hexafluoropropylene

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P271, P304+P340, P317, P319, P403+P233, P405, and P501 (click each P-code to see the statement)

H280 (89.5%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H351 (48.6%): Suspected of causing cancer [Warning Carcinogenicity]

H371 (34.6%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H373 (38.1%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H412 (26.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P264, P270, P271, P273, P280, P304+P340, P308+P316, P317, P318, P319, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 457 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P260, P261, P264, P270, P271, P304+P340, P308+P316, P317, P319, P321, P405, P410+P403, and P501 (click each P-code to see the statement)

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Refer to the "General First Aid" section. Specific First Aid: In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts. (ERG, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Use extinguishing agent suitable for type of surrounding fire.

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. Some of these materials, if spilled, may evaporate leaving a flammable residue. (ERG, 2024)

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Allow substance to evaporate.

· Ventilate the area.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

Large Spill

· Consider initial downwind evacuation for at least 500 meters (1/3 mile).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2024)

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Interim

40 [ppm]

91 [ppm]

480 [ppm]

0.1 [ppm]

· Use extinguishing agent suitable for type of surrounding fire.

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· Some of these materials, if spilled, may evaporate leaving a flammable residue.

ERPG-1: 10 ppm - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

ERPG-2: 50 ppm - one hour exposure limit: 2 = impaired ability to take protective action [AIHA]

ERPG-3: 500 ppm - one hour exposure limit: 3 = life threatening health effects [AIHA]

Emergency Response Planning Guidelines (ERPG): ERPG(1) 10 ppm (no more than mild, transient effects) for up to 1 hr exposure; ERPG(2) 50 ppm (without serious, adverse effects) for up to 1 hr exposure; ERPG(3) 500 ppm (not life threatening) up to 1 hr exposure.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Hexafluoropropylene is an odorless, colorless gas. It is noncombustible. It can asphyxiate by the displacement of air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket.

Liquid; Gas Vapor

An odorless, colorless, noncombustible gas that can act as a simple asphyxiant; [CAMEO]

Colorless gas

Odorless gas

-29.6 °C

-29.6 °C @760 [mm Hg]

-156.5 °C

1.583 AT -40 °C/4 °C

1.583 @ -40°C

4900.0 [mmHg]

4.9X10+3 mm Hg at 25 °C /from experimentally derived coefficients/

750 [mm Hg] @-30.6 °C

When heated to decomposition it emits toxic fumes of ... /hydrogen fluoride/.

Schoenflies notation

Boiling point

Chemical bond

Diamagnetic susceptibility

Heat of sublimation

Internuclear distance

Magnetic susceptibility

Molecular structure

Nuclear quadrupole coupling

Nuclear quadrupole moment

Point group

Rotational excitation cross section

Vapor pressure

Vibrational mode frequency

Other Classes -> Halogenated Aliphatics, Unsaturated

Reactive agents - 1st degree

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

PFAS -> Intentionally added food contact chemicals

PFAS -> Other/unspecified

PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008

No rapid reaction with air. No rapid reaction with water.

Halogenated Organic Compounds

Hydrocarbons, Aliphatic Unsaturated

Halogenated aliphatic compounds, such as HEXAFLUOROPROPYLENE, are moderately or very reactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Above a minimum oxygen pressure, the reaction of oxygen difluoride and hexafluoropropene to yield the hexafluoropropylene oxide becomes explosive, Chem. Abs., 1987, 107, 175302. The reaction of hexafluoropropene with grignard reagent (subst. phenylmagnesium bromides) led to explosion, Fluorine Chem., 1981, 18, 25.

Reaction of various substituted phenylmagnesium bromides with hexafluoropropene under pressure at ambient temp had been effected on the 0.2-0.6 g mol scale without incident. An attempt to scale up to 0.8 g mol with phenylmagnesium bromide led to an explosion.

Incompatible with combinations of air and tetrafluoroethylene, and oxygen and oxygen difluoride.

