N,N-dimethyl-1,3-propanediamine

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1360) of reports.

H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]

H302+H312 (33.7%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]

H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (52.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (> 99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (55.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335 (21.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1360 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 1360 reports by companies.

There are 27 notifications provided by 1359 of 1360 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P273, and P501 (click each P-code to see the statement)

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

Use water spray, powder, carbon dioxide, alcohol-resistant foam. In case of fire: keep drums, etc., cool by spraying with water.

To fight fire, use alcohol foam, carbon dioxide, dry chemical.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water. Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

A) PREVENT CONTACT WITH ALIPHATIC AMINES ... PROCESS THEM IN CLOSED VESSELS. B) ... USE SUITABLE BARRIER CREAMS /ON HANDS/. C) DECR CONCN OF ... VAPORS BY GOOD VENTILATION ... AMINES WITH HEAVY VAPORS ... SHOULD BE DRAWN OFF BY DESCENT. /ALIPHATIC AMINES/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs. Well closed.

6.0 [mg/m3]

14 [mg/m3]

81 [mg/m3]

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. Medical observation is indicated.

Repeated or prolonged contact may cause skin sensitization.

RECOMMENDED RESPIRATOR: When working with this chemical, wear a NIOSH-approved full face chemical cartridge respirator equipped with the appropriate organic vapor cartridges. If that is not available, a half face respirator similarly equipped plus airtight goggles can be substituted. However, please note that half face respirators provide a substantially lower level of protection than do full face respirators.

RECOMMENDED GLOVE MATERIALS: It is recommended that two different glove types be used for best protection. However, if this chemical makes direct contact with your gloves, or if a tear, puncture or hole develops, remove them at once.

SUGGESTED GLOVES: Butyl rubber (NTP, 1992)

... B) PROTECT HANDS WITH RUBBER GLOVES ... /ALIPHATIC AMINES/

NO open flames, NO sparks and NO smoking. Above 35 °C use a closed system, ventilation and explosion-proof electrical equipment.

AVOID ALL CONTACT!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Dimethylaminopropylamine is a colorless liquid. (NTP, 1992)

Liquid; CBI

Colorless liquid; [HSDB]

COLOURLESS LIQUID.

Colorless liquid

Ammoniacal odor

253 °F at 760 mmHg (NTP, 1992)

123 °C @760 [mm Hg]

less than -94 °F (NTP, 1992)

FP: -70 °C

60 °F (NTP, 1992)

[ICSC] 90 °F

95 °F CC

35 °C c.c.

Soluble (NTP, 1992)

Sol in water and org solvents

Soluble in oxygenated solvents

Solubility in water: miscible

0.81 (NTP, 1992) - Less dense than water; will float

0.8100 @ 30 °C

Relative density (water = 1): 0.81

0.8100 @ 30°C

3.5 (AIR= 1)

Relative vapor density (air = 1): 3.5

9.75 [mmHg]

Vapor pressure, kPa at 30 °C: 1.33

10 [mm Hg] @30 °C

When heated to decomposition it emits toxic fumes of nitroxides.

35.6 kJ/mol

Odor Threshold Low: 0.1 [ppm]

Odor threshold from CHEMINFO

Index of refraction: 1.4328 @ 25 °C/D

Sets to a glass below freezing point of -70 °C

Boiling point

Fusion temperature

Heat of sublimation

Melting temperature

Phase transition

Transition enthalpy

Vapor pressure

Highly flammable. Temperature sensitive and possibly sensitive to air. Water soluble.

Amines, Phosphines, and Pyridines

Highly Flammable

DIMETHYLAMINOPROPYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Ignites on contact with cellulose nitrate of high surface area.

Reaction with 1,2-dichloroethane produces explosive acetylene gas.

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing. Symptoms may be delayed.

Pain. Redness. Serious skin burns.

Pain. Blurred vision. Severe deep burns.

Burning sensation. Abdominal pain. Shock or collapse.

