diethylamine

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H301+H311+H331 (17%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H301 (27.6%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (72.4%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (31.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H312 (68.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (30.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (17%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (83%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (31.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2588 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting. Thus, the risk of increasing the medical problems by inducing vomiting of a volatile corrosive chemical is very high. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use powder, alcohol-resistant foam, water in large amounts, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Use water spray to keep fire exposed containers cool. Use water spray, dry chemical, or "alcohol resistant" foam. Aqueous solutions will burn unless diluted thoroughly with spray.

For more Fire Fighting Procedures (Complete) data for DIETHYLAMINE (6 total), please visit the HSDB record page.

Vapors are heavier than air & may travel to a source of ignition & flash back.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Remove all ignition sources. Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Ventilation. Collect leaking liquid in sealable plastic containers. Carefully collect remainder. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

1. Remove all ignition sources; 2. Ventilate area of spill or leak; 3. For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn paper in suitable location away from combustible materials.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Neutralize with sodium bisulfate (NaHSO4).

Environmental considerations-water spill: Add sodium bisulfate (NaHSO4). If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Diethylamine is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Flash back possible over considerable distance. Container explosion may occur under fire conditions. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidizers, strong acids, organic compounds and food and feedstuffs. Cool. Well closed. Store only in original container. Store in an area without drain or sewer access.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids.

Separate from oxidizing materials, acids, & sources of halogens. Store in cool, dry, well-ventilated, noncombustible location.

Keep well closed.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

184.0 [ppm]

2.0 [ppm]

15 [ppm]

33 [ppm]

200 [ppm]

10 ppm (30 mg/m³)

25 ppm (75 mg/m³)

TWA 10 ppm (30 mg/m3) ST 25 ppm (75 mg/m3)

25.0 [ppm]

TWA 25 ppm (75 mg/m3) See Appendix G

200 ppm (NIOSH, 2024)

200.0 [ppm]

Excerpts from Documentation for IDLHs: Human data: It has been stated that the simple alkyl amines are generally more toxic than ammonia [ACGIH 1991]. The American Conference of Governmental Industrial Hygienists TLV for diethylamine (10 ppm TWA, 25 ppm STEL) was based on an analogy to ammonia (25 ppm TWA, 35 ppm STEL) [ACGIH 1991].

See: 109897

5.0 [ppm]

15.0 [ppm]

8 hr Time Weighted Avg (TWA): 5 ppm; 15 min Short Term Exposure Limit (STEL): 15 ppm, skin.

A4: Not classifiable as a human carcinogen.

5 ppm as TWA; 15 ppm as STEL; (skin); A4 (not classifiable as a human carcinogen).

5 ppm [2012]

15 ppm [2012]

6.1 mg/m

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Australia: 10 ppm, STEL 25 ppm (1990); Federal Republic of Germany: 10 ppm, short-term level 20 ppm, 10 min, 4 times per shift (1990); Sweden: 10 ppm, short-term value 15 ppm, 15 min, skin (1984); United Kingdom: 10 ppm, 10-min STEL 25 ppm (1991).

Diethylamine appears as a clear colorless liquid with an ammonia-like odor. Density 5.9 lb / gal. Flash point -15 °F. A respiratory irritant. Corrosive to the eyes and skin. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Colorless liquid with a fishy, ammonia-like odor; [NIOSH]

COLOURLESS LIQUID WITH PUNGENT ODOUR.

Colorless liquid with a fishy, ammonia-like odor.

Colorless liquid

Fishy, ammonia-like odor

131.9 °F at 760 mmHg (NTP, 1992)

55.00 to 58.00 °C. @ 760.00 mm Hg

55.5 °C @760 [mm Hg]

-58 °F (NTP, 1992)

-49.8 °C

-20 °F (NTP, 1992)

-22.99 °C (-9.38 °F) - closed cup

< -26 °C, closed cup

5 °F open cup

Less than - 17.8 °C closed cup

-28 °C c.c.

greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)

In water, infinitely soluble /1X10+6 mg/L/ at 25 °C

Miscible with water, alcohol

Soluble in ether and carbon tetrachloride

Miscible with most organic solvents

For more Solubility (Complete) data for DIETHYLAMINE (6 total), please visit the HSDB record page.

