methylcyclohexane

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P261, P264, P271, P273, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P319, P321, P331, P332+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H304 (100%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H336 (99.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H400 (19.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (17.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

H411 (84.9%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 1536 reports by companies from 43 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P264+P265, P271, P273, P280, P301+P316, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P331, P337+P317, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P273, P391, and P501 (click each P-code to see the statement)

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P319, P330, P331, P332+P317, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest. Refer for medical attention .

Excerpt from NIOSH Pocket Guide for Methylcyclohexane:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: SOAP WASH PROMPTLY - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For mixtures containing alcohol or polar solvent, alcohol-resistant foam may be more effective.

SMALL FIRE: Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

LARGE FIRE: Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. For petroleum crude oil, do not spray water directly into a breached tank car. This can lead to a dangerous boil over. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

FOAM, CARBON DIOXIDE, DRY CHEMICAL

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Absorb on paper. Evaporate on a glass or iron dish in hood. Burn the paper.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personal hazard. Use water spray to knock-down vapors.

Spray into the furnace. Incineration will become easier by mixing with a more flammable solvent.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Work clothing that becomes wet should be immediately removed due to its flammability hazard.

The worker should immediately wash the skin when it becomes contaminated.

Personnel protection: Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants.

Storage rooms should be bunded to prevent the spread of escaping liquid & electrical installations should be of flameproof type.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

200.0 [ppm]

400 [ppm]

1700 [ppm]

10000 [ppm]

400 ppm (1600 mg/m³)

TWA 400 ppm (1600 mg/m3)

500.0 [ppm]

500 ppm (2000 mg/m³)

TWA 500 ppm (2000 mg/m3) See Appendix G

1200 ppm ; Based on the lower explosive limit. (NIOSH, 2024)

1200.0 [ppm]

Excerpts from Documentation for IDLHs: Basis for original (SCP) IDLH: With no reported human toxicological data, the chosen IDLH is based on the statement by Browning [1965] that Treon et al. [1943] were able to produce light narcosis in mice at 10,054 ppm. Browning [1965] also reported that Lazarew [1929] found the narcotic dose for mice to be 7,500 to 10,000 ppm. ACGIH [1971] noted that this narcotic dose (7,500 to 10,000 ppm) was for a 2­hour exposure [Lazarew 1929; Treon et al. 1943]. . . . Human data: None relevant for use in determining the revised IDLH.

1200 ppm [Based on 10% of the lower explosion limit for safety considerations even though the relevant toxicological data indicated that irreversible health efects or impairment of escape existed only at higher concentrations.]

1200 ppm

1200 ppm [LEL]

See: 108872

100.0 [ppm]

8 hr Time Weighted Avg (TWA): 400 ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

400 ppm as TWA.

400 ppm [1962]

810 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

CAUTION: For mixtures containing alcohol or polar solvent, alcohol-resistant foam may be more effective.

Small Fire

· Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

Large Fire

· Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· For petroleum crude oil, do not spray water directly into a breached tank car. This can lead to a dangerous boil over.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

The substance is irritating to the eyes and skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. Exposure could cause lowering of consciousness.

Methylcyclohexane appears as a clear colorless liquid with a petroleum-like odor. Flash point 25 °F. Less dense than water and insoluble in water. Vapors heavier than air.

Liquid; CBI

Colorless liquid with a faint, benzene-like odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a faint, benzene-like odor.

COLORLESS LIQUID

Colorless liquid.

Faint, benzene-like odor.

213.8 °F at 760 mmHg (USCG, 1999)

100.9 °C @ 760 MM HG

100.3 °C @760 [mm Hg]

-194.8 °F (USCG, 1999)

-126.6 °C

-126.7 °C

-126.4 °C

25 °F (USCG, 1999)

25 °F (-4 °C)(Closed cup)

-6 °C o.c.

Insoluble (NIOSH, 2024)

SOL IN ALCOHOL, ETHER, ACETONE, BENZENE

MISCIBLE WITH PETROLEUM ETHER, CARBON TETRACHLORIDE

14.0 mg/l at 20 °C /water/

water solubility = 14.0 mg/l @ 25 °C

Solubility in water: none

Insoluble

0.77 (USCG, 1999) - Less dense than water; will float

0.7694 @ 20 °C/4 °C

Relative density (water = 1): 0.8

0.77 @ 20°C

3.39 (air= 1)

Relative vapor density (air = 1): 3.4

83.29 mmHg (USCG, 1999)

46.0 [mmHg]

46 MM HG @ 25 °C

Vapor pressure, kPa at 25 °C: 5.73

46 [mm Hg] @25 °C

log Kow = 3.61

482 °F (USCG, 1999)

482 °F (250 °C)

4565.3 kJ/mol at 25 °C (liquid)

Highly flammable. Insoluble in water.

