aldicarb

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

H300+H310+H330 (32.2%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (33.3%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H311 (66.7%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 87 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Give a slurry of activated charcoal in water to drink. Refer for medical attention .

Signs and Symptoms of Acute Aldicarb Exposure: Acute exposure to aldicarb usually leads to a cholinergic crisis, with signs and symptoms that may include increased salivation, lacrimation (tearing), perspiration, and spontaneous defecation and urination. Pinpoint pupils, blurred vision, tremor, muscle twitching, shortness of breath, mental confusion, convulsions, and coma may also occur. Gastrointestinal effects include nausea, vomiting, diarrhea, and abdominal pain. Bradycardia (slow heart rate) occurs frequently.

Emergency Life-Support Procedures: Acute exposure to aldicarb may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to aldicarb.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. Transport to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to aldicarb.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas twice with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. Transport to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of aldicarb is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step

4.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of aldicarb may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step

4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.

4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. Transport to a health care facility. (EPA, 1998)

(Non-Specific -- Carbamate Pesticide, Solid) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.

(Non-Specific -- Carbamate Pesticide, Solid) Some of these materials may burn but none of them ignite readily. Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog or foam. (EPA, 1998)

Use water spray, powder, foam, carbon dioxide.

Move the container of aldicarb from the fire area, if possible, and fight the fire from the maximum distance, using agents suitable for the type of surrounding fire. In case of small fires, use dry chemical powder, carbon dioxide, water spray, or standard foam. For larger fires, use water spray, fog, or standard foam. Thermal decomposition products may include toxic oxides of nitrogen, sulfur, and carbon. Avoid breathing toxic dusts and fumes from burning material.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

In case of spillage during storage or transport, isolate the affected area, cover the spills with a sweeping compound, and post danger signs. Cover the area with suitable sheets, transfer spoiled material in reclaim containers for disposal. Decontaminate the area with 5% sodium hydroxide solution. Use all personal protective devices for handling spills. All tools and equipment should be decontaminated, rinsed, and dried. All clothing should be laundered.

A system for removing pesticides from the wash water produced by pesticide applicators as they clean their equipment has been developed. The first step is the flocculation/coagulation and sedimentation of the pesticide-contaminated wash water. The supernatant from the first step is then passed through activated carbon columns. /Pesticides/

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P070, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Potential candidate for rotary kiln incineration with a temperature range of 820-1600 °C and a residence time of seconds for liquids and gases and hours for solids. Also, a potential candidate fluidized bed incineration with a temperature range of 450-980 °C and a residence time of seconds for liquids and gases and for solids longer.

Aldicarb is stable, except to concentrated alkali, is non-corrosive to metal containers and equipment and is non-flammable. Recommendable methods: Incineration & landfill. Peer review: Incineration in a unit with effluent gas scrubbing is recommendable. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Disposal of aldicarb should be in accordance with the recommended procedures for the disposal and storage of pesticides and pesticide containers (40 Code of Federal Regulations 165, USA). Product residues and sorbent media can be packaged in 17H epoxy-lined drums and disposed of at an approved landfill site. Alternatively, they can be destroyed in a high temperature incineration unit with effluent gas scrubbing equipment.

Change contaminated clothing daily & wash in strong washing soda solution & rinse thoroughly before re-use. ... Wash hands and face before eating or smoking. Bathe at the end of work day, washing entire body and hair with soap and water.

Carefully avoid contact with eyes, skin, and inhalation of the vapor. Do not mix granules with water.

Do not eat, drink, or smoke during work. Wash hands before eating.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Caution : Avoid sources of heat including fire. Aldicarb will liberate toxic nitrogen and sulfur oxide gases when heated.

(Non-Specific -- Carbamate Pesticide, solid) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors.

Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal.

Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs.

Store aldicarb indoors in an isolated, well-ventilated, clean, dry, cool area (not above 46 °C). Store away from incompatible substances, such as highly alkaline materials. Aldicarb should be stored in a manner that will preclude mixing with water, because the resultant solution may be seriously hazardous. Do not store near food, animal feed, or other items intended for human or animal consumption. Make certain that the storage area is inaccessible to children.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: mg/m3)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: mg/m3)

AEGL 3: Life-threatening health effects or death (Unit: mg/m3)

0.16 mg/m3

0.47 mg/m3

0.11 mg/m3

0.32 mg/m3

0.087 mg/m3

0.26 mg/m3

0.053 mg/m3

0.027 mg/m3

0.081 mg/m3

NOTE THAT VALUES ARE IN mg/m3, NOT ppm.