Solubility in water: miscible

Miscible

0.708 at 68 °F (USCG, 1999) - Less dense than water; will float

0.7056 g/cu cm at 20 °C

Critical density: 0.246 g/cc

Saturated liquid density: 44.090 lb/cu ft; liquid heat capacity: 0.601 Btu/lb-F; liquid thermal conductivity: 0.850 Btu-inch/hr-sq ft-F; saturated vapor pressure: 3.933 lb/sq in; saturated vapor density: 0.05059 lb/cu ft (all at 70 °F)

Relative density (water = 1): 0.7

1.39 @ 20°C

2.53 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

2.52 (Air = 1)

Relative vapor density (air = 1): 2.5

195 mmHg at 68 °F ; 200 mmHg at 70 °F (NTP, 1992)

237.0 [mmHg]

237 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 25.9

192 mmHg

237 [mm Hg] @25 °C

Highly flammable. Soluble in water. Sensitive to heat. May be sensitive to prolonged exposure to air.

Amines, Phosphines, and Pyridines

Highly Flammable

DIETHYLAMINE is strongly alkaline. Incompatible with strong oxidizing agents and with strong acids. Violent reactions occur with sulfuric acid. Causes ignition on contact with cellulose nitrate. Explodes on contact with dicyanofurazan or dicyanofuroxan. Attacks some forms of plastics, rubber and coatings. (NTP, 1992)

Incompatible materials: Aldehydes, alcohols, dicyanofurazan, ketones, phenols, acids, halogenated hydrocarbon, oxidizing agents, epoxides.

Contact with strong acids will cause spattering.

Diethylamine fumes from a reactor were usually absorbed in a glass scrubber through which sulfuric acid was circulated, but an unresolved fault in the level sensor caused the acid circulation pump to operate intermittently. While the pump was not running, amine fumes condensed in the dip pipe, forming a solid crust (of the sulfate) which allowed a quantity of condensed amine to accumulate out of contact with the acid. When the pump was restarted, the neutralization exotherm was sufficient to shatter the scrubber and distort the mesh guard around it.

Contact of dicyanofurazan N-oxide or the parent furazan with ... diethylamine or /its/ mixtures is instantaneously explosive.

For more Hazardous Reactivities and Incompatibilities (Complete) data for DIETHYLAMINE (8 total), please visit the HSDB record page.

Strong oxidizers, strong acids, cellulose nitrate

IDENTIFICATION AND USE: Diethylamine (DEN) is a colorless liquid with fishy, ammonia-like odor. It is used in petroleum industry, in flotation agents, dyes, pharmaceuticals. It also used as a selective solvent for the removal of impurities from oils, fats, and waxes, and as a corrosion inhibitor in iron, steel, and metal industries. HUMAN EXPOSURE AND TOXICITY: Adult volunteers were exposed to 25 ppm (75 mg/cu m) diethylamine in a climate chamber for 15 min in order to study the acute nasal reactions to an exposure equivalent to the present threshold limit value-short-term exposure limit. Exposure to a concentration increasing from 0 to 12 ppm took place for 60 min, equal to an average concentration of 10 ppm (30 mg/cu m). A moderate to strong olfactory response and distinct nasal and eye irritation were observed. Edema of the epithelium of the cornea, generally without pain, has been produced by diethylamine vapors, causing colored halos to be seen around lights. The edema of the corneal epithelium, which is principally responsible for the disturbance of vision, clears spontaneously by the next day, but after exceptionally intense exposures the edema and blurring have taken several days to clear and have been accompanied by photophobia and discomfort from roughness of the corneal surface. ANIMAL STUDIES: Rabbits were exposed to DEN vapors at 50 and 100 ppm, 7 hours/day, 5 days/week for 6 weeks. All rabbits survived the exposures and had normal body weights without demonstrating any outward signs of response to the chemical. At 100 ppm, lungs contained cellular infiltration and bronchopneumonia; livers had parenchymatous degeneration with evidence of cell regeneration; and kidneys showed nephritis. The same changes, but to a lesser degree, were produced at 50 ppm. A suggestion of very slight cardiac muscle degeneration was seen in rabbits inhaling 50 ppm but was not evident at 100 ppm. Male and female rats were exposed at 0,25 or 250 ppm diethylamine (DEA) vapor, 6.5 hr per day, 5 days per week, for 24 weeks in order to assess cardiac and other organ system toxicity. During the first 2 weeks of exposure, the rats exposed at 250 ppm DEA did not gain weight. After 2 weeks, however, the rate of weight gain of these rats was greater than that of controls. Nevertheless, mean body weights for both sexes of rats exposed at 250 ppm DEA remained depressed compared to controls throughout the study. Sneezing, tearing, and reddened noses were seen in rats exposed at 250 ppm DEA. Histopathologic examinations revealed lesions of the nasal mucosa of rats exposed at 250 ppm DEA. These lesions of the respiratory epithelium consisted of squamous metaplasia, suppurative rhinitis, and lymphoid hyperplasia. There were no pronounced treatment-related effects on organ weights, hematology, or clinical chemistry indices except for blood urea nitrogen which was evaluated in rats of both sexes exposed at 250 ppm DEA for 24 weeks. In contrast to the high-dose animals, no treatment-related effects were observed in rats intermittently exposed at 25 ppm DEA for up to 24 weeks. No evidence of cardiotoxicity was seen in rats exposed to either DEA concentration for up to 24 weeks. Diethylamine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay. Diethylamine was tested at doses of 0, 10, 33, 100, 333, 1000, and 3333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) with or without metabolic activation. Diethylamine was negative in these tests. Diethylamine was not mutagenic in either of two independent bacterial mutagenicity assays, each conducted with and without exogenous metabolic activation enzymes. Bacterial strains tested included Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA/pKM101. In addition to the negative results in the two bacterial assays, no significant increases in the frequencies of micronucleated erythrocytes were seen in peripheral blood of male or female mice from the 3-month study. NTP conducted 2 year inhalation studies in rats and mice. There was no evidence of carcinogenic activity of diethylamine in male or female rats exposed to 31, 62.5, or 125 ppm. There was no evidence of carcinogenic activity of diethylamine in male or female mice exposed to 16, 31, or 62.5 ppm. Exposure to diethylamine resulted in increased incidences of nonneoplastic lesions of the nose in male and female rats and mice, of the cornea in male rats, and of the pleura and lung in female rats.

