tetraethylenepentamine

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P270, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1834) of reports.

H302+H312 (10.6%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]

H302 (99.9%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (90.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (43.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H334 (31.1%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H411 (93.1%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P362+P364, P363, P391, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1834 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 1834 reports by companies.

There are 21 notifications provided by 1833 of 1834 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

This chemical does not meet GHS hazard criteria for 100% (59 of 59) of all reports.

Not Classified

Reported as not meeting GHS hazard criteria by 59 of 59 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 59 reports by companies from 1 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria per 59 of 59 reports by companies.

There are 0 notifications provided by 0 of 59 reports by companies with hazard statement code(s).

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

P260, P261, P262, P264, P264+P265, P270, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P333+P317, P361+P364, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P320, P321, P330, P333+P317, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Put clothes in sealable container. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use dry powder, carbon dioxide, water in large amounts, foam.

WATER OR FOAM MAY CAUSE FROTHING. "ALCOHOL" FOAM.

If material /is/ involved in /a/ fire use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

If material /is/ not involved in /a/ fire keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard.

Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Avoid bodily contact with material.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Provision to contain effluent from fire extinguishing. Separated from strong acids, strong oxidants, chlorinated hydrocarbons and food and feedstuffs. Dry. Store in an area without drain or sewer access.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

15 [mg/m3]

69 [mg/m3]

420 [mg/m3]

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of mist may cause severe swelling of the throat.

Repeated or prolonged contact may cause skin sensitization.

Air-supplied respirator; rubber gloves; complete eye protection; impervious apron (USCG, 1999)

NO open flames.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work. Wash hands before eating.

Tetraethylenepentamine appears as a viscous liquid. Slightly less dense than water. Vapors heavier than air. Corrosive to the eyes, skin, mouth, throat and stomach. Vapors irritate the eyes and corrosive to the upper respiratory tract. Vapors may irritate the eyes. Flash point 325 °F.

Liquid; Liquid; Other Solid; CBI

Yellow viscous, hygroscopic liquid; [HSDB]

COLOURLESS-TO-YELLOW HYGROSCOPIC VISCOUS LIQUID.

VISCOUS, HYGROSCOPIC LIQUID

Yellow liquid

AMMONIACAL; DIAGREEABLE, PENETRATING

644 °F at 760 mmHg (NTP, 1992)

340.30 °C @ 760 MM HG

320 - 340 °C

333 °C @760 [mm Hg]

-40 °F (NTP, 1992)

FP: -30 °C

-46 - -30 °C

325 °F (NTP, 1992)

325 °F (163 °C) (OPEN CUP)

163 °C o.c.

greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)

SOL IN MOST ORGANIC SOLVENTS & WATER

Solubility in water: miscible

0.998 at 68 °F (USCG, 1999) - Less dense than water; will float

0.9980 @ 20 °C/20 °C

Bulk density 8.3 lb/gal

Relative density (water = 1): 0.99

0.998 @25 °C

6.53 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

6.53 (AIR= 1)

Relative vapor density (air = 1): 6.5

less than 0.01 mmHg at 68 °F (NTP, 1992)

0.0000008 [mmHg]

Vapor pressure= <1 Torr @ 20 °C

Vapor pressure: > 0.01 mm Hg @ 20 °C

8.0X10-7 mm Hg at 25 °C

Vapor pressure, Pa at 20 °C: 1.3

log Kow= 1.503

-3.16 (calculated)

Henry's Law constant= 3X10-20 atm-cu m/mole at 25 °C

610 °F (USCG, 1999)

610 °F (321 °C)

96.2 cP @ 20 °C

Soluble in water. Hygroscopic.

Amines, Phosphines, and Pyridines

TETRAETHYLENEPENTAMINE is hygroscopic. This compound can react with oxidizing materials and strong acids. It may attack some forms of plastics. (NTP, 1992)

Serious local effects by all routes of exposure.

Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing.

Redness. Pain. Skin burns.