AEGLs Status: Proposed

0.015 [mg/m3]

0.30 [mg/m3]

9.5 [mg/m3]

0.005 [mg/m3], inhalable fraction and vapor

(inhalable fraction and vapour): 0.005 mg/m

0.005 mg/m³ (inhalable fraction and vapor) [2017]

Workplace Environmental Exposure Level (WEEL): 8-hr Time-weighted Average (TWA) 0.0001 ppm, skin.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.

The substance may cause effects on the nervous system. This may result in convulsions and respiratory depression. Cholinesterase inhibition. Exposure could cause death. The effects may be delayed. Medical observation is indicated.

Tolerances are established for combined residues of the insecticide and nematocide aldicarb (2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl) oxime and its cholinesterase-inhibiting metabolites 2-methyl 2-(methylsulfinyl) propionaldehyde O-(methylcarbamoyl) oxime and 2-methyl-2-(methylsulfonyl) propionaldehyde O-(methylcarbamoyl) oxime in or on the following food commodities:[Table#3187]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Approved respirator. Chemical-resistant apron when cleaning equipment, mixing, or loading. Chemical-resistant footwear plus socks. Chemical-resistant headgear for overhead exposure. Coveralls over short-sleeved shirt and short pants. Protective eyewear. Waterproof gloves.

NO open flames.

AVOID ALL CONTACT! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!

Use ventilation (not if powder), local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work. Wash hands before eating.

Aldicarb appears as white crystals with a slightly sulfurous odor. Commercial formulations are granular Used as an insecticide, acaricide, and nematocide. (EPA, 1998)

White crystals with a slightly sulfurous odor; [CAMEO]

COLOURLESS CRYSTALS.

White crystals with a slightly sulfurous odor. Commercial formulations are granular.

Crystals from isopropyl ether

Slightly sulfurous odor

Decomposes (NTP, 1992)

decomposes

210 to 214 °F (EPA, 1998)

99-100 °C

210-214 °F

0.1 to 1.0 mg/mL at 72 °F (NTP, 1992)

Sparingly soluble in certain organic solvents, most soluble in chloroform and acetone

Aldicarb solubilities (expressed as %) at various temperatures.

Table: Percent Solubility [Table#3193]

350 g/kg, acetone; 300 g/kg, dichloromethane; 150 g/kg, benzene; 150 g/kg, xylene; all at 25 °C

In water, 4,930 mg/L at 20 °C

Practically insoluble in hexane

Solubility in water, g/100ml at 25 °C: 0.6

1.195 at 77 °F (EPA, 1998) - Denser than water; will sink

Specific gravity: 1.1950 at 25 °C

1.195 @25 °C

Less than 0.5 at 68F (EPA, 1998)

0.0000347 [mmHg]

2.9X10-5 mm Hg at 20 °C

Vapor pressure, Pa at 25 °C: 0.01

<0.5 mmHg

0.0000001 [mm Hg] @20 °C

log Kow = 1.13

Aldicarb is stable under normal storage conditions and in acidic media but decomposes rapidly in alkaline media and at temperatures above 100 °C.

Analysis ... indicated that this material had not changed under storage conditions for approx 4 years.

Stable in neutral, acidic, & weakly alkaline media.

When heated to decomposition it emits very toxic fumes of /nitrogen oxides and sulfur oxides/.

... Decomposes rapidly in alkaline media & at temperatures above 100 °C.

Rapidly converted by oxidizing agents to the sulfoxide, which is more slowly oxidized to the sulfone (aldoxycarb q.v.).

Non-corrosive to common metals and plastics

Positive

Agilent XCT

Electrospray ionization

formic acid (5.3nM)

Slightly water soluble.

Carbamates

ALDICARB is a carbamate ester. This chemical decomposes at temperatures greater than 212 °F. This chemical is incompatible with highly alkaline substances. It is rapidly converted by oxidizing agents. (NTP, 1992)

Incompatible with alkaline materials.