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LD50 Rabbit skin 600 ul/kg

D) EMPLOYEES PRONE TO SENSITIZATION OR WITH LIVER DEFICIENCY SHOULD BE REMOVED FROM ... /EXPOSURE/. WORKMEN ... SHOULD BE MEDICALLY EXAMINED AT REGULAR INTERVALS. /ALIPHATIC AMINES/

... VAPOR HAS CAUSED CORNEAL DISTURBANCE & BLURRED VISION. WORKERS EXPOSED TO CONCN THOUGHT TO BE ABOUT 30 PPM IN AIR NOTED DURING SEVERAL DAYS THAT VISION BECAME BLURRED TOWARD END OF WORK DAY, SOMETIMES WITH APPEARANCE OF HALOES AROUND LIGHTS, PAIN, PHOTOPHOBIA & HEADACHE, USUALLY BETTER BY NEXT DAY.

IN THREE WORKERS WHO HAD SYMPTOMS PERSISTING TWO TO THREE DAYS AFTER EXPOSURE, THE CORNEAL EPITHELIUM WAS SEEN TO BE EDEMATOUS, BUT NO OTHER OCULAR ABNORMALITIES WERE OBSERVED.

DURING 1974 A GROUP OF 25 WORKERS WERE EXPOSED TO AN EPOXY RESIN SYSTEM IN MOLD ROOM OF SKI MFR PLANT. 3-DIMETHYLAMINO PROPYLAMINE (3-DMAPA) WAS ONLY VOLATILIZED SUBSTANCE. ASSEMBLERS (A SUBGROUP) IN HIGHEST BREATHING ZONE (0.9 PPM) HAD HIGHEST PREVELANCE OF SYMPTOMS & SIGNIFICANT DECR IN LUNG FUNCTION OVER WORKSHIFT. EXTENSIVE IMPROVEMENTS IN LOCAL VENTILATION REDUCED AVG BREATHING ZONE EXPOSURE TO NEARLY 1/7 OF CONCN. CROSS-SECTIONAL STUDY IN 1977 SHOWED THAT AT THIS LEVEL THERE WAS MARKED REDUCTION IN SYMPTOMS & EXPIRATORY FUNCTION OF ASSEMBLERS NO LONGER DECR OVER WORKSHIFT. LONGITUDINAL COMPARISON OF LUNG FUNCTION OF WORKERS EXPOSED MORE THAN 2 YR SHOWED EVIDENCE OF DECR FROM 1975 TO 1977, BUT NONE FROM 1977 TO 1978.

TOXIC BY INGESTION & INHALATION, STRONG IRRITANT.

For more Human Toxicity Excerpts (Complete) data for N,N-DIMETHYL-1,3-PROPANEDIAMINE (8 total), please visit the HSDB record page.

A 1:100 AQUEOUS SOLN AT PH 12 ... CAUSED SEVERE ALKALI-TYPE CORNEAL INJURY IN RABBITS, BUT 1:100000 SOLN AT PH 7.6 CAUSED ALMOST NO INJURY.

3-Dimethylaminopropylamine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. DMP doses of 0, 33, 100, 333, 1000, 1666, 3333, 6666, and 10,000 ug/plate were tested in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. These tests were negative and the highest ineffective dose level tested in all four Salmonella tester strains under all treatment conditions was 3333 ug/plate. A slight clearing of the background lawn was reported at this dose level when tested in the presence of hamster liver S9. Data were not shown for all four strains with the two highest dose levels.

3-Dimethylaminopropylamine (CAS # 109-55-7) was evaluated for subchronic oral toxicity in groups of Wistar rats (5/sex/group) administered doses of 0, 10, 50, and 250 mg/kg-day by oral gavage for 28 days. Due to a high rate of mortality (3/5) among the 250 mg/kg females during the initial study, a second trial in 5 female rats receiving 250 mg/kg was conducted with data combined for 10 high-dose females. All animals were necropsied on the 29th day of study. Females of the high dose group only (4/10) died during the 28-day treatment period. Clinical signs, observed intermittently in this group between study days 11 and 24 and mainly among the intercurrent decedents, included hypoactivity, stilted gait, swollen abdomen, and labored breathing. A solitary high-dose male demonstrated impaired respiration. Bodyweights, organ weights, food and water consumption, urinalyses, and hematological and clinical chemistry evaluations did not deviate significantly from those of controls in any dose group. Upon necropsy, discolored lungs with surface red spots and foamy content, and a solitary small spleen characterized the gross pathology, identified solely in the decedent females. Microscopic examination revealed distinct lesions among these animals, which included organ congestion, hemorrhagic and/or edematous lungs, and profound loss and atrophy of splenic lymphatic follicles and lymphoid sheath, respectively. One symptomatic male of a 250 mg/kg dose group exhibited focal epithelial degeneration of the forestomach which authors claimed was likely due to an irritative effect of the compound.