Redness. Pain. Burns.

Burns in mouth and throat. Burning sensation in the throat and chest. Shock or collapse.

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 > 9.9 ppm/8h

LD50 Rabbit single dose dermal 0.66 g/kg

LD50 White rat single-dose oral 2.1 g/kg

LD50 Rat oral 3.99 g/kg

EARLY TREATMENT FOR CORROSIVE BURNS OF ESOPHAGUS CONSISTS OF IV FLUID THERAPY, BROAD SPECTRUM ANTIBIOTICS, SEDATION, PARENTERAL HYDROCORTISONE & MORE IMPORTANTLY MAINTAINING PATENCY OF ESOPHAGUS FOLLOWED BY DILATATION. /ALKALIES/

... LIQUID CAN CAUSE SLIGHT SKIN BURNS.

FIVE DROPS OF LIQ IN EYES OF RABBITS CAUSES SEVERE BURNS.

Tetraethylenepentamine was found to be positive when tested for mutagenicity using the Salmonella/ microsome preincubation assay, using the standard protocol approved by the National Toxicology Program. Tetraethylenepentamine was tested at doses of 0.033, 0.100, 0.333, 1.000, 3.333, in as many as 5 Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98, and TA100) in the presence and absence of rat and hamster liver S-9, at doses of 0.033, 0.100, 0.333, 1.000, 3.333, 6.666, and 10.000 mg/plate. The lowest positive dose tested in any Salmonella typhimurium strain was 0.100 mg/plate in strain TA100 without activation. At this dose the number of revertants per plates approached double the controls. The compound was also positive in TA100 with activation and in TA98 both with and without activation.

Produces intense skin irritation and moderate eye injury in rabbits but not so severe as lower homologues.

Dermal oncogenicity of four ethyleneamines was investigated in male C3H mice. The compounds were diethylenetriamine in high purity and commercial samples, triethylenetetramine, tetraethylenepentamine, and a residue mixture of ten carbon and higher polymeric amines, polyamine-HPA-No-2. Groups of 50 C3H/HeJ mice were treated on their backs, three times a week for their complete life span, with applications of 25 ul of one of the substances. Hair was clipped from the treatment areas once a week. Approximate doses were 1.25 mg for high purity diethylenetriamie, commercial diethylenetriamine, and triethylenetetramine, 6.25 mg for tetraethylenepentamine, and 2.5 mg for HPA-No-2. Mean survival time was 587 to 662 days for the five groups of treated mice and 626 days for water treated controls. No epidermal tumors were seen except for a papilloma on the upper lip of one mouse in the triethylenetetramine group, but this was not considered to be treatment related because of its location. Three other cutaneous or subcutaneous neoplasms (two in treated groups, one in the control group) were considered to be spontaneous. Twenty cases of hyperkeratosis and 13 of epidermal necrosis were observed in the tetraethylenepentamine group, indicating that tetraethylenepentamine induced irritation, but there was no epidermal hyperplasia or dermal fibrosis. Absence of irritation in the other groups probably resulted from the lower doses used. It was concluded that there is no evidence of an oncogenic effect of any member of the tested series of ethyleneamines under the conditions studied.

The substance is toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.

Tetraethylenepentamine is probably released to the environment in waste streams from its production and various uses as a solvent, oil additive and chemical intermediate. If released to soil, tetraethylenepentamine is expected to leach (estimated Koc of 3.6); it will exist primarily as a cation under environmental conditions (pH 5-9) and no experimental data are available which suggest whether the cation will adsorb to soil more strongly than its estimated Koc value indicates. No data were located which suggest biodegradation is an important fate process of tetraethylenepentamine in soil or water. If released to water, tetraethylenepentamine may hydrolyze; however, no experimental data were located. Its complete water solubility suggests that it may be susceptible to long distance transport in aquatic environments. Volatilization, adsorption to sediment and bioconcentration in aquatic organisms are not expected to be environmentally important removal processes in aquatic systems. If released to the atmosphere, tetraethylenepentamine is expected to exist in both the vapor and particulate phases. Vapor-phase tetraethylenepentamine is expected to degrade rapidly by reaction with photochemically produced hydroxyl radicals (estimated half-life of 1.2 hrs). Particulate phase tetraethylenepentamine may be susceptible to dry deposition. Also, based on its complete water solubility, removal from air via wet deposition may occur. In occupational settings, exposure of tetraethylenepentamine may occur through eye and skin contact. (SRC)

