Ethylene glycol monomethyl ether acetate

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]

P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)

H226 (39.6%): Flammable liquid and vapor [Warning Flammable liquids]

H302+H312+H332 (38.6%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H360 (99%): May damage fertility or the unborn child [Danger Reproductive toxicity]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P321, P330, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 101 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P337+P317, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P203, P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

To fight fire, use CO2, dry chemical.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME...TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN SUITABLE COMBUSTION CHAMBER. LIQ...SHOULD NOT BE ALLOWED TO ENTER CONFINED SPACE, SUCH AS SEWER, BECAUSE OF POSSIBILITY OF EXPLOSION.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL & DISPOSING IN SECURED SANITARY LANDFILL. 2. BY ATOMIZING IN SUITABLE COMBUSTION CHAMBER.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

If...agitated or heated, or if skin contact is extensive & prolonged, it is advisable to protect personnel by enclosing process or providing local exhaust ventilation. Skin & eye protection should also be worn if possibility of such contact exists. ...ingestion /hazard/ can...be prevented by keeping them in properly labelled containers. /Glycols & derivatives/

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet or significantly contaminated should be removed and replaced.

For more Preventive Measures (Complete) data for METHYL CELLOSOLVE ACETATE (9 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids. Keep in the dark.

Fire proof. Separated from strong oxidants, strong bases, strong acids. Keep in the dark.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - 2-Methoxyacetic acid in urine = 1 mg/g creatinine; end of shift at end of workweek; [ACGIH]

1.0 [ppm], sum of concentrations of CAS 109-86-4 and its acetate in air[German Research Foundation (DFG)]

2.0 [ppm]

670 [ppm]

4000 [ppm]

0.1 ppm (0.5 mg/m³)

TWA 0.1 ppm (0.5 mg/m3) [skin]

25.0 [ppm]

25 ppm (120 mg/m³)

TWA 25 ppm (120 mg/m3) [skin]

200 ppm (NIOSH, 2024)

200.0 [ppm]

Excerpts from Documentation for IDLHs: Human data: It has been stated that methyl Cellosolve® acetate is slightly less toxic than methyl Cellosolve® [Gosselin et al. 1984].

See: 110496

0.1 [ppm]

8 hr Time Weighted Avg (TWA): 0.1 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed three times the TLV-TWA for no more than a total of 30 min during a work day, and under no circumstances should they exceed five times the TLV-TWA, provided that the TLV-TWA is not exceeded. /2-Methoxyethyl acetate (EGMEA)/

0.1 ppm as TWA; (skin); BEI issued.

0.1 ppm [2005]

1 ppm as TWA; (skin)

4.9 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

· Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Vapor hazard index (VHI) is defined as concn of saturated vapor divided by TLV multiplied by 1000. The dimension of the VHI is temperature dependent and is an indication of vapor hazard potential. VHI number= 0.1 at 20 °C.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The vapour is mildly irritating to the eyes. The substance may cause effects on the bone marrow and central nervous system. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. Exposure far above the OEL could cause unconsciousness.

Ethylene glycol monomethyl ether acetate appears as a clear colorless liquid with a pleasant odor. Flash point of 135 °F. Denser than water and soluble in water. Vapors are heavier than air.

Colorless liquid with a pleasant odor; [CAMEO]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a mild, ether-like odor.

Colorless liquid

Pleasant odor

Ester-like odor

293 °F at 760 mmHg (NTP, 1992)

143 °C @760 [mm Hg]

-85 °F (NTP, 1992)

-65.1 °C

111 °F (NTP, 1992)

45 °C (120 °F) (CLOSED CUP)

55.6 °C (Open cup)

45 °C c.c.

greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

Hildebrand solubility parameter(delta) = 18.8 MPa; Coefficient of expansion = 0.00110 °C-1 at 20 °C

Miscible with most organic solvents, oils

Very soluble in water, ethyl ether, and ethanol; soluble in carbon tetrachloride.

