Isopropylethanediol

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P261, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P317, P321, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.2% (1 of 648) of reports.

H226 (41.7%): Flammable liquid and vapor [Warning Flammable liquids]

H312 (99.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H315 (32.1%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (99.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (99.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 648 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 648 reports by companies.

There are 9 notifications provided by 647 of 648 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

Excerpt from NIOSH Pocket Guide for 2-Isopropoxyethanol:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: WATER WASH IMMEDIATELY - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Fire Extinguishing Agents: Water, carbon dioxide, dry chemical, alcohol foam. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

"ALCOHOL" FOAM. WATER MAY BE INEFFECTIVE

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible.

SEE ETHERS. ONLY ELECTRICAL EQUIPMENT OF EXPLOSION-PROOF TYPE (GROUP C CLASSIFICATION) IS PERMITTED TO BE OPERATED IN ETHER AREAS. /ETHERS/

...ADVISABLE TO PROTECT PERSONNEL BY ENCLOSING PROCESS OR PROVIDING LOCAL EXHAUST VENTILATION. MAIN HAZARD...THAT OF INGESTION, CAN USUALLY BE PREVENTED BY KEEPING /CHEM/ IN PROPERLY LABELLED CONTAINERS. /GLYCOL & DERIV/

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet should be immediately removed due to its flammability hazard.

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors.

SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Cool. Fireproof. Separated from strong oxidants.

SEE ETHERS. ETHERS SHOULD NOT BE STORED NEAR POWERFUL OXIDIZERS OR IN AREAS OF HIGH FIRE HAZARD. THEY SHOULD BE KEPT COOL AND THE CONTAINERS ELECTRICALLY GROUNDED TO AVOID SPARKS. /ETHERS/

10.0 [ppm]

See Appendix D

none See Appendix G

See: IDLH INDEX

25.0 [ppm]

8 hr Time Weighted Avg (TWA): 25 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

25 ppm as TWA; (skin).

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes. The substance is mildly irritating to the skin and respiratory tract.

The substance may have effects on the blood. This may result in anaemia.

Excerpt from NIOSH Pocket Guide for 2-Isopropoxyethanol:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)

SKIN & EYE PROTECTION SHOULD...BE WORN IF POSSIBILITY OF /CHEMICAL/ CONTACT EXISTS. /GLYCOL & DERIV/

Wear appropriate personal protective clothing to prevent skin contact.

Wear appropriate eye protection to prevent eye contact.

Important additional information about respirator selection

NO open flames, NO sparks and NO smoking. Above 44 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

Do not eat, drink, or smoke during work.

Ethylene glycol isopropyl ether appears as a clear liquid. An irritant.

Colorless liquid with a mild, ethereal odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a mild, ethereal odor.

COLORLESS LIQUID

Colorless liquid.

MILD ETHEREAL ODOR

Mild, ethereal odor.

BITTER TASTE

285.8 °F at 760 mmHg (USCG, 1999)

144 °C @ 743 MM HG

at 99kPa: 139.5-144.5 °C

91.4 °F (USCG, 1999)

92 °F (33 °C) OC

44 °C c.c.

(oc) 92 °F

Miscible (NIOSH, 2024)

SOL IN ALL PROP IN WATER, ALC, ETHER; SOL IN ACETONE

Solubility in water, g/100ml at 25 °C: 100

Miscible

0.91 (USCG, 1999) - Less dense than water; will float

0.9030 @ 20 °C/4 °C

Relative density (water = 1): 0.903 (20 °C)

3.6 (AIR= 1)

Relative vapor density (air = 1): 3.6

3 mmHg (NIOSH, 2024)

1.6 [mmHg]

5.2 MM HG @ 25 °C

Vapor pressure, kPa at 20 °C: 0.44

VOLATILE

INDEX OF REFRACTION: 1.4095 @ 20 °C/D

Boiling point

Dielectric constant

Heat of sublimation

Optical coefficient

Phase diagram

Phase equilibrium

Refractive index

Vapor pressure

Vapor-liquid equilibrium

Highly flammable. Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164].

Alcohols and Polyols

Highly Flammable

Peroxidizable Compound

ETHYLENE GLYCOL ISOPROPYL ETHER acts both as an alcohol and ether. May react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

Oxidizers.

Oxidizers

The substance can be absorbed into the body by inhalation of its vapour and through the skin.

inhalation, skin absorption, ingestion, skin and/or eye contact

MAY BE ABSORBED! Redness.

Redness. Pain.

