Glycol monoethyl ether acetate

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P321, P330, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 8.8% (36 of 410) of reports.

H226 (90.5%): Flammable liquid and vapor [Warning Flammable liquids]

H302 (91.2%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (91.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H332 (91.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H360 (91%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Aggregated GHS information provided per 410 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 36 of 410 reports by companies.

There are 12 notifications provided by 374 of 410 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P303+P361+P353, P304+P340, P308+P316, P317, P318, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P203, P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P273, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

P203, P210, P233, P240, P241, P242, P243, P264+P265, P280, P301+P317, P303+P361+P353, P305+P351+P338, P318, P332+P317, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

TO FIGHT FIRE, USE ALCOHOL FOAM, CO2, DRY CHEMICAL.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

The worker should immediately wash the skin when it becomes contaminated.

For more Preventive Measures (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (8 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids. Keep in the dark.

MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ...

Keep away from heat and open flame.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - 2-Ethoxyacetic acid in urine = 40 mg/g creatinine; end of shift at end of workweek;

2.0 [ppm], sum of the concentrations of CAS 110-80-5 and its acetate in air[German Research Foundation (DFG)]

16 [ppm]

83 [ppm]

500 [ppm]

0.5 ppm (2.7 mg/m³)

TWA 0.5 ppm (2.7 mg/m3) [skin]

100.0 [ppm]

100 ppm (540 mg/m³)

TWA 100 ppm (540 mg/m3) [skin]

500 ppm (NIOSH, 2024)

500.0 [ppm]

Excerpts from Documentation for IDLHs: Basis for original (SCP) IDLH: Patty [1963] reported that guinea pigs survived a 1­hour exposure to an atmosphere essentially saturated with vapor (estimated to be less than 4,000 ppm) [Lehmann and Flury 1943]. Because the data concerning the concentration is not very specific, the IDLH is based on the concentration of 2­ethoxyethylacetate in saturated air at 20 C (i.e., 2,600 ppm). . . . Human data: None relevant for use in determining the revised IDLH.

See: 111159

5.0 [ppm]

8 hr Time Weighted Avg (TWA): 5 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed three times the TLV-TWA for no more than a total of 30 min during a work day, and under no circumstances should they exceed five times the TLV-TWA, provided that the TLV-TWA is not exceeded.

Biological Exposure Index (BEI): Determinant: 2-ethoxyacetic acid in urine; Sampling Time: end of shift at end of workweek; BEI: 100 mg/g creatinine.

5 ppm as TWA; (skin); BEI issued.

5 ppm [1981]

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

· Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The vapour is mildly irritating to the eyes. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness.

The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood. This may result in lesions of blood cells, anaemia and kidney impairment. May cause toxicity to human reproduction or development.

Excerpt from NIOSH Pocket Guide for 2-Ethoxyethyl acetate:

Ethylene glycol monoethyl ether acetate appears as a clear colorless liquid with a pleasant odor. Flash point of 120 °F. Less dense than water. Vapors are heavier than air.

Colorless liquid with a mild odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a mild odor.

Colorless liquid

MILD ESTER-LIKE ODOR BECOMES OBJECTIONABLE IN HIGH CONCN ...

Pleasant odor

... A BITTER ACID TASTE

313 °F at 760 mmHg (NTP, 1992)

156.4 °C

156.4 °C @760 [mm Hg]

-79.1 °F (NTP, 1992)

-61.7 °C

135 °F (NTP, 1992)

52 °C (Closed cup)

51.1 °C c.c.

greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)

Coefficient of expansion = 0.00112 °C-1 at 20 °C; Dielectric constant = 7.567 at 30 °C; Water azeotrope = 44.4 wt % at 97 °C; Hildebrand solubility parameter(delta) = 17.8 MPa

Very soluble in ethyl alcohol, ethyl ether

MISCIBLE WITH OLIVE OIL IN ALL PROP

Miscible with aromatic hydrocarbons

In water, 187,000 mg/L at 20 °C

Solubility in water, g/100ml at 20 °C: 23

0.974 at 68 °F (USCG, 1999) - Less dense than water; will float

Specific gravity: 0.975 at 20 °C/20 °C

Relative density (water = 1): 0.97 (20 °C)

0.9740 @ 20°C

4.72 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.72 (Air = 1)

Relative vapor density (air = 1): 4.7

1.2 mmHg at 68 °F ; 3.8 mmHg at 86 °F (NTP, 1992)

2.0 [mmHg]

2.00 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 0.27

0.75 [mm Hg] @14 °C

log Kow = 0.24

Henry's Law constant = 3.20X10-6 atm-cu m/mole at 25 °C

715 °F (USCG, 1999)

715 °F (379 °C)

WHEN HEATED TO DECOMPOSITION IT EMITS ACRID SMOKE AND IRRITATING FUMES.

