diallylamine

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H314 (40.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (59.8%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (59.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331 (25.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (14.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (59.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H412 (66.1%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 174 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Not Classified

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Provision to contain effluent from fire extinguishing. Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Store in an area without drain or sewer access.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

4.0 [ppm]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Workplace Environmental Exposure Level (WEEL): 8-hr Time-weighted Average (TWA) 1 ppm, skin.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of fumes may cause lung oedema. Exposure could cause severe swelling of the throat. The substance may cause effects on cardiovascular system and nervous system. This may result in cardiac disorders and impaired functions. The effects may be delayed. Medical observation is indicated.

Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract and lungs. This may result in chronic inflammation and impaired functions.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Prevent build-up of electrostatic charges (e.g., by grounding).

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Diallylamine appears as a liquid with a disagreeable odor. Less dense than water. May be toxic by inhalation and skin absorption. Irritates skin and eyes. Used to make other chemicals.

Colorless liquid with an ammonia-like odor; [AIHA]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

RECOGNIZABLE BUT REFRESHING ODOR @ 4-9 PPM

Unpleasant odor

SWEETISH TASTE

232 °F at 760 mmHg (NTP, 1992)

-127.1 °F (NTP, 1992)

-88.4 °C

8.6 g/100mL (NTP, 1992)

Soluble in ethanol and ethyl ether

In water, 8.6X10+4 mg/l @ room temperature

Solubility in water, g/100ml at 20 °C: 9

0.7627 at 50 °F (NTP, 1992) - Less dense than water; will float

0.7889 @ 20 °C

Relative density (water = 1): 0.8

3.35 (Air= 1)

Relative vapor density (air = 1): 3.4

20.2 [mmHg]

20.2 mm Hg @ 25 °C

Vapor pressure, kPa at 20 °C: 2.42

log Kow= 1.11

1.46X10-2 Pa.sec @ 184.75 K

4.86X10+7 J/Kmol @ 184.75 K

4.44X10-2 N/m @ 184.75 K

Odor Threshold Low: 2.0 [ppm]

Odor Threshold High: 9.0 [ppm]

[ICSC] Odor threshold from CHEMINFO "At 2 ppm odour was recognized by most test subjects. At 9 ppm it was recognized by all people tested." VP from ChemIDplus

/IN EXPTL HUMAN EXPOSURES/...RECOGNIZABLE BUT NOT UNPLEASANT @ 2 TO 9 PPM...

Index of Refraction: 1.4387 @ 20 °C

pKa= 9.29 (conjugate acid)

pKb = 4.87 @ 25 °C

Conversion units: 1 mg/l= 252 ppm, 1 ppm= 3.97 mg/cu m

Boiling point

Heat of sublimation

Optical coefficient

Refractive index

Vapor pressure

Nitrogen Compounds -> Amines, Aliphatic

Flammable agents - 3rd degree

Highly flammable. Soluble in water.

Amines, Phosphines, and Pyridines

Hydrocarbons, Aliphatic Unsaturated

Highly Flammable

DIALLYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Serious local effects by all routes of exposure.

Cough. Headache. Nausea. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Pain. Serious skin burns.

Watering of the eyes. Redness. Pain. Blurred vision. Severe burns. Loss of vision.

Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain. Vomiting. Diarrhoea. Shock or collapse.

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 795 ppm/8h

/IN EXPTL HUMAN EXPOSURES/...RECOGNIZABLE BUT NOT UNPLEASANT @ 2 TO 9 PPM, MUCOUS MEMBRANE IRRITATION & CHEST DISCOMFORT IN A FEW SUBJECTS @ 22 PPM, NOT INTOLERABLE @ 70 PPM.

...INHALATION STUDIES IN MICE USING HEAVY DOSES OF...DIALLYLAMINE; ALMOST ALL ANIMALS DIED WITHIN 10 MIN @ CONCN OF 0.88 MMOL (1.9%).

REPEATED INHALATIONS IN RATS, (7 HR X 50 EXPOSURES @ 200 PPM), PRODUCED CHANGES IN LIVER & KIDNEY WEIGHTS, REDUCED GROWTH, & DEATH. /FROM TABLE/

/IN ACUTE STUDIES WITH RATS, PERCUTANEOUS DIALLYLAMINE WAS/...SEVERELY IRRITATING TO SKIN... ACUTE EXPOSURES TO VAPORS PRODUCED...RESPIRATORY TRACT IRRITATION.

PATHOLOGICAL CHANGES OBSERVED IN RATS FOLLOWING REPEATED INHALATION INCLUDED CHEMICAL PNEUMONIAS & SOME LIVER & KIDNEY DAMAGE. THE MOST PROMINENT PATHOLOGICAL EFFECT...WAS MYOCARDITIS...WHICH OCCURRED AFTER REPEATED INHALATION OF ALL THREE ALLYLAMINES /MONOALLYLAMINE, DIALLYLAMINE, & TRIALLYLAMINE/.

For more Non-Human Toxicity Excerpts (Complete) data for DIALLYLAMINE (7 total), please visit the HSDB record page.

