2,4-dinitrotoluene

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H350: May cause cancer [Danger Carcinogenicity]

H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

H301+H311+H331 (26.7%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H301+H311 (37%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (98.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H330 (38.4%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H331 (61.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H341 (99.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H350 (99.3%): May cause cancer [Danger Carcinogenicity]

H361 (49.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361f (50.5%): Suspected of damaging fertility [Warning Reproductive toxicity]

H373 (99.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (98.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (98.6%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 281 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P260, P261, P264, P270, P271, P273, P280, P301+P316, P304+P340, P308+P316, P318, P319, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

P273, P391, and P501 (click each P-code to see the statement)

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H351: Suspected of causing cancer [Warning Carcinogenicity]

P203, P260, P264, P270, P280, P301+P317, P318, P319, P330, P332+P317, P405, and P501 (click each P-code to see the statement)

H361f: Suspected of damaging fertility [Warning Reproductive toxicity]

P203, P260, P264, P270, P273, P280, P308+P316, P318, P319, P321, P391, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

WATER, DRY CHEMICAL, OR CARBON DIOXIDE FROM PROTECTED LOCATION.

Use extreme caution in approaching a fire as the material may explode when exposed to heat or flame. No attempt should be made to fight advanced or massive fires except for remote manual activation of installed fire extinguishing equipment, or with unmanned fixed turrets and hose nozzles. The surrounding area should be evacuated.

If material on fire or involved in fire: Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources. /Dinitrotoluenes, molten/

If material on fire or involved in fire: Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Solid streams of water may be ineffective. Use foam, dry chemical, or carbon dioxide. /Dinitrotoluene, liquid; dinitrotoluene, solid/

Use water spray, dry chemical, or carbon dioxide. Fight fire from protected location or maximum possible distance. Use water spray to keep fire-exposed containers cool.

DECOMP IS SELF-SUSTAINING @ 280 °C.

Closed containers may rupture violently when heated.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

1) REMOVE ALL IGNITION SOURCES. 2) VENTILATE AREA OF SPILL. 3) FOR SMALL QUANTITIES, SWEEP ONTO PAPER OR OTHER SUITABLE MATERIAL & BURN IN SUITABLE COMBUSTION CHAMBER WHICH ALLOWS BURNING IN UNCONFINED CONDITION & IS EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. LARGE QUANTITIES MAY BE RECLAIMED; ... IF ... NOT PRACTICAL, DISSOLVE IN FUEL OIL & ATOMIZE IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated. ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

The adsorption and desorption of 2,4-dinitrotoluene on activated-carbon were investigated. Known amounts of granular FS300, FS400, powdered FS300, and regenerated spent FS300 and FS400 activated carbon were equilibrated with aqueous 2,4-dinitrotoluene solutions. The aqueous phase was analyzed by HPLC or UV spectrophotometry. The solid phases were dried, weighed, and desorbed with water, acetone, a 1:1 acetone/water mixture, and methanol. The solvent extracts were analyzed by UV spectrophotometry, HPLC, and GC/MS. The equilibrium adsorptive capacities of 2,4-dinitrotoluene on the activated carbons were assessed by constructing Freundlich adsorption isotherms. Both types of activated-carbon effectively adsorbed 2,4-dinitrotoluene from the solutions. The adsorptive capacities ranged from 0.21 to 0.30 grams 2,4-dinitrotoluene per gram carbon. Acetone and methanol were better solvents than water for desorbing 2,4-dinitrotoluene. More 2,4-dinitrotoluene could be recovered from spent FS400 than from spent FS300. 2,4-Dinitrotoluene derivatives such as 2,4-dinitrobenzyl alcohol, 2,4-dinitrobenzaldehyde, 2,4-dinitrobenzoic acid, and methyl-2,4-dinitrobenzoate were identified in the extracts. The authors conclude that 2,4-dinitrotoluene contaminated carbons can be regenerated by extracting them with methanol, acetone, or their mixtures with water. Some of the adsorbed 2,4-dinitrotoluene is converted to its derivatives, probably as a result of side chain oxidation.

Environmental considerations - water spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. Remove trapped material with suction hoses. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Dinitrotoluene, liquid; dinitrotoluene, solid/

For more Cleanup Methods (Complete) data for 2,4-DINITROTOLUENE (6 total), please visit the HSDB record page.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U105 and D030, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.[

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquidsand gases, and longer for solids.