A4: Not classifiable as a human carcinogen.

Diethylamine

TR-566: Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies) (2011 )

11/19/09

No Evidence

Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenic activity of diethylamine in male or female F344/N rats exposed to 31, 62.5, or 125 ppm. There was no evidence of carcinogenic activity of diethylamine in male or female B6C3F1 mice exposed to 16, 31, or 62.5 ppm.

Exposure to diethylamine resulted in increased incidences of nonneoplastic lesions of the nose in male and female rats and mice, of the cornea in male rats, and of the pleura and lung in female rats.

No indication of carcinogenicity to humans (not listed by IARC).

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Sore throat. Cough. Shortness of breath. Burning sensation behind the breastbone. Symptoms may be delayed.

Redness. Pain. Blisters. Serious skin burns.

Redness. Pain. Burns.

Burning sensation in the throat and chest. Abdominal pain. Diarrhoea. Vomiting. Shock or collapse.

irritation eyes, skin, respiratory system; in animals; myocardial degeneration

Eyes, skin, respiratory system, cardiovascular system

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

ACGIH Carcinogen - Not Classifiable.

LC50 (rat) = 4,000 ppm/4H

LD50 Rat oral 540 mg/kg

LC50 Rat inhalation 4000 ppm/4 hr

LD50 Rabbit skin 820 mg/kg

LD50 Rabbit dermal 580 mg/kg

Infant C57BL and C3HF1 male mice were given diethylamine hydrochloride (DEA-HCl) and sodium nitrite (50 ug/g intragastrically either singly or in combination). Animals were sacrificed periodically up to 110 wk. Histological exam of the liver revealed that mice given DEA-HCl and sodium nitrite had significantly more liver tumors compared to mice given only sodium nitrate or DEA-HCl. This suggests the formation of a potent carcinogen in vivo by the interaction of DEA-HCl and sodium nitrite. /DEA-HCl/

Nitrite ... is used as a food additive in meats and smoked fish. Some fish, vegetables, and fruit juices contain secondary amines. The acidic environment of the stomach facilitates a chemical reaction between nitrite and secondary amines, leading to the formation of carcinogenic nitrosamines. /Secondary amines/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/amines and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

... Employee who is exposed to diethylamine at potentially hazardous levels ... should be screened for history of certain medical conditions ... /skin, eye, chronic respiratory diseases/ which might place the employee at increased risk from diethylamine exposure. ... Any employee developing ... /these/ conditions should be referred for further medical exam.