Flammable. Slightly soluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Mixing ETHYLENE GLYCOL MONOETHYL ETHER ACETATE in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, oleum, and vinyl acetate, NFPA 1991.

Incompatibilities: Nitrates, strong oxidizers, strong alkalies, strong acids.

Nitrates; strong oxidizers, alkalis & acids.

Nitrates; strong oxidizers, alkalis & acids

2-Ethoxyethyl acetate

B*: Compounds that form peroxides on concentration (distillation/evaporation)

Kelly, Clark

"Mild" explosions have been reported after distillations. See Bretherick's under "Ethyl Glycol Acetate".

On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Ethoxyethanol and Ethoxyethanol Acetate are unsafe for use in cosmetic products.

The ingredient is unsafe for use in cosmetics

... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studied than that of 2-MEA and 2-EEA. 2-ME and 2-EE and their acetates have similar lethalities after single exposures and they show low acute lethality whether exposure is via the dermal, oral, or inhalation route. Oral LD60 values for a variety of species range between 900 and 3400 mg/kg body weight for 2-ME, 1400 and 5500 mg/kg for 2-EE, 1250 and 3930 mg/kg for 2-MEA, and 1300 and 5100 mg/kg for 2-EEA. ... 2-EE was found to be teratogenic (in the presence of slight maternal toxicity). Another study reported fetotoxicity but no malformations in rats exposed to 184 or 920 mg 2-EE/cu m, and in rabbits exposed to 644 mg 2-EE/cu m. NOEL values for developmental effects were 37 mg/cu m for rats and 184 mg/cu m for rabbits. Behavioral and neurochemical alterations were seen in the offspring of rats exposed to 368 mg 2-EE/cu m on days 7-13 or 14-20 of gestation. Rats treated by dermal application of 0.25 mL undiluted 2-EE (four times daily on gestation days 7-16) exhibited marked fetotoxicity and a high incidence of malformation in the absence of maternal toxicity. Similar effects were noted following 2-EEA treatment of rats, using the same protocol, at an equimolar dose (0.35 mL, four times daily). Inhalation exposure of rabbits to 2-EEA on gestation days 6-18 produced teratogenic responses at 2176 mg/cu m and 544 mg/cu m in two different studies, the developmental NOEL values in these two studies being 135 mg/m3 and 270 mg/m3. Exposure of rats to 2-EEA on days 6-15 of gestation produced fetotoxicity at 540 mg/cu m and malformation at 1080 mg/cu m. The developmental NOEL was 170 mg/cu m. Effects on humans: Information on the toxic effects of these four glycol ethers on humans is limited. The results from the few case reports and workplace epidemiological studies are consistent with the adverse effects seen in experimental animals. No reports quantifying general population exposure and health effects have been found. ...

2-Ethoxyethyl acetate

Volatile Organic Compound (VOC)

Based on PPRTV

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Dizziness. Drowsiness. Headache. Unconsciousness.

MAY BE ABSORBED! Dry skin. Further see Inhalation.

Redness.

Nausea. Vomiting. Further see Inhalation.

irritation eyes, nose; vomiting; kidney damage; paralysis; In Animals: reproductive, teratogenic effects

Eyes, respiratory system, gastrointestinal tract, reproductive system, hematopoietic system

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Ethoxyethanol Acetate

1 x 10^-1 mg/kg-day

1 mg/kg-day

6 x 10^-2 mg/m^3

PDF Document

Inadequate information to assess carcinogenic potential

PPRTV Current

LC50 (rat) = 12,100 mg/m3/8 hr

The lethal oral dose /of ethylene glycols/ in humans is approximately 1.4 mL/kg, which would be equivalent to approximately 100 mL for a 70 kg person. /Ethylene glycols/