1) BY MAKING PACKAGES OF DINITROTOLUENE IN PAPER OR OTHER FLAMMABLE MATERIAL & BURNING IN SUITABLE COMBUSTION CHAMBER WHICH ALLOWS BURNING IN UNCONFINED CONDITION & IS EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. 2) BY DISSOLVING IN FUEL OIL & ATOMIZING IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. /DINITROTOLUENE/

For more Disposal Methods (Complete) data for 2,4-DINITROTOLUENE (13 total), please visit the HSDB record page.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

Eating and smoking should not be permitted in areas where dinitrotoluene or liquids containing dinitrotoluene are handled, processed, or stored. Employees who handle dinitrotoluene or liquids containing dinitrotoluene should wash their hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities. /Dinitrotoluene/

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. /Dinitrotoluene, liquid; dinitrotoluene, solid/

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. /Dinitrotoluenes, molten/

For more Preventive Measures (Complete) data for 2,4-DINITROTOLUENE (24 total), please visit the HSDB record page.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Fireproof. Separated from strong bases, food and feedstuffs, oxidants and strong reducing agents. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

Store away from oxidizing or reducing materials. Protect containers against physical damage.

Normally stored as a molten liquid. Separate from strong oxidizing materials and reducing agents. Hot water coils should not exceed 194 °F (90 °C).

0.60 [mg/m3]

8.8 [mg/m3]

53 [mg/m3]

NIOSH considers dinitrotoluene to be a potential occupational carcinogen. [50 mg/cu m] /Dinitrotoluene/

8 hr Time Weighted Avg (TWA): 0.2 mg/cu m, skin. /Dinitrotoluene/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Dinitrotoluene/

BEI (Biological Exposure Index): Determinant: Methemoglobin in blood; Sampling time:during or end of shift; BEI: 1.5% of hemoglobin. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. The determinant is nonspecific, since it is also observed after exposure to other chemicals. The biological determinant is an indicator of exposure to the chemical, but the quantitative interpretation of the measurement is ambiguous. These determinants should be used as a screening test if a quantitative test is not practical, or as a confirmatory test if the quantitative test is not specific and the origin of the determinant is in question. /Methemoglobin inducers/

A3: Confirmed animal carcinogen with unknown relevance to humans. /Dinitrotoluene/

Acute Oral: 0.05 mg/kg/day (L134)

Chronic Oral: 0.002 mg/kg/day (L134)

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the blood. This may result in the formation of methaemoglobin. This substance is possibly carcinogenic to humans.

Air-line mask or self-contained breathing apparatus; safety goggles and face shield; rubber gloves and boots; protective clothing. (USCG, 1999)

Wear appropriate clothing to prevent any possibility or probability of skin contact with molten liquids or repeated or prolonged contact with solutions. Wear eye protection to prevent any possibility of eye contact with molten material. /Dinitrotoluene/

Employees should be provided with, and required to use, impervious clothing, gloves, face-shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with molten or liquid dinitrotoluene, or liquids containing dinitrotoluene. /Dinitrotoluene/

PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... Gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

Wear appropriate personal protective clothing to prevent skin contact. /Dinitrotoluene/

For more Personal Protective Equipment (PPE) (Complete) data for 2,4-DINITROTOLUENE (9 total), please visit the HSDB record page.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

Do not eat, drink, or smoke during work. Wash hands before eating.

Heated yellow liquid. Solidifies if allowed to cool. Insoluble in water and more dense than water. Toxic by skin absorption, inhalation and ingestion. Easily absorbed through the skin. Produces toxic oxides of nitrogen during combustion. Used to make dyes and other chemicals.

Other Solid; Dry Powder

Yellow solid; [ICSC] Yellow to red solid; Yellow liquid when heated; [CHRIS]

YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR.

Orange-yellow crystalline solid with a characteristic odor.

