triethylenetetramine

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P272, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.4% (10 of 2507) of reports.

H302+H312 (18.4%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]

H302 (34.2%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (90.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (99.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (99.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (39.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H412 (99.5%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2507 reports by companies from 30 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 10 of 2507 reports by companies.

There are 29 notifications provided by 2497 of 2507 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P333+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P273, P391, and P501 (click each P-code to see the statement)

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P333+P317, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P320, P321, P330, P333+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use powder, alcohol-resistant foam, water spray, carbon dioxide. In case of fire: keep cylinder cool by spraying with water.

CARBON DIOXIDE, DRY CHEMICAL, ALCOHOL FOAM.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

.../IT WAS/ CONCLUDED THAT CONTROL PROBLEM WAS PRIMARILY ONE OF PREVENTING DIRECT SKIN CONTACT. SUCCESSFUL CONTROL REQUIRES GOOD PERSONNEL TRAINING AND SCRUPULOUS HANDLING TECHNIQUES.

C) DECR CONCN OF AMINE VAPOR BY GOOD VENTILATION. AMINES WITH HEAVY VAPOR... SHOULD BE DRAWN OFF BY DESCENT. D) EMPLOYEES PRONE TO SENSITIZATION OR LIVER DEFICIENCY...REMOVED FROM SHOPS HANDLING HARDENERS. /ALIPHATIC AMINES/

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Separated from food and feedstuffs. See Chemical Dangers. Cool. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

IN GENERAL, MATERIALS...TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN COOL...VENTILATED PLACE, OUT OF...SUN, AWAY FROM...FIRE HAZARD...BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

3.0 [mg/m3]

83 [mg/m3]

500 [mg/m3]

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

Workplace Environmental Exposure Level (WEEL): 8-hr Time-weighted Average (TWA) 1 ppm, skin.

The WEEL for triethylenetetramine (TETA; CAS No. 112-24-3), originally established in 1991, was updated in 1998 and 2009. Literature searches to identify possible new information were performed in 2016 and January 2021 and no new studies or data relevant to the WEEL were found. From a subchronic drinking water study in mice, 600 ppm (95 mg/kg-day) was the no-observed-adverse-effect level (NOAEL) and the point of departure (POD). This NOAEL was converted to an equivalent inhalation concentration. The resulting 8-h time-weighted average WEEL value of 1 ppm is expected to provide a significant margin of safety against any potential adverse health effects in workers exposed to airborne TETA.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.

Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.

Amine-type canister; goggles or face shield; rubber gloves. (USCG, 1999)

B) PROTECT HANDS WITH RUBBER GLOVES &...BARRIER CREAMS. /ALIPHATIC AMINES/

NO open flames. NO contact with oxidizing agents.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work. Wash hands before eating.

Triethylenetetramine appears as a yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.

CBI; Liquid

Viscous, colourless to yellow liquid with an ammonia-like odor; [CHEMINFO]

COLOURLESS-TO-YELLOW HYGROSCOPIC VISCOUS LIQUID WITH CHARACTERISTIC ODOUR.

A yellowish liquid with a strong ammonia odor.

MODERATELY VISCOUS, YELLOWISH LIQUID

511 to 513 °F at 760 mmHg (NTP, 1992)

266-267 °C @ 760 MM HG

511-513 °F

272 °C @760 [mm Hg]

54 °F (NTP, 1992)

275 °F (NTP, 1992)

135 °C c.c.

greater than or equal to 100 mg/mL at 68.4 °F (NTP, 1992)

SOL IN ALCOHOL, ACID

COMPLETE SOLUBILITY IN WATER

Solubility in water: miscible

0.982 at 68 °F (USCG, 1999) - Less dense than water; will float

0.9818 @ 20 °C/20 °C

0.98 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00

0.982 @25 °C

5.04 (AIR= 1)

Relative vapor density (air = 1): 5.04

less than 0.01 mmHg at 68 °F (NTP, 1992)

0.000412 [mmHg]

LESS THAN 0.01 MM HG, 20 °C

Vapor pressure, Pa at 20 °C: 1.3

<0.01 mmHg

-1.4/-1.66

VOLATILE

640 °F (USCG, 1999)

27.24 mm²/s at 20 °C

STRONGLY BASIC (PH 10 IN 1% AQ SOLN)

INDEX OF REFRACTION: 1.4971 @ 20 °C/D; SADTLER REF NUMBER: 532 (IR, PRISM)

129.98 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

CONVERSION UNITS: 1 MG/L= 167 PPM, 1 PPM= 5.98 MG/CU M

WT 8.2 LB/GAL @ 20 °C

CAN REACT WITH OXIDIZING MATERIALS

15N nuclear magnetic resonance spectrum

Soluble in water.

Amines, Phosphines, and Pyridines

TRIETHYLENETETRAMINE is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934).

While TETA is severely irritating to the skin and eyes and produces skin sensitization, it is of low to moderate acute toxicity orally and dermally. Effects on lungs, liver, and spleen were found in mice in subchronic studies but were not found in rats. While TETA was genotoxic/mutagenic in short-term in vitro assays, it was not genotoxic/mutagenic in in vivo assays. No data on reproductive toxicity were available, and embryo/fetal toxicity was associated with copper deficiency and occurred at maternally toxic doses. The use of TETA·2HCl for treatment of Wilson’s disease during pregnancy in humans resulted in no miscarriages or fetal abnormalities. There was no evidence of carcinogenicity in a lifetime dermal mouse study.

