIZED IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

DIISOPROPYLAMINE SHOULD NOT BE ALLOWED TO ENTER A CONFINED SPACE, SUCH AS A SEWER, BECAUSE OF THE POSSIBILITY OF AN EXPLOSION. SEWERS DESIGNED TO PRECLUDE THE FORMATION OF EXPLOSIVE CONCN OF...VAPORS ARE PERMITTED.

Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Absorb in noncombustible material for proper disposal.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

DIISOPROPYLAMINE MAY BE DISPOSED OF BY ATOMIZING IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The worker should immediately wash the skin when it becomes contaminated.

For more Preventive Measures (Complete) data for DIISOPROPYLAMINE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs. Store only in original container. Store in an area without drain or sewer access.

Store in a cool, dry, well-ventilated location. Separate from acids; oxidizing material, plastics.

Protect containers against physical damage. Keep containers well closed. In factories, store in standard combustible liquid storage rooms or cabinets.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

5.0 [ppm]

33 [ppm]

200 [ppm]

5 ppm (20 mg/m³)

TWA 5 ppm (20 mg/m3) [skin]

200 ppm (NIOSH, 2024)

200.0 [ppm]

Excerpts from Documentation for IDLHs: Human data: Complaints of nausea, headache, and temporary dimness in vision were reported in workers 2 to 3 hours following several 5­ to 10­minute exposures to about 176 ppm; concentrations otherwise during the workshift averaged about 24 to 48 ppm [Treon et al. 1949].

See: 108189

8 hr Time Weighted Avg (TWA): 5 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

5 ppm as TWA; (skin)

5 ppm [1979]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Contact of the vapour with the eyes may cause visual disturbances. Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest.

Repeated or prolonged contact with skin may cause dermatitis.

Excerpt from NIOSH Pocket Guide for Diisopropylamine:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT (>5%) - Wear appropriate eye protection to prevent eye contact. (>5%)

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point 5%) - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection. (>5%) (NIOSH, 2024)

AIR-SUPPLIED MASK; PLASTIC GLOVES; MONOGOGGLES; RUBBER APRON

Wear appropriate personal protective clothing to prevent skin contact.

Diisopropylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point 30 °F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.

Colorless liquid with an ammonia- or fish-like odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with an ammonia- or fish-like odor.

Colorless liquid ...

... Ammonia or fish-like odor.

183 °F at 760 mmHg (NTP, 1992)

84 °C @ 760 mm Hg

-78 °F (NTP, 1992)

30 °F (NTP, 1992)

30 °F (-1 °C)(OPEN CUP)

-6 °C o.c.

Slightly soluble (NTP, 1992)

Very soluble in acetone, benzene, ether, and ethanol.

In water, 1.1X10+5 mg/l @ 25 °C

Solubility in water, g/l: 10 (slightly soluble)

Miscible

0.717 at 68 °F (USCG, 1999) - Less dense than water; will float

0.7169 @ 20 °C/4 °C

Relative density (water = 1): 0.72

0.715 @ 20°C

3.5 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

3.5 (AIR= 1)

Relative vapor density (air = 1): 3.5

129.25 mmHg (USCG, 1999)

79.4 [mmHg]

79.4 mm Hg @ 25 °C

Vapor pressure, kPa at 20 °C: 9.3

79.4 [mm Hg] @25 °C

log Kow= 1.4

VOLATILE

600 °F (USCG, 1999)

600 °F (316 °C)

When heated to decomposition it emits toxic fumes of nitroxides.

0.40 cP @ 25 °C

MAY ATTACK SOME FORMS OF PLASTIC

-11000 CAL/G

8.265 kcal/mole @ 25 °C

Strongly alkaline

19.64 DYNES/CM @ 20 °C

Highly flammable. Soluble in water. Sensitive to heat and air.

Amines, Phosphines, and Pyridines

Highly Flammable

DIISOPROPYLAMINE can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Strong oxidizers, strong acids.

Strong oxidizers, strong acids

On the basis of the data presented in this report, the CIR Expert Panel concludes that Diisopropylamine is safe as a cosmetic ingredient as presently used. Diisopropylamine should not be used in products containing N-nitrosating agents.

Safe for use in cosmetics, with qualifications

Serious local effects by all routes of exposure.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing.

Redness. Pain. Serious skin burns.

Redness. Pain. Blurred vision. Severe burns.