Yellow needles or monoclinic prisms

Yellow or orange crystals

SLIGHT ODOR

572 °F at 760 mmHg (Decomposes) (NTP, 1992)

300 °C (decomposes)

153 to 158 °F (NTP, 1992)

405 °F (NTP, 1992)

404 °F (207 °F) (Closed cup)

169 °C c.c.

less than 0.1 mg/mL at 63 °F (NTP, 1992)

Soluble in ethanol, chloroform, benzene and ethyl ether; very soluble in acetone, pyridine

Ethanol, at 15 °C, 30.46 g/L; diethyl ether, at 22 °C, 94 g/L; carbon disulfide, at 17 °C, 21.9 g/L

In water, 2.70X10+2 mg/L at 22 °C

In water, 200 mg/L at 25 °C

Solubility in water: very poor

1.379 at 68 °F (USCG, 1999) - Denser than water; will sink

Density = 1.521 g/mL at 15 °C

Density = 1.3208 g/mL at 71 °C

1.52 g/cm³

1.3208 @ 71°C

6.27 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

6.27 (Air = 1)

Relative vapor density (air = 1): 6.28

1 mmHg at 68 °F (NTP, 1992)

0.000147 [mmHg]

Vapor pressure = 6X10-5 mm Hg at 15 °C

1.47X10-4 mm Hg at 22 °C

Vapor pressure, Pa at 25 °C: 0.02

log Kow = 1.98

Henry's Law constant = 5.40X10-8 atm-cu m/mole at 25 °C

Spontaneously decomposes above 536 °F (280 °C) and will cause an explosive if confined. ... Air or oxygen is not required for decomposition or oxidation.

When heated to decomposition it emits toxic fumes of /nitrogen oxides/. Decomposes when heated to 250 °C. Mixture with sodium carbonate can decompose with significant pressure increase at 210 °C.

0.0034553 Pa.s at 342.65 deg K

Liquid dinitrotoluene will attack some forms of plastics, rubber, and coatings.

3.568 MJ/Mol

Insoluble in water.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Explosive

Strong Oxidizing Agent

DINITROTOLUENE is incompatible with strong oxidizing agents, caustics, active metals, tin and zinc (NTP, 1992). Decomposition occurs at 250 °C. Prolonged heating below 250 °C causes some decomposition, and the presence of impurities may decrease the decomposition temperatures. Decomposition is self-sustaining at 280 °C. Containers may explode in a fire (USCG, 1999). May react violently in the presence of a base or when heated to the boiling point. Attacks some forms of plastics, rubbers and coatings (NTP, 1992).

Dinitrotoluene held at 210 °C (rather than 125 °C as intended) for 10 days in a 50 mm steam heated transfer pipeline exploded. Subsequent tests showed decomposition at 210 °C (producing a significant pressure rise) in 1 day, and presence of sodium carbonate (but not rust) reduced the induction period. A maximum handling temperature of 150 °C was recommended, (when the induction period was 32 days, or 14 days for alkali contaminated material).

2,4-DNT may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are removed by catabolism, leading to the development of anemia. Some metabolites of 2,4-DNT are also transported back from the bile to the liver, where the amine group is N-hydroxylated by cytochrome P-450 to form an unstable sulfate conjugate. The sulfate conjugate is degraded into carbonium or nitrenium ions. These ions covalently bind to hepatic macromolecules (DNA, RNA), leading to mutations and subsequently liver tumors. They also bind to DNA of the lung and the intestine. (L276, T45, A171, L280)

2,4-Dinitrotoluene

Hematologic

2 x 10 ^-3 mg/kg-day

Semi-Volatile Organic Compound (SVOC)

Data are for 2,4/2,6-Dinitrotoluene mixture

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2,4-dinitrotoluene. ... There is sufficient evidence in experimental animals for the carcinogenicity of 2,4-dinitrotoluene. ... Overall evaluation: 2,4-Dinitrotoluene ... /is/ possibly carcinogenic to humans (Group 2B).

This substance/agent has not undergone a complete evaluation under U.S. EPA's IRIS program for evidence of human carcinogenic potential.

A3: Confirmed animal carcinogen with unknown relevance to humans. /Dinitrotoluene/

Group 2B: Possibly carcinogenic to humans

Volume 65: (1996) Printing Processes and Printing Inks, Carbon Black and Some Nitro Compounds

TR-054: Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity (CASRN 121-14-2) (1978 )

01/18/78

Clear Evidence

No Evidence

Under the conditions of this bioassay dietary administration of 2,4-dinitrotoluene to Fischer 344 rats induced benign tumors (i.e., fibroma of the skin and subcutaneous tissue in males and fibroadenoma of the mammary gland in females). No evidence was provided for the carcinogenicity of the compound in B6C3F1 mice of either sex.

