Ethyl vinyl ether

H225 (29%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H319 (68.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H336 (22.3%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 710 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H224: Extremely flammable liquid and vapor [Danger Flammable liquids]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer immediately for medical attention.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

Call a doctor.

INHALATION: Remove from contaminated area and administer artificial respiration and oxygen if necessary.

EYES: Flush with copious amounts of water.

SKIN: Wash with copious amounts of water.

INGESTION: Gastric lavage and saline cathartics. (USCG, 1999)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible); polymerization hazard]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use foam, dry powder, carbon dioxide, water. In case of fire: keep drums, etc., cool by spraying with water.

Alcohol Foam.

Water May be Ineffective.

To fight fire, use alcohol foam, foam, CO2, dry chemical.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. Further information: Use water spray to cool unopened containers.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible); polymerization hazard]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Evacuate danger area! Consult an expert! Remove all ignition sources. Ventilation. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Wash away remainder with plenty of water. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible); polymerization hazard]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants and acids. See Chemical Dangers. Cool. Keep under inert gas. Store only if stabilized.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Handle and open container with care. Air sensitive.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

10 [ppm]

110 [ppm]

690 [ppm]

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used.

CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. This may result in unconsciousness and narcosis. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

The substance defats the skin, which may cause dryness or cracking. Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and kidneys. This may result in organ disturbances.

Full face mask, self-contained breathing apparatus, eye protection, and rubber gloves. (USCG, 1999)

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Impervious clothing, flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

NO open flames, NO sparks and NO smoking. See Chemical Dangers. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.

PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Vinyl ethyl ether appears as a clear colorless low-boiling liquid (35-36 °C) with an ether-like odor. Flash point below -50 °F. May polymerize exothermically if heated or contaminated. If polymerization takes place inside a container, the container may rupture violently. Less dense than water and slightly soluble in water. Hence floats on water. Vapors are heavier than air.

Clear colorless liquid with an ether-like odor; Boiling point = 36 deg C; [ICSC]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid

Ether-like odor

96 °F at 760 mmHg (USCG, 1999)

35.6 °C @760 [mm Hg]

-175 °F (USCG, 1999)

-115.8 °C

less than -50 °F (USCG, 1999)

< -50 °F (< -46 °C) /closed cup/

In water, 7800 mg/L at 25 °C

In water, 10000 mg/L at 37 °C

Slightly soluble in carbon tetrachloride; soluble in ethanol; miscible in ether

Solubility in water, g/l at 15 °C: 8.3 (slightly soluble)

0.7589 at 68 °F (USCG, 1999) - Less dense than water; will float

0.7589 at 20 °C

Relative density (water = 1): 0.8

0.754 @25 °C

2.5 (Air = 1)

Relative vapor density (air = 1): 2.5

511.0 [mmHg]

515 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 56

428 [mm Hg] @20 °C

log Kow = 1.04

Stable under recommended storage conditions. Contains the following stabilizer(s): N,N-Diethylaniline (0.1 %).

395 °F (USCG, 1999)

Hazardous decomposition products formed under fire conditions. - Carbon oxides

When heated to decomposition it emits acrid smoke and irritating fumes.

0.3 mm²/s

-14.326 Btu/lb = -7959 cal/g = -333 X 10+5 J/kg

26.2 kJ/mol at 35.5 °C

Explosive polymerization is catalyzed by methane sulfonic acid.

Index of refraction: 1.3767 at 20 °C

A very dangerous fire and explosion hazard when exposed to heat or flame; can react vigorously with oxidizing materials.

May polymerize exothermically if heated or contaminated. If polymerization takes place inside a container, the container may rupture violently.

Henry's Law constant = 6.3X10-3 atm-cu m/mole at 25 °C (estimated from vapor pressure and water solubility)

Hydroxyl radical reaction rate constant = 7.79X10-11 cu cm/molec-sec at 25 °C

Nitrate radical reaction rate constant = 1.40X10-12 cu cm/molec-sec at 25 °C

Highly flammable. Slightly soluble in water. Tends to form explosively unstable peroxides when exposed to oxygen.