In clinical trials conducted in children with Wilson disease, serum aminotransferase levels generally improved or were stable during treatment with trientine. There have been no clinical reports of acute liver injury with jaundice attributed to trientine, even with overdoses. Patients with Wilson disease typically have mild-to-moderate serum aminotransferase elevations and may have signs and symptoms of cirrhosis. Improvement in liver injury in Wilson disease typically requires months to years of treatment.

Likelihood score: E (unlikely cause of clinically apparent liver injury).

Drug Class: Chelating Agents, Wilson Disease Agents

Other Drugs in the Subclass, Wilson Disease: Dimercaprol, Penicillamine, Zinc

◉ Summary of Use during Lactation

Limited information indicates that trientine is not detectable in breastmilk, and no adverse effects have been reported among breastfed infants whose mothers were taking the drug. The effect of trientine on breastmilk copper and zinc concentrations in milk is somewhat conflicting,but breastfed infants appear to have normal serum copper and zinc plasma levels. Based on available data, it appears that trientine is acceptable to use during breastfeeding.

◉ Effects in Breastfed Infants

Three infants were breastfed during maternal treatment of Wilson's disease with trientine. Serum zinc and copper concentrations were normal in these infants.

A center in Türkiye reported 23 infants born to mothers with Wilson's disease over a 20-year period. One patient was treated with 600 mg of trientine plus 100 mg of zinc daily. All of the infants were breastfed (extent and duration not specified). One premature infant died at 3 weeks of age (maternal drug not specified), but the other infants had no apparent complications over a median of 51 months (range 13 to 105 months) of follow-up.

A center in Germany reports 32 patients with Wilson's disease who became pregnant. Four of the patients were taking trientine in dosages of 600 to 1200 mg daily. Of the 31 women who delivered a live infant, 27 of them breastfed their infants (extent not stated). Four of the infants had neonatal jaundice, but its relationship to trientine cannot be determined. The exact number of women who breastfed while taking trientine is unclear in the report.

Six patients with Wilson’s disease were taking trientine in dosages of 1000 to 1750 mg daily and breastfed their infants. Maternal reports indicate that all infants exhibited normal development.

◉ Effects on Lactation and Breastmilk

Conflicting data exist on breastmilk concentrations of zinc and copper during therapy of Wilson's disease with trientine. One abstract reported that breastmilk concentrations were normal during therapy, but another abstract from the same authors reported lower milk concentrations of zinc and copper.

A more recent study compared copper and zinc concentration in the milk of 6 mothers taking trientine compared to 25 control mothers without Wilson’s disease. The zinc concentration in the colostrum (0-4 days postpartum) from one mother treated with trientine was higher than normal. In the colostrum from another mother treated with trientine, the zinc concentration was normal. The copper concentration in transitional milk was slightly lower in a mother treated with trientine and a mother treated with zinc compared with the minimum levels in the control samples. Copper and zinc concentrations were normal in mature breastmilk (>14 days postpartum) from all mothers treated with trientine, despite the low copper concentrations in maternal serum.

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Serious local effects by all routes of exposure.

Sore throat. Cough. Burning sensation. Laboured breathing. Shortness of breath.

Redness. Pain. Skin burns. Blisters.

Redness. Pain. Loss of vision. Severe deep burns.

Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain. Shock or collapse.

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

WORKMEN...MEDICALLY EXAM @ REGULAR INTERVALS. /ALIPHATIC AMINES/

EXPOSURE TO THE HOT VAPOR RESULTS IN RESPIRATORY TRACT IRRITATION AND ITCHING OF THE FACE WITH ERYTHEMA AND EDEMA.

...MARKED SENSITIZATION /NOTED/ IN 6-20 WORKMEN EMPLOYED IN ELECTRICAL EQUIPMENT...FACTORY. THIS SHOWED ITSELF AS SERIOUS SKIN LESIONS, VESICULAR PAPULAR ECZEMA, SOMETIMES WEEPING, LOCALIZED PARTICULARLY ON HANDS, FOREARMS, & GENITAL & INGUINAL REGIONS, TOGETHER WITH FACIAL EDEMA.

ACUTE TOXICITY IN RABBITS: SKIN IRRITATION GRADE 6. 6= MORE NECROSIS FROM UNDILUTED, LESS THAN EDEMA FROM 10%. /FROM TABLE/

THERE WERE NO DEATHS IN RATS EXPOSED TO SATURATED VAPOR FOR 4 HR. /FROM TABLE/

...RATED 5 ON RABBIT EYES. /MOST SEVERE INJURIES HAVE BEEN RATED 10/.

IN NONPREGNAT RATS TREATED DERMALLY WITH TRIETHYLENETETRAMINE STABILIZER, GAMMA-GLUTAMYLTRANSPEPTIDASE ACTIVITY IN KIDNEYS & AMINOTRANSFERASES ACTIVITY IN LIVER INCR. ACETYLCHOLINESTERASES ACTIVITY IN BRAIN WAS INHIBITED.

For more Non-Human Toxicity Excerpts (Complete) data for TRIETHYLENETETRAMINE (10 total), please visit the HSDB record page.

EMPLOYEES PRONE TO SENSITIZATRION OR LIVER DEFICIENCY...REMOVED FROM SHOPS HANDLING HARDENERS. /ALIPHATIC AMINES/

The substance is toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.

The substance is toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for TRIETHYLENETETRAMINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive

Do not transport with food and feedstuffs.

Symbol: C; R: 21-34-43-52/53; S: (1/2)-26-36/37/39-45-61

UN Hazard Class: 8; UN Pack Group: II