2B, possibly carcinogenic to humans. (L135)

2,4-Dinitrotoluene poisoning may cause methemoglobinemia, anemia, leukopenia, and liver necrosis. Liver injury may be more common than cyanosis. (T48, L276)

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Dermal (T44) ; eye contact (T44) ; inhalation (T44) ; oral (T44)

Blue lips, fingernails and skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Unconsciousness.

MAY BE ABSORBED! See Inhalation.

See Inhalation.

Symptoms of 2,4-dinitrotoluene poisoning include blue lips or finger nails, blue skin, vertigo, fatigue, dizziness, weakness, nausea, vomiting, dyspnea, arthralgia, insomnia, tremor, paralysis, unconsciousness, chest pain, shortness of breath, palpitation, anorexia, and loss of weight. (T45, L272)

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

ACGIH Carcinogen - Confirmed Animal.

ATSDR Final

IRIS Current

LD50: 268 mg/kg (Oral, Rat) (T14)

LD50: 790 mg/kg (Oral, Mouse) (T14)

LD50: 1300 mg/kg (Oral, Guinea pig) (T14)

LD50 Mouse ip 500 mg/kg bw

LD50 Rat dermal >2500 mg/kg bw

LD50 Mouse oral 1630 mg/kg bw

LD50 Mouse oral 1340 mg/kg bw

For more Non-Human Toxicity Values (Complete) data for 2,4-DINITROTOLUENE (13 total), please visit the HSDB record page.

Following oral exposure, immediately dilute with 4 to 8 ounces (120 to 240 mL) of water or milk (not to exceed 4 ounces/120 mL in a child). Administer charcoal as a slurry. Gastric lavage and oxygen administration is recommended. Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. Following eyes exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water, and administer a benzodiazepine IV in case of irritation. In all those cases, a physician may need to examine the area if irritation or pain persists. (T36)

Ingestion of alcohol has a synergistic effect on the toxicity of 2,4-DNT.

EC50; Species: Pseudokirchneriella subcapitata (Green Algae) exponential growth phase; Conditions: freshwater, static, 25 °C, pH 6.0-7.5; Concentration: 14.3 uM for 96 hr (95% confidence interval: 10.5-19.2 uM); Effect: decreased population abundance

EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal, 25 °C, pH >7; Concentration: 38000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation/

EC50; Species: Daphnia magna (Water flea) age < or = 24 hr; Conditions: freshwater, static, 25 °C, pH >7.0, dissolved oxygen > or =58%; Concentration: 38000 ug/L for 24 hr; Effect: intoxication, immobilization /formulation/

EC50; Species: Daphnia magna (Water flea) age <24 hr, larvae, 1st instar; Conditions: freshwater, static, 22 °C, pH 7.7 (7.0-8.2), hardness 154.5 (89.5-180) mg/L CaCO3, alkalinity 137.7 (95-156) mg/L CaCO3; Concentration: 26200 ug/L for 48 hr (95% confidence interval: 22500-30500 ug/L); Effect: intoxication, immobilization /formulation/

For more Ecotoxicity Values (Complete) data for 2,4-DINITROTOLUENE (7 total), please visit the HSDB record page.

/BIRDS and MAMMALS/ ...A controlled dosing regime (gavage) /was followed/ using 2,4-dinitrotoluene (2,4-DNT) in the Northern Bobwhite (Colinus virginianus) for 60 days following a 14-day range-finding study and the determination of a LD50 using the up/down method. The LD50 was determined to be 55 mg/kg using corn oil as a vehicle. Individuals dosed exceeding this level were moribund or died within 60 hr of exposure. Morbidity and death occurred during the 14-day range-finding study at dosing regimens of 35 and 55, but not at 15, 5, and 0.5 mg/kg/day. Compound-related morbidity/mortality occurred in the 60-day study during the first week of exposure at 25 and 15, but not at 5, 1, and 0 mg/kg/day. Overt signs of toxicity occurred with both sexes at the onset of exposure. Signs included weight loss, diarrhea, and lethargy. Dose-related changes in egg production, ovary, kidney, and brain mass, and body weight, but not feed consumption, were found. Changes in kidney mass and histological observations suggest accumulation of nitrogenous waste may be the cause of morbidity. These data suggest that oral 2,4-DNT exposures are more acutely toxic and has a different etiology than 2,4,6-trinitrotoluene in birds.