Other Poison - Simple Asphyxiant

LC50 (rat) = 2000-3000 ppm/4H

MALE RATS EXPOSED TO AIR CONTAINING SUBLETHAL CONCN OF HEXAFLUOROPROPENE SHOWED INCR IN URINARY FLUORIDE AFTER EXPOSURE. INHALATION ALSO PRODUCED INCR IN URINARY EXCRETION OF POTASSIUM ION (K-+) & CREATININE, & A DIURESIS WHICH PERSISTED FOR 2 WK POST-EXPOSURE. HISTOLOGICALLY, FRANK NECROSIS OF PROXIMAL RENAL TUBULES WERE OBSERVED.

MALE FISCHER-344 RATS WERE SUBJECTED TO 4 HR INHALATION OF HEXAFLUOROPROPENE AT 380-1200 PPM. WITHIN 2 DAYS RATS EXHIBITED DOSE-RELATED PROXIMAL TUBULAR NECROSIS, DIURESIS, INCREASES IN URINARY FLUORIDE, URINARY LACTIC DEHYDROGENASE (LDH) ACTIVITY, SERUM CREATININE & BLOOD UREA NITROGEN. IT PRODUCED NECROSIS OF PARS RECTA & PARS CONVOLUTA PORTIONS OF PROXIMAL TUBULE. AT LOWEST CONCN DIURESIS WAS MOST SENSITIVE INDEX OF TOXICITY MANIFESTING 50% INCR IN WATER INTAKE & 25% DECR IN URINE OSMOLALITY. INCREASES IN URINARY LDH ACTIVITY CORRELATED WITH DEGREE OF PROXIMAL RENAL TUBULAR NECROSIS, WITH GREATER THAN 100-FOLD INCR AT HIGHEST CONCN. ALL CONCN PRODUCED NECROSIS WITHIN 24 HR POSTEXPOSURE, WITH TUBULAR CELL REGENERATION APPARENT WITHIN 4 DAYS.

The ability of hexafluoropropene (HFP) to cause aberrations in Chinese hamster ovary (CHO) cells in vitro was evaluated in the presence and absence of rat liver S9 metabolic activation. Based on preliminary toxicity tests, nonactivated cultures were treated with 0, 0.01, 0.02, 0.10, 0.17, 0.29, 0.37, 0.43 or 0.59% HFP and activated cultures were treated with 0, 0.09, 0.17, 0.33, 0.46, 0.55, 0.67, 0.85, 1.40% HFP. Significant increases were observed in numbers of aberrations/cell, percent abnormal cells, and percent cells with >1 aberration relative to controls in nonactivated and activated cultures at the highest four dose levels (0.29% and 0.55% and above, respectively). Positive dose-related trends were observed for all three measurements in both nonactivated and activated cultures.

Hexafluoropropene's production and use in the manufacture of copolymers and hexafluoropropylene oxide, may result in its release to the environment through various waste streams. Based on a vapor pressure of 4.9X10+3 mm Hg at 25 °C, hexafluoropropene is expected to exist solely in the vapor-phase in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules with atmospheric half-lives of about 21 and 95 days, respectively. Hexafluoropropene is expected to have moderate mobility in soil based upon an estimated Koc value of 470. Rapid volatilization from dry soil surfaces is expected based upon the vapor pressure of this compound. Volatilization from moist soil surfaces is expected based upon the estimated Henry's Law constant of 5.34 atm-cu m/mole. Biodegradation is not expected to be an important environmental fate process. In water, hexafluoropropene is expected to adsorb to sediment or particulate matter given its estimated Koc value. This compound is expected to volatilize rapidly from water surfaces given its estimated Henry's Law constant. Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively. Bioconcentration is expected to be low based upon an estimated BCF value of 24. Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where hexafluoropropene is produced or used. (SRC)

Hexafluoropropene's production and use in the manufacture of copolymers and hexafluoropropylene oxide(1), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to have moderate mobility in soil(SRC). Volatilization of hexafluoropropene is expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Hexafluoropropene is expected to rapidly volatilize from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg(SRC), determined from a fragment constant method(4). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to adsorb to suspended solids and sediment in water(SRC). Hexafluoropropene is expected to volatilize rapidly from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 24(3,SRC), from an estimated log Kow of 2.12(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexafluoropropene, which has a vapor pressure of 4.9X10+3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules(SRC); the half-lives for these reactions in air are estimated to be about 21(3,SRC) and 95(4,SRC) days, respectively.

Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(1).

The rate constant for the vapor-phase reaction of hexafluoropropene with photochemically-produced hydroxyl radicals has been estimated as 7.74X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 21 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constant for the vapor-phase reaction of hexafluoropropene with ozone has been measured as 7.7X10-20 cu cm/molecule-sec at 25 °C(2). This corresponds to an atmospheric half-life of about 95 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2,SRC). Hexafluoropropene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(SRC).

An estimated BCF value of 24 was calculated for hexafluoropropene(SRC), using an estimated log Kow of 2.12(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for hexafluoropropene can be estimated to be about 470(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that hexafluoropropene is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for hexafluoropropene is estimated as 5.34 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that hexafluoropropene will volatilize rapidly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 116 hours(2,SRC). Hexafluoropropene's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is expected(SRC). Hexafluoropropene is expected to volatilize rapidly from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg at 25 °C(3).

Hexafluoropropene was identified, not quantified, in the stack emissions of a hazardous waste incinerator(1).

Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where hexafluoropropene is produced or used. (SRC)

Hexafluoropropene's production and use in the manufacture of copolymers and hexafluoropropylene oxide, may result in its release to the environment through various waste streams. Based on a vapor pressure of 4.9X10+3 mm Hg at 25 °C, hexafluoropropene is expected to exist solely in the vapor-phase in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules with atmospheric half-lives of about 21 and 95 days, respectively. Hexafluoropropene is expected to have moderate mobility in soil based upon an estimated Koc value of 470. Rapid volatilization from dry soil surfaces is expected based upon the vapor pressure of this compound. Volatilization from moist soil surfaces is expected based upon the estimated Henry's Law constant of 5.34 atm-cu m/mole. Biodegradation is not expected to be an important environmental fate process. In water, hexafluoropropene is expected to adsorb to sediment or particulate matter given its estimated Koc value. This compound is expected to volatilize rapidly from water surfaces given its estimated Henry's Law constant. Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively. Bioconcentration is expected to be low based upon an estimated BCF value of 24. Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where hexafluoropropene is produced or used. (SRC)

Hexafluoropropene's production and use in the manufacture of copolymers and hexafluoropropylene oxide(1), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to have moderate mobility in soil(SRC). Volatilization of hexafluoropropene is expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Hexafluoropropene is expected to rapidly volatilize from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg(SRC), determined from a fragment constant method(4). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to adsorb to suspended solids and sediment in water(SRC). Hexafluoropropene is expected to volatilize rapidly from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 24(3,SRC), from an estimated log Kow of 2.12(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexafluoropropene, which has a vapor pressure of 4.9X10+3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules(SRC); the half-lives for these reactions in air are estimated to be about 21(3,SRC) and 95(4,SRC) days, respectively.

Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(1).

The rate constant for the vapor-phase reaction of hexafluoropropene with photochemically-produced hydroxyl radicals has been estimated as 7.74X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 21 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constant for the vapor-phase reaction of hexafluoropropene with ozone has been measured as 7.7X10-20 cu cm/molecule-sec at 25 °C(2). This corresponds to an atmospheric half-life of about 95 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2,SRC). Hexafluoropropene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(SRC).

An estimated BCF value of 24 was calculated for hexafluoropropene(SRC), using an estimated log Kow of 2.12(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for hexafluoropropene can be estimated to be about 470(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that hexafluoropropene is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for hexafluoropropene is estimated as 5.34 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that hexafluoropropene will volatilize rapidly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 116 hours(2,SRC). Hexafluoropropene's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is expected(SRC). Hexafluoropropene is expected to volatilize rapidly from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg at 25 °C(3).

Hexafluoropropene was identified, not quantified, in the stack emissions of a hazardous waste incinerator(1).

Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where hexafluoropropene is produced or used. (SRC)

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Fire or Explosion: Some may burn, but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for 1,1,2,3,3,3-HEXAFLUORO-1-PROPENE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Non-Flammable Gas