Infinitely soluble in water at 25 °C; water infinitely soluble in methyl cellosolve acetate at 25 °C

Solubility in water: miscible

Miscible

1.006 at 68 °F (USCG, 1999) - Denser than water; will sink

1.0074 g/cu cm at 19 °C

Bulk density: 8.4 lb/gal at 20 °C

Relative density (water = 1): 1.01

1.005 @ 20°C

4.07 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.1 (Air = 1)

Relative vapor density (air = 1): 4.1

2 mmHg at 68 °F (NTP, 1992)

7.0 [mmHg]

Vapor pressure = 2 torr at 20 °C

7.0 mm Hg at 20 °C

Vapor pressure, kPa at 20 °C: 0.27

2 [mm Hg] @20 °C

740 °F (USCG, 1999)

394 °C, 740 °F

When heated to decomposition it emits acrid smoke and fumes.

1.1 cP at 25 °C

Flammable. Water soluble. Reacts slowly in water to form acetic acid and methyl alcohol; the reaction is not violent.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Nitrates, strong oxidizers, alkalis & acids

Nitrates; strong oxidizers, alkalis & acids

2-Methoxyethyl acetate

D: Other compounds that may form peroxides

... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studied than that of 2-MEA and 2-EEA. 2-ME and 2-EE and their acetates have similar lethalities after single exposures and they show low acute lethality whether exposure is via the dermal, oral, or inhalation route. Oral LD60 values for a variety of species range between 900 and 3400 mg/kg body weight for 2-ME, 1400 and 5500 mg/kg for 2-EE, 1250 and 3930 mg/kg for 2-MEA, and 1300 and 5100 mg/kg for 2-EEA. ... Short-term inhalation exposure (up to 90 days) of experimental animals to high concentrations (> 9313 mg 2-ME/cu m ... has been shown to lead to adverse effects on blood parameters, the nervous system, and testes, thymus, kidney, liver, and lung. At lower exposure levels, effects are observed on the hemopoietic system and testes. For example, rats exposed by inhalation to 2-ME for 13 weeks at levels between 93 and 930 mg/cu m exhibited reduced packed cell volume and white blood cell, hemoglobin, platelet, and serum protein concentrations at the highest dose only, while similarly exposed rabbits had decreased thymus size, in addition to the decreased blood parameters, at 930 mg/cu m. ... The mutagenicity of 2-ME has been investigated in a range of in vitro systems using bacteria and mammalian cells. Although most studies yielded negative results, there were reports of positive mutagenicity results at very high 2-ME concentrations in CHO cells when investigated for chromosome aberration (at 6830 ug/mL or more) and sister chromatid exchange (3170 ug/mL or more). However, in vivo studies for chromosome aberrations and micronuclei were negative. ... The effect of 2-ME on the male reproductive system has been intensively investigated following both oral and inhalation exposure in rodents. Degenerative changes in the germinal epithelium of the seminiferous tubules were consistently noted. ... Oral dosing of rats with 2-ME for 1-11 days resulted in a dose-related decrease in sperm count and changes in sperm motility and morphology at dose levels of 100 mg/kg body weight or more. Marked histological damage was seen in the testes at autopsy. The no-observed-effect level (NOEL) was 50 mg/kg. Reduced fertility was still evident 8 weeks after exposure to 200 mg/kg. ... Fertility studies following a single oral dose of 250 mg 2-ME/kg or more revealed complete sterility in both rats and mice at 5 weeks post dosing, some decrease in fertility being seen at 125 mg/kg. When the inhalation route was investigated, similar degenerative changes in the testes were seen with 2-ME. Effects were observed following a single exposure (4 hr) to 1944 mg/m3 or more but not to 933 mg/cu m. NOEL values were 311 mg/cu m in rats following exposure for 13 weeks (6 hr/day, 5 day/week) and 933 mg/cu m (6 hr/day) in mice following exposure on 9 occasions over 11 days. Exposure of rabbits to 2-ME for 13 weeks (6 hr/day, 5 days/week) resulted in marked effects on the testes at 311 mg/cu m or more; marginal effects were seen at 93 mg/cu m, and a NOEL was not identified. ... Developmental toxicity has been observed in several species of laboratory animals following exposure by all routes of administration, i.e. oral, inhalation, and dermal. 2-ME produced teratogenic effects in mice, rats, rabbits, and monkeys. ... Although 2-MEA has not been tested for developmental toxicity, metabolic profiles suggest that it is reasonable to expect that 2-MEA would have a toxicity similar to that of 2-ME. The widest range of dose/response data (doses of 31.25 to 1000 mg/kg per day) is available for 2-ME. In this gavage study using mice, (2-ME was administered on days 7 to 14 of gestation), the NOEL for maternal toxicity was 125 mg/kg per day. However, malformations were observed at 62.5 mg/kg per day and skeletal variations at 31.25 mg/kg per day. A NOEL for developmental toxicity was not reported. In single-dose studies, mice were treated with 2-ME by gavage on gestation day 11; 100 mg/kg was not fetotoxic, while 175 mg/kg produced digit defects without other signs of maternal or fetal toxicity. Cardiovascular defects and ECG abnormalities were observed in neonatal rats following treatment on days 7 to 13 of gestation with 25 mg/kg per day. Since that was the lowest dose tested, this study yielded no developmental NOEL (maternal toxicity was not observed at that dose). Similarly, no NOEL for developmental toxicity could be determined when monkeys were treated by gavage with 2-ME at 0.16, 0.32, or 0.47 mmol/kg per day on days 20 to 45 of gestation. Fetotoxicity in mice and rats and malformations in rabbits were observed following exposure by inhalation to 2-ME at 156 mg/m3. For all three species, the NOEL for developmental effects was 31 mg/cu m. However, behavioral and neurochemical alterations were seen in the offspring of rats exposed to 78 mg 2-ME/cu m on days 7-13 or 14-20 of gestation. Following inhalation exposure of rats (743 mg/m3) and rabbits (589 mg/m3), 2-EE was found to be teratogenic (in the presence of slight maternal toxicity). ... Information on the toxic effects of these four glycol ethers on humans is limited. The results from the few case reports and workplace epidemiological studies are consistent with the adverse effects seen in experimental animals. ...