LD50 RAT MALE ORAL 3900 MG/KG

LD50 RAT FEMALE ORAL 2900 MG/KG

LD50 Rat oral 5.1 g/kg

LD50 Rabbit /dermal/ 10,300 mg/kg

For more Non-Human Toxicity Values (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (13 total), please visit the HSDB record page.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ethylene glycol, glycols, and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethylene glycol, glycols, and related compounds/

/HUMAN EXPOSURE STUDIES/ Male volunteers were exposed to 14, 28, and 50 mg/cu m at both rest and exercise, with each exposure lasting 4 hours. Unexposed periods lasted 2-3 weeks. Maximal ethoxyacetic acid excretion took place 3-4 hours after exposure was discontinued, with an elimination half-life of 23.6 hours. After physical exercise, a second maximum of excretion was observed. Approximately 22% of the absorbed ethylene glycol monoethyl ether acetate was recovered in the urine as ethoxyacetic acid after 42 hours.

/SIGNS AND SYMPTOMS/ SYMPTOMATOLOGY: 1. Central nervous depression, although probably less prominent than with ethylene glycol. 2. No hypocalcemic tetany or metabolic acidosis with the possible exception of poisonings due to ethylene glycol monomethyl ether. 3. Nausea, vomiting, and sometimes diarrhea. 4. Prominent headache. Later abdominal and lumbar pain and costovertebral angle tenderness. 5. Transient polyuria & then oliguria, progressing to anuria. 6. Acute renal failure ... 7. Less critical pathological lesions may appear in brain, lung, liver, meninges and heart. 8. Observations in animals suggest the remote possibility of pulmonary edema, intravascular hemolysis & bone marrow depression, at least with some ether derivatives of ethylene and diethylene glycols. ... /Ethylene glycol (Group B compounds)/

/SIGNS AND SYMPTOMS/ The effects /of alkyl derivatives of ethylene glycol/ ... upon the CNS include headache, drowsiness, weakness, slurred speech, recrudescent stuttering, staggering gait, tremor, and blurred vision. Changes of personality are often noted ... These changes are such that the patient, in the absence of an accurate occupational history, may be treated for schizophrenia or narcolepsy. In acute poisoning with the ethylene glycol monoalkyl ethers, there is ... renal injury: albuminuria and hematuria. /Ethylene glycol monoalkyl ethers/

/SIGNS AND SYMPTOMS/ Ethylene glycol monoethyl ether acetate (EGEEA) has fairly low single-dose oral toxicity, is somewhat irritating to the eyes, is not appreciably irritating to the skin, is poorly absorbed through the skin, and is not especially toxic when inhaled in amounts likely to be encountered under ordinary conditions. It can cause central nervous system depression, blood changes, and lung and kidney injury.

For more Human Toxicity Excerpts (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (18 total), please visit the HSDB record page.

LC50; Species: Pimephales promelas (Fathead minnow, weight 148 mg); Conditions: flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 °C; Concentration: 44.0 (43.0-45.1) mg/L for 24 hr /Purity 99%/

LC50; Species: Pimephales promelas (Fathead minnow, weight 148 mg); Conditions: flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 °C 43.5 (31.4-60.3) mg/L for 48 hr /Purity 99%/

LC50; Species: Pimephales promelas (Fathead minnow, weight 148 mg); Conditions: flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 °C; Concentration: 42.6 (41.4-43.8) mg/L for 72 hr /Purity 99%/

LC50; Species: Pimephales promelas (Fathead minnow, weight 148 mg); Conditions: flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 °C; Concentration: 42.2 (40.7-43.6) mg/L for 96 hr /Purity 99%/

For more Ecotoxicity Values (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (11 total), please visit the HSDB record page.

/AQUATIC SPECIES/.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L.

2.60e+03

1.40e+04

6.30e+01

2.60e+02

1.20e+02

2.00e+00

2.50e-02

1.00e-01

6.00e-02

Volatile

2.38e+04

7.70e+03

4.30e+04

1.90e+02

7.90e+02

3.50e+02

The substance is harmful to aquatic organisms.

