2,6-Lutidine

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (22.5%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (19.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (14.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 338 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P317, P303+P361+P353, P330, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

3.1 [ppm]

34 [ppm]

200 [ppm]

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Lutidine appears as a colorless liquid with a peppermint odor. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make other chemicals.

Oily liquid; [Merck Index] Colorless liquid; [MSDSonline]

Colourless oily liquid; Diffusive minty aroma, nutty, coffee-like

Oily liq

Odor of pyridine plus peppermint

144 °C @ 760 mm Hg

143.00 to 145.00 °C. @ 760.00 mm Hg

143-145 °C

144 °C @760 [mm Hg]

Slightly soluble in ethanol; soluble in ethyl ether and acetone

Sol in water (% wt/wt): 27.2% @ 45.3 °C; 18.1% @ 48.1 °C; 12.1% @ 57.5 °C; 9.5% @ 74.5 °C; miscible with dimethylformamide and tetrahydrofuran

In water, 3.00X10+5 mg/l @ 34 °C

300 mg/mL at 34 °C

Soluble in water; Slightly soluble in fat

Soluble (in ethanol)

0.9252 @ 20 °C/4 °C

DENSITY: 0.942 @ 0 °C/4 °C

0.917-0.923

0.9252 @ 20°C

3.70 (Air= 1)

5.65 [mmHg]

5.65 mm Hg @ 25 °C

5.65 [mm Hg] @25 °C

log Kow = 1.68

Henry's Law constant = 1.04X10-5 atm-cu m/mol @ 25 °C

When heated to decomposition it emits toxic vapors of /nitrogen oxide/.

Positive

Agilent XCT

Electrospray ionization

formic acid (5.3nM)

MeCN (80%)

DOI:10.1007/s13361-016-1563-1

Index of refraction: 1.4953 @ 20 °C/D

1.495-1.501

pKa = 6.60 (conjugate acid)

15N nuclear magnetic resonance spectrum

Boiling point

Chemical shift

Composition

Diamagnetic susceptibility

Highly flammable. Soluble in water.

Amines, Phosphines, and Pyridines

Highly Flammable

CSL00111

WATER + Mercury(II) perchlorate hydrate + 2,6 lutidine + TETRAHYDROFURAN

Explosion tetrahydrofuran, water, 2,6 lutidine, and mercury perchlorate hydrate

M (up to 100g)

dithiane hydrolysis

The reaction chemicals were scaled up, but the amount of solvent was not scaled up to an equivalent proportion. The amount of material used in the reaction was approximately 20 times more concentrated than the quantity specified in the literature. Electronic software was used to calculate the quantities of all reactants but not the quantity of solvent. Additionally, the lesser amount of solvent used in this reaction made it difficult for the magnetic stirrer bar to effectively mix

User-Reported

11/14/17

LUTIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Neurotoxin - Other CNS neurotoxin

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

LCLo (rat) = 7,500 ppm/1h

LD50 Rat oral 400 mg/kg

LD50 Guinea pig skin 2500 mg/kg

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aniline and related compounds/

...LUTIDINES...CAUSE SYMPTOMS RESEMBLING THOSE OBSERVED WITH PYRIDINE. THESE ARE LARGELY NONSPECIFIC & INCLUDE WEAKNESS, ATAXIA, DIARRHEA, & UNCONSCIOUSNESS. ... MAJORITY OF DERIV...ARE PRIMARY IRRITANTS & PENETRATE INTACT GUINEA PIG SKIN READILY. ... CAUSE...INTENSE SKIN & EYE IRRITATION. /PYRIDINE DERIVATIVES/

INHALATION OF 7500 PPM CONCN VAPOR OF 2,6-LUTIDINE BY RATS CAUSED 100% MORTALITY IN 1.2 HR.

IN DOGS WITH A UREA LOAD, IV ADMIN OF 2,6-LUTIDINE MARKEDLY INCR URINE VOL & UREA CLEARANCE.

2,6-Lutidine's production and use as a chemical intermediate in the production of pharmaceuticals, resins, dyestuffs, rubber accelerators and insecticides may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 5.65 mm Hg at 25 °C indicates 2,6-lutidine will exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,6-lutidine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 6 days. If released to soil, 2,6-lutidine is expected to have moderate mobility based upon an estimated Koc of 200. The pKa of 2,6-lutidine is 6.6, which indicates that 2,6-lutidine will partially exist in the protonated form in moist soils and cations adsorb to soil surfaces more strongly than neutral compounds. Volatilization from moist soil surfaces is expected to be an important fate process for the neutral species based upon a Henry's Law constant of 1.04X10-5 atm-cu m/mole. 2,6-Lutidine may volatilize from dry soil surfaces based upon its vapor pressure. 2,6-Lutidine is expected to undergo slow biodegradation under aerobic conditions. The half-life of 2,6-lutidine in an unpolluted surface soil was approximately 1 month under aerobic conditions with 100% degradation observed after 3 months; in another soil, complete biodegradation ocurred in 32 days. Little degradation was observed under denitrifying and sulfate-reducing conditions. If released into water, 2,6-lutidine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process for the neutral species based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2 and 31 days, respectively. The protonated form of 2,6-lutidine will not volatilize. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to 2,6-lutidine may occur through inhalation and dermal contact with this compound at workplaces where 2,6-lutidine is produced or used. Monitoring data indicate that the general population may be exposed to 2,6-lutidine via ingestion of food and drinking water. Since this compound is a constituent of coal tar and coal tar creosote, the general population may be exposed to 2,6-lutidine from consumer products which contain coal tar or coal tar creosote. (SRC)