Hydrocarbons, Aliphatic Unsaturated

Polymerizable Compounds

Highly Flammable

Polymerizable

Peroxidizable Compound

VINYL ETHYL ETHER is a very dangerous fire and explosion hazard when exposed to heat or flame. Undergoes autooxidation with formation of peroxides in the air. Can react vigorously with oxidizing materials. Undergoes explosive polymerization in contact with methanesulfonic acid [Eaton, P. E. et al., J. Org. Chem., 1972, 37, p. 1947].

Vapors may form explosive mixture with air.

... can react vigorously with oxidizing materials.

Ethyl vinyl ether

D: Other compounds that may form peroxides

Explosive polymerizations have occured. See Bretherick's and Eaton, P. E. et al. J. Org. Chem., 1972, 37, 1947

Eaton, P. E. et al. J. Org. Chem., 1972, 37, 1947

Yoshida, 1980, 288

IDENTIFICATION AND USE: Vinyl ethyl ether is a flammable liquid. It is used in proteomics research and organic synthesis. It was studied as an anesthetic agent in the 1950s. HUMAN STUDIES: Vinyl ethyl ether was studied in clinical trials to investigate whether it was suitable as an anesthetic. Some patients participating in these studies suffered complications (generalized convulsions due to hypercarbia and respiratory and circulatory depression as well as respiratory and cardiac arrest), which were attributed to overdosage. The degree of muscle relaxation obtained with this type of anesthesia was considered to be inadequate. Liver function tests conducted after several hours of anesthesia showed that hepatic function was not affected. Urinalyses, blood counts and electrocardiograms obtained after anesthesia revealed slight, reversible changes in some cases. There is a report of one case of transient damage to the human cornea, which was reversible after 48 hr. ANIMAL STUDIES: In rabbits, it caused only very mild irritation to the skin and eye. On acute oral administration, dermal application and inhalation exposure, vinyl ethyl ether was found to be of low toxicity. A rapid induction of CNS depression and rapid recovery from narcosis was noted with monkeys, dogs, rats. The clinical signs of intoxication were characterized by the CNS depressant effect of the substance. In the Salmonella/microsome assay, vinyl ethyl ether was found to test negative both with and without metabolic activation. In the sister chromatid exchange assay in Chinese hamster ovary cells, the chemical caused a significant increase in sister chromatid exchange rate.

The substance can be absorbed into the body by inhalation of its vapour.

Cough. Incoordination. Dizziness. Drowsiness. Headache. Wheezing. Unconsciousness.

Redness. Dry skin.

Redness.

Aspiration hazard! Headache. Nausea.

Neurotoxin - Other CNS neurotoxin

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

LCLo (rat) = 16,000 ppm/4hr

LD50 Rabbit dermal > 15000 mg/kg bw

LD50 Rat oral 6153 mg/kg bw

LC50 Rat inhalation > 21200 mg/cu m/4 hr

Alkyl ether-degrading Rhodococcus sp. strain DEE5151, isolated from activated sewage sludge, has an activity for the oxidation of a variety of alkyl ethers, aralkyl ethers and dibenzyl ether. The whole cell activity for diethyl ether oxidation was effectively inhibited by 2,3-dihydrofurane, ethyl vinyl ether and glutaraldehyde. Glutaraldehyde of less than 30 uM inhibited the activity by a competitive manner with the inhibition constant, K(I) of 7.07+/-1.36 uM. The inhibition type became mixed at higher glutaraldehyde concentrations >30 uM, probably due to the inactivation of the cell activity by the Schiff-base formation. Structurally analogous ethyl vinyl ether inhibited the diethyl ether oxidation activity in a mixed manner with decreasing the apparent maximum oxidation rate, v(max)(app), and increasing the apparent Michaelis-Menten constant, K(M)(app). The mixed type inhibition by ethyl vinyl ether seemed to be introduced not only by the structure similarity with diethyl ether, but also by the reactivity of the vinyl ether with cellular components in the whole cell system.