N,N-Dimethyl-1,3-propanediamine (CAS # 109-55-7) was evaluated for dermal sensitization in 15 female Hartley guinea pigs by maximization test. Induction consisted of 3 pairs of 0.1 mL intradermal injections flanking the dorsal midline upon the clipped shoulder area, the respective twin injections including a 1-5% v/v solution in distilled water (unspecified pretest concentration that produces neither local or systemic reactions), a 1-5% v/v solution in Freunds Complete Adjuvant (FCA), and FCA alone. Following the 7-day induction, 48-hour challenge was administered with a 0.3 mL topical application of 1% solution in distilled water under occluded patch covering the entire test area. A second 48-hour challenge was performed 21 days later with a 0.3 mL topical application of 5% solution and another of vehicle alone, each on either side of the dorsal midline to cover triplet test sites. Although pretest irritation results were not provided, the authors concluded that positive reaction in 93% (14/15) of the test animals, relative to 0% response (0/6) in the vehicle/FCA control group and 100% response in the dinitrochlorobenzene (positive control) group following 5% N,N-dimethyl-1,3-propanediamine second challenge, established a maximization grading of "extreme" sensitization.

The substance is harmful to aquatic organisms.

WASTEWATERS FROM PETROLEUM CHEM PLANTS & OIL REFINERIES CONTAIN N,N-DIMETHYL-1,3-PROPANEDIAMINE. IN RELATION TO PURIFICATION OF WASTEWATER CONTAINING THIS COMPD, CONCN SOLN WERE OBTAINED IN LAB. BIOLOGICAL OXIDIZABILITY (BO) WAS DETERMINED AS RATIO BOD20/COD. BIOLOGICAL TREATMENT SCHEME IS DESCRIBED THROUGH USE OF ACTIVATED SLUDGE IN AERATION LAGOONS. DURING BIODEGRADATION, INCR IN CONTENT OF NH3-N WAS OBSERVED WHICH IS ALSO USED IN STABILIZATION OF PH. BIOLOGICAL OXIDIZABILITY OVER WIDE PH INTERVAL IS RELATED TO CONCN IN ORIGINAL WASTEWATER. MAX CONTENTS NOT AFFECTING BIOLOGICAL OXIDIZABILITY UNDER OPTIMUM CONDITIONS WAS 800 MG/L (COD 2.14 G O2/L); AFTER BIOLOGICAL OXIDATION IT WAS REDUCED TO 16.4 MG/L.

The substance is harmful to aquatic organisms.

WASTEWATERS FROM PETROLEUM CHEM PLANTS & OIL REFINERIES CONTAIN N,N-DIMETHYL-1,3-PROPANEDIAMINE. IN RELATION TO PURIFICATION OF WASTEWATER CONTAINING THIS COMPD, CONCN SOLN WERE OBTAINED IN LAB. BIOLOGICAL OXIDIZABILITY (BO) WAS DETERMINED AS RATIO BOD20/COD. BIOLOGICAL TREATMENT SCHEME IS DESCRIBED THROUGH USE OF ACTIVATED SLUDGE IN AERATION LAGOONS. DURING BIODEGRADATION, INCR IN CONTENT OF NH3-N WAS OBSERVED WHICH IS ALSO USED IN STABILIZATION OF PH. BIOLOGICAL OXIDIZABILITY OVER WIDE PH INTERVAL IS RELATED TO CONCN IN ORIGINAL WASTEWATER. MAX CONTENTS NOT AFFECTING BIOLOGICAL OXIDIZABILITY UNDER OPTIMUM CONDITIONS WAS 800 MG/L (COD 2.14 G O2/L); AFTER BIOLOGICAL OXIDATION IT WAS REDUCED TO 16.4 MG/L.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Corrosive Flammable Liquid

Do not transport with food and feedstuffs.

Symbol: C; R: 10-22-34-43; S: (1/2)-26-36/37/39-45

UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II