Diallylamine (CAS # 124-02-7) was evaluated for acute oral toxicity in fasted male Sprague-Dawley albino rats fed single undiluted doses of 215, 464, 1000, and 2150 mg/kg by oral gavage and observed for 14 days. Treatment was associated with increasing dose-related lethargy and mortality consistent with an oral LD50 for male rats of 316 (205-488) mg/kg. Fasted females fed undiluted doses of 215, 464, 1000, and 4640 mg/kg exhibited moderate lethargy from doses of 464 mg/kg and mortality (all within 20 hours of dosing) consistent with an oral LD50 of 501 (344-730) mg/kg. Female rats of 215 mg/kg suffered no apparent untoward effects of treatment. No additional comments regarding protocol, results, or pathology were provided.

Diallylamine (CAS # 124-02-7) was evaluated for acute dermal toxicity in New Zealand white albino rabbits (2/sex/group) administered topical occluded applications of 215, 464, 1,000, and 2,150 mg/kg upon clipped intact abdominal skin for 24 hours. Test sites were examined prior to cleansing and rewrap in a gauze binder for 14-day observation of systemic toxicity. Local effects included necrosis, erythema, and edema. Treatment was also associated with mortality primarily within 4 hours and consistent with a dermal LD50 of 563 (383-825) mg/kg.

Diallylamine (CAS # 124-02-7) was evaluated for acute inhalation toxicity in Sprague-Dawley albino rats (5/sex/group) exposed to a dynamically-generated atmosphere of 6.3 mg/l in a 32 liter, positive pressure environmental chamber for 1 hour. Treatment was associated with moderate eye irritation and depression which persisted to 24 hours post-exposure. Exposed animals exhibited no other signs of toxicity and no mortality throughout 14-day post-exposure observation.

Diallylamine (CAS # 124-02-7) was evaluated for eye irritation in 6 New Zealand rabbits each administered 0.1 ml instillations (concentration unspecified) into the conjunctival sac of one eye for 4 hours, the second eye serving as control. Treatment was associated with phonation upon contact with the eye, with severe corneal damage to obscure iritic examination, and conjunctival erythema, chemosis, and discharge at 24, 48, and 72 hours post-instillation. No apparent remission occurred throughout 7-day observation.

The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

Diallylamine's production and use as an intermediate in the production of pharmaceuticals and resins, in crop protection, as an auxiliary in paper making, and as a solvent may result in its direct release to the environment. If released to air, a vapor pressure of 20.2 mm Hg at 25 °C indicates diallylamine will exist solely in the vapor phase in the ambient atmosphere. Vapor-phase diallylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 11 hrs. If released to soil, Diallylamine is expected to have high mobility based upon an estimated Koc of 96. A pKa value of 9.29 suggests that diallylamine will exist primarily in the protonated form in moist soils and the protonated form of diallylamine is expected to bind strongly to soil surfaces. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole. However, the pKa of diallylamine indicates that this compound will exist primarily in the protonated form in the environment and cations generally adsorb to suspended solids and sediment more strongly than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process because the cation is not expected to volatilize. Diallylamine may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, diallylamine is not expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. However, the pKa of diallylamine indicates that this compound will exist primarily in the protonated form in the environment and cations generally adsorb to suspended solids and sediment more strongly than their neutral counterparts. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. However, the protonated form is expected to be non-volatile. Estimated volatilization half-lives for a model river and model lake are 20 hrs and 13 days, respectively. An estimated BCF of 1.4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to diallylamine may occur through inhalation and dermal contact with this compound at workplaces where diallylamine is produced or used. (SRC)

Diallylamine's production and use as an intermediate in the production of pharmaceuticals and resins(1) and in crop protection, as an auxiliary in paper making(2), and as a solvent(3) may result in its direct release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 96(SRC), determined from a log Kow of 1.11(2) and a regression-derived equation(3), indicates that diallylamine is expected to have high mobility in soil(SRC). However, a pKa of 9.29(6), indicates that this compound will exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts, thus reducing mobility. Volatilization of diallylamine from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 20.2 mm Hg(5), and water solubility, 8.6X10+4 mg/l(4). The potential for volatilization of diallylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 20.2 mm Hg(5). However, adsorption to soil is expected to attenuate volatilization when the compound is in the cation form(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 96(SRC), determined from a log Kow of 1.11(2) and a regression-derived equation(3), indicates that diallylamine is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 20.2 mm Hg(7), and water solubility, 8.6X10+4 mg/l(8). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 20 hrs and 13 days, respectively(SRC). A pKa of 9.29(4) indicates diallylamine will exist almost entirely in the protonated form in aqueous environments and the protonated form of diallylamine is not expected to volatilize from water surfaces. According to a classification scheme(5), an estimated BCF of 1.4(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diallylamine, which has a vapor pressure of 20.2 mm Hg at 25 °C(2), will exist solely in the vapor phase in the ambient atmosphere. Vapor-phase diallylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hrs(SRC), calculated from its rate constant of 1.33X10-10 cu cm/molecule-sec at 25 °C(3) determined using a structure estimation method(3).