1. In rats, surgically anesthetized with Urethane, an increase in the depth of anesthesia upon administration of ethyl carbamate (Urethane), pentobarbitone sodium (Nembutal), thiopentone sodium (Intraval), althesin, ketamine, trichloroethylene, halothane, methoxyflurane, diethyl ether, ethyl-vinyl ether, cyclopropane, enflurane or chloroform resulted in a dose-dependent increase in the latency, the decrease in the amplitudes of the initial positive and negative components of the short latency cortical response to electrical stimuli applied to the forepaw. 2. The same changes were seen when starting from initially unanesthetized rats and anesthetizing them with Urethane. 3. With all the inhalational agents used, these changes lasted for as long as the administration except with nitrous oxide where the changes in the cortical response were transient. 4. The tranquilizing agents diazepam, chlordiazepoxide, and haloperidol showed no such action. Chloral hydrate and chlorpromazine, on the other hand, produced moderate changes in the evoked cortical response similar to those seen with the other anesthetic agents used.

The effects of ten inhalational anesthetic agents on drug metabolism were studied in rats. Male Sprague Dawley-rats were exposed to below anesthetic concentrations of the test agents 7 hours a day for 1 to 7 days, or up to 15 days when nitrous-oxide was used. A single intraperitoneal injection of 125 milligrams per kilogram (mg/kg) hexobarbital, a sleep inducer, was given 20 to 22 hours after the last exposure to the anesthetic, and sleeping time was determined. Some animals were given an intraperitoneal injection of 50 mg/kg SKF-525-A, an inhibitor of hepatic microsomal enzyme activity, 30 minutes before the hexobarbital injection. Liver homogenates prepared from some rats pretreated with diethyl-ether or halothane were incubated with hexobarbital and assayed for O-demethylase activity and aniline-hydroxylase activity. Hexobarbital sleeping time was significantly reduced after a single 7 hour exposure to diethyl-ether, isopropyl-ether, fluroxene, enflurane, and Forane. Two exposures to halothane and ethyl-vinyl-ether were required to cause a significant reduction in sleeping time. Chloroform caused an increase in sleeping time after one exposure, no change with two or four exposures, and a decrease after five or more exposures. Nitrous-oxide and cyclopropane had no effect on hexobarbital sleeping time. SKF-525-A blocked the decrease in sleeping time caused by diethyl-ether and halothane. The rate of hydroxylation of hexobarbital and aniline by rat liver homogenates was increased by pretreatment with either diethyl-ether or halothane, but demethylase activity was increased only by diethyl-ether pretreatment. The authors conclude that exposure to inhalation anesthetics can enhance the ability of rats to metabolize drugs. ...

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethers and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Ethers and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethers and related compounds/

/HUMAN EXPOSURE STUDIES/ ... /CNS depression/ was also studied in one human subject. The induction period was 60 seconds, duration of light anesthesia was 6 minutes. Recovery was rapid and uneventful. Blood pressure and pulse were not altered. The subject stated that the vapors did not irritate the upper respiratory tract.

/HUMAN EXPOSURE STUDIES/ In the 1950s, ethoxyethene was studied in clinical trials to investigate whether it was suitable as an anesthetic. Some patients participating in these studies suffered complications (generalized convulsions due to hypercarbia and respiratory and circulatory depression as well as respiratory and cardiac arrest), which were attributed to overdosage. The degree of muscle relaxation obtained with this type of anesthesia was considered to be inadequate. Liver function tests conducted after several hours of anesthesia showed that hepatic function was not affected. Urinalyses, blood counts and electrocardiograms obtained after anesthesia revealed slight, reversible changes in some cases.