Ethylene glycol monoethyl ether acetate's production and use as a solvent, in the manufacture of lacquers, varnish removers, wood stains, textiles, and leather, as well as a chemical intermediate may result in its release to the environment through various waste streams. Biogenicly-produced non-terpenoid volatile organic compounds such as ethylene glycol monoethyl ether acetate are found in emissions from woody Mediterranean plants species. If released to the air, ethylene glycol monoethyl ether acetate will exist solely in the vapor phase in the ambient atmosphere, based on a vapor pressure of 2.00 mm Hg at 25 °C. Vapor-phase ethylene glycol monoethyl ether acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 0.7 days. Ethylene glycol monoethyl ether acetate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil ethylene glycol monoethyl ether acetate is expected to have very high mobility in soil based on an estimated Koc of 32. Volatilization from moist soil surfaces is expected to be a fate process based upon a Henry's Law constant of 3.2X10-6 atm-cu m/mole. Ethylene glycol monoethyl ether acetate may volatilize from dry soil surfaces based upon its vapor pressure. Several biodegradation screening tests have demonstrated that ethylene glycol monoethyl ether acetate is readily biodegradable; 80% biodegradation was measured for ethylene glycol monoethyl ether acetate in a 20 day screening test. If released into water, ethylene glycol monoethyl ether acetate is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an environmental fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 13 days and 100 days, respectively. An estimated BCF of 3.0 suggests the potential for bioconcentration in aquatic organisms is low. This compound is expected to hydrolyze with estimated half-lives of 305 and 30 days at pH values of 7 and 8, respectively. Occupational exposure to ethylene glycol monoethyl ether acetate may occur through inhalation and dermal contact with this compound at workplaces where ethylene glycol monoethyl ether acetate is produced or used. Monitoring data indicate that the general population may be exposed to ethylene glycol monoethyl ether acetate via inhalation of ambient air. (SRC)

Biogenicly-produced non-terpenoid volatile organic compounds such as ethylene glycol monoethyl ether acetate are found in emissions from woody Mediterranean plants species such as Arbutus unedo, Bupleurum fruticosum, Erica arborea, Pinus halepensis, Quercus coccifera, and Q. ilex(1).

Ethylene glycol monoethyl ether acetate's production and use as a solvent for nitrocellulose, oils, and resins, in lacquers, varnish removers, wood stains, textiles, and leather(1), and as a chemical intermediate(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a measured Kow of 0.24(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether acetate will have very high mobility in soil(SRC). Volatilization of ethylene glycol monoethyl ether acetate from moist soil surfaces may be an important fate process(SRC) given its Henry's Law constant of 3.2X10-6 atm-cu m/mole(4). Ethylene glycol monoethyl ether acetate is expected to volatilize from dry soil surfaces(SRC) based on its vapor pressure of 2.00 mm Hg(5). Several screening biodegradation tests have demonstrated that ethylene glycol monoethyl ether acetate is readily biodegradable(6-9); 80% biodegradation was measured for ethylene glycol monoethyl ether acetate in a 20 day screening test(7) suggesting that biodegradation may be an important fate process in soil(SRC).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 32(SRC), using a log Kow of 0.24(2) and a regression-derived equation(1), indicates that ethylene glycol monoethyl ether acetate should not adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces may occur(1) based on a Henry's Law constant of 3.2X10-11 atm-cu m/mole(3). Using this Henry's Law constant and an estimation method(1), volatilization half-lives for a model river and model lake are 13 and 100 days, respectively(SRC). According to a classification scheme(4),an estimated BCF value of 3.0(SRC), determined from its log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation of ethylene glycol monoethyl ether acetate in a 28 day river die-away test resulted in classification as easily degraded(5) and 80% biodegradation occurred in a 20 day screening test(6) which suggest biodegradation as an important environmental fate process in water(SRC). This compound is expected to hydrolyze with estimated half-lives of 305 and 30 days at pH values of 7 and 8, respectively(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monoethyl ether acetate, which has a measured vapor pressure of 2.00 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monoethyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 0.7 days(SRC), calculated from its measured rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol monoethyl ether acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: A 5-day BOD test showed a 41% of theoretical BOD for ethylene glycol monoethyl ether acetate using a sewage inoculum and the standard dilution method(1). BOD values which were 36, 79, 82, and 80% of the theoretical value were measured for 5, 10, 15, and 20 days incubation, respectively, using a non-acclimated, settled wastewater seed(2). BOD values of 10, 44, 59, and 69% of the theoretical BOD were measured for 5, 10, 15, and 20 days incubation, respectively, using a non-acclimated seawater seed with added raw wastewater(2). Ethylene glycol monoethyl ether acetate is considered to be "well-biodegradable" (theoretical BOD > 30% after 14 days of inoculation) using the Japanese MITI protocol(3). A 5-day BOD 18.1% of the theoretical value was measured using a sewage inoculum and the standard dilution method(4); a 5-day BOD 1.1% of the theoretical value was measured using a seawater inoculum and a seawater dilution method(4). Ethylene glycol monoethyl ether acetate was classified as easily degraded using the TOC die-away method in two river waters, with a 28 day incubation(5).

