trimethyl phosphite

H226 (99.6%): Flammable liquid and vapor [Warning Flammable liquids]

H302 (98.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (24.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H315 (73.7%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (61%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (12.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (24.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (73.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H361 (11.4%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 236 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P301+P317, P302+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P260, P264, P270, P301+P317, P319, P330, and P501 (click each P-code to see the statement)

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Excerpt from NIOSH Pocket Guide for Trimethyl phosphite:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: SOAP FLUSH IMMEDIATELY - If this chemical contacts the skin, immediately flush the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

LARGE FIRE: Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use foam, carbon dioxide, powder. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

Suitable extinguishing media: Dry powder.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

To fight fire, use water, foam, fog, /carbon dioxide/.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Do not flush with water.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Principles and methods for destruction of chemical weapons: ... "Destruction of chemical weapons" means a process by which chemicals are converted in an essentially irreversible way to a form unsuitable for production of chemical weapons, and which in an irreversible manner renders munitions and other devices unusable as such. ... Each ... /nation/ shall determine how it shall destroy chemical weapons, except that the following processes may not be used: dumping in any body of water, land burial or open-pit burning. It shall destroy chemical weapons only at specifically designated and appropriately designed and equipped facilities. ... Each ... /nation/ shall ensure that its chemical weapons destruction facilities are constructed and operated in a manner to ensure the destruction of the chemical weapons; and that the destruction process can be verified under the provisions of this Convention.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

For more Preventive Measures (Complete) data for TRIMETHYL PHOSPHITE (8 total), please visit the HSDB record page.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from oxidants and strong bases.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Never allow product to get in contact with water during storage. Storage class (TRGS 510): Flammable liquids.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Interim

6.1 [ppm]

61 [ppm]

310 [ppm]

2 ppm (10 mg/m³)

TWA 2 ppm (10 mg/m3)

none See Appendix G

See: IDLH INDEX

2.0 [ppm]

8 hr Time Weighted Avg (TWA) 2 ppm

Peak Exposure Recommendation: Transient increases in workers' exposure levels may exceed 3 times the value of the TLV-TWA level for no more than 15 minutes at a time, on no more than 4 occasions spaced 1 hour apart during a workday, and under no circumstances should they exceed 5 times the value of the TLV-TWA level. In addition, the 8-hour TWA is not to be exceeded for an 8-hour work period.

2 ppm as TWA.

2 ppm [1980]

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

Large Fire

· Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

DOE Protective Action Criteria (PAC): Temporary Emergency Exposure Limits (TEELs) for Trimethyl phosphite: TEEL-0: 2 ppm; PAC-1: 60 ppm; PAC-2: 500 ppm; PAC-3: 750 ppm (TEEL-0: The threshold concentration below which most people will experience no adverse health effects; PAC-1: The maximum concentration in air below which it is believed nearly all individuals could be exposed for up to one hour without experiencing other than mild transient adverse health effects or perceiving a clearly defined objectionable odor; PAC-2: The maximum concentration in air below which it is believed nearly all individuals could be exposed for up to one hour without experiencing or developing irreversible or other serious health effects or symptoms that could impair their abilities to take protective action; PAC-3: The maximum concentration in air below which it is believed nearly all individuals could be exposed for up to one hour without experiencing or developing life-threatening health effects).

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is severely irritating to the eyes and skin.

Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Excerpt from NIOSH Pocket Guide for Trimethyl phosphite:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99 °F. Denser than water and insoluble in water. Vapors heavier than air. Used to make other chemicals.

Other Solid; Liquid

Colorless liquid with a distinctive, pungent odor; [NIOSH]

COLOURLESS LIQUID WITH PUNGENT ODOUR.

Colorless liquid with a distinctive, pungent odor.

Colorless liquid

Irritating, pungent, oily, pyridine-like odor

Distinctive, pungent odor.

Powerful, sickly odor

232 °F at 760 mmHg (USCG, 1999)

111.5 °C

-108 °F (USCG, 1999)

82 °F (USCG, 1999)

28 °C (82 °F) - closed cup

130 °F (54 °C) (open cup)

23 °C c.c.