/AQUATIC SPECIES/ 2,4-Dinitrotoluene (DNT) was tested for the induction of sex-linked recessive mutations in Drosophila melanogaster using a standard protocol approved by the National Toxicology Program. Canton-S wild-type males were treated with concentrations of DNT that resulted in approximately 30% mortality and were mated individually to 3 harems of Basc virgin females to produce 3 broods for analysis. DNT was positive at dose of 10,000 ppm when administered to males by injection.

/AQUATIC SPECIES/ ...The purpose of this study is to characterize the effects of 2,4-dinitrotoluene and the associated mechanisms of toxicity in the freshwater fish species, fathead minnow (Pimephales promelas), through the use of DNA microarray technology. ...A fathead minnow cDNA microarray containing 5,000 anonymous ESTs made from RNA extracted from fish at different developmental stages from embryo to adult /was used/. Adult fish were exposed to four concentrations of 2,4- DNT (11, 22, 44, 88 uM respectively) for 10 days. RNA extracted from the liver of exposed fish and from unexposed control fish were converted into cDNA, labeled using Cy3 and Cy5 and hybridized to the cDNA microarrays. Statistical analysis of hybridization signals was used to identify 72 cDNAs that are affected by exposure to different concentrations of 2,4-DNT. Sequence analysis of the cDNA revealed that several apolipoprotein subunit genes as well as a fatty acid binding protein were down-regulated in the livers of exposed fish suggesting that 2,4-DNT interferes with lipid metabolism. ...Results also indicate that 2,4-DNT interferes with oxygen transport in the blood as suggested by its effect on the expression of the hemoglobin alpha chain gene, two transferrin genes as well as genes coding for mitochondrial respiratory chain components. These observations correlate well with the results of a 2,4-DNT toxicity study which indicated that high doses of 2,4-DNT cause methemoglobinemia and anemia in exposed animals as well as an almost total absence of body fat. Our study on 2,4-DNT toxicity using a fathead minnow microarray platform suggests that cDNA microarrays can be useful to identify the mechanisms of toxicity and as a predictive tool for toxicity in mammals.

/AQUATIC SPECIES/ The individual and joint toxicities of binary mixtures of 2,4-Dinitrotoluene (2,4-DNT) and 8 nitrobenzenes and anilines to Vibrio fischeri were determined respectively and their mixture toxicity effects were assessed using the Additivity Index (Al). ... The joint toxic effects derived from AI values show that the mixture toxicity of 2,4-DNT and the other nitrobenzenes is synergistic (AI>0), whilst the mixture toxicity of 2,4-DNT and the anilines is antagonistic (AI<0). These results confirm that the mixture toxicity is mainly related to intracellular oxidation and reduction. -E(LUMO) values of nitrobenzenes are higher. The nitrobenzenes when mixed with 2,4-DNT make the mixture systems easily reduced; the mixture toxicity effect is synergism. On the other hand, -E(LUMO) values of anilines are lower. The anilines when mixed with 2,4-DNT can make the mixture systems less easily reduced, and the mixture toxicity effect is antagonism.

For more Ecotoxicity Excerpts (Complete) data for 2,4-DINITROTOLUENE (14 total), please visit the HSDB record page.

1.70e+00

7.40e+00

3.20e-02

1.40e-01

2.40e-01

5.00e+00

3.20e-04

3.10e-01

2.00e-03

Volatile

1.70e+02

7.40e+02

3.20e+00

1.40e+01

2.40e+01

The substance is harmful to aquatic organisms.