Burns in mouth and throat. Burning sensation behind the breastbone. Abdominal pain. Vomiting. Shock or collapse.

irritation eyes, skin, respiratory system; nausea, vomiting; headache; visual disturbance

Eyes, skin, respiratory system

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 4,800 mg/m3/2h

LD50 Mouse oral 2,120 mg/kg

LD50 Rabbit oral 4,700 mg/kg

LD50 Rat oral 770 mg/kg

LD50 Guinea pig oral 2800 mg/kg

For more Non-Human Toxicity Values (Complete) data for DIISOPROPYLAMINE (6 total), please visit the HSDB record page.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related cmpds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconsious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related cmpds/

Employees should be screened for history of certain medical conditions which might place the employee at increased risk from diisopropylamine exposure. /These are/ ... chronic respiratory disease ... skin disease ... /and/ eye disease. ... Any employee developing the above-listed conditions should be referred for further medical examination.

Symptoms: Nausea in low concentrations and pulmonary edema in high concentrations.

Inhalation of vapors causes irritation, sometimes with nausea and vomiting; can also cause burns to the respiratory system. ... /Liquid/ causes smarting of the skin and first-degree burns on short exposure; may cause second-degree burns on long exposure.

In humans, diisopropylamine is an eye irritant. When exposed to concentrations between 25 and 50 ppm, workers complained of disturbances of vision. There were also complaints of nausea and headache.

Edema of the epithelium of the cornea, generally without pain, has been produced by amine vapors, causing colored haloes to be seen around lights, usually in the evening, after industrial exposure to the vapors of various amines including ... diisopropylamine.

TEMPORARY IMPAIRMENT OF VISION HAS OCCURRED IN MEN AFTER EXPOSURE TO VAPOR CONCN...AS LOW AS 25 TO 50 PPM IN AIR DURING DISTILLATION OF DIISOPROPYLAMINES /PRESUMABLY DUE TO INJURY TO CORNEAL EPITHELIUM/...

AFTER EXPOSURE OF RATS TO 8000 PPM FOR 4 HR, 2 OUT OF 6 ANIMALS DIED. IN SATURATED VAPOR, TIME FOR NO DEATHS WAS 5 MIN. /FROM TABLE/

After exposure of rabbits to 261 ppm for 7 hr/day, 2 to 20 days, 4 out of 5 animals died. /From table/

After exposure of rats to 597 ppm for 7 hr/day, for 5 days, 1 out of 2 animals died. /From table/

After exposure of rats to 261 ppm for 7 hr/day, for 19 days, 1 out of 2 rats died. /From table/

For more Non-Human Toxicity Excerpts (Complete) data for DIISOPROPYLAMINE (13 total), please visit the HSDB record page.

Diisopropylamine (CAS # 108-18-9) was evaluated for dermal sensitization in Harlet guinea pigs (5/sex) inducted with 0.3 ml occluded topical applications of 10% (v/v) test solution to shaved backs, 6 hours/day, 3 days/week for 3 weeks. Upon a third application, increasing dermal irritation required reduction of dosage to 0.3 ml of a 5% (v/v) solution, which continued to produce irritation ranging from moderate to severe. Two weeks later, the non-irritating dermal challenge upon virgin application sites produced no such signs of irritation, confirming cumulative irritation without dermal sensitization. Conversely, dermal irritation acquired during induction with DCNB (positive control) was identified as delayed hypersensitivity upon challenge 2 weeks later, which produced universal dermal irritation in response to an otherwise non-irritating dose.

Acute inhalation toxicity was evaluated in groups of 10 Sprague-Dawley rats (5 male and 5 female) exposed to diisopropylamine at analytical concentrations of 0, 5.0 and 5.3 mg/l of air for four hours. Mortality was observed in one male rat in the 5.3 mg/l group and the LC50 for both sexes was considered to be greater than 5.3 mg/l. Clinical observations of animals at one or both exposure levels immediately following exposure and during the 14 day post-exposure period included labored breathing, tremors, high-pitched respiratory sounds, partially or completely closed eyes, nasal and ocular discharges and encrustation, ocular opacity, and pitted/raised corneal surface. After an initial body weight decrease in most exposed animals on post-exposure day 2, all animals gained weight and exceeded their pre-exposure weights by post-exposure day 14. Gross necropsy revealed corneal opacity.

Diisopropylamine (CAS # 108-18-9) was evaluated in hepatocyte primary culture DNA repair assay. Isolated liver cells from Fischer-344 rats cultured in triplicate were exposed simultaneously to tritiated thymidine plus 10 concentrations of diisopropylamine ranging from 0.1 to 5000 ug/ml (cytotoxic concentration in preliminary assay), and 6 concentrations in the replicate assay from 10 to 2500 ug/ml for 18-21 hours at 37 degrees C. Each culture, washed and swelled in hypotonic solution, fixed and mounted on slides, was then dipped in autoradiographic emulsion and the cells exposed at -20 degrees C for 7 days, then developed and stained in methylgreen Pyronin Y. Thirty cells/culture, a total of 90 morphologically intact cells for each assay, were then subjected to quantitative autoradiographic grain counting to determine the net nuclear grain count (the nuclear count adjusted for background cytoplasmic uptake). Net grain counts were negative for all concentrations of test material and solvent control, reflecting a lack of diisopropylamine-induced DNA damage. Conversely, 2-AAF (the positive control) produced 39.9 and 51.2 net grain counts, respectively, in preliminary and replicate assays.