/HUMAN EXPOSURE STUDIES/ The pharmacological effects were studied in 29 patients, aged 14 to 58 years (7 males, 22 females). Gynecological and orthopedic cases prevailed. Ethyl vinyl ether (EVE) was used in combination with other common anesthetics. In brief, findings were as follows: Liver function was unchanged in 58% of the patients. Bromsulphthalein excretion was observed in some cases. In two of these, large doses up to 110 mL EVE had been used. Urinalysis: no changes were noted in 68% of the patients. Six patients (20%) showed findings (traces of acetone (n=6), increased sugar (n=2), traces of albumin (n=3) which had returned to normal on day 5 post treatment. Blood: no changes in 82% of the patients; the remainder showed slight leucocytosis. ECG: no change in 48% of the patients. Tachycardia, auricular and ventricular premature contractions were all seen. Mild myocardial depression was noted in 5 cases (17%). Nausea, vomiting: was seen in 10 out of 29 patients. Salivation: was quite severe at times; was treatable with atropine.

/CASE REPORTS/ There is a report of one case of transient damage to the human cornea, which was reversible after 48 hr.

/OTHER TOXICITY INFORMATION/ A rapid induction of /CNS depression/ and rapid recovery from narcosis was noted with monkeys, dogs, rats, and man. Compared with diethylether approximately 50% less the quantity was required.

/LABORATORY ANIMALS: Acute Exposure/ On acute oral administration, dermal application and inhalation exposure, ethoxyethene is found to be of low toxicity (LD50 rat oral 6153 mg/kg body weight; LD50 rabbit dermal > 15000 mg/kg body weight; LC50 rat, 4 hours, > 21200 mg/cu m). The clinical signs of intoxication are characterized by the /CNS depressing/ effect of the substance.

/LABORATORY ANIMALS: Acute Exposure/ In rabbits, ethoxyethene causes no or only very mild irritation to the skin and eye.

/LABORATORY ANIMALS: Acute Exposure/ 1. Experiments were carried out to determine the anesthetic effects of divinyl /ether/, ethyl vinyl /ether/ and diethyl ether on mice. 2. The concentrations necessary to produce surgical anesthesia and respiratory arrest were, for divinyl ether 8 and 12 vol. per cent, for ethyl vinyl ether 6 and 16 vol. per cent and for diethyl ether 6 and 18 vol. per cent. Induction time was short and nearly the same for the three ethers in the range 8-14 vol. per cent. Recovery was prolonged following anesthesia with diethyl ether especially when higher concentrations were used. Thus, our results indicate that divinyl ether is the least potent agent for producing surgical anesthesia and the most potent for producing respiratory arrest. It is, therefore, the most dangerous of the three ethers. Ethyl vinyl ether was found to be rapid in action, potent and safe. Recovery time following its use was short.

/LABORATORY ANIMALS: Acute Exposure/ In the animal studies using various species (rat, frog, dog, monkeys), ethyl vinyl ether did not significantly change blood pressure, Electrocardiogram (ECG), Electroencephalogram (EEG), blood urea, carbon dioxide combining power. There was no hemolysis. Clotting time was increased by 10-15%. Liver function was normal, and there were no pathological changes noted in liver and kidney

For more Non-Human Toxicity Excerpts (Complete) data for Vinyl ethyl ether (9 total), please visit the HSDB record page.