2,4-Dinitrotoluene's production and use in the manufacturing of toluene diisocyanate and explosives and for organic synthesis and dye production may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.47X10-4 mm Hg at 22 °C indicates 2,4-dinitrotoluene will exist solely as a vapor in the ambient atmosphere. However, at 15 °C, 2,4-dinitrotoluene has a vapor pressure of 6X10-5 mm Hg which indicates it will exist in both the vapor and particulate phases in the ambient atmosphere. 2,4-Dinitrotoluene has been detected in atmospheric particulate matter. Vapor-phase 2,4-dinitrotoluene will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 75 days. Particulate-phase 2,4-dinitrotoluene may be removed from the air by wet or dry deposition. 2,4-Dinitrotoluene is susceptible to direct photolysis in sunlight. If released to soil, 2,4-dinitrotoluene may have high to low mobility based upon an experimentally determined Koc range of 57-2000 in various soils. Leaching of 2,4-dinitrotoluene has been observed in soil column transport studies and the compound has been detected in groundwater samples beneath ammunition plants indicating 2,4-dinitrotoluene can leach from soil. Volatilization from moist soil surfaces is not expected to be an important fate process based upon a measured Henry's Law constant of 5.4X10-8 atm-cu m/mole at 25 °C. 2,4-Dinitrotoluene may undergo direct photolysis on soil surfaces based on observed photolysis of 2,4-dinitrotoluene in water. Biodegradation of 2,4-dinitrotoluene is expected to be an important fate process in soil and water based on results of various screening tests that demonstrated microbial degradation. If released into water, 2,4-dinitrotoluene is expected to be susceptible to adsorption to suspended solids and sediment in water based upon the Koc range. Volatilization from water surfaces is not an important fate process based upon this compound's Henry's Law constant. An estimated BCF of 9 suggests the potential for bioconcentration in aquatic organisms is low. Photolysis of 1.0 ppm 2,4-dinitrotoluene in distilled and natural waters gave half-lives of 43 hrs in distilled water and 2.7, 9.6, and 3.7 hrs in river, bay and pond waters, respectively. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Occupational exposure to 2,4-dinitrotoluene may occur through dermal contact with this compound at workplaces where 2,4-dinitrotoluene is produced or used. The main group to be at high risk for exposure to 2,4-dinitrotoluene is industrial workers involved in the manufacture or handling of 2,4-dinitrotoluene in places such as ammunition, dye, and polyurethane plants. (SRC)

2,4-Dinitrotoluene's production and use in the manufacturing of toluene diisocyanate and explosives(1) and for organic synthesis and dye production(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 57-2000, determined from two adsorption studies(2,3), indicates that 2,4-dinitrotoluene can have high to low mobility in soil(SRC). Leaching of 2,4-dinitrotoluene has been observed in soil column transport studies(4) and it has been detected in groundwater samples beneath ammunition plants(5,6) indicating 2,4-dinitrotoluene can leach from soil. Volatilization of 2,4-dinitrotoluene from moist soil surfaces is not expected to be an important fate process(SRC) given a measured Henry's Law constant 5.4X10-8 atm-cu m/mole at 25 °C(7). 2,4-Dinitrotoluene is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.47X10-4 mm Hg(8). 2,4-Dinitrotoluene may undergo direct photolysis on soil surfaces, based on observed photolysis of 2,4-dinitrotoluene in water(9). Biodegradation of 2,4-dinitrotoluene is expected to be an important fate process in soil based on results of various screening tests that demonstrated microbial degradation(10-14).

AQUATIC FATE: Based on a classification scheme(1), a Koc range of 57-2000, determined from two adsorption studies(2,3), indicates that 2,4-dinitrotoluene is expected to be susceptible to some adsorption to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 5.4X10-8 atm-cu m/mole at 25 °C(5). According to a classification scheme(6), an estimated BCF of 9(SRC), from its log Kow of 1.98(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Photolysis of 1.0 ppm 2,4-dinitrotoluene in distilled and natural waters gave half-lives of 43 hrs in distilled water and 2.7, 9.6, and 3.7 hrs in river, bay and pond waters, respectively(9). 2,4-Dinitrotoluene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(4). Biodegradation of 2,4-dinitrotoluene is expected to be an important fate process in water based on results of various screening tests that demonstrated microbial degradation(10-14).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,4-dinitrotoluene, which has a vapor pressure of 1.47X10-4 mm Hg at 22 °C(2), is expected to exist solely as a vapor in the ambient atmosphere at 22 °C. However, at 15 °C, 2,4-dinitrotoluene has a vapor pressure of 6X10-5 mm Hg(3) which indicates it will exist in both the vapor and particulate phases in the ambient atmosphere. 2,4-Dinitrotoluene has been detected in atmospheric particulate matter(4). Vapor-phase 2,4-dinitrotoluene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 75 days(SRC), calculated from its rate constant of 2.2X10-13 cu cm/molecule-sec at 25 °C(SRC), determined using a structure estimation method(5). Particulate-phase 2,4-dinitrotoluene may be removed from the air by wet or dry deposition(SRC). 2,4-Dinitrotoluene is susceptible to direct photolysis in sunlight(6).

