Phloroglucinol

This chemical does not meet GHS hazard criteria for 1.9% (2 of 108) of reports.

H315 (81.5%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (41.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H319 (81.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (81.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H341 (11.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H361 (11.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H412 (12%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 108 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 2 of 108 reports by companies.

There are 22 notifications provided by 106 of 108 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

White solid; Discolored by light; [Merck Index] White or cream colored powder; [MSDSonline] Crystallizes in anhydrous or dihydrate form; Sweet tasting crystals; [Ullmann]

218.5 °C

10.6 mg/mL at 20 °C

0.00016 [mmHg]

121.6 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID3046586]

13C nuclear magnetic resonance spectrum

Schoenflies notation

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Other Classes -> Phenols

Pharmaceuticals -> Listed in ZINC15

Cosmetic ingredients (Phloroglucinol) -> CIR (Cosmetic Ingredient Review)

Hair dyeing

Potential endocrine disrupting compound

On the basis of the available data, the CIR Panel cannot conclude that Phloroglucinol is safe for use in cosmetic products until the appropriate safety data have been obtained and evaluated.

Ingredients for which the data are insufficient and their use in cosmetics is not supported

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

Phloroglucinol

DILI Positive

DOI:10.1016/j.drudis.2019.09.022