Diisopropylamine (CAS # 108-18-9) was evaluated for subchronic dermal toxicity in groups of Charles River CD(SD)BR rats (3/sex/group) exposed 5 consecutive days/week for 1 month to 15, 50 or 150 mg/kg applications, undiluted doses at or below the established NOEL in range-finding study. A plastic collar hindered ingestion of test material during treatment. Volatility analysis of the undiluted test material under the conditions of study established that evaporation would results in diminished diisopropylamine availability at the sites of application (application site and manner of occlusion, if any, were unspecified). No overt effects of treatment were noted, other than mild dryness at the application sites and may have been attributable to repeated dosing and evaporation. Terminal necropsy revealed significantly decreased absolute (19%) and relative (12%) heart weights and increased absolute (4-5%) and relative (10-14%) testes weights in mid- and high-dose males. There was neither lost bodyweight nor any microscopic changes indicative of expressed toxicity in these organs. A dose-response relationship was not established for mild splenic congestion in females of all treatment groups and hematological and clinical chemistry findings were not clinically or biologically significant.

Subchronic inhalation toxicity was evaluated in groups of 15 female and 15 male Charles River CD(SD)BR rats exposed to diisopropylamine vapor at mean concentrations (measured with an automatic infrared analyzer system) of 0, 0.1, 0.6 and 2.0 mg/l for 6 h/d, 5 d/week for about 4 weeks. The test atmosphere was generated by metering the test material through a nebulizer and introducing the resulting vapor along with air into the test chamber. There were 3 mortalities in the high-dose group. Clinical observations included eye and respiratory tract irritation and decreased body weights in mid- and high-dose rats and dose-related corneal keratopathy. Hematological studies revealed dose-dependent decreases in mean corpuscular volume, serum chloride, total protein, and albumin as well as dose-dependent increases in serum cholesterol in both sexes; increased red blood cell counts, hemoglobin, and hematocrit measurements in high-dose males and mid- and high-dose females; and lowered white blood cell counts (reduced absolute number of lymphocytes) in treated males. Necropsy revealed inflammatory lesions in the nasal passages of males and females at all levels, thymic and seminal vesicle atrophy in high-dose males, and inflammatory lesions in the trachea, lung and corneas of high-dose males and females.

In persons with impaired pulmonary function, expecially those with obstructive airway diseases, the breathing of diisopropylamine might cause exacerbation of symptoms due to its irritant properties. ... Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. ... Those with pre-existing eye problems may be at increased risk from exposure.

The substance is harmful to aquatic organisms.

Diisopropylamine's production and use as a chemical intermediate and catalyst may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 79.4 mm Hg at 25 °C indicates diisopropylamine will exist solely as a vapor in the ambient atmosphere. Vapor-phase diisopropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. If released to soil, diisopropylamine is expected to have high mobility based upon an estimated Koc of 140. The pKa of diisopropylamine is 11.07 indicating that this compound will exist in the protonated form in the environment and cations generally adsorb to organic carbon and clays more strongly than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process because the cation will not volatilize. Diisopropylamine may volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation may be important in soil and water providing a sufficient acclimation has occurred. High concns (> 50 ppm) of diisopropylamine may be toxic to microorganisms. If released into water, diisopropylamine's pKa value indicates that the protonated form will be the dominant species under most environmental conditions. The neutral species is not expected to adsorb to suspended solids and sediment in the water column based upon the estimated Koc; however the cation is expected to adsorb to suspended solids and sediment. Volatilization from water surfaces is not expected to be an important fate process since this compound is expected to exist in the protonated form in water surfaces at environmental pH. An estimated BCF of 2 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to diisopropylamine may occur through inhalation and dermal contact with this compound at workplaces where diisopropylamine is produced or used. (SRC)

The substance is harmful to aquatic organisms.

Diisopropylamine's production and use as a chemical intermediate and catalyst may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 79.4 mm Hg at 25 °C indicates diisopropylamine will exist solely as a vapor in the ambient atmosphere. Vapor-phase diisopropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. If released to soil, diisopropylamine is expected to have high mobility based upon an estimated Koc of 140. The pKa of diisopropylamine is 11.07 indicating that this compound will exist in the protonated form in the environment and cations generally adsorb to organic carbon and clays more strongly than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process because the cation will not volatilize. Diisopropylamine may volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation may be important in soil and water providing a sufficient acclimation has occurred. High concns (> 50 ppm) of diisopropylamine may be toxic to microorganisms. If released into water, diisopropylamine's pKa value indicates that the protonated form will be the dominant species under most environmental conditions. The neutral species is not expected to adsorb to suspended solids and sediment in the water column based upon the estimated Koc; however the cation is expected to adsorb to suspended solids and sediment. Volatilization from water surfaces is not expected to be an important fate process since this compound is expected to exist in the protonated form in water surfaces at environmental pH. An estimated BCF of 2 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to diisopropylamine may occur through inhalation and dermal contact with this compound at workplaces where diisopropylamine is produced or used. (SRC)

Diisopropylamine was detected as a volatile constituent of raw beef(1).