/HUMAN EXPOSURE STUDIES/ Adult volunteers were exposed to 25 ppm (75 mg/cu m) diethylamine in a climate chamber for 15 min in order to study the acute nasal reactions to an exposure equivalent to the present threshold limit value-short-term exposure limit. Changes in nasal volume and nasal resistance were measured by acoustic rhinometry and by rhinomanometry. Acute change in nasal volume, usually seen as acute nasal mucosa response to thermal stimuli, was not observed, nor was an acute change in nasal airway resistance. In a subsequent experiment, the aim was to measure acute sensory effects. Exposure to a concentration increasing from 0 to 12 ppm took place for 60 min, equal to an average concentration of 10 ppm (30 mg/cu m). A moderate to strong olfactory response and distinct nasal and eye irritation were observed.

/SIGNS AND SYMPTOMS/ Edema of the epithelium of the cornea, generally without pain, has been produced by amine /incl diethylamine/ vapors, causing colored halos to be seen around lights ... .

/SIGNS AND SYMPTOMS/ There have been reports of temporary blue hazy vision /(halo vision)/ from subtle disturbance of the corneal epithelium in people exposed to ethylamines. ... Diethylamine has been identified as having this effect...

/SIGNS AND SYMPTOMS/ ... Vision has become misty and halos have appeared several hr after workmen have been exposed to the vapors of ... amines /including diethylamine, dimethylamine, ethylenediamine/ at concn too low to cause discomfort or disability during several hours of exposure. ... The edema of the corneal epithelium, which is principally responsible for the disturbance of vision, clears spontaneously by the next day, but after exceptionally intense exposures the edema and blurring have taken several days to clear and have been accompanied by photophobia and discomfort from roughness of the corneal surface.

/LABORATORY ANIMALS: Acute Exposure/ Sensory irritation due to inhalation of diethyl-, triethyl-, dibutyl-, tributyl- and cyclohexylamine was estimated from the decrease in respiratory rate in normal mice (American Standard Method E981-84). The concentration-effect relations followed Michaelis-Menten equations, except for diethylamine, for which a threshold was found. The concentrations depressing the respiratory rate by 50% (RD50) for diethyl-, triethyl-, dibutyl- and cyclohexylamine were 184, 186, 81 and 27 ppm, respectively. ... Pulmonary irritation was estimated from the decrease in respiratory rate in tracheal-cannulated mice. The respective concentrations depressing the respiratory rate by 50% (tRD50) were 549, 691, 101, 96 and 78 ppm for diethyl-, triethyl-, dibutyl-, tributyl- and cyclohexylamine.

/LABORATORY ANIMALS: Acute Exposure/ Diethylamine when administered ip to rats was moderate in its inhibitory activity with respect to liver/monoamine oxidase.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Rabbits were exposed to diethylamine vapors at 50 and 100 ppm, 7 hours/day, 5 days/week for 6 weeks. All rabbits survived the exposures and had normal body weights without demonstrating any outward signs of response to the chemical. At 100 ppm, lungs contained cellular infiltration and bronchopneumonia; livers had parenchymatous degeneration with evidence of cell regeneration; and kidneys showed nephritis. The same changes, but to a lesser degree, were produced at 50 ppm. A suggestion of very slight cardiac muscle degeneration was seen in rabbits inhaling 50 ppm but was not evident at 100 ppm.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Male and female Fischer 344 (F-344) rats were exposed at 0,25 or 250 ppm diethylamine (DEA) vapor, 6.5 hr per day, 5 days per week, for 24 weeks in order to assess cardiac and other organ system toxicity. Scheduled sacrifices were performed following 30, 60, and 120 days of exposure. During the first 2 weeks of exposure, the rats exposed at 250 ppm DEA did not gain weight. After 2 weeks, however, the rate of weight gain of these rats was greater than that of controls. Nevertheless, mean body weights for both sexes of rats exposed at 250 ppm DEA remained depressed compared to controls throughout the study. Sneezing, tearing, and reddened noses were seen in rats exposed at 250 ppm DEA. Histopathologic examinations revealed lesions of the nasal mucosa of rats exposed at 250 ppm DEA (rats exposed at 25 ppm were not evaluated). These lesions of the respiratory epithelium consisted of squamous metaplasia, suppurative rhinitis, and lymphoid hyperplasia. There were no pronounced treatment-related effects on organ weights, hematology, or clinical chemistry indices except for blood urea nitrogen which was evaluated in rats of both sexes exposed at 250 ppm DEA for 24 weeks. In contrast to the high-dose animals, no treatment-related effects were observed in rats intermittently exposed at 25 ppm DEA for up to 24 weeks. No evidence of cardiotoxicity was seen in rats exposed to either DEA concentration for up to 24 weeks.