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Dizziness. Drowsiness. Headache.

MAY BE ABSORBED! Dry skin. Further see Inhalation.

Redness.

Abdominal pain. Nausea. Vomiting. Weakness. Unconsciousness. Further see Inhalation.

irritation eyes, nose, throat; kidney, brain damage; In Animals: narcosis; reproductive, teratogenic effects

Eyes, respiratory system, kidneys, brain, central nervous system, peripheral nervous system, reproductive system, hematopoietic system

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

2-Methoxyethanol Acetate

8 x 10^-3 mg/kg-day

3 x 10^-2 mg/kg-day

1 x 10^-3 mg/m^3

1 x 10^-2 mg/m^3

PDF Document

Inadequate information to assess carcinogenic potential

PPRTV Current

LCLo (rat) = 7,000 ppm/4 hr

LD50 Rat oral 3.93 g/kg

LD50 Rat oral 1.25 g/kg

LD50 Guinea pig oral 1.25 g/kg

LD50 Rabbit oral 0.5 or 1.0 mL/kg

For more Non-Human Toxicity Values (Complete) data for METHYL CELLOSOLVE ACETATE (11 total), please visit the HSDB record page.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ethylene glycol, glycols, and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethylene glycol, glycols, and related compounds/

SRP: Medical surveillance should emphasize monitoring of central nervous system, kidney and hematology in employees.

/SIGNS AND SYMPTOMS/ Symptomatology B) ... 3. Nausea, vomiting and sometimes diarrhea. 4. Prominent headache. Later abdominal and lumbar pain and costovertebral angle tenderness. 5. Transient polyuria and then oliguria, progressing to anuria. 6. Acute renal failure with uremia, peripheral edema, ascites, pulmonary edema, drowsiness, cyanosis, coma and death in 7-10 days. 7. Less critical pathological lesions may appear in brain, lungs, liver, meninges and heart. /Ethylene glycol/

/SIGNS AND SYMPTOMS/ Blood disorders, CNS effects/ kidney damage

/SIGNS AND SYMPTOMS/ Ethylene glycol monomethyl ether acetate (EGMEA) has low single-dose oral toxicity, is not significantly irritating to the eyes or skin, is poorly absorbed through the skin, and is moderately toxic when inhaled. Its effects are similar to those of ethylene glycol monomethyl ether and are centered in the blood, kidneys, brain, and testes.