Reacts with water (NIOSH, 2024)

Reacts (hydrolyzes) with water

Very soluble in ethanol, ether

Soluble in hexane, benzene, acetone, carbon tetrachloride, and kerosene

Solubility in water: reaction

1.046 at 68 °F (USCG, 1999) - Denser than water; will sink

1.0518 g/cu cm at 20 °C

Relative density (water = 1): 1.1

1.046 @25 °C

4.3 (Air = 1)

Relative vapor density (air = 1): 4.3

24 mmHg at 77 °F (NIOSH, 2024)

24.0 [mmHg]

Vapor pressure = 24 torr at 25 °C (saturates in air at 32,000 ppm)

24 mm Hg at 25 °C

Vapor pressure, kPa at 25 °C: 3.2

(77 °F): 24 mmHg

Stable under recommended storage conditions.

Hazardous decomposition products formed under fire conditions - Carbon oxides, oxides of phosphorus.

... When heated to decomposition can emit highly toxic fumes of /phosphorus oxides/.

42.5 kJ/mol at 302-342 °C

Odor Threshold Low: 0.001 [ppm]

Odor threshold from AIHA

Odor threshold (tested by means of a laboratory test panel) are on the order of 0.1 ppb.

Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol.

Sulfonates, Phosphonates, and Thiophosphonates, Organic

Reducing Agents, Weak

Highly Flammable

CSL00179

Trimethyl phosphite + Trimethylsilyl triflate

Reaction resulted in an explosion

Explosive

Not Available

User Reported

05/05/2022

04/22/2022

As soon as TRIMETHYL PHOSPHITE contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).

Incompatible materials: Oxidizing agents, strong bases.

In the exothermic reaction /of trimethylplatinum(iv)azide tetramer/ with trimethyl phosphite to give cis-dimethyl-bis(trimethyl phosphito)platinum, the azide must be added in small portions with stirring. Addn of the phosphite to solid azide led to a violent explosion, probably involving the transitory by-product methyl azide.

Contact between /magnesium perchlorate & trimethyl phosphite/ caused violent explosions on several occasions. (Methyl perchlorate may have been formed).

Magnesium perchlorate, water [Note: Reacts (hydrolyzes) with water].

For more Hazardous Reactivities and Incompatibilities (Complete) data for TRIMETHYL PHOSPHITE (7 total), please visit the HSDB record page.

Magnesium perchlorate, water [Note: Reacts (hydrolyzes) with water.]

IDENTIFICATION AND USE: Trimethyl phosphite (TMP) is a colorless liquid. It is used primarily as an intermediate in the manufacture of pesticides. It is also used as a fireproofing agent in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst. HUMAN EXPOSURE AND TOXICITY: Examination of 179 employees involved in manufacturing of TMP failed to reveal any indications of ocular changes or other adverse effects on worker health associated with occupational exposure to trimethyl phosphite. It is only moderately toxic by oral ingestion and an irritant to eyes, skin and upper respiratory system. ANIMAL STUDIES: Topical application of trimethyl phosphite produced moderately severe but persistent irritation on rabbit skin. Instillation of undiluted trimethyl phosphite into the rabbit eye caused severe ocular irritation and swelling, which lasted for several days. No permanent damage to the eye could be detected. Marked mortality (> 70%) /was demonstrated/ among rats exposed at 600 ppm, 6 hours/day, 5 days/week for 4 weeks. Ten percent of the rats exposed at 300 ppm also died. Gross histological evidence of lung inflammation was observed in the animals exposed at 600 ppm, but no such changes occurred in those subjected to 300 or 100 ppm. Clinical signs of ocular irritation occurred in the animals exposed at 100 ppm or higher concentrations. Severe cataract developed in the 600 ppm exposure group, and mild cataracts from 300 ppm; 100 ppm exposures caused mild, reversible "striate opacities" of the lenses of a few animals. TMP was administered by gavage to pregnant rats at rates of 16, 49, or 164 mg/kg/day, on gestation Days 6 through 15. Acetyl salicylic acid (250 mg/kg/day) was also administered to a group of rats as a positive control. Teratologic evaluation revealed gross fetal abnormalities, skeletal defects, and soft tissue defects at a dose rate of 164 mg/kg/day of trimethyl phosphite, but not at the two lesser rates. An increased frequency of fetal resorption was also observed at 164 mg/kg/day. Trimethyl phosphite was genotoxic in three separate mouse lymphoma assays, either with or without microsomal activation. Trimethyl phosphite was also positive in a battery of Drosophila melanogaster mutagenicity assays and in a bacterial DNA damage/repair suspension assay using various strains of Escherichia coli and Salmonella typhimurium. Trimethyl phosphite failed to show evidence for genetic toxicity in Salmonella and Saccharomyces strains, in a cell transformation assay, in a bacterial DNA repair assay (Escherichia coli, Salmonella typhimurium) or in two Salmonella/mammalian-microsome preincubation assays.