LC50; Species: Pimephales promelas (Fathead minnow) age 30 days; Conditions: flow through, 24.7 °C, pH 7.71, dissolved oxygen 7.1 mg/L, hardness 48.5 mg/L CaCO3, alkalinity 49.5 mg/L CaCO3; Concentration: 855 mg/L for 96 hr /98% purity/

LC50; Species: /Oncorhynchus mykiss/ (rainbow trout); Concentration: 25-182 mg/L for 96 hr /conditions of bioassay not specified/

EC50; Species: Anabaena subcylindrica (Blue-green algae) axenic, 1-3x 10+7 cells/mL; Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 7.8x10-8 ug/cell for < or = 3 hr; Effect: decreased nitrogen fixation

EC50; Species: Anabaena subcylindrica (Blue-green algae) axenic, 1-3x 10+7 cells/mL; Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 7.7x10-8 ug/cell for < or = 3 hr; Effect: decreased photosynthesis, oxygen production

For more Ecotoxicity Values (Complete) data for DIETHYLAMINE (10 total), please visit the HSDB record page.

The substance is harmful to aquatic organisms.

Diethylamine's production and use in rubber chemicals, textile specialties, selective solvent, dyes, flotation agents, resins, pesticides, polymerization inhibitors, pharmaceuticals, petroleum chemicals, electroplating, and corrosion inhibitors may result in its release to the environment through various waste streams. Diethylamine occurs naturally in many foods and plants. If released to air, a vapor pressure of 237 mm Hg at 25 °C indicates diethylamine will exist solely as a vapor in the atmosphere. Vapor-phase diethylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5 hours. Diethylamine does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, diethylamine is expected to have very high mobility based upon an estimated Koc of 27. The pKa of diethylamine is 11.09, indicating that this compound will exist entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. Diethylamine may volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 69-89% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is an important environmental fate process in soil. If released into water, diethylamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Based on a biodegradation half-life of 0.9 days in stream water and 38% biodegradation in freshwater/sediment, diethylamine is expected to biodegrade in water. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's pKa. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to diethylamine may occur through inhalation and dermal contact with this compound at workplaces where diethylamine is produced or used. Monitoring data indicate that the general population may be exposed to diethylamine via inhalation of ambient air, ingestion of food and contaminated drinking water, the use of tobacco products, and dermal contact with consumer products containing diethylamine. (SRC)

... amines from decomposing fish ... /Amines/

Diethylamine occurs naturally in many foods and plants(1,2).

Diethylamine's production and use in rubber chemicals, textile specialties, selective solvent, dyes, flotation agents, resins, pesticides, polymerization inhibitors, pharmaceuticals, petroleum chemicals, electroplating, and corrosion inhibitors(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 27(SRC), determined from a structure estimation method(2), indicates that diethylamine is expected to have very high mobility in soil(SRC). The pKa of diethylamine is 11.09(3), indicating that this compound will exist entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of diethylamine from moist soil surfaces is not expected to be an important fate process(SRC) given its cationic state(SRC). Diethylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 237 mm Hg at 25 °C(5). Between 69 and 89% of the Theoretical BOD was achieved for diethylamine using an activated sludge inoculum digested for 4 weeks(6), suggesting biodegradation may be an important fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 27(SRC), determined from a structure estimation method(2), indicates that diethylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 11.09(3) indicates diethylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Diethylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.58(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethylamine, present at 10 ppm, reached 38% of its Theoretical BOD in 12 days using freshwater/sediment inoculum(7). The biodegradation half-life of diethylamine in stream water was 0.9 days at an initial concentration of 10 mg/L(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylamine, which has a vapor pressure of 237 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 8.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diethylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Diethylamine, present at 100 mg/L, reached 69-89% of its Theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In a screening study, diethylamine at 10 ppm degraded with both an activated sludge and freshwater/sediment inoculum, 59 and 38% of the Theoretical BOD was obtained after 12 days of incubation, respectively(2). Inhibition was noted at moderate concentrations and sizeable reductions in BOD were noted at 50 ppm(2). Diethylamine was degraded slowly by activated sludge even when acclimatized (53% of Theoretical BOD was achieved after 13 days)(3). However the concentration levels used in this study could not be ascertained. When added to stream water, the maximum rate of biodegradation of diethylamine was proportional to an initial amine concentration over a concentration range from several nanograms to several milligrams per liter(4). At the highest concentration studied, 10 mg/L, the half-life of diethylamine was 0.9 days(4).