IDENTIFICATION: Aldicarb is a carbamate ester pesticide. It is a white crystalline solid, moderately soluble in water, and susceptible to oxidation and hydrolytic reactions. HUMAN EXPOSURE: Exposure of the general population to aldicarb and its toxic metabolites (the sulfoxide and sulfone) occurs mainly through food. The ingestion of contaminated food has led to poisoning incidents from aldicarb and its toxic metabolites (the sulfoxide and sulfone). Due to the high acute toxicity of aldicarb, both inhalation and skin contact under occupational exposure conditions may be dangerous for workers if preventive measures are inadequate. There have been a few incidents of accidental exposure of workers due to improper use or lack of protective measures. Aldicarb is efficiently absorbed from the gastrointestinal tract and, to a lesser extent, through the skin. It could be readily absorbed by the respiratory tract if dust were present. It is metabolically transformed to the sulfoxide and the sulfone (both of which are toxic), and is detoxified by hydrolysis to oximes and nitriles. The excretion of aldicarb and its metabolites is rapid and primarily via the urine. A minor part is also subject to biliary elimination and, consequently, to enterohepatic recycling. Aldicarb does not accumulate in the body as a result of long-term exposure. The inhibition of cholinesterase activity in vitro by aldicarb is spontaneously reversible, the half-life being 30-40 min. The inhibition of acetylcholinesterase at the nervous synapse and myoneural junction is the only recognized effect of aldicarb in humans and is similar to the action of organophosphates. The carbamyolated enzyme is unstable, and spontaneous reactivation is relatively rapid compared with that of a phosphorylated enzyme. Non-fatal poisoning in man is rapidly reversible. Recovery is aided by the administration of atropine. ANIMAL STUDIES: Aldicarb is a potent inhibitor of cholinesterases and has a high acute toxicity. Recovery from its cholinergic effects is spontaneous and complete within 6 hr, unless death results. There is no substantial evidence to indicate that aldicarb is teratogenic, mutagenic, carcinogenic, or immunotoxic. Birds and small mammals have been killed as a result of ingesting aldicarb granules not fully incorporated into the soil as recommended. In laboratory tests, aldicarb is acutely toxic to aquatic organisms.

Aldicarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of the enzymes. This inhibition is reversible. A cholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.

Aldicarb

1 x 10 ^-3 mg/kg-day

Pesticide

HBSL calculated using aPAD value. Based on the acute endpoint, which is protective of longer-term exposures because effects are rapidly reversible. USEPA OW recommends that the concentration of any combination of two or more of the three aldicarb compounds should not be greater than 7 ug/L because of similar mode of action. USEPA issued administrative stay on an MCL for aldicarb.

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Evaluation: No data were available from studies in humans. There is inadequate evidence for the carcinogenicity of aldicarb in experimental animals. Overall evaluation: Aldicarb is not classifiable as to its carcinogenicity to humans (Group 3).

Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Aldicarb was not found to induce statistically significant increases in tumor incidence in mice or rats in feeding studies or mice in a skin painting study. In the feeding studies there were, however, significant trends in pituitary tumors in female rats and fibrosarcomas in the male mouse. This evidence, together with the fact that less than maximum tolerated doses were used, indictes that the available assays are inadequate to assess the carcinogenic potential of aldicarb. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Inadequate. /Based on former classification system/

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 53: (1991) Occupational Exposures in Insecticide Application, and Some Pesticides

TR-136: Bioassay of Aldicarb for Possible Carcinogenicity (CASRN 116-06-3) (1979 )

12/13/78

No Evidence

It is concluded that under the conditions of this bioassay, technical-grade aldicarb was not carcinogenic for F344 rats or B6C3F1 mice of either sex.

3, not classifiable as to its carcinogenicity to humans. (L135)

Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, increased bronchial secretions, increased salivation, lacrimation, sweating, peristalsis, and urination can occur. Chronically high (>10 years) exposure leads to neuropsychological consequences including disturbances in perception and visuo-motor processing (A15321).

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Inhalation (L793) ; oral (L793); dermal (L793)

Sweating. Pupillary constriction, muscle cramp, excessive salivation. Dizziness. Laboured breathing. Nausea. Vomiting. Convulsions. Unconsciousness.

MAY BE ABSORBED! Further see Inhalation.

Abdominal cramps. Diarrhoea. Nausea. Further see Inhalation.

As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. Unlike organophosphate poisoning, carbamate poisonings tend to be of shorter duration because the inhibition of nervous tissue acetylcholinesterase is reversible, and carbamates are more rapidly metabolized. Muscle weakness, dizziness, sweating and slight body discomfort are commonly reported early symptoms. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Contraction of the pupils with blurred vision, incoordination, muscle twitching and slurred speech have been reported. (L795)

Chemical: ALDICARB

Other Poison - Carbamate

ACGIH Carcinogen - Not Classifiable.

The results of long-term feeding studies in rats & dogs have been reviewed. ... These studies have establised no-observed-effect levels of 0.1 mg/kg body wt in both species. Using a safety factor of 100 for the animal study results the committee obtained a value (0.001 mg/kg/day) identical to that obtained in human studies with both probit & logit dose-response models for 30% inhibition & a safety factor of 10. This value results in the calculation of a 0.007 mg/L ADI for aldicarb.