The substance can be absorbed into the body through the skin and by ingestion.

inhalation, ingestion, skin and/or eye contact

Cough. Sore throat.

Redness. Pain.

irritation eyes, skin, upper respiratory system; dermatitis; In Animals: teratogenic effects

Eyes, skin, respiratory system, reproductive system

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LCLo (rat) = 32,700 mg/m3/6h

LD50 Rabbit dermal 2600 mg/kg

LD50 Rat oral 2500-2890 mg/kg

LD50 Rat oral 1600 mg/kg

LD50 Mouse ip 4180 mg/kg

For more Non-Human Toxicity Values (Complete) data for TRIMETHYL PHOSPHITE (7 total), please visit the HSDB record page.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/EPIDEMIOLOGY STUDIES/ Analyses of workplace air /from a plant engaged in the manufacture of trimethyl phosphite revealed concentrations averaging up to 8 ppm in 1969 and 1971. More thorough studies in this and another facility in 1979 indicated average exposures generally between 0.3 and 4 ppm, with occasional values as high as 15 ppm. Examination of 179 employees in these plants failed to reveal any indications of ocular changes or other adverse effects on worker health associated with occupational exposure to trimethyl phosphite.

/OTHER TOXICITY INFORMATION/ It is only moderately toxic by oral ingestion and an irritant to eyes, skin and upper respiratory system. No information of chronic toxicity of vapors. Exposure of workers during its manufacture and handling may involve low-level inhalation of vapors.

/LABORATORY ANIMALS: Acute Exposure/ Topical application of trimethyl phosphite produced moderately severe but persistent irritation on rabbit skin. Instillation of undiluted trimethyl phosphite into the rabbit eye caused severe ocular irritation and swelling, which lasted for several days. No permanent damage to the eye could be detected.

/LABORATORY ANIMALS: Acute Exposure/ The studies on toxic properties of trimethyl and triethyl phosphites involved: determination of acute general toxic effect on white rats following intragastric and intraperitoneal administration of these compounds, based on LD50 test, determination of damaging effect direction, by histopathological examination of animals' internal organs, determination of intensity of primarily irritating action on the skin, eye and conjunctiva, as well as sensitizing effect on guinea-pigs. LD50 value for trimethyl phosphite following intragastric administration was found to be 2.45 g/kg and following intraperitoneal administration--2.25 g/kg; for triethyl phosphite these values were: 4.00 g/kg after intragastric administration and 1.50 g/kg after intraperitoneal administration, respectively. In local action both phosphites mildly irritate the skin, eye and conjunctiva. A weak sensitizing effect of triethyl phosphite was found. Trimethyl and triethyl phosphites have general toxic effects. A particular direction of their action is demonstrated by acroparalysis. Apart from general action they were found to show systemic action and induce parenchymatous degeneration of the liver and kidneys, whatever route of administration. Administered intragastrically, they result in mucosa necrosis, ulceration and fibrino-purulent exudate, exfoliating the mucosa.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Five rats inhaled 500 +/- 75 ppm trimethyl phosphite 7.5 hours/day, 5 days/week for 8 weeks. The exposure concentration selected was sublethal but high enough to produce moderate to severe respiratory distress. Although no animals died, this exposure resulted in reduced body weight gain (in comparison to the concurrent control); necropsy revealed severe pulmonary and cutaneous pathology. Hematologic parameters and other vital organ systems were unaffected. ... /It was concluded that/ the pathologic findings ... /were/ due to the high degree of local irritation from the material rather than to inherent systemic toxicity.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ ... Marked mortality (> 70%) /was demonstrated/ among rats exposed at 600 ppm, 6 hours/day, 5 days/week for 4 weeks. Ten percent of the rats exposed at 300 ppm also died. Gross histological evidence of lung inflammation was observed in the animals exposed at 600 ppm, but no such changes occurred in those subjected to 300 or 100 ppm. Clinical signs of ocular irritation occurred in the animals exposed at 100 ppm or higher concentrations. Severe cataract developed in the 600 ppm exposure group, and mild cataracts from 300 ppm; 100 ppm exposures caused mild, reversible "striate opacities" of the lenses of a few animals.