In Animals: irritation eyes, skin; hematuria (blood in the urine), anemia, pulmonary edema

Eyes, skin, respiratory system, blood

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Hemolytic anemia - Decreased hemoglobin or number of red blood cells.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

LC50 (rat) = 3,100 mg/m3/4h

SYMPTOMATOLOGY: 1. CENTRAL NERVOUS DEPRESSION CHARACTERIZED BY TRANSIENT EXHILARATION, DRUNKENNESS, ATAXIA, VERTIGO PROGRESSING TO STUPOR &...COMA, WITH OR WITHOUT TRANSIENT PERIOD OF CONVULSIONS. DEATH FROM RESP ARREST OR...CARDIOVASCULAR COLLAPSE... /ETHYLENE GLYCOL/

SYMPTOMATOLOGY: 2. NAUSEA, VOMITING, ABDOMINAL PAIN, DEHYDRATION, WEAKNESS, MUSCLE TENDERNESS. 3. HYPERPNEA MAY INDICATE EITHER SEVERE METABOLIC ACIDOSIS OR PULMONARY EDEMA. 4. ...CARPOPEDAL SPASM OR OTHER SIGNS OF HYPOCALCEMIC TETANY. /ETHYLENE GLYCOL/

SYMPTOMATOLOGY: 5. LUMBAR PAIN, ALBUMINURIA, HEMATURIA, OLIGURIA PROGRESSING TO ANURIA. 6. ACUTE RENAL FAILURE WITH UREMIA, PERIPHERAL EDEMA, ASCITES, PULMONARY EDEMA, DROWSINESS, CYANOSIS, COMA, & DEATH IN 7 TO 10 DAYS. /ETHYLENE GLYCOL/

SEE GLYCOLS. THERE IS SOME EVIDENCE THAT THE GLYCOL ETHERS ARE MORE TOXIC THAN OTHER MEMBERS OF THE GLYCOL GROUP. /GLYCOLS/

For more Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (7 total), please visit the HSDB record page.

THE MATERIAL IS APPRECIABLY IRRITATING TO EYES OF RABBITS CAUSING INJURY TO CONJUNCTIVAL MEMBRANES, CORNEA, &...SOME IRITIS. HEALING APPEARED TO BE COMPLETE WITHIN A WEEK.

THE MATERIAL IS NOT APPRECIABLE IRRITATING TO THE SKIN UNDER ORDINARY CONDITIONS OF EXPOSURE, BUT IF IT IS CONFINED FOR PROLONGED PERIODS, IT MAY CAUSE APPRECIABLE IRRITATION, EVEN A BURN. ...THE MATERIAL MAY READILY BE ABSORBED THROUGH THE INTACT SKIN IN LETHAL AMT.

FOUR/FOUR RATS DIED DURING 7 HR OF EXPOSURE TO VAPORS AT ESSENTIALLY SATURATED CONCN, AT 100 °C & COOLED TO ROOM TEMP. AFTER 3 HR, BLOOD APPEARED IN URINE; 1 RAT AUTOPSIED AFTER EXPOSURE HAD BLACK & SEVERELY ENLARGED KIDNEYS. /FROM TABLE/

TWO/THREE RATS DIED DURING 4 HR OF EXPOSURE TO VAPORS AT ESSENTIALLY SATURATED CONCN. BLOODY URINE WAS PASSED IMMEDIATELY AFTER EXPOSURE. THERE WAS EXCESS URINE. THREE DAYS AFTER EXPOSURE THE KIDNEYS WERE SEVERELY NECROTIC AND DARK IN COLOR. /FROM TABLE/

For more Non-Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (10 total), please visit the HSDB record page.

NO REPORTS OF ADVERSE EFFECTS FROM THE HANDLING OR USE OF ETHYLENE GLYCOL MONOISOPROPYL ETHER HAVE BEEN MADE. ...THIS MAY BE BECAUSE OF ITS LIMITED USE TO DATE.

...NO DATA AVAILABLE THAT WOULD ALLOW THE ESTABLISHMENT OF A HYGIENIC STANDARD FOR REPEATED EXPOSURE TO VAPORS. IN VIEW OF HIGH TOXICITY.../TO/ ANIMALS, IT WOULD SEEM...PRUDENT TO TAKE PARTICULAR CARE TO PREVENT ALL POSSIBLE EXPOSURE OF HUMAN BEINGS TO THIS MATERIAL...

NO REPORTS OF ADVERSE EFFECTS FROM THE HANDLING OR USE OF ETHYLENE GLYCOL MONOISOPROPYL ETHER HAVE BEEN MADE. ...THIS MAY BE BECAUSE OF ITS LIMITED USE TO DATE.

...NO DATA AVAILABLE THAT WOULD ALLOW THE ESTABLISHMENT OF A HYGIENIC STANDARD FOR REPEATED EXPOSURE TO VAPORS. IN VIEW OF HIGH TOXICITY.../TO/ ANIMALS, IT WOULD SEEM...PRUDENT TO TAKE PARTICULAR CARE TO PREVENT ALL POSSIBLE EXPOSURE OF HUMAN BEINGS TO THIS MATERIAL...

Poison Flammable Liquid

Symbol: Xn; R: 20/21-36; S: (2)-24/25

UN Hazard Class: 3; UN Pack Group: III