Suggested No-Adverse-Response Level (SNARL) 0.7 ug/L (adult), 0.2 ug/L (child) at 20% cholinesterase inhibition; and 3.5 ug/L (adult), 2.1 ug/L (child) at 30% cholinesterase inhibition (upper 95% confidence limit from logit & probit models).

FAO/WHO ADI: 0.003 mg/kg

IRIS Current

HEAST Current

LC50 (rat) = 200 mg/m3/5h

LD50: 650 ug/kg (Oral, Rat) (T14)

LD50: 2500 ug/kg (Dermal, Rat) (T14)

LC50: 200 mg/m3 over 5 hours (Inhalation, Rat) (T14)

LD50 Rabbit dermal >5.0 mg/kg (Technical aldicarb)

LD50 Rat oral 0.650 mg/kg

LC50 Rat inhalation 200 mg/cu m/5 hr

LD50 Rat dermal 2.5 mg/kg

For more Non-Human Toxicity Values (Complete) data for ALDICARB (10 total), please visit the HSDB record page.

If the compound has been ingested, rapid gastric lavage should be performed using 5% sodium bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered the eyes, they should be washed with large quantities of isotonic saline or water. In serious cases, atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in conjunction with pralidoxime or other pyridinium oximes (such as trimedoxime or obidoxime), though the use of '-oximes' has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine is a muscarinic antagonist, and thus blocks the action of acetylcholine peripherally.

LC50; Species: Phasianus colchicus (ring-necked pheasant) age 10 days; oral >300 ppm in 5-day diet ad libitum (no mortality to 300 ppm) /Technical material, 99.0%/

LC50; Species: Anas platyrhynchos (mallard duck) age 10 days; oral <1000 ppm in 5-day diet ad libitum (70% mortality at 1000 ppm) /Technical material, 99.0%/

LC50; Species: Anas platyrhynchos (mallard duck) age 5 days; oral 594 ppm in 5-day diet ad libitum (95% confidence limit 507-695 ppm) /Technical material, 99.0%/

LC50; Species: Coturnix japonica (Japanese quail) age 14 days; oral 381 ppm in 5-day diet ad libitum (95% confidence limit 317-453 ppm) /Technical material, 99.0%/

For more Ecotoxicity Values (Complete) data for ALDICARB (19 total), please visit the HSDB record page.

/BIRDS and MAMMALS/ Homing pigeons (Columba livia) were used as a model to assess the effects of chlorpyrifos and aldicarb on flight times at sub-lethal, environmentally relevant concentrations. A significant increase in flight times of birds dosed with aldicarb and with chlorpyrifos was observed. Plasma cholinesterase activity was measured over time following exposure to either compound. The results suggest that the time of peak inhibition would correlate with migratory flight activity after exposure. In total, the results of these studies show that sub-lethal exposure to cholinesterase-inhibiting pesticides can affect the flying ability of non-target avian species.

/AQUATIC SPECIES/ Fluctuations in several environmental variables, such as salinity, can influence the interactions between organisms and pollutants in aquatic organisms, and, therefore, affect the toxicity of xenobiotics. In this study, after 2 species of fish, rainbow trout (Oncorhynchus mykiss) and hybrid striped bass (Morone saxatilis x chrysops) were acclimated to 4 salinity regimens of 1.5, 7, 14, and 21 ppt for 1 week and then exposed to 0.5 mg/L aldicarb. Mortality, brain, and muscle cholinesterase levels were measured after 96 hr. Rates of (14)C-aldicarb sulfoxide formation were determined in kidney (trout only), liver, and gill microsomes from each species acclimated to the 4 salinity regimens. Salinity significantly enhanced aldicarb toxicity, cholinesterase inhibition, and (14)C-aldicarb sulfoxide formation in rainbow trout but not in striped bass. In vitro incubations with (14)C-aldicarb and the cytochrome p450 (CYP) inhibitor, N-benzylimidazole, did not significantly alter aldicarb sulfoxide formation in tissue microsomes from either species of fish, indicating CYP did not contribute to aldicarb sulfoxidation. Salinity increased flavin-containing monooxygenase (FMO) mRNA expression and catalytic activities in microsomes of liver, gill, and kidney of rainbow trout, which was consistent with the salinity-induced enhancement of aldicarb toxicity. Salinity did not alter flavin-containing monooxygenase mRNA expression and catalytic activities in striped bass, which was also consistent with the lack of an effect of salinity on aldicarb toxicity in this species. These results suggest that salinity-mediated enhancement of aldicarb toxicity is species-dependent, and at least partially due to the salinity-related upregulation of flavin-containing monooxygenases, which, in turn, increases the bioactivation of aldicarb to aldicarb sulfoxide, which is a more potent inhibitor of cholinesterase than aldicarb.