For more Non-Human Toxicity Excerpts (Complete) data for TRIMETHYL PHOSPHITE (8 total), please visit the HSDB record page.

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of July 7, 2016: http://actor.epa.gov/dashboard/]

The ability of 1,3-dioxolane to induce morphological transformation in the C3H/10T 1/2 mouse cell line (Cell Transformation Assay) without metabolic activation was evaluated. Based on preliminary toxicity tests (exposure time=24 hrs), 1,3-dioxolane was tested at 10 concentrations between 1.0-20,000 ul/ml, with cell survival ranging from 100% to 66%. 1,3-Dioxolane exhibited a weak transformation potential using this test system.

Teratogenicity was evaluated in pregnant female BLU:(SD)BR albino rats (25/group) orally exposed by gavage to trimethyl phosphite at dose levels of 0, 16, 49 or 164 mg/kg/day on gestation days (GD) 6-15. Surviving animals were sacrificed on GD 20. Significant differences were observed between treated and control animals in the following (high-dose group unless otherwise noted): decreased body weight minus gravid uterine weight, increased incidence of morphological abnormalities in soft tissues and skeletal system and gross abnormalities (including widening of cal sutures, increased incidence of abnormalities, primarily partial ossification of the long bones, along with anomalies of several sternebrae and vertebrae, and all treated groups exhibited increased incidence of dams with fetuses afflicted with teratologic effects of any kind. No significant differences were observed between treated and control animals in the following: maternal mortality, pharmacological examination, food consumption or body weight, live fetuses/dam, average fetal weight, numbers of live litters, implantation sites, resorptions, and dead fetuses.

The mutagenicity of trimethyl phosphite was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA1538 (Ames Test) and in Saccharomyces cerevisiae strain D4, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity determinations, trimethyl phosphite, diluted with DMSO, was tested at concentrations up to 5.0ul/plate using the plate incorporation technique. Trimethyl phosphite did not cause a positive response in any of the tester strains with or without metabolic activation.

The mutagenicity of trimethyl phosphite was evaluated in the germ cells of Drosophila melanogaster by inhalation exposure employing the Y chromosome loss test, dominant lethal test, bithorax test of levels and sex-linked recessive lethal test. Based on preliminary toxicity determinations, trimethyl phosphite, was administered at 10mM to male flies and then mated. Trimethyl phosphite cause a significant increase in genetic damage in the treated Drosophila under the experimental conditions used. Also employed was the white-ivory mosaic test, which did not produce a positive response.

For more TSCA Test Submissions (Complete) data for TRIMETHYL PHOSPHITE (10 total), please visit the HSDB record page.

Environmental effects from the substance have not been investigated adequately.