The rate constant for the vapor-phase reaction of diallylamine with photochemically-produced hydroxyl radicals has been estimated as 1.33X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours(SRC) at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1).

An estimated BCF of 1.4 was calculated for diallylamine(SRC), using a log Kow of 1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of diallylamine is estimated as 96(SRC), using a log Kow of 1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diallylamine is expected to have high mobility in soil. The pKa of diallylamine is 9.29(4), indicating that this compound will exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts.

The Henry's Law constant for diallylamine is estimated as 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 20.2 mm Hg(1), and water solubility, 8.6X10+4 mg/l(2). This Henry's Law constant indicates that diallylamine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 20 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 13 days(SRC). Diallylamine's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of diallylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 20.2 mm Hg(1). However, adsorption to soil is expected to attenuate volatilization when the compound is in the cation form(SRC).

Occupational exposure to diallylamine may occur through inhalation and dermal contact with this compound at workplaces where diallylamine is produced or used. (SRC)

The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

Diallylamine's production and use as an intermediate in the production of pharmaceuticals and resins, in crop protection, as an auxiliary in paper making, and as a solvent may result in its direct release to the environment. If released to air, a vapor pressure of 20.2 mm Hg at 25 °C indicates diallylamine will exist solely in the vapor phase in the ambient atmosphere. Vapor-phase diallylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 11 hrs. If released to soil, Diallylamine is expected to have high mobility based upon an estimated Koc of 96. A pKa value of 9.29 suggests that diallylamine will exist primarily in the protonated form in moist soils and the protonated form of diallylamine is expected to bind strongly to soil surfaces. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole. However, the pKa of diallylamine indicates that this compound will exist primarily in the protonated form in the environment and cations generally adsorb to suspended solids and sediment more strongly than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process because the cation is not expected to volatilize. Diallylamine may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, diallylamine is not expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. However, the pKa of diallylamine indicates that this compound will exist primarily in the protonated form in the environment and cations generally adsorb to suspended solids and sediment more strongly than their neutral counterparts. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. However, the protonated form is expected to be non-volatile. Estimated volatilization half-lives for a model river and model lake are 20 hrs and 13 days, respectively. An estimated BCF of 1.4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to diallylamine may occur through inhalation and dermal contact with this compound at workplaces where diallylamine is produced or used. (SRC)

Diallylamine's production and use as an intermediate in the production of pharmaceuticals and resins(1) and in crop protection, as an auxiliary in paper making(2), and as a solvent(3) may result in its direct release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 96(SRC), determined from a log Kow of 1.11(2) and a regression-derived equation(3), indicates that diallylamine is expected to have high mobility in soil(SRC). However, a pKa of 9.29(6), indicates that this compound will exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts, thus reducing mobility. Volatilization of diallylamine from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 20.2 mm Hg(5), and water solubility, 8.6X10+4 mg/l(4). The potential for volatilization of diallylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 20.2 mm Hg(5). However, adsorption to soil is expected to attenuate volatilization when the compound is in the cation form(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 96(SRC), determined from a log Kow of 1.11(2) and a regression-derived equation(3), indicates that diallylamine is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 20.2 mm Hg(7), and water solubility, 8.6X10+4 mg/l(8). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 20 hrs and 13 days, respectively(SRC). A pKa of 9.29(4) indicates diallylamine will exist almost entirely in the protonated form in aqueous environments and the protonated form of diallylamine is not expected to volatilize from water surfaces. According to a classification scheme(5), an estimated BCF of 1.4(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diallylamine, which has a vapor pressure of 20.2 mm Hg at 25 °C(2), will exist solely in the vapor phase in the ambient atmosphere. Vapor-phase diallylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hrs(SRC), calculated from its rate constant of 1.33X10-10 cu cm/molecule-sec at 25 °C(3) determined using a structure estimation method(3).

The rate constant for the vapor-phase reaction of diallylamine with photochemically-produced hydroxyl radicals has been estimated as 1.33X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours(SRC) at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1).

An estimated BCF of 1.4 was calculated for diallylamine(SRC), using a log Kow of 1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of diallylamine is estimated as 96(SRC), using a log Kow of 1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diallylamine is expected to have high mobility in soil. The pKa of diallylamine is 9.29(4), indicating that this compound will exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts.

The Henry's Law constant for diallylamine is estimated as 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 20.2 mm Hg(1), and water solubility, 8.6X10+4 mg/l(2). This Henry's Law constant indicates that diallylamine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 20 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 13 days(SRC). Diallylamine's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of diallylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 20.2 mm Hg(1). However, adsorption to soil is expected to attenuate volatilization when the compound is in the cation form(SRC).

Occupational exposure to diallylamine may occur through inhalation and dermal contact with this compound at workplaces where diallylamine is produced or used. (SRC)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for DIALLYLAMINE (8 total), please visit the HSDB record page.

UN 2359; Diallyamine

IMO 3.2; Diallyamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid Poison Corrosive

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

UN Hazard Class: 3; UN Subsidiary Risks: 6.1 and 8; UN Pack Group: II