The rate constant for the vapor-phase reaction of ethylene glycol monoethyl ether acetate with photochemically-produced hydroxyl radicals has been measured to be 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC). This corresponds to an atmospheric half-life of about 0.7 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 305 and 30 days at pH values of 7 and 8, respectively(2). Ethylene glycol monoethyl ether acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF value of 3.0 was calculated for ethylene glycol monoethyl ether acetate(SRC), using a measured log Kow of 0.24(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of ethylene glycol monoethyl ether acetate is estimated as 32(SRC), using a log Kow of 0.24(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethylene glycol monoethyl ether acetate is expected to have a very high mobility in soil(SRC).

The Henry's Law constant for ethylene glycol monoethyl ether acetate is 3.2X10-6 atm-cu m/mole(1). This Henry's Law constant indicates that ethylene glycol monoethyl ether is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as approximately 13 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as approximately 100 days(SRC). Henry's Law constant indicates that volatilization of ethylene glycol monoethyl ether from moist soil surfaces may occur(SRC). The potential for volatilization to occur from dry soil surfaces may exist based upon a vapor pressure of 2.00 mm Hg(3). Ethylene glycol monoethyl ether acetate has a relative evaporation rate of 0.2 (relative to n-butyl acetate = 1) from non-adsorbing surfaces, classifying it as a slow-evaporating solvent(4); the actual evaporation rate from a non-adsorbing surface at 25 °C (0-5% relative humidity, constant air-flow) is 50% evaporated in 25 min(5).

GROUND WATER: Ethylene glycol monoethyl ether acetate was detected, not qunatified in groundwater 30 meters beneath a paint factory in Milan, Italy(1).

SURFACE WATER: Ethylene glycol monoethyl ether acetate was present in 1 of 8 rivers and brooks samples in southwest Germany at unreported concentrations; the contaminated river sample was collected downstream from a paint manufacturer(1).

The emission rate of ethylene glycol monoethyl ether acetate into the atmosphere from painting operations at an automotive assembly plant in Janesville, WI was estimated to be 37.9 gallons/hr(1). Emission rates of ethylene glycol monoethyl ether acetate were measured for a new vehicle (4.4 ug/hr), 20 day old vehicle (1.4 ug/hr) and a 40 day old vehicle (1.3 ug/hr); (mean of n = 6 different new cars)(2). Emission rates of ethylene glycol monoethyl ether acetate from poly vinyl chloride (PVC) cushions were measured for a 3 day old cushion (7 ug/cu m-hr) and a 28 day old cushion (4 ug/cu m-hr); each value represents the mean of 10 determinations(3).

RURAL/REMOTE: Ethylene glycol monoethyl ether acetate was qualitatively detected in ambient air samples collected near the Southern Black Forest in Germany during 1984-5 monitoring(1).

INDOOR AIR: 19% of the indoor air samples collected from 26 houses contained ethylene glycol monoethyl ether acetate at unreported concentrations(1). Ethylene glycol monoethyl ether acetate levels of 2-130 ug/cu m were in indoor air of 5 residential apartments in Italy during 1983-4 monitoring(2).

Emission rates of ethylene glycol monoethyl ether acetate from a variety of woody Mediterranean species during the spring was experimentally determined for Arbutus unedo (10.69 ug/g-hr), Bupleurum fruticosum (8.36 ug/g-hr), Erica arborea (8.13 ug/g-hr), Pinus halepensis (0.26 ug/g-hr), Quercus coccifera (0.18 ug/g-hr), and Q. ilex (3.66 ug/g-hr); each value represents the man of 3 determinations.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (8 total), please visit the HSDB record page.

UN 1172; Cellosolve acetate or ethylene glycol monoethyl ether acetate

IMO 3.3; Cellosolve acetate or ethylene glycol monoethyl ether acetate

49 131 17; Ethylene glycol monoethyl ether acetate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: T; R: 60-61-20/21/22; S: 53-45; Note: E

UN Hazard Class: 3; UN Pack Group: III