Trimethyl phosphite's production and use as an intermediate, especially for production of pesticides, may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 24 mm Hg at 25 °C indicates trimethyl phosphite will exist solely as a vapor in the atmosphere. Vapor-phase trimethyl phosphite will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 33 minutes. Trimethyl phosphite does not absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, adsorption to soil, volatilization from moist soil surfaces, and biodegradation are not expected to be important fate processes due to a rapid hydrolysis of trimethyl phosphite. Trimethyl phosphite may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, adsorption to suspended solids and sediment, volatilization from water surfaces, bioconcentration, and biodegradation are not expected to be important fate processes due to the rapid hydrolysis of triethyl phosphite. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis product, dimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite. In acid solution (pH = 4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol. At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed. At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours. Occupational exposure to trimethyl phosphite may occur through inhalation and dermal contact with this compound at workplaces where trimethyl phosphite is produced or used. Exposure of the general population to trimethyl phosphite is unlikely since it is used as a chemical intermediate and it is expected to hydrolyze rapidly in the environment. (SRC)

Trimethyl phosphite's production and use as an intermediate, especially for production of pesticides(1), as a fireproofing agent in the production of textiles, as an intermediate in production of flame-retardant polymers for polyurethane foams, and as a catalyst(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Trimethyl phosphite hydrolyzes rapidly in the presence of water(1,2) and therefore, adsorption to soil, volatilization from moist soil surfaces, and biodegradation are not expected to be important fate processes(SRC). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(3). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(3). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(3). Trimethyl phosphite is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 24 mm Hg at 25 °C(4). Dimethyl phosphite, an hydrolysis product of trimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable(1).

AQUATIC FATE: Trimethyl phosphite hydrolyzes rapidly in the presence of water(1,2) and therefore, adsorption to sediment, volatilization from water surfaces, bioconcentration and biodegradation are not expected to be important fate processes(SRC). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(1,2). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(3). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(3). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(3). Dimethyl phosphite, an hydrolysis product of trimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable(1).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl phosphite, which has a vapor pressure of 24 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethyl phosphite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 33 minutes(SRC), calculated from its rate constant of 7.1X10-10 cu cm/molecule-sec at 25 °C(3). Trimethyl phosphite does not absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Biodegradation is not expected to be an important environmental fate process(SRC) because trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(1). Dimethyl phosphite, present at 100 mg/L, reached 48% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1) which indicates the hydrolysis product of trimethyl phosphite is not readily biodegradable(SRC). Analogy to triethyl phosphite(SRC) suggests hydrolysis is a prerequisite for biodegradation(2) and that the hydrolysis product is inherently biodegradable(2).

The rate constant for the vapor-phase reaction of trimethyl phosphite with photochemically-produced hydroxyl radicals is 7.1X10-10 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 33 minutes at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(3,4). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(5). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(5). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(5). The UV absorption spectrum of trimethyl phosphite suggests that trimethyl phosphite does not absorb at wavelengths >290 nm(6) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Bioconcentration is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite (CAS 868-85-9) which has a reported low bioconcentration in fish(2).

Environmental effects from the substance have not been investigated adequately.

Trimethyl phosphite's production and use as an intermediate, especially for production of pesticides, may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 24 mm Hg at 25 °C indicates trimethyl phosphite will exist solely as a vapor in the atmosphere. Vapor-phase trimethyl phosphite will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 33 minutes. Trimethyl phosphite does not absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, adsorption to soil, volatilization from moist soil surfaces, and biodegradation are not expected to be important fate processes due to a rapid hydrolysis of trimethyl phosphite. Trimethyl phosphite may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, adsorption to suspended solids and sediment, volatilization from water surfaces, bioconcentration, and biodegradation are not expected to be important fate processes due to the rapid hydrolysis of triethyl phosphite. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis product, dimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite. In acid solution (pH = 4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol. At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed. At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours. Occupational exposure to trimethyl phosphite may occur through inhalation and dermal contact with this compound at workplaces where trimethyl phosphite is produced or used. Exposure of the general population to trimethyl phosphite is unlikely since it is used as a chemical intermediate and it is expected to hydrolyze rapidly in the environment. (SRC)

Trimethyl phosphite's production and use as an intermediate, especially for production of pesticides(1), as a fireproofing agent in the production of textiles, as an intermediate in production of flame-retardant polymers for polyurethane foams, and as a catalyst(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Trimethyl phosphite hydrolyzes rapidly in the presence of water(1,2) and therefore, adsorption to soil, volatilization from moist soil surfaces, and biodegradation are not expected to be important fate processes(SRC). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(3). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(3). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(3). Trimethyl phosphite is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 24 mm Hg at 25 °C(4). Dimethyl phosphite, an hydrolysis product of trimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable(1).