/SIGNS AND SYMPTOMS/ Effects on the central nervous system are the most prominent features of 2-methoxyethanol intoxication. Metabolic acidosis and kidney damage have been seen after acute ingestion and anemia has resulted from prolonged exposure to high vapor concentration in the workplace. /2-Methoxyethanol/

For more Human Toxicity Excerpts (Complete) data for METHYL CELLOSOLVE ACETATE (13 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ One hr inhalation exposures at near saturated concentrations (4500 ppm) were tolerated by mice, guinea pigs and rabbits with only irritation of accessible mucous membranes. Three-hour inhalations at the same concentration were tolerated by mice and rabbits, but guinea pigs and cats died 36 hr to 21 days later of bronchopneumonia.

/LABORATORY ANIMALS: Acute Exposure/ Cats ... survived one 7 hr exposure to 1500 ppm but ... increase in blood clotting time and ... changes in brain /were observed/. ... Repeated 8 hr exposures ... at 500 ppm ... /produced/ slight /CNS depression/. ... Cats tolerated repeated 4-6 hr exposures to 200 ppm ... .

/LABORATORY ANIMALS: Acute Exposure/ Liquid 2-methoxyethyl acetate is mildly irritating to eyes of rabbits but not significantly irritating to skin.

/LABORATORY ANIMALS: Acute Exposure/ Cutaneous irritation was determined in the rabbit following the EEC method (European Economic Communities) and the Draize protocol, and the sensitizing effect was evaluated in the guinea pig by the maximized Magnusson and Kligman method. The results showed no delayed cutaneous hypersensitivity, and all glycol ethers studied were classified from slightly irritant to severely irritant according to the Draize protocol, though only 2-butoxyethanol and isopropoxyethanol were classified as skin irritants with the EEC method. Glycol ethers should be handled with all the care that should be taken in the safe use of organic solvents. /Glycol ethers/

LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static bioassay in fresh water at 23 °C, mild aeration applied after 24 hr; Concentration: 45 ppm for 96 hr

LC50; Species: Menidia beryllina /(Inland silverside)/; Conditions: static bioassay in synthetic seawater at 23 °C, mild airation applied after 24 hr; Concentration: 40 ppm for 96 hr

LC50; Species: Carassius auratus (Goldfish, weight 3.3 g); Conditions: freshwater, static, 20 °C, pH 7.0, dissolved oxygen >4.0 mg/L; Concentration: 190000 ug/L for 24 hr

/AQUATIC SPECIES/ Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L ...

1.10e+02

5.10e+02

1.00e+00

4.40e+00

2.10e+00

4.00e+01

4.20e-04

8.00e-03

1.00e-03

Volatile

1.15e+05

3.20e+02

1.50e+03

3.10e+00

1.30e+01

6.20e+00

The substance is harmful to aquatic organisms.

Methyl cellosolve acetate's production and use as a solvent for nitrocellulose, cellulose acetate, various gums, resins, waxes, oils; in textile printing; photographic film; lacquers; and dopes may result in its release to the environment through various waste streams. If released to air, a measured vapor pressure of 7.0 mm Hg at 20 °C indicates that methyl cellosolve acetate will exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl cellosolve acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 1.1 days. Methyl cellosolve acetate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, methyl cellosolve acetate is expected to have very high mobility based upon an estimated Koc of 30. Volatilization from moist soil surfaces may be an important fate process based upon an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole. Estimated volatilization half-lives for a model river and model lake are 24 days and 270 days, respectively. This compound's vapor pressure indicates that volatilization from dry soil surfaces is possible. Using aqueous screening tests methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days, suggesting that biodegradation may be an important environmental fate process. If released into water, the estimated Koc suggests that methyl cellosolve acetate is not expected to adsorb to suspended solids and sediment in the water column. Volatilization from water surfaces is expected to be important based on this compound's estimated Henry's Law constant. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis half-lives of 140 and 14 days at pH values of 7 and 8, respectively, suggest that hydrolysis is not expected to be an important process except under basic conditions. Occupational exposure to methyl cellosolve acetate may occur through inhalation and dermal contact with this solvent at workplaces where methyl cellosolve acetate is produced or used. (SRC)