Vinyl ethyl ether's production and use in copolymerizations and as a chemical intermediate may result in its release to the environment through various waste streams. Vinyl ethyl ether is released to air in emissions from turbine engines. If released to air, a vapor pressure of 515 mm Hg at 25 °C indicates vinyl ethyl ether will exist solely as a vapor in the atmosphere. Vapor-phase vinyl ethyl ether will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals, ozone and nitrate radicals; the half-lives for these reactions in air are estimated to be 5, 1.4 and 0.6 hours respectively. Vinyl ethyl ether does not absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, vinyl ethyl ether is expected to have very high mobility based upon an estimated Koc of 10. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 6.3X10-3 atm-cu m/mole. Vinyl ethyl ether is expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Zahn-Wellens test, 100% degradation was reached in 5 days indicating that biodegradation is an important environmental fate process. If released into water, vinyl ethyl ether is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2.6 hours and 3.4 days, respectively. An estimated BCF of 2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Indirect photolysis may occur in natural waters exposed to sunlight with a half-life of about 25 days. Occupational exposure to vinyl ethyl ether may occur through inhalation and dermal contact with this compound at workplaces where vinyl ethyl ether is produced or used. Vinyl ethyl ether was used as an anaesthetic drug for general and thoracic surgery which exposed patients via inhalation. Use of vinyl ethyl ether as an inhaled narcotic in the 1950s has been reported. (SRC)

Vinyl ethyl ether's production and use in copolymerizations and as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC). Vinyl ethyl ether is released to air in emissions from turbine engines(2). Vinyl ethers are released to the atmosphere entirely from anthropogenic sources(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that vinyl ethyl ether is expected to have very high mobility in soil(SRC). Volatilization of vinyl ethyl ether from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.3X10-3 atm-cu m/mole(SRC), derived from its vapor pressure, 515 mm Hg(3), and water solubility, 7800 mg/L(4). Vinyl ethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure. A 100% degradation using activated sludge in the OECD Guideline 302B (Inherent biodegradability: Zahn-Wellens/EMPA) test(4) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that vinyl ethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 6.3X10-3 atm-cu m/mole(SRC), derived from its vapor pressure, 515 mm Hg(4), and water solubility, 7800 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.6 hours and 3.4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 2(SRC), from its log Kow of 1.04(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 100% degradation using activated sludge in the OECD Guideline 302B (Inherent biodegradability: Zahn-Wellens/EMPA) test(5) suggests that biodegradation is an important environmental fate process in water(SRC). Vinyl ethyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Vinyl ethyl ether is an olefin and olefins react with photooxidants in natural waters (such as hydroxyl, peroxy and singlet oxygen) exposed to sunlight with a half-life on the order of 25 days(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), vinyl ethyl ether, which has a vapor pressure of 515 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase vinyl ethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 7.79X10-11 cu cm/molecule-sec at 25 °C(3). Vapor-phase vinyl ethyl ether is also degraded in the atmosphere by reaction with ozone and nitrate radicals(SRC); the half-lives for these reactions in air is estimated to be 1.4 and 0.6 hours(SRC), calculated from respective rate constants of 2.0X10-16 and 1.40X10-12 cu cm/molecule-sec at 25 °C(3). Vinyl ethyl ether does not absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Using OECD Guideline 302B (Inherent biodegradability: Zahn-Wellens/EMPA Test) with an activated, non-adapted industrial sludge inoculum, vinyl ethyl ether, at 400 mg/L, reached 100% degradation (DOC removal) after 5 days of incubation. Using OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels, Headspace Test) with a domestic activated sludge, the analog isobutyl vinyl ether, at 27.7 mg/L, reached 60-70% after 28 days of incubation(1); the interpretation of the test result was readily biodegradable, but failing the 10-day window(1).

The rate constant for the vapor-phase reaction of vinyl ethyl ether with photochemically-produced hydroxyl radicals has been measured as 7.79X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). The rate constant for the vapor-phase reaction of vinyl ethyl ether with ozone has been measured as 2.0X10-16 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 1.4 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). The rate constant for the vapor-phase reaction of vinyl ethyl ether with atmospheric nitrate radicals is 1.40X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of approximately 0.6 hours at an atmospheric concentration of 2.5X10+8 nitrate radicals per cu cm(3). Vinyl ethyl ether does not absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Vinyl ethyl ether is an olefin and olefins react with photooxidants in natural waters (such as hydroxyl, peroxy and singlet oxygen) exposed to sunlight with a half-life on the order of 25 days(5). Vinyl ethyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(6).