Tetraethylenepentamine's use as a solvent for sulfur, acid gases, various resins and dyes, as a saponifying agent for acidic materials, in the manufacture of synthetic rubber, as a dispersant in motor oils, and as an intermediate for oil additives(1) indicates that it may be released to the environment in waste streams from its production and use(SRC).

TERRESTRIAL FATE: An estimated Koc value of 3.6(1,SRC) for tetraethylenepentamine indicates high mobility in soil(2) and leaching may occur(SRC). However, tetraethylenepentamine will exist primarily as a cation under environmental conditions (pH 5-9) and no experimental data are available which suggest whether it will adsorb to soil more strongly than its estimated Koc value indicates. Volatilization from moist soils is not expected to be rapid based upon a low Henry's Law constant. Amines are potentially susceptible to hydrolysis(1). Therefore, tetraethylenepentamine is expected to hydrolyze in moist soils; however, no rates were located(SRC). Furthermore, no data were located which suggest biodegradation is an important terrestrial fate process of tetraethylenepentamine(SRC).

AQUATIC FATE: Based on an estimated Henry's Law constant of 3.0X10-20 atm-cu m/mole at 25 °C(2), tetraethylenepentamine is expected to be essentially nonvolatile from water(1). An estimated Koc of 3.6 and BCF of 4.2 suggest that adsorption to sediment and bioconcentration in aquatic organisms may not be important fate processes for tetraethylenepentamine in water systems(1). Based on pKa1, pKa2, pKa3, pKa4, and pKa5 values of 9.68, 9.10, 8.08, 4.72, and 2.98(3), respectively, tetraethylenepentamine will exist primarily as a cation under environmental conditions (pH 5-9). However, no experimental data are available which suggest whether it will adsorb to sediment more strongly than its estimated Koc value indicates. Amines are potentially susceptible to hydrolysis(4). Therefore, tetraethylenepentamine may hydrolyze in aquatic environments, but no rates were located(SRC). Furthermore, no data were located which suggest biodegradation is an important environmental fate process of tetraethylenepentamine in aquatic systems(SRC).

ATMOSPHERIC FATE: Based on a measured vapor pressure of 8.0X10-7 mm Hg at 25 °C(1), tetraethylenepentamine may exist in both the particulate and vapor phases in the ambient atmosphere(3). Vapor phase tetraethylenepentamine is degraded in the ambient atmosphere by reaction with photochemically formed hydroxyl radicals; the half-life for this reaction in air can be estimated to be about 1.2 hrs(2,SRC). Particulate phase tetraethylenepentamine may be susceptible to dry deposition. Also, based on its complete water solubility at 20 °C(4), removal from air via wet deposition is likely to occur(SRC).

Based on a measured vapor pressure of 8.0X10-7 mm Hg at 25 °C(1), tetraethylenepentamine may exist in both the particulate and vapor phases in the ambient atmosphere(3). The rate constant for the vapor-phase reaction of tetraethylenepentamine with photochemically produced hydroxyl radicals can be estimated to be 3.06X10-10 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 1.2 hr at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(2). Amines are potentially susceptible to hydrolysis(4). Therefore, tetraethylenepentamine is expected to hydrolyze; however, no rates were located(SRC).

Based on an estimated log Kow of -1.503(2), the BCF for tetraethylenepentamine can be estimated to be 4.2(SRC) using a recommended regression derived equation(1). This BCF value suggests that tetraethylenepentamine would not bioconcentrate in aquatic organisms(SRC).