Diisopropylamine's production and use as a chemical intermediate and catalyst(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 140(SRC) from a log Kow of 1.4(2) and a regression derived equation(3) indicates that diisopropylamine is expected to have high mobility in soil(SRC). A pKa value of 11.07(4) indicates that the protonated form of diisopropylamine will be the dominant species in moist soil surfaces and cations generally adsorb to organic carbon and clays more strongly than their neutral counterparts(SRC). Volatilization of diisopropylamine from moist soil surfaces is not expected to be an important fate process since the cation will not volatilize. The potential for volatilization of diisopropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 79.4 mm Hg at 25 °C(5). Based on screening tests(6,7), biodegradation may be an important fate process in soil, providing sufficient acclimation has occured. However, high concns of diisopropylamine (> 50 ppm) appear to be toxic to microorganisms and, thus, may reduce biodegradation(6,7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 140(SRC) from a log Kow of 1.4(2) and a regression derived equation(3) indicates that diisopropylamine is not expected to adsorb to suspended solids and sediment in water(SRC). A pKa value of 11.07(4) indicates that the protonated form of diisopropylamine will be the predominant species in water and cations generally adsorb more strongly than their neutral counterparts. Volatilization from water surfaces is not expected to be important fate process(SRC) since the protonated form is not expected to volatilize at environmental pH. According to a classification scheme(5), an estimated BCF of 2(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on screening tests(7,8), biodegradation may be an important fate process in aquatic systems providing sufficient acclimation has occurred.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diisopropylamine, which has a vapor pressure of 79.4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diisopropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), from its rate constant of 9.7X10-11 cu cm/molecule-sec at 25 °C(3). Diisopropylamine is not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum(SRC).

Diisopropylamine achieved 1% of the theoretical BOD over an incubation period of 5 days in an aerobic screening study at 20 °C using sewage inoculum(1). In a second run of the same screening study using acclimated sewage seed, 43% of the theoretical BOD was achieved after 5 days(1). At an initial concn of 10 ppm diisopropylamine, 0% of the theoretical BOD was observed after an incubation period of 14 days in a screening study using sludge inoculum(2). In the same study using acclimated sludge inoculum, 31.5% of the theoretical BOD was observed after 15 days using the same initial concn of diisopropylamine(2). Furthermore, in the same study, initial concns of 50 and 100 ppm diisopropylamine appeared to be inhibitory to microbial growth(2).

The rate constant for the vapor-phase reaction of diisopropylamine with photochemically-produced hydroxyl radicals has been estimated as 9.7X10-11 cu cm/molecule-sec at 25 °C(SRC)(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Diisopropylamine will exist predominantly in the protonated form in the environment based on a pKa value of 11.07(2). Diisopropylamine is not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum(SRC).

An estimated BCF of 2 was calculated for diisopropylamine(SRC), using a log Kow of 1.4(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of diisopropylamine was estimated as 140(SRC), using a log Kow of 1.4(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diisopropylamine is expected to have high mobility in soil(SRC). The pKa of diisopropylamine is 11.07(4), indicating that the protonated form will be the predominant species in moist soils and cationic molecules generally adsorb to organic carbon and clays more strongly than their neutral counterparts(SRC).

With a pKa of 11.07(1), diisopropylamine will exist predominantly in its protonated form in the environment and the protonated form of diisopropylamine will not volatilize from water or moist soil surfaces at environmental pH(2). Diisopropylamine may volatilize from dry soil surfaces(SRC) based on its vapor pressure of 79.4 mm Hg at 25 °C(3).

Diisopropylamine was qualitatively identified in soil samples taken from the region of Moscow(1).

Diisopropylamine was detected in raw beef at a concn of 0.05 ug/kg(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,354 workers (729 of these are female) are potentially exposed to diisopropylamine in the US(1). Occupational exposure to diisopropylamine may occur through inhalation and dermal contact with this compound at workplaces where diisopropylamine is produced or used(SRC).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

DIISOPROPYLAMINE MAY BE DISPOSED OF BY ATOMIZING IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for DIISOPROPYLAMINE (8 total), please visit the HSDB record page.

IMO 3.2; Diisopropylamine

UN 1158; Diisopropylamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid Corrosive

Do not transport with food and feedstuffs.

UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: II