An estimated BCF of 2 was calculated in fish for vinyl ethyl ether(SRC), using a log Kow of 1.04(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of vinyl ethyl ether can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that vinyl ethyl ether is expected to have very high mobility in soil.

The Henry's Law constant for vinyl ethyl ether is estimated as 6.3X10-3 atm-cu m/mole(SRC) derived from its vapor pressure, 515 mm Hg(1), and water solubility, 7800(2). This Henry's Law constant indicates that vinyl ethyl ether is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 2.6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 3.4 days(SRC). Vinyl ethyl ether's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Vinyl ethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure.

Vinyl ethyl ether has been detected in emissions from turbine engines(1).

According to the 2016 TSCA Inventory Update Reporting data, 3 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of vinyl ethyl ether in the United States may be as low as <10 workers and as high as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

Vinyl ethyl ether's production and use in copolymerizations and as a chemical intermediate may result in its release to the environment through various waste streams. Vinyl ethyl ether is released to air in emissions from turbine engines. If released to air, a vapor pressure of 515 mm Hg at 25 °C indicates vinyl ethyl ether will exist solely as a vapor in the atmosphere. Vapor-phase vinyl ethyl ether will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals, ozone and nitrate radicals; the half-lives for these reactions in air are estimated to be 5, 1.4 and 0.6 hours respectively. Vinyl ethyl ether does not absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, vinyl ethyl ether is expected to have very high mobility based upon an estimated Koc of 10. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 6.3X10-3 atm-cu m/mole. Vinyl ethyl ether is expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Zahn-Wellens test, 100% degradation was reached in 5 days indicating that biodegradation is an important environmental fate process. If released into water, vinyl ethyl ether is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2.6 hours and 3.4 days, respectively. An estimated BCF of 2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Indirect photolysis may occur in natural waters exposed to sunlight with a half-life of about 25 days. Occupational exposure to vinyl ethyl ether may occur through inhalation and dermal contact with this compound at workplaces where vinyl ethyl ether is produced or used. Vinyl ethyl ether was used as an anaesthetic drug for general and thoracic surgery which exposed patients via inhalation. Use of vinyl ethyl ether as an inhaled narcotic in the 1950s has been reported. (SRC)

Vinyl ethyl ether's production and use in copolymerizations and as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC). Vinyl ethyl ether is released to air in emissions from turbine engines(2). Vinyl ethers are released to the atmosphere entirely from anthropogenic sources(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that vinyl ethyl ether is expected to have very high mobility in soil(SRC). Volatilization of vinyl ethyl ether from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.3X10-3 atm-cu m/mole(SRC), derived from its vapor pressure, 515 mm Hg(3), and water solubility, 7800 mg/L(4). Vinyl ethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure. A 100% degradation using activated sludge in the OECD Guideline 302B (Inherent biodegradability: Zahn-Wellens/EMPA) test(4) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that vinyl ethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 6.3X10-3 atm-cu m/mole(SRC), derived from its vapor pressure, 515 mm Hg(4), and water solubility, 7800 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.6 hours and 3.4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 2(SRC), from its log Kow of 1.04(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 100% degradation using activated sludge in the OECD Guideline 302B (Inherent biodegradability: Zahn-Wellens/EMPA) test(5) suggests that biodegradation is an important environmental fate process in water(SRC). Vinyl ethyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Vinyl ethyl ether is an olefin and olefins react with photooxidants in natural waters (such as hydroxyl, peroxy and singlet oxygen) exposed to sunlight with a half-life on the order of 25 days(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), vinyl ethyl ether, which has a vapor pressure of 515 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase vinyl ethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 7.79X10-11 cu cm/molecule-sec at 25 °C(3). Vapor-phase vinyl ethyl ether is also degraded in the atmosphere by reaction with ozone and nitrate radicals(SRC); the half-lives for these reactions in air is estimated to be 1.4 and 0.6 hours(SRC), calculated from respective rate constants of 2.0X10-16 and 1.40X10-12 cu cm/molecule-sec at 25 °C(3). Vinyl ethyl ether does not absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Using OECD Guideline 302B (Inherent biodegradability: Zahn-Wellens/EMPA Test) with an activated, non-adapted industrial sludge inoculum, vinyl ethyl ether, at 400 mg/L, reached 100% degradation (DOC removal) after 5 days of incubation. Using OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels, Headspace Test) with a domestic activated sludge, the analog isobutyl vinyl ether, at 27.7 mg/L, reached 60-70% after 28 days of incubation(1); the interpretation of the test result was readily biodegradable, but failing the 10-day window(1).

