butyllithium

This chemical does not meet GHS hazard criteria for 16.1% (55 of 341) of reports.

H250 (83.9%): Catches fire spontaneously if exposed to air [Danger Pyrophoric liquids]

H260 (83%): In contact with water releases flammable gases which may ignite spontaneously [Danger Substances and mixtures which in contact with water, emit flammable gases]

H302 (10.6%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (83.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (10.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (70.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P210, P222, P223, P231, P231+P232, P233, P260, P261, P264, P264+P265, P270, P272, P280, P301+P317, P301+P330+P331, P302+P335+P334, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P362+P364, P363, P370+P378, P402+P404, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 341 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 55 of 341 reports by companies.

There are 13 notifications provided by 286 of 341 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H250: Catches fire spontaneously if exposed to air [Danger Pyrophoric liquids]

H260: In contact with water releases flammable gases which may ignite spontaneously [Danger Substances and mixtures which in contact with water, emit flammable gases]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P210, P222, P223, P231, P231+P232, P233, P240, P241, P242, P243, P260, P261, P263, P264, P264+P265, P270, P271, P280, P301+P330+P331, P302+P335+P334, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P363, P370+P378, P402+P404, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P203, P210, P222, P223, P231, P231+P232, P233, P240, P241, P242, P243, P280, P302+P335+P334, P303+P361+P353, P318, P370+P378, P402+P404, P403+P235, P405, and P501 (click each P-code to see the statement)

0.18 [mg/m3]

4.5 [mg/m3]

27 [mg/m3]

Wet Solid; Liquid

Available in solution of C5 to C7 hydrocarbons; [Hawley] In cyclohexane solution: Water-white to pale yellow liquid with a petroleum-like odor; [CAMEO] In n-hexane solution: Yellow liquid; [MSDSonline]

0.765 @25 °C

Metals -> Metals, Organic Compounds

Flammable agents - 4th degree

Reactive agents - 2nd degree

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

CSL00127

Perfluorethyllithium + Phosphorus Trichloride,Phosphorus + N-BUTYLLITHIUM + CHLOROPENTAFLUOROETHANE

Avoid temperatures below -90 C

Substitution

Several times in our laboratory, we have experienced a violent decomposition of the ethereal C2F5Cl/n-BuLi solution after the addition of just a few drops of (R)nPCl3=n. In each of these cases, the metal-halogen exchange temperature was maintained below -90 C. We believe that this problem is due to a buildup of starting reagents at low temperatures.

CSL00134

OXYGEN + COPPER(II) CHLORIDE DIHYDRATE + 2,6-DIBROMOPYRIDINE + N-BUTYLLITHIUM + DIETHYL ETHER

O2 reacted with the organocopper (or remaining organolithium) reagent to form some peroxides which exploded

Explosive

Ullmann coupling

ACS Safety Letters

Neurotoxin - Other CNS neurotoxin

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.