AQUATIC FATE: Trimethyl phosphite hydrolyzes rapidly in the presence of water(1,2) and therefore, adsorption to sediment, volatilization from water surfaces, bioconcentration and biodegradation are not expected to be important fate processes(SRC). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(1,2). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(3). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(3). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(3). Dimethyl phosphite, an hydrolysis product of trimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable(1).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl phosphite, which has a vapor pressure of 24 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethyl phosphite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 33 minutes(SRC), calculated from its rate constant of 7.1X10-10 cu cm/molecule-sec at 25 °C(3). Trimethyl phosphite does not absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Biodegradation is not expected to be an important environmental fate process(SRC) because trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(1). Dimethyl phosphite, present at 100 mg/L, reached 48% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1) which indicates the hydrolysis product of trimethyl phosphite is not readily biodegradable(SRC). Analogy to triethyl phosphite(SRC) suggests hydrolysis is a prerequisite for biodegradation(2) and that the hydrolysis product is inherently biodegradable(2).

The rate constant for the vapor-phase reaction of trimethyl phosphite with photochemically-produced hydroxyl radicals is 7.1X10-10 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 33 minutes at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(3,4). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(5). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(5). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(5). The UV absorption spectrum of trimethyl phosphite suggests that trimethyl phosphite does not absorb at wavelengths >290 nm(6) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Bioconcentration is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite (CAS 868-85-9) which has a reported low bioconcentration in fish(2).

Adsorption to soils or suspended solids and sediment in water is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1).

Volatilization from water surfaces or moist soil is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1). Trimethyl phosphite is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 24 mm at 25 °C(1).

According to the 2012 TSCA Inventory Update Reporting data, 1 reporting facility estimates the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of trimethyl phosphite (121-45-9) in the United States as <10 workers; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH has statistically estimated that 14,191 workers (6,311 of these were female) were potentially exposed to trimethyl phosphite in the US(1). Occupational exposure to trimethyl phosphite may occur through inhalation and dermal contact with this compound at workplaces where trimethyl phosphite is produced or used(SRC). Exposure of the general population to trimethyl phosphite is unlikely since it is used as a chemical intermediate and it is expected to hydrolyze rapidly in the environment(SRC).

With respect to employee health protection, /it has been concluded that/...long term, low level exposures to trimethyl phosphite vapors are not likely to produce any adverse effects if workroom air concentrations are maintained well below the level of subjective irritation.

Analysis of air in.../plants engaged in manufacture of trimethyl phosphite/ in 1979 indicated average exposures generally between 0.3 and 4 ppm, with occasional values as high as 15 ppm. Examination of 179 employees in these plants failed to reveal any indications of ocular changes or other adverse effects on worker health associated with occupational exposure to /Trimethyl phosphite/.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Principles and methods for destruction of chemical weapons: ... "Destruction of chemical weapons" means a process by which chemicals are converted in an essentially irreversible way to a form unsuitable for production of chemical weapons, and which in an irreversible manner renders munitions and other devices unusable as such. ... Each ... /nation/ shall determine how it shall destroy chemical weapons, except that the following processes may not be used: dumping in any body of water, land burial or open-pit burning. It shall destroy chemical weapons only at specifically designated and appropriately designed and equipped facilities. ... Each ... /nation/ shall ensure that its chemical weapons destruction facilities are constructed and operated in a manner to ensure the destruction of the chemical weapons; and that the destruction process can be verified under the provisions of this Convention.

/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for TRIMETHYL PHOSPHITE (8 total), please visit the HSDB record page.

UN 2329; Trimethyl phosphite

IMO 3; Trimethyl phosphite

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Trimethyl phosphite is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Trimethyl phosphite is included on the dangerous goods list.

Flammable Liquid

UN Hazard Class: 3; UN Pack Group: III