The rate constant for the vapor-phase reaction of vinyl ethyl ether with photochemically-produced hydroxyl radicals has been measured as 7.79X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). The rate constant for the vapor-phase reaction of vinyl ethyl ether with ozone has been measured as 2.0X10-16 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 1.4 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). The rate constant for the vapor-phase reaction of vinyl ethyl ether with atmospheric nitrate radicals is 1.40X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of approximately 0.6 hours at an atmospheric concentration of 2.5X10+8 nitrate radicals per cu cm(3). Vinyl ethyl ether does not absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Vinyl ethyl ether is an olefin and olefins react with photooxidants in natural waters (such as hydroxyl, peroxy and singlet oxygen) exposed to sunlight with a half-life on the order of 25 days(5). Vinyl ethyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(6).

An estimated BCF of 2 was calculated in fish for vinyl ethyl ether(SRC), using a log Kow of 1.04(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of vinyl ethyl ether can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that vinyl ethyl ether is expected to have very high mobility in soil.

The Henry's Law constant for vinyl ethyl ether is estimated as 6.3X10-3 atm-cu m/mole(SRC) derived from its vapor pressure, 515 mm Hg(1), and water solubility, 7800(2). This Henry's Law constant indicates that vinyl ethyl ether is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 2.6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 3.4 days(SRC). Vinyl ethyl ether's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Vinyl ethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure.

Vinyl ethyl ether has been detected in emissions from turbine engines(1).

According to the 2016 TSCA Inventory Update Reporting data, 3 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of vinyl ethyl ether in the United States may be as low as <10 workers and as high as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

Occupational exposure to vinyl ethyl ether may occur through inhalation and dermal contact with this compound at workplaces where vinyl ethyl ether is produced or used(SRC). Vinyl ethyl ether was used as an anaesthetic drug for general and thoracic surgery(1) which exposed patients via inhalation. Use of vinyl ethyl ether as an inhaled narcotic in the 1950s has been reported(2).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

/GUIDE 127P FLAMMABLE LIQUIDS (Water-Miscible)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Vinyl ethyl ether, stabilized/

/GUIDE 127P FLAMMABLE LIQUIDS (Water-Miscible)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. /Vinyl ethyl ether, stabilized/

/GUIDE 127P FLAMMABLE LIQUIDS (Water-Miscible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind, uphill and/or upstream. Ventilate closed spaces before entering. /Vinyl ethyl ether, stabilized/

/GUIDE 127P FLAMMABLE LIQUIDS (Water-Miscible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Vinyl ethyl ether, stabilized/

For more DOT Emergency Guidelines (Complete) data for Vinyl ethyl ether (8 total), please visit the HSDB record page.

1302 127P

UN 1302; Vinyl ethyl ether, stabilized

IMO 1302; Vinyl ethyl ether, stabilized

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Vinyl ethyl ether, stabilized is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Vinyl ethyl ether, stabilized is included on the dangerous goods list.

Flammable Liquid

Airtight.

UN Hazard Class: 3; UN Pack Group: I