2,6-Lutidine's production and use as a chemical intermediate in the production of pharmaceuticals, resins, dyestuffs, rubber accelerators and insecticides(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a measured log Kow of 1.68(2) and a regression-derived equation(3), indicates that 2,6-lutidine is expected to have moderate mobility in soil(SRC). The pKa of 2,6-lutidine is 6.6(4), which indicates that 2,6-lutidine will partially exist in the protonated form in moist soils and cations adsorb to soil surfaces more strongly than neutral compounds(SRC). Volatilization of the neutral species of 2,6-lutidine from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.04X10-5 atm-cu m/mole(5), but the protonated form will not volatilize. The potential for volatilization of 2,6-lutidine from dry soil surfaces may exist based upon a vapor pressure of 5.65 mm Hg(6). 2,6-Lutidine biodegrades in soils under aerobic conditions(7). The half-life of 2,6-lutidine was approximately 1 month in an unpolluted surface soil under aerobic conditions with 100% degradation observed after 3 months(7) in a second, 2,6-lutadine was completely degraded in 32 days(8). Little degradation was observed under denitrifying and sulfate-reducing conditions(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a measured log Kow of 1.68 (2) and a regression-derived equation(3), indicates that 2,6-lutidine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.04X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 and 31 days, respectively(SRC). The pKa of 2,6-lutidine is 6.6(5), which indicates that 2,6-lutidine will partially exist in the protonated form in water and cations will not volatilize(SRC). According to a classification scheme(6), an estimated BCF of 4(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 2,6-Lutidine was shown to biodegrade under aerobic conditions in soil (especially polluted soil), but the rate of degradation was slower under anaerobic conditions(8); similar biodegradation in water is expected. 2,6-Lutidine was degraded approximately 30% over the course of a 35 day incubation period in column experiments using contaminated groundwater from a coal tar producing chemical facility as inoculum(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,6-lutidine, which has a vapor pressure of 5.65 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,6-lutidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 days(SRC), calculated from its rate constant of 2.8X10-12 cu cm/molecule-sec at 25 °C (SRC) determined using a structure estimation method(3).

An initial concn of 214 ppm 2,6-lutidine incubated in a Fincastle silt loam, was degraded 19, 22.2, 29.5, 42.4, 57.9 and 100% after 1, 2, 4, 8, 16 and 32 days, respectively(1). Mixed cultures isolated from a polluted soil were shown to degrade 2,6-lutidine(2). The half-life of 2,6-lutidine was approximately 1 month in an unpolluted surface soil under aerobic conditions with 100% degradation observed after 3 months, while little degradation was observed under denitrifying and sulfate reducing conditions(3). The half-life was about 0.5 months in polluted surface and subsurface soils with 100% degradation observed after 1 month(3). 2,6-Lutidine was degraded approximately 30% during a 35 day incubation period in column experiments using contaminated groundwater from a coal tar producing chemical facility as inoculum(4). The half-life of 2,6-lutidine in polluted subsurface sediments was 6 days(4).

The rate constant for the vapor-phase reaction of 2,6-lutidine with photochemically-produced hydroxyl radicals has been estimated as 2.8X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The pKa of 2,6-lutidine is 6.6(2), which indicates that 2,6-lutidine will partially exist in the protonated form in the environment(SRC). Analogous 3,5-lutidine has a weak absorption band that extends into the environmental UV spectrum(3), which suggests that direct photolysis is not likely to occur for alkylated pyridines(SRC).

An estimated BCF of 4 was calculated for 2,6-lutidine(SRC), using a log Kow of 1.68(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 2,6-lutidine is estimated as 200(SRC), using a measured log Kow of 1.68(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,6-lutidine is expected to have moderate mobility in soil. The pKa of 2,6-lutidine is 6.6(4), which indicates that 2,6-lutidine will partially exist in the protonated form in moist soils and cations adsorb to soil surfaces more strongly than neutral compounds(SRC).