/AQUATIC SPECIES/ ...The effects of the sex steroids, 17beta estradiol (E2) and testosterone (T) on aldicarb toxicity was examined. Adult Japanese medaka were separated by sex and exposed to 100 ug/L E2 or T for 6 days followed by exposure to the 96-hr LC50 /dose/ (0.5 mg/L) of aldicarb. The toxicity of aldicarb to adult males was significantly lowered by E2 and T whereby the mortality percentage was reduced to 23.3 +/- 5.8% and 3.3 +/- 5.8%, espectively, compared to the fish not receiving steroids (46.7 +/- 5.8% mortality). In females, T caused significant reduction in aldicarb toxicity to 16.7 +/- 5.8%, while E2 significantly enhanced the toxicity to 96.7 +/- 5.8% mortality. Since the flavin-containing monooxygenase (FMO) enzyme system had been shown to play a critical role in aldicarb toxicity, the effect of E2 and T on FMO expression was examined. Gill FMO activity showed a direct correlation with the overall toxicity of aldicarb in both male and female medaka. Expression of FMO1-like protein was significantly reduced by T in male livers and gills, and T did not affect the expression of FMOs in female tissues. In contrast, E2 significantly reduced FMO1-like protein expression in male gills and female livers, as well as FMO3 expression in both male and female livers, but significantly increased gill FMO1 expression in females. Since aldicarb acts by inhibiting the enzyme cholinesterase (ChE), the effect of sex hormones on the activity of this enzyme was also examined. In both male and female medaka, T counteracted the inhibitory effect of aldicarb on muscle ChE. In male fish, E2 had similar effects but did not seem to counteract the ChE inhibition in females. In conclusion, E2 and T modulation of aldicarb toxicity in Japanese medaka seems to be mediated via alteration of gill FMO and ChE actitivies.

/AQUATIC SPECIES/ The effects of salinity, gender, and development on the acute toxicity of aldicarb were examined in the euryhaline fish, Japanese medaka (Oryzias latipes). The 96-hr median lethal concentrations (LC50s) at 1.5 parts per thousand salinity were not significantly different between adults and juveniles but larvae were significantly more sensitive to aldicarb. A 2-wk exposure to increased salinity significantly enhanced the toxicity of 0.5 ppm aldicarb to both sexually mature male and female medaka. After 48 hr of aldicarb exposure, mortality significantly increased (p<0.05) in males from 13 + or - 5.7% at 1.5 per thousand, salinity to 56 + or - 5.7% at 20 per thousand; in females mortality significantly increased (p<0.01) from 17 + or -5.7% to 76 + or - 5.6%. A time-course study was conducted in which muscle acetylcholinesterase (AChE) inhibition was monitored after exposure to aldicarb. In general, AChE in females was inhibited to a greater degree at 12.0 and 20.0 per thousand salinity regimens than AChE in males. Muscle AChE in females residing at 20.0 per thousand was inhibited 93 + or - 3.3% by 8 hr of exposure to 0.95 ppm aldicarb, whereas in males the max inhibition was 80 + or - 7.4% after 8 hr of exposure to 0.86 ppm aldicarb at 20 per thousand salinity. These results indicate that environmental factors, such as salinity, in addition to gender and development, have significant impacts on the acute toxicity of aldicarb to Japanese medaka.

For more Ecotoxicity Excerpts (Complete) data for ALDICARB (12 total), please visit the HSDB record page.