Methyl cellosolve acetate's production and use as a solvent for nitrocellulose, cellulose acetate, various gums, resins, waxes, oils; in textile printing; photographic film; lacquers; and dopes(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from an estimated log Kow of 0.10(2) and a regression-derived equation(3), indicates that methyl cellosolve acetate is expected to have very high mobility in soil(SRC). Volatilization of methyl cellosolve acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg at 20 °C(4), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). The potential for volatilization of methyl cellosolve acetate from dry soil surfaces may exist(SRC) based on its vapor pressure(4). Using aqueous screening tests methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days(6,7), suggesting that biodegradation may be an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from an estimated log Kow of 0.10(2) and a regression-derived equation(3), indicates that methyl cellosolve acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg(4), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 24 days and 270 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3.2(3), from an estimated log Kow(2), and a regression derived equation(7) suggests that bioconcentration in aquatic organisms is low(SRC). Hydrolysis half-lives of 140 and 14 days at pH values of 7 and 8, respectively(10), suggest that hydrolysis is not expected to be an important process except under basic conditions(SRC). Using aqueous screening tests, methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days(8,9), suggesting that biodegradation may be an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl cellosolve acetate, which has a measured vapor pressure of 7.0 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl cellosolve acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 1.1 days(SRC) calculated from its rate constant of 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC)that was derived using a structure estimation method(3). Methyl cellosolve acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Methyl cellosolve present at 100 mg/L, reached 86.9% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Methyl cellosolve acetate reached 30% of its theoretical BOD after 5 days using a sewage seed(2). 69% of the theoretical BOD for methyl cellosolve acetate was reached over a period of 10 days in a biodegradation study employing dispersed seed aeration(3).

The rate constant for the vapor-phase reaction of methyl cellosolve acetate with photochemically-produced hydroxyl radicals has been estimated as 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.1 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.263 L/mol-sec(SRC) was measured for methyl cellosolve acetate(2); this corresponds to half-lives of 140 and 14 days at pH values of 7 and 8, respectively(2). Methyl cellosolve acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3.2 was calculated for methyl cellosolve acetate(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of methyl cellosolve acetate is estimated as approximately 30(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that methyl cellosolve acetate is expected to have very high mobility in soil(SRC).

The Henry's Law constant for methyl cellosolve acetate is estimated as 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg at 20 °C(1), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(2). This value indicates that methyl cellosolve acetate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 24 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 270 days(SRC). The Henry's Law constant of methyl cellosolve acetate indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of methyl cellosolve acetate from dry soil surfaces may exist(SRC) based on its measured vapor pressure(1).

INDOOR AIR: Methyl cellosolve acetate was detected in a sample of indoor air from an unspecified building in Northern Italy between 1983 and 1984 at a concentration of 4 ug/cu m(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 9,982 workers (2,801 of these were female) were potentially exposed to methyl cellosolve acetate in the US(1). Occupational exposure to methyl cellosolve acetate may occur through inhalation and dermal contact with this compound at workplaces where methyl cellosolve acetate is produced or used(SRC).

The geometric mean concentration of methyl cellosolve acetate obtained during personal sampling of workplace air, 16 personal air samples of 4 to 8 hours duration from seven different companies during the manufacture of wafers, was 0.01 ppm(1). 5 of 111 personal air samples collected in silk-screen printing installations contained methyl cellosolve acetate at a mean concentration of 0.8 mg/cu m(2).

ENVIRONMENTAL INVESTIGATIONS WERE CONDUCTED TO EVALUATE EXPOSURE TO MATERIALS USED BY ARTISTS & CRAFTMEN. EXPOSURES TO METHYL CELLUSOLVE ACETATE ARE POTENTIALLY TOXIC AT CONCN MEASURED DURING EVALUATION.

Exposure in an automobile body shop ... .

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL & DISPOSING IN SECURED SANITARY LANDFILL. 2. BY ATOMIZING IN SUITABLE COMBUSTION CHAMBER.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for METHYL CELLOSOLVE ACETATE (8 total), please visit the HSDB record page.

UN 1189; METHYL CELLOSOLVE ACETATE; ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE

IMO 3.3; Methyl cellosolve acetate; ethylene glycol monomethyl ether acetate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: T; R: 60-61-20/21/22; S: 53-45; Note: E

UN Hazard Class: 3; UN Pack Group: III