The Henry's Law constant for 2,6-lutidine is 1.04X10-5 atm-cu m/mole(1). This Henry's Law constant indicates that 2,6-lutidine is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 days (SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 31 days(SRC). 2,6-Lutidine's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). The pKa of 2,6-lutidine is 6.6(3), which indicates that 2,6-lutidine will partially exist in the protonated form in water and moist soils and cations will not volatilize(SRC). 2,6-Lutidine may volatilize from dry soil surfaces(SRC) based on its vapor pressure of 5.65 mm Hg at 25 °C(4).

Unspecified isomers of lutidine were detected in streamwater and groundwater from an abandoned creosote manufacturing plant in Pensacola, FL at concns of 0.0058 and 0.1 mg/l, respectively(1). 2,6-Lutidine was detected in groundwater near a creosote manufacturing plant in Indianapolis, IN at 1,928 mg/l(2). 2,6-Lutidine was identified, not quantified, in drinking water in the US(3).

2,6-Lutidine was detected in oil shale retort water in Australia at a concn of 3 mg/l(1). Effluent from a municipal treatment plant in Hamilton, Ontario released 2,6-lutidine at a rate of 0.42 kg/day(2). Unspecified isomers of lutidine were detected in feedwater and permeate water from an abandoned creosote manufacturing plant in Pensacola, FL at concns of 2.48 and 0.032 mg/l, respectively(3).

2,6-Lutidine was identified, not quantified, in soil from Moscow, Russia(1).

2,6-Lutidine was identified, not quantified, in boiled beef(1) and roasted filberts(2).

Occupational exposure to 2,6-lutidine may occur through inhalation and dermal contact with this compound at workplaces where 2,6-lutidine is produced or used. Monitoring data indicate that the general population may be exposed to 2,6-lutidine via ingestion of food and drinking water. Since this compound is a constituent of coal tar and coal tar creosote, the general population may be exposed to 2,6-lutidine from consumer products which contain coal tar or coal tar creosote. (SRC)

2,6-Lutidine's production and use as a chemical intermediate in the production of pharmaceuticals, resins, dyestuffs, rubber accelerators and insecticides may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 5.65 mm Hg at 25 °C indicates 2,6-lutidine will exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,6-lutidine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 6 days. If released to soil, 2,6-lutidine is expected to have moderate mobility based upon an estimated Koc of 200. The pKa of 2,6-lutidine is 6.6, which indicates that 2,6-lutidine will partially exist in the protonated form in moist soils and cations adsorb to soil surfaces more strongly than neutral compounds. Volatilization from moist soil surfaces is expected to be an important fate process for the neutral species based upon a Henry's Law constant of 1.04X10-5 atm-cu m/mole. 2,6-Lutidine may volatilize from dry soil surfaces based upon its vapor pressure. 2,6-Lutidine is expected to undergo slow biodegradation under aerobic conditions. The half-life of 2,6-lutidine in an unpolluted surface soil was approximately 1 month under aerobic conditions with 100% degradation observed after 3 months; in another soil, complete biodegradation ocurred in 32 days. Little degradation was observed under denitrifying and sulfate-reducing conditions. If released into water, 2,6-lutidine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process for the neutral species based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2 and 31 days, respectively. The protonated form of 2,6-lutidine will not volatilize. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to 2,6-lutidine may occur through inhalation and dermal contact with this compound at workplaces where 2,6-lutidine is produced or used. Monitoring data indicate that the general population may be exposed to 2,6-lutidine via ingestion of food and drinking water. Since this compound is a constituent of coal tar and coal tar creosote, the general population may be exposed to 2,6-lutidine from consumer products which contain coal tar or coal tar creosote. (SRC)

2,6-Lutidine's production and use as a chemical intermediate in the production of pharmaceuticals, resins, dyestuffs, rubber accelerators and insecticides(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a measured log Kow of 1.68(2) and a regression-derived equation(3), indicates that 2,6-lutidine is expected to have moderate mobility in soil(SRC). The pKa of 2,6-lutidine is 6.6(4), which indicates that 2,6-lutidine will partially exist in the protonated form in moist soils and cations adsorb to soil surfaces more strongly than neutral compounds(SRC). Volatilization of the neutral species of 2,6-lutidine from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.04X10-5 atm-cu m/mole(5), but the protonated form will not volatilize. The potential for volatilization of 2,6-lutidine from dry soil surfaces may exist based upon a vapor pressure of 5.65 mm Hg(6). 2,6-Lutidine biodegrades in soils under aerobic conditions(7). The half-life of 2,6-lutidine was approximately 1 month in an unpolluted surface soil under aerobic conditions with 100% degradation observed after 3 months(7) in a second, 2,6-lutadine was completely degraded in 32 days(8). Little degradation was observed under denitrifying and sulfate-reducing conditions(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a measured log Kow of 1.68 (2) and a regression-derived equation(3), indicates that 2,6-lutidine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.04X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 and 31 days, respectively(SRC). The pKa of 2,6-lutidine is 6.6(5), which indicates that 2,6-lutidine will partially exist in the protonated form in water and cations will not volatilize(SRC). According to a classification scheme(6), an estimated BCF of 4(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 2,6-Lutidine was shown to biodegrade under aerobic conditions in soil (especially polluted soil), but the rate of degradation was slower under anaerobic conditions(8); similar biodegradation in water is expected. 2,6-Lutidine was degraded approximately 30% over the course of a 35 day incubation period in column experiments using contaminated groundwater from a coal tar producing chemical facility as inoculum(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,6-lutidine, which has a vapor pressure of 5.65 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,6-lutidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 days(SRC), calculated from its rate constant of 2.8X10-12 cu cm/molecule-sec at 25 °C (SRC) determined using a structure estimation method(3).