6.30e+01

8.20e+02

2.00e+01

3.00e+00

4.90e-03

7.50e-04

1.00e-03

Volatile

1.90e+02

2.50e+03

5.90e+01

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds, bees, mammals, soil organisms and water quality. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Aldicarb's production may result in its release to the environment through various waste streams; its use as an insecticide will result in its direct release to the environment. Effective Jan 1, 2012 the US EPA canceled the use of aldicarb under the brand 'Temik' on citrus and potatoes; however, uses on all other crops will remain. If released to air, a vapor pressure of 2.9X10-5 mm Hg at 24 °C indicates aldicarb will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase aldicarb will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 42 hours. Particulate-phase aldicarb will be removed from the atmosphere by wet or dry deposition. Aldicarb does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, aldicarb is expected to have very high to high mobility based upon Koc values of 7 to 80. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.5X10-9 atm-cu m/mole. Aldicarb is not expected to volatilize from dry soil surfaces based upon its vapor pressure. In soil, aldicarb degrades primarily by oxidation and hydrolysis to aldicarb sulfoxide and aldicarb sulfone which are more toxic and mobile than the parent compound. A general range for the persistence of aldicarb in soil of 1-15 days has been reported. If released into water, aldicarb is not expected to adsorb to suspended solids and sediment based upon the Koc values. The half-life of aldicarb was reported as 62 days in anaerobic groundwater and 34 to 94 days in aerobic groundwater, under varying conditions. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Aldicarb hydrolysis half-lives have been reported at various pH and temperatures and range from 6 days at pH 9.89 and 20 °C to 3240 days at pH 5.5 and 15 °C. Occupational exposure to aldicarb may occur through inhalation of dust and dermal contact with this compound at workplaces where aldicarb is produced or used. Monitoring data indicate that the general population may be exposed to aldicarb via inhalation or ingestion of food and drinking water. Temik has been found in shallow groundwater drinking wells located in vulnerable areas near agricultural areas treated with Temik. (SRC)

Aldicarb's production may result in its release to the environment through various waste streams; its use as an insecticide(1) will result in its direct release to the environment(SRC). Effective Jan 1, 2012 the US EPA canceled the use of aldicarb under the brand 'Temik' on citrus and potatoes, however, uses on all other crops will remain(2).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 7 to 80(2), indicate that aldicarb is expected to have very high to high mobility in soil(SRC). Volatilization of aldicarb from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-9 atm-cu m/mole(SRC), based upon its vapor pressure, 2.9X10-5 mm Hg(3), and water solubility, 4930 mg/L(3). Aldicarb is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). In soil, aldicarb degrades primarily by oxidation and hydrolysis to toxic mobile aldicarb sulfoxide and aldicarb sulfone(4). A general range for the persistence of aldicarb in soil of 1-15 days has been reported(5); however, its persistence in acidic soils (pH < 5.5) is expected to be longer(6).

TERRESTRIAL FATE: The movement and degradation of aldicarb was studied under field conditions in two Florida citrus groves(1). Following application of aldicarb to the top 5 cm of the soil, a relatively rapid decrease in aldicarb concentration and an increase in aldicarb sulfoxide and aldicarb sulfone was observed. The half-lives for the dissipation of aldicarb was about 7 and 11 days at the 2 sites studied(1). The initial half-life for aldicarb sulfoxide and aldicarb sulfone was approximately 20 days; however, successive half-lives were longer and did not follow first-order kinetics(1). Aldicarb is rapidly oxidized to aldicarb sulfoxide in soils (half-life of about 7 days) and to aldicarb sulfone much more slowly (pH dependent half-lives range from a few minutes at pH>12 to about 560 days at pH 6)(2).

AQUATIC FATE: Based on a classification scheme(1), Koc values of 7 to 80(2), indicate that aldicarb is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.5X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 2.9X10-5 mm Hg(4), and water solubility, 4,930 mg/L(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 1.13(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Aldicarb hydrolysis half-lives have been reported at various pH and temperatures and range from 6 days at pH 9.89 and 20 °C to 3240 days at pH 5.5 and 15 °C(8-10). The half-life of aldicarb was reported as 62 days in anaerobic groundwater and 34 to 94 days in aerobic groundwater, under varying conditions(11).