ANAEROBIC: Diethylamine, at an initial concentration of 100 mg/L, digested at 35 °C for 50 days was partially degraded anaerobically(1).

The rate constant for the vapor-phase reaction of diethylamine with photochemically-produced hydroxyl radicals has been estimated as 8.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Diethylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Diethylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for diethylamine(SRC), using a log Kow of 0.58(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of diethylamine can be estimated to be 27(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylamine is expected to have very high mobility in soil. The pKa of diethylamine is 11.09(3), indicating that this compound will exist entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

A pKa of 11.09(1) indicates diethylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water and moist soil surfaces is not expected to be an important fate process(SRC). Diethylamine is expected to volatilize from dry soil surfaces(SRC) based upon a its vapor pressure of 237 mm Hg(2).

GROUNDWATER: Diethylamine was detected in ground water samples collected from Jiaula River Basin, China at <0.06-1.04, 0.06-0.80 and 0.08-0.46 ug/L in samples collected Nov 2010, Jan 2011 and Mar 2011, respectively(1).

DRINKING WATER: In source and finished water samples collected from 12 drinking water treatment plants in China, diethylamine was detected in 8 and 11 samples at 0.3-2.4 and 0.1-1.8 ug/L, respectively; samples were collected Nov and Dec 2010(1).

SURFACE WATER: Diethylamine was detected in 8 rivers in Germany at a maximum concentration of 14 ppb(1). Diethylamine was detected in surface water samples collected from Jiaula River Basin, China at 0.43-1.23, 0.20-1.52 and 0.19-1.2 ug/L in samples collected Nov 2010, Jan 2011 and Mar 2011, respectively(2).

RAIN/SNOW: Diethylamine was detected at <30-220 nanomols/L in the rain water samples from Sweden(1).

Diethylamine was identified, not quantified, in volatiles from a cattle feed yard(1), the exhaust from a gasoline engine(2), furniture coatings(3) and textile floor coverings(4). The emission rate of diethylamine from the interior materials to the air in new cars was 9.6, 8.1 and 5.7 ug/hour after aging 0, 20 and 40 days, respectively(5). Diethylamine was detected in effluent from waste water treatment plants collected from Jiaula River Basin, China at 1.41, 0.22-10.53 and 0.86-1.76 ug/L in samples collected Nov 2010, Jan 2011 and Mar 2011, respectively(6).

Diethylamine was qualitatively identified in soil samples taken from Moscow(1).

URBAN/SUBURBAN: Diethylamine was detected at 14-410 picomols/cu m in ambient air samples from Sweden(1).

RURAL/REMOTE: Samples collected May to Oct 2011 from a boreal forest in Hyytiala, Finland contained diethylamine at 6.7-15.5 parts/trillion volume(1).

Fresh fruit and vegetables, preserved and processed foods purchased from retail outlets were analyzed for the content of diethylamine. It was not detected in fresh cabbage, red cabbage, cauliflower, kale, white or red beet, carrots, large or red radish, celery, rhubarb, corn, green salad, preserved kale, pickled cabbage, cheese, coffee, cocoa, tea or white wine. Other food products contained diethylamine as follows(1):[Table#1504]

Diethylamine has been identified as a volatile component of boiled beef(1).

Diethylamine has been identified in tobacco leaf at 0.1-35 ppm(1). Diethylamine was identified, not quantified, in various plants and roots from Africa(2).

Diethylamine has been identified in tobacco, tobacco smoke and substitute tobacco smoke(1). Concentrations in tobacco smoke were reported as 0-0.4 ppm(2,3).

According to the 2012 TSCA Inventory Update Reporting data, 4 reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of diethylamine in the United States may be as low as <10 workers up to the range of 50-99 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 28,361 workers (6878 of these are female) were potentially exposed to diethylamine in the US(1). Occupational exposure to diethylamine may occur through inhalation and dermal contact with this compound at workplaces where diethylamine is produced or used. Monitoring data indicate that the general population may be exposed to diethylamine via inhalation of ambient air, ingestion of food and contaminated drinking water, the use of tobacco products, and dermal contact with consumer products containing diethylamine(SRC).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Diethylamine is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for DIETHYLAMINE (8 total), please visit the HSDB record page.

UN 1154; Diethylamine

IMO 3; Diethylamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Diethylamine is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Diethylamine is included on the dangerous goods list.

Flammable Liquid Corrosive

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

Symbol: F, C; R: 11-20/21/22-35; S: (1/2)-3-16-26-29-36/37/39-45

UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: II