Methanesulfonyl chloride

H290 (47.5%): May be corrosive to metals [Warning Corrosive to Metals]

H300 (15%): Fatal if swallowed [Danger Acute toxicity, oral]

H301+H311 (20.7%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]

H301 (72.9%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (11.8%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (86%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H312 (12.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (22.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (75.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H335 (66.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H412 (12.7%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P234, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P333+P317, P361+P364, P362+P364, P363, P390, P403+P233, P405, P406, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 314 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer immediately for medical attention.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

Note: Most foams will react with the material and release corrosive/toxic gases. CAUTION: For Acetyl bromide (UN1716), use CO2 or dry chemical only.

SMALL FIRE: CO2, dry chemical, dry sand, alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use water spray, powder, foam, carbon dioxide.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible Use "alcohol" foam, dry chemical or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· A vapor-suppressing foam may be used to reduce vapors.

· FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors.

· DO NOT GET WATER on spilled substance or inside containers.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Prevent entry into waterways, sewers, basements or confined areas.

Small Spill

· Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain.

· Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3246 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- ISOLATE in all directions: 60 m (200 ft)

- PROTECT people from downwind during DAY time: 0.2 km (0.2 mi)

- PROTECT people from downwind during NIGHT time: 0.3 km (0.2 mi)

- PROTECT people from downwind during DAY time: 0.7 km (0.5 mi)

- PROTECT people from downwind during NIGHT time: 1.0 km (0.6 mi)

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable dry containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Environmental considerations- land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Environmental considerations- water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.

Environmental considerations- air spill: Apply water spray or mist to knock down vapors.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment Wash away any material which may have contacted the body with copious amounts of water or soap and water.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2024)

Separated from food and feedstuffs and incompatible materials. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

NR = Not recommended due to insufficient data

AEGLs Status: Final

0.019 [ppm]

0.21 [ppm]

0.62 [ppm]

· Note: Most foams will react with the material and release corrosive/toxic gases.

CAUTION: For Acetyl bromide (UN1716), use CO2 or dry chemical only.

Small Fire

· CO2, dry chemical, dry sand, alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.

Repeated or prolonged contact may cause skin sensitization.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Protective measures: Gloves, goggles, acid resistant protective suit, safety shoes, complete antiacid chemical protection suite if any problems.

Personnel protection: Wear positive pressure self-contained breathing apparatus. ... Wear appropriate chemical protective clothing.

NO open flames.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles, face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Methanesulfonyl chloride appears as a pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.

Liquid; CBI

Colorless to pale yellow, fuming liquid; [ICSC] Unpleasant odor; [HSDB]

COLOURLESS-TO-PALE-YELLOW LIQUID WITH PUNGENT ODOUR.

Pale yellow liquid

Unpleasant odor

62 °C at 18 mm Hg; 161 °C at 730 mm Hg

at 97.3kPa: 161 °C

Freezing point: -32 °C

Soluble in most organic solvents

Practically insoluble in water; soluble in alcohol, ether

Solubility in water: reaction

1.4805 at 18 °C/4 °C

Relative density (water = 1): 1.5

1.4805 @ 18°C

3.9 (Air = 1)

Relative vapor density (air = 1): 4.0

3.09 [mmHg]

3.09 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 0.27

18 [mm Hg] @62 °C

When heated to decompositionit emits toxic vapors of /sulfur oxides and hydrogen chloride/.

1.33 centistokes at 25 °C

349 kJ/kg

Index of refraction: 1.451 at 23 °C/D

Index of refraction: 1.4573 at 20 °C/D

Schoenflies notation

Chemical bond

Chemical shift

Dielectric constant

Electric dipole moment

Internuclear distance

Lineshape

Molecular structure

Nuclear quadrupole resonance spectroscopy

Optical coefficient

Point group

Quadrupole coupling

Refractive index

Rotational excitation cross section

May produce corrosive and toxic fumes of hydrogen chloride gas in contact with moist air or water.

Experimental work at Argonne National Laboratory has determined that there is essentially no HCl gas formation; the substance is quite unreactive in water. This does not prevent HCl formation by a catalytic mechanism, but under normal conditions methanesulfonyl chloride is quite unreactive (Argonne Report ANL/DIS-00-1, October 2000).

Acyl Halides, Sulfonyl Halides, and Chloroformates

Water-Reactive

METHANESULFONYL CHLORIDE reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

The substance can be absorbed into the body by inhalation, by ingestion and through the skin.

Cough. Sore throat. Burning sensation. Laboured breathing. Shortness of breath.

Redness. Pain. Blisters.

Redness. Pain. Severe burns.

See Inhalation.

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LCLo = 620 mg/m3/6hr

LD50 Rat oral 255 mg/kg

LC50 Rat inhalation 200 ppm/1 hr

LC50 Rat inhalation (4 hr) = 0.117 mg/l

LC50 Rat inhalation 25 ppm/4 hr

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Aggressive airway control may be needed. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Monitor for shock and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... /Organophosphates and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously and consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... Administer atropine. Correct hypoxia before giving atropine ... Administer pralidoxime chloride (2 PAM). USE UNDER DIRECT PHYSICIAN ORDERS ONLY ... Treat