AQUATIC FATE: A four month study of the degradation of aldicarb in anaerobic sediment resulted in a half-life of 2 hours; one day after applied dose, degradation products of aldicarb acid, aldicarb alcohol and aldicarb nitrile represented 23 to 34% of initial dose(1).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), aldicarb, which has a vapor pressure of 2.9X10-5 mm Hg at 24 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase aldicarb is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 42 hours(SRC), calculated from its rate constant of 9.2X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase aldicarb may be removed from the air by wet or dry deposition(SRC). Aldicarb does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Aldicarb has been extensively studied both in the laboratory under controlled conditions and in the field(1). Under aerobic conditions, it has been shown to oxidize at the sulfur atom to form first the sulfoxide, followed by further oxidation to the sulfone. Under anaerobic conditions, reduction to the corresponding aldehyde and nitrile is the proposed degradation pathway. It has not been definitively shown that these reactions are abiotic or biotic(1). Mineralization half-lives for the aerobic incubation of aldicarb were 20-361 days in surface soils up to 30 cm depth, and 131-233 days (223-1130 days anaerobic) in subsurface soils between 20 and 183 cm in depth(2). Metabolites detected in aerobic soils included aldicarb sulfoxide and sulfone and their oximes and aldicarb sulfoxide nitrile; under anaerobic conditions no aldicarb sulfone or its degradation products were detected(2). Aldicarb did not degrade in sterile or unsterile groundwater under anaerobic conditions in 60-65 days at pH 5.2 and 6.0 or in 40 days in aerated groundwater at pH 7.6 (with or without added sieved limestone)(3). In unfiltered anaerobic groundwater and anaerobic groundwater amended with limestone and filtered with membrane filters to remove microorganisms, the half-lives of aldicarb were 62 and 433 days, respectively(4). Using this same groundwater, but aerated with sterile air under laboratory conditions, the half-life of aldicarb ranged from 34 to 94 days at pH 8.5(4). Aldicarb sulfoxide and aldicarb sulfone degraded more rapidly, with half-lives in the range of 10-47 days (sulfoxide) and 4-32 days (sulfone) under aerobic conditions. Under anaerobic conditions the half-lives ranged from 25-32 days (sulfoxide) and 26-109 days (sulfone)(4). Aldicarb sulfoxide has been shown to be reduced to aldicarb in groundwater under anaerobic conditions in groundwater to which glucose had been added(4). Aldicarb degraded faster in soil which had been previously treated with carbofuran. After 1 day, 68% of aldicarb applied remained in soil not treated with carbofuran, whereas 16% remained in soil treated 4 times with carbofuran between 1-13 weeks prior to treatment with aldicarb. Zero% remained in soil treated once with carbofuran 13 weeks prior to treatment with aldicarb(5).

Aldicarb Transformation Rates Per Day in different media(1).[Table#3188]

The rate constant for the vapor-phase reaction of aldicarb with photochemically-produced hydroxyl radicals has been estimated as 9.2X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 42 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the reaction of hydroxyl radicals in aqueous solutions at pH 3.5 is 8.1X10+9 L/mol-sec(2); this corresponds to an aquatic half-life of 100 days at an aquatic concentration of 1X10-17 hydroxyl radicals per liter(3). The hydrolysis reactions of aldicarb are both acid and base catalyzed(4). Aldicarb is susceptible to oxidation to aldicarb sulfoxide(5); however, some of this oxidation may be due to biodegradation, especially in the saturated zone(SRC). While aldicarb is susceptible to photolysis when irradiated in acetonitrile at 254 nm(6), aldicarb does not contain chromophores that absorb at wavelengths >290 nm(7) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Representative examples of reported hydrolysis half-lives for aldicarb(1-5).

Table: Aldicarb Hydrolysis Half-lives [Table#3186]

An estimated BCF of 3 was calculated in fish for aldicarb(SRC), using a log Kow of 1.13(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Aldicarb had mean log bioconcentration ratios of 0.263 and -0.92 for plant/soil in above and below ground plants, respectively(4).

The species of free-living soil nematodes (Aphelenchus avenae & Panagrellus redivivus) were exposed to aldicarb. Although the levels of aldicarb which accumulate were similar in the 2 species, the rates of uptake, metabolism & elimination were greater in Panagrellus redivivus. The level of toxic metabolites was higher in Aphelenchus avenae after 24 hr.

Koc values for aldicarb have been reported from data in the UK database in 1993 to range from 7 to 80(1). Measured Koc values have also been reported as 30(2) and 32(3). In Valois sand (30.1% sand, 55.2% silt, 14.7% clay, 1.64% organic carbon) the Koc was 22(4). According to a classification scheme(5), these Koc values suggest that aldicarb is expected to have very high to high mobility in soil. Aldicarb and its metabolites are rapidly degraded in soils, which can limit the mobility and leaching potential of these compounds(6-8).

In spring, the insecticide and nematocide, aldicarb, in the granular formulation Temik 10G was broadcast on 3 potato fields and incorporated by rotary cultivation. Ridges were formed by repeated runs with ridging implements. The soil was sampled in layers of 0.1-0.8 m depth 3-4 times during the growing season. Aldicarb itself was almost completely converted to its sulfone and sulfoxide derivatives on a humic sand soil and 2 loam soils within 1 month. During the growing season, its sulfoxide and sulfone, which are toxic ... were retained mainly in the top 0.3 m of all 3 soils. Relatively high concentrations were measured only in the top 0.2 m, indicating limited redistribution by leaching. Low to very low contents were found down to 0.8 m depth especially on one of the loam soils where the highest total rainfall was measured from May-Oct (328 mm). In a humic sand soil, leaching in the furrow was deeper than below the ridge. At the end of the growing season, the sulfoxide plus sulfone corresponded to a mass fraction of 5.7-6.7% of the dosage in the 2 loam soils and to 17% in the humic sand soil. These residues were mainly concentrated in the center of the ridges(1).