An initial concn of 214 ppm 2,6-lutidine incubated in a Fincastle silt loam, was degraded 19, 22.2, 29.5, 42.4, 57.9 and 100% after 1, 2, 4, 8, 16 and 32 days, respectively(1). Mixed cultures isolated from a polluted soil were shown to degrade 2,6-lutidine(2). The half-life of 2,6-lutidine was approximately 1 month in an unpolluted surface soil under aerobic conditions with 100% degradation observed after 3 months, while little degradation was observed under denitrifying and sulfate reducing conditions(3). The half-life was about 0.5 months in polluted surface and subsurface soils with 100% degradation observed after 1 month(3). 2,6-Lutidine was degraded approximately 30% during a 35 day incubation period in column experiments using contaminated groundwater from a coal tar producing chemical facility as inoculum(4). The half-life of 2,6-lutidine in polluted subsurface sediments was 6 days(4).

The rate constant for the vapor-phase reaction of 2,6-lutidine with photochemically-produced hydroxyl radicals has been estimated as 2.8X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The pKa of 2,6-lutidine is 6.6(2), which indicates that 2,6-lutidine will partially exist in the protonated form in the environment(SRC). Analogous 3,5-lutidine has a weak absorption band that extends into the environmental UV spectrum(3), which suggests that direct photolysis is not likely to occur for alkylated pyridines(SRC).

An estimated BCF of 4 was calculated for 2,6-lutidine(SRC), using a log Kow of 1.68(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 2,6-lutidine is estimated as 200(SRC), using a measured log Kow of 1.68(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,6-lutidine is expected to have moderate mobility in soil. The pKa of 2,6-lutidine is 6.6(4), which indicates that 2,6-lutidine will partially exist in the protonated form in moist soils and cations adsorb to soil surfaces more strongly than neutral compounds(SRC).

The Henry's Law constant for 2,6-lutidine is 1.04X10-5 atm-cu m/mole(1). This Henry's Law constant indicates that 2,6-lutidine is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 days (SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 31 days(SRC). 2,6-Lutidine's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). The pKa of 2,6-lutidine is 6.6(3), which indicates that 2,6-lutidine will partially exist in the protonated form in water and moist soils and cations will not volatilize(SRC). 2,6-Lutidine may volatilize from dry soil surfaces(SRC) based on its vapor pressure of 5.65 mm Hg at 25 °C(4).

Unspecified isomers of lutidine were detected in streamwater and groundwater from an abandoned creosote manufacturing plant in Pensacola, FL at concns of 0.0058 and 0.1 mg/l, respectively(1). 2,6-Lutidine was detected in groundwater near a creosote manufacturing plant in Indianapolis, IN at 1,928 mg/l(2). 2,6-Lutidine was identified, not quantified, in drinking water in the US(3).

2,6-Lutidine was detected in oil shale retort water in Australia at a concn of 3 mg/l(1). Effluent from a municipal treatment plant in Hamilton, Ontario released 2,6-lutidine at a rate of 0.42 kg/day(2). Unspecified isomers of lutidine were detected in feedwater and permeate water from an abandoned creosote manufacturing plant in Pensacola, FL at concns of 2.48 and 0.032 mg/l, respectively(3).

2,6-Lutidine was identified, not quantified, in soil from Moscow, Russia(1).

2,6-Lutidine was identified, not quantified, in boiled beef(1) and roasted filberts(2).

Occupational exposure to 2,6-lutidine may occur through inhalation and dermal contact with this compound at workplaces where 2,6-lutidine is produced or used. Monitoring data indicate that the general population may be exposed to 2,6-lutidine via ingestion of food and drinking water. Since this compound is a constituent of coal tar and coal tar creosote, the general population may be exposed to 2,6-lutidine from consumer products which contain coal tar or coal tar creosote. (SRC)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Corrosive Flammable Liquid