Based on an estimated log Kow of -1.503(2) and a recommended regression derived equation(1), the Koc for tetraethylenepentamine can be estimated to be about 3.6(SRC). This Koc value suggests that tetraethylenepentamine will be highly mobile in soil and sediment(4). Based on pKa1, pKa2, pKa3, pKa4, and pKa5 values of 9.68, 9.10, 8.08, 4.72, and 2.98(3), respectively, tetraethylenepentamine will exist primarily as a cation under environmental conditions (pH 5-9); no experimental data are available which suggest whether the cation will adsorb more strongly than its estimated Koc value indicates(SRC).

The Henry's Law constant for tetraethylenepentamine can be estimated to be approximately 3X10-20 atm-cu m/mole at 25 °C using a chemical structure estimation method(1,SRC). This value of Henry's Law constant suggests that tetraethylenepentamine is essentially nonvolatile from water(2).

In occupational settings, workers may be exposed to tetraethylenepentamine through eye and skin contact. (SRC)

NIOSH (NOHS Survey 1972-1974) has statistically estimated that 18,020 workers are potentially exposed to tetraethylenepentamine in the USA(1). NIOSH (NOES Survey 1981-1983) has statistically estimated that 35,585 workers are potentially exposed to tetraethylenepentamine in the USA(2).

The substance is toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.

Tetraethylenepentamine is probably released to the environment in waste streams from its production and various uses as a solvent, oil additive and chemical intermediate. If released to soil, tetraethylenepentamine is expected to leach (estimated Koc of 3.6); it will exist primarily as a cation under environmental conditions (pH 5-9) and no experimental data are available which suggest whether the cation will adsorb to soil more strongly than its estimated Koc value indicates. No data were located which suggest biodegradation is an important fate process of tetraethylenepentamine in soil or water. If released to water, tetraethylenepentamine may hydrolyze; however, no experimental data were located. Its complete water solubility suggests that it may be susceptible to long distance transport in aquatic environments. Volatilization, adsorption to sediment and bioconcentration in aquatic organisms are not expected to be environmentally important removal processes in aquatic systems. If released to the atmosphere, tetraethylenepentamine is expected to exist in both the vapor and particulate phases. Vapor-phase tetraethylenepentamine is expected to degrade rapidly by reaction with photochemically produced hydroxyl radicals (estimated half-life of 1.2 hrs). Particulate phase tetraethylenepentamine may be susceptible to dry deposition. Also, based on its complete water solubility, removal from air via wet deposition may occur. In occupational settings, exposure of tetraethylenepentamine may occur through eye and skin contact. (SRC)

Tetraethylenepentamine's use as a solvent for sulfur, acid gases, various resins and dyes, as a saponifying agent for acidic materials, in the manufacture of synthetic rubber, as a dispersant in motor oils, and as an intermediate for oil additives(1) indicates that it may be released to the environment in waste streams from its production and use(SRC).

TERRESTRIAL FATE: An estimated Koc value of 3.6(1,SRC) for tetraethylenepentamine indicates high mobility in soil(2) and leaching may occur(SRC). However, tetraethylenepentamine will exist primarily as a cation under environmental conditions (pH 5-9) and no experimental data are available which suggest whether it will adsorb to soil more strongly than its estimated Koc value indicates. Volatilization from moist soils is not expected to be rapid based upon a low Henry's Law constant. Amines are potentially susceptible to hydrolysis(1). Therefore, tetraethylenepentamine is expected to hydrolyze in moist soils; however, no rates were located(SRC). Furthermore, no data were located which suggest biodegradation is an important terrestrial fate process of tetraethylenepentamine(SRC).