Hydrocarbons, Aliphatic Saturated

Highly Flammable

Saturated aliphatic hydrocarbons, such as METHYLCYCLOHEXANE, may be incompatible with strong oxidizing agents like nitric acid. Charring of the hydrocarbon may occur followed by ignition of unreacted hydrocarbon and other nearby combustibles. In other settings, aliphatic saturated hydrocarbons are mostly unreactive. They are not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents.

Strong oxidizers

Dangerous /disaster hazard/; upon exposure to heat or flame, can react vigorously with oxidizing materials.

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

inhalation, ingestion, skin and/or eye contact

Dizziness. Drowsiness.

Dry skin.

Redness.

Nausea. Further see Inhalation.

irritation eyes, skin, nose, throat; dizziness, drowsiness; In Animals: narcosis

Eyes, skin, respiratory system, central nervous system

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Methylcyclohexane

1 x 10^-2 mg/kg-day

1 x 10^-1 mg/m^3

PDF Document

Inadequate information to assess carcinogenic potential

SCREEN Current

PPRTV Current

LCLo (rat) = 82,000 mg/m3/1H

LC25 Rabbit inhalation 7300 ppm, 6 hr/day, 5 day/wk, 2 wk

VAPOR CAUSES BRIEF CENTRAL NERVOUS DEPRESSION LIKE CYCLOHEXANE. ... NO SYSTEMIC POISONINGS REPORTED ... .

Nervous system disturbances - /CNS depression/.

Lightheadedness, drowsiness; ... .

No toxic effects from industrial exposure nor any case of intoxication in humans by methylcyclohexane has been reported.

... IRRITANT & DEFATTING ACTION ON THE SKIN. /CYCLOPARAFFINS/

INHALATION ... OF 7500 TO 10,000 PPM FOR TWO HOURS CAUSED PROSTRATION IN WHITE MICE, AND 10,000 TO 12,500 PPM WAS FATAL. ... ACUTE TOXICITY OF METHYLCYCLOHEXANE WAS GREATER THAN THAT OF HEPTANE, BUT LESS THAN THAT OF OCTANE. ... 1200 PPM /WAS REPORTED/ TO BE INNOCUOUS FOR RABBITS. PROLONGED EXPOSURE AT 370 PPM APPEARED TO BE HARMLESS TO MONKEYS.

NO EFFECTS RESULTED FROM REPEATED EXPOSURES OF RABBITS AT 1160 PPM FOR 10 WEEKS, AND ONLY SLIGHT KIDNEY AND LIVER INJURY WAS OBSERVED AT 3330 PPM.

ORAL DOSE IN RABBITS CAUSED MILD LETHARGY, SEVERE DIARRHEA AND CIRCULATORY COLLAPSE. VASCULAR & DEGENERATIVE LESIONS ARE SEEN IN KIDNEY & LIVER.

RABBITS EXPOSED TO 15,000 PPM ... DIED IN 70 MIN. EFFECTS OBSERVED PRECEDING DEATH WERE: CONJUNCTIVAL CONGESTION, SALIVATION, LABORED BREATHING ... ./SRP: CNS DEPRESSION/ CONVULSIONS.

For more Non-Human Toxicity Excerpts (Complete) data for METHYLCYCLOHEXANE (15 total), please visit the HSDB record page.

LC50 Golden shiner 72.0 mg/l/96 hr (emulsion) /Conditions of bioassay not specified/

9.80e+01

4.10e+02

9.90e+01

4.20e+02

2.00e+02

4.00e+01

4.40e-01

9.50e-02

Volatile

6.76e+01

LC50 Golden shiner 72.0 mg/l/96 hr (emulsion) /Conditions of bioassay not specified/

9.80e+01

4.10e+02

9.90e+01

4.20e+02

2.00e+02

4.00e+01

4.40e-01

9.50e-02

Volatile

6.76e+01

2.90e+02

1.20e+03

3.00e+02

5.90e+02

Occurs naturally in Russian and Galician petroleum ... .

... In cracked petroleums.

Biodegradation: 75% after 192 hr at 13 °C (initial concentration: 0.05 ug/l)

Inhalation, ingestion, eye and skin contact.

No toxic effects from industrial exposure nor any case of intoxication in humans by methylcyclohexane has been reported.

The air in 7 shoe (4 shoe and 3 shoe upper) factories was measured for the concentration of solvents including methylcyclohexane at different work places throughout the plant. Methylcyclohexane was found in the air in both places. The threshold limit value was exceeded in the gluing work places of factories without ventilation systems and in all shoe upper factories.

Spray into the furnace. Incineration will become easier by mixing with a more flammable solvent.

/GUIDE 128: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substances may be transported hot.

/GUIDE 128: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 128: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 128: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for METHYLCYCLOHEXANE (8 total), please visit the HSDB record page.

UN 2296; Methylcyclohexane

IMO 3.2; Methylcyclohexane

49 093 30; Methylcyclohexane

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: F, Xn, N; R: 11-38-51/53-65-67; S: (2)-9-16-33-61-62

UN Hazard Class: 3; UN Pack Group: II