Samples of 14-C labeled aldicarb were incorporated into 4 soil types at a depth of 38 mm below the soil surface in order to study the movement and degradation of aldicarb in soils. The data indicate that leaching occurred in course sand, but very little movement was observed in clay loam and muck soils. Following a 7 week incubation period, the majority of radiolabel was recovered from the top layer in the loam and clay soils where it was originally applied. In the sandy soil however, most of the radiolabel was recovered at a depth of 75-128 mm. The evolution of 14-CO2 from the treated soil suggested that aldicarb and its metabolites were readily degraded in these soils(1).

Laboratory studies indicated that clay soils retained the highest amounts of aldicarb residues followed by loam soils. The lowest amount of aldicarb residues were found in sandy, sandy-loam, and peat soils(1). Aldicarb residues recovered in drainage water from different types of soil were determined. The highest levels were found in water from sandy, sandy-loam and peat soils(1).

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P070, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Potential candidate for rotary kiln incineration with a temperature range of 820-1600 °C and a residence time of seconds for liquids and gases and hours for solids. Also, a potential candidate fluidized bed incineration with a temperature range of 450-980 °C and a residence time of seconds for liquids and gases and for solids longer.

Aldicarb is stable, except to concentrated alkali, is non-corrosive to metal containers and equipment and is non-flammable. Recommendable methods: Incineration & landfill. Peer review: Incineration in a unit with effluent gas scrubbing is recommendable. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Disposal of aldicarb should be in accordance with the recommended procedures for the disposal and storage of pesticides and pesticide containers (40 Code of Federal Regulations 165, USA). Product residues and sorbent media can be packaged in 17H epoxy-lined drums and disposed of at an approved landfill site. Alternatively, they can be destroyed in a high temperature incineration unit with effluent gas scrubbing equipment.

/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Carbamate pesticide, liquid, flammable, poisonous; Carbamate pesticide, liquid, flammable, toxic; Carbamate pesticide, liquid, poisonous, flammable; Carbamate pesticide, liquid, toxic, flammable/

/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Carbamate pesticide, liquid, flammable, poisonous; Carbamate pesticide, liquid, flammable, toxic; Carbamate pesticide, liquid, poisonous, flammable; Carbamate pesticide, liquid, toxic, flammable/

/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Carbamate pesticide, liquid, flammable, poisonous; Carbamate pesticide, liquid, flammable, toxic; Carbamate pesticide, liquid, poisonous, flammable; Carbamate pesticide, liquid, toxic, flammable/

/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Carbamate pesticide, liquid, flammable, poisonous; Carbamate pesticide, liquid, flammable, toxic; Carbamate pesticide, liquid, poisonous, flammable; Carbamate pesticide, liquid, toxic, flammable/

For more DOT Emergency Guidelines (Complete) data for ALDICARB (16 total), please visit the HSDB record page.

UN 2757; Carbamate pesticides, solid, toxic

UN 2758; Carbamate pesticides, liquid, flammable, toxic, flashpoint less than 23 °C

UN 2991; Carbamate pesticides, liquid, toxic, flammable, flashpoint not less than 23 °C

UN 2992; Carbamate pesticides, liquid, toxic

For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for ALDICARB (6 total), please visit the HSDB record page.

49 216 25; Carbamate pesticide, liquid, nos (compounds and preparations) (agricultural insecticides, nec liquid)

49 105 27; Carbamate pesticide, liquid, nos (compounds and preparations) (insecticides, other than agricultural, nec)

49 105 28; Carbamate pesticide, liquid, nos (compounds and preparations) (agricultural insecticides, nec)

49 216 24; Carbamate pesticide, liquid, nos (compounds and preparations) (insecticides, other than agricultural, nec)

49 216 27; Carbamate pesticide, solid, nos (compounds and preparations) (insecticides, nec)

49 216 26; Carbamate pesticide, solid, nos (compounds and preparations) (insecticides, other than agricultural, nec)

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Do not transport with food and feedstuffs. Marine pollutant.

Symbol: T+, N; R: 24-26/28-50/53; S: (1/2)-22-36/37-45-60-61

UN Hazard Class: 6.1; UN Pack Group: I