AQUATIC FATE: Based on an estimated Henry's Law constant of 3.0X10-20 atm-cu m/mole at 25 °C(2), tetraethylenepentamine is expected to be essentially nonvolatile from water(1). An estimated Koc of 3.6 and BCF of 4.2 suggest that adsorption to sediment and bioconcentration in aquatic organisms may not be important fate processes for tetraethylenepentamine in water systems(1). Based on pKa1, pKa2, pKa3, pKa4, and pKa5 values of 9.68, 9.10, 8.08, 4.72, and 2.98(3), respectively, tetraethylenepentamine will exist primarily as a cation under environmental conditions (pH 5-9). However, no experimental data are available which suggest whether it will adsorb to sediment more strongly than its estimated Koc value indicates. Amines are potentially susceptible to hydrolysis(4). Therefore, tetraethylenepentamine may hydrolyze in aquatic environments, but no rates were located(SRC). Furthermore, no data were located which suggest biodegradation is an important environmental fate process of tetraethylenepentamine in aquatic systems(SRC).

ATMOSPHERIC FATE: Based on a measured vapor pressure of 8.0X10-7 mm Hg at 25 °C(1), tetraethylenepentamine may exist in both the particulate and vapor phases in the ambient atmosphere(3). Vapor phase tetraethylenepentamine is degraded in the ambient atmosphere by reaction with photochemically formed hydroxyl radicals; the half-life for this reaction in air can be estimated to be about 1.2 hrs(2,SRC). Particulate phase tetraethylenepentamine may be susceptible to dry deposition. Also, based on its complete water solubility at 20 °C(4), removal from air via wet deposition is likely to occur(SRC).

Based on a measured vapor pressure of 8.0X10-7 mm Hg at 25 °C(1), tetraethylenepentamine may exist in both the particulate and vapor phases in the ambient atmosphere(3). The rate constant for the vapor-phase reaction of tetraethylenepentamine with photochemically produced hydroxyl radicals can be estimated to be 3.06X10-10 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 1.2 hr at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(2). Amines are potentially susceptible to hydrolysis(4). Therefore, tetraethylenepentamine is expected to hydrolyze; however, no rates were located(SRC).

Based on an estimated log Kow of -1.503(2), the BCF for tetraethylenepentamine can be estimated to be 4.2(SRC) using a recommended regression derived equation(1). This BCF value suggests that tetraethylenepentamine would not bioconcentrate in aquatic organisms(SRC).

Based on an estimated log Kow of -1.503(2) and a recommended regression derived equation(1), the Koc for tetraethylenepentamine can be estimated to be about 3.6(SRC). This Koc value suggests that tetraethylenepentamine will be highly mobile in soil and sediment(4). Based on pKa1, pKa2, pKa3, pKa4, and pKa5 values of 9.68, 9.10, 8.08, 4.72, and 2.98(3), respectively, tetraethylenepentamine will exist primarily as a cation under environmental conditions (pH 5-9); no experimental data are available which suggest whether the cation will adsorb more strongly than its estimated Koc value indicates(SRC).

The Henry's Law constant for tetraethylenepentamine can be estimated to be approximately 3X10-20 atm-cu m/mole at 25 °C using a chemical structure estimation method(1,SRC). This value of Henry's Law constant suggests that tetraethylenepentamine is essentially nonvolatile from water(2).

In occupational settings, workers may be exposed to tetraethylenepentamine through eye and skin contact. (SRC)

NIOSH (NOHS Survey 1972-1974) has statistically estimated that 18,020 workers are potentially exposed to tetraethylenepentamine in the USA(1). NIOSH (NOES Survey 1981-1983) has statistically estimated that 35,585 workers are potentially exposed to tetraethylenepentamine in the USA(2).

/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Health: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for TETRAETHYLENEPENTAMINE (8 total), please visit the HSDB record page.

UN 2320; Tetraethylenepentamine

IMO 8.0; Tetraethylenepentamine

49 352 16; Tetraethylenepentamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive

Do not transport with food and feedstuffs.

Symbol: C, N; R: 21/22-34-43-51/53; S: (1/2)-26-36/37/39-45-61

UN Hazard Class: 8; UN Pack Group: III