AEROBIC: 2,4-Dinitrotoluene was reduced by 80%, of which 22% was transformed to 4-amino-2-nitrotoluene and 6% to 2-amino-4-nitrotoluene, by a mixture of microorganisms indigenous to an aquifer which underlies an explosives contaminated site(1); in the same study, approximately 28% of the 2,4-dinitrotoluene was mineralized to carbon dioxide within 28 days, while approximately 20% was not degraded within 28 days(1). In a wastewater treatment plant handling munitions wastewater, aerobic biodegradation of 2,4-dinitrotoluene was accelerated by addition of ethanol and phosphate(2); 4-amino-2-nitrotoluene and 2-amino-4-nitrotoluene were consistently observed as the main biodegradation reduction products(2). 2,4-Dinitrotoluene, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test that suggests the compound is not readily biodegradable(3). In soil column studies using a munitions plant soil previously exposed to 2,4-nitrotoluene, 2,4-nitrotoluene biodegradation of 2,4-dinitrotoluene was rapid in the presence of natural mineral water, but slower in the presence of deionized water(4).

AEROBIC: 2,4-Dinitrotoluene, as the sole carbon and energy source, did not degrade in an aerobic batch culture after 14 days of incubation(1). 2,4-Dinitrotoluene concentration was from 5-25 mg/L and the inoculum was municipal activated sludge(1). On the other hand, natural surface water microorganisms could use 10 ppm 2,4-dinitrotoluene as a sole carbon source(2). After a 2-3 day lag period, > 90% of 10 ppm 2,4-dinitrotoluene was transformed in aerated water after 6 days of incubation. This same culture was acclimated to grow on 120 ppm 2,4-dinitrotoluene(2). 2,4-Dinitrotoluene degraded rapidly in 2 days in a batch culture containing glucose and inoculated with an industrial seed(3). The industrial seed contained four bacterial genera (Actinobacter, Alcaligenes, Flavobacterium and Pseudomonas) and one yeast (Rhodotorula). Municipal seed (conventional activated sludge organisms), however, were inhibited by 2,4-dinitrotoluene concentrations as low as 10 mg/L(3). 2,4-Dinitrotoluene biodegradability was studied in a static screening test in which each flask contained 2,4-dinitrotoluene at either 5 or 10 mg/L, 5 mg/L yeast extract and settled domestic sewage as the inoculum. Percent biodegradation after 7 days in the original culture and the first, second and third subculture were 77, 61, 50 and 27%, respectively, at 5 mg/L initial concentration; 50, 49, 44 and 23% biodegradation, respectively, was observed at 10 mg/L initial concentration(4). The percent of 2,4-dinitrotoluene biodegraded decreased with each subculture.

... Soviet scientists estimated that 95 to 97% of 2,4-DNT was removed after the second stage of activated sludge digestion.

ANAEROBIC: Three of six methanogenic bacteria studied were capable of degrading 50-98% of 2,4-dinitrotoluene in aqueous solution in 30 days; degradation was not observed for the other three organisms(1). Greater than 99.9% of 2,4-dinitrotoluene, present at 2.1 mmoles, was removed in 162-202 days in an upflow anaerobic sludge bed reactor, using granular sludge and glucose or a volatile fatty acid mixture as cosubstrate(2). In an anaerobic cyclone fermentor study, 2,4-dinitrotoluene (at 10 mg/L initial concentration) had half-lives of 78.3 and 1.7 days under metabolism and co-metabolism conditions respectively(3). In anaerobic tests using wastewater from a munitions production facility, initial 2,4-dinitrotoluene degraded by 40% in non-sterile conditions and by 28% in sterile conditions over a 36-day incubation period(4).

PURE CULTURE: Products of microbial transformation by Microsporium species were 2-amino-4-nitrotoluene; 4-amino-2-nitrotoluene; 2,2'-dinitro-4,4'-azoxytoluene; 4,4'-dinitro-2,2'-azoxytoluene AND 4-acetamido-2-nitrotoluene. Another 2,4'-azoxy or 4,2'-azoxy compound were not identified(1). Of 190 fungi representing 98 genera screened, only 5 organisms were able to transform 2,4-dinitrotoluene at an initial concentration of 100 mg/L(2).

... 2,4-Dinitrotoluene is photochromic, ie, it has the property of becoming colored on exposure to light and then becoming colorless in the dark. When dilute solutions of ... 2,4-dinitrotoluene ... are irradiated with ultraviolet light, it becomes intensely colored and then slowly fades with the cessation of irradiation. ... The environmental consequence of this phenomenon should be the reduction, in sunlight, of the nitro group to a hydroxylamino, nitroso, or amino-group, with concomitant oxidation of the methyl group to an alcohol, aldehyde, or carboxylic acid group. ... /This photolysis is/ probably responsible for the color development in munition plant effluents.

The rate constant for the vapor-phase reaction of 2,4-dinitrotoluene with photochemically-produced hydroxyl radicals has been estimated as 2.2X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 75 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2,4-Dinitrotoluene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). 2,4-Dinitrotoluene concentration did not change after 2 weeks incubation in sterile, natural water(3). In aqueous solution, 2,4-dinitrotoluene has a quantum yield of 0.000656 at 313 nm(4) indicating that it is susceptible to direct photolysis by sunlight(SRC). Photolysis of 1.0 ppm 2,4-dinitrotoluene in distilled and natural waters gave half-lives of 43 hrs in distilled water and 2.7, 9.6, and 3.7 hrs in river, bay and pond waters, respectively(3). The rate of photolysis in water was found to increase at a factor of 2.4-4.6 in the presence of dissolved humic material obtained from water and soil(5).

Bioconcentration factor (weighted average) = 3.8 (calculated) for aquatic organisms that contain about 7.6% lipids.

An estimated BCF of 9 was calculated for 2,4-dinitrotoluene(SRC), using a log Kow of 1.98(1) and a regression-derived equation(2). The BCF for dinitrotoluene (mixed isomers) has been measured to be low (BCF values of 0.6 to 21.2) in carp (Carprinus carpio)(3). According to a classification scheme(4), these BCF values suggest the potential for bioconcentration in aquatic organisms is low. An experimental BCF of 204 (fat basis) was determined for 2,4-dinitrotoluene in the guppy (Poecilia reticulata)(5).

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U105 and D030, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.[

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquidsand gases, and longer for solids.

1) BY MAKING PACKAGES OF DINITROTOLUENE IN PAPER OR OTHER FLAMMABLE MATERIAL & BURNING IN SUITABLE COMBUSTION CHAMBER WHICH ALLOWS BURNING IN UNCONFINED CONDITION & IS EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. 2) BY DISSOLVING IN FUEL OIL & ATOMIZING IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. /DINITROTOLUENE/

For more Disposal Methods (Complete) data for 2,4-DINITROTOLUENE (13 total), please visit the HSDB record page.

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Dinitrotoluenes; Dinitrotoluenes, liquid; Dinitrotoluenes, molten; Dinitrotoluenes, solid/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Dinitrotoluenes; Dinitrotoluenes, liquid; Dinitrotoluenes, molten; Dinitrotoluenes, solid/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Dinitrotoluenes; Dinitrotoluenes, liquid; Dinitrotoluenes, molten; Dinitrotoluenes, solid/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Dinitrotoluenes; Dinitrotoluenes, liquid; Dinitrotoluenes, molten; Dinitrotoluenes, solid/

For more DOT Emergency Guidelines (Complete) data for 2,4-DINITROTOLUENE (8 total), please visit the HSDB record page.

UN 1600; Dinitrotoluenes, molten

UN 2038; Dinitrotoluenes, solid or liquid

IMO 6.1; Dinitrotoluenes, solid, liquid or molten

49 631 20; Dinitrotoluene, liquid

49 631 15; Dinitrotoluene, solid

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Do not transport with food and feedstuffs.

Symbol: T, N; R: 45-23/24/25-48/22-62-68-51/53; S: 53-45-61; Note: E

UN Hazard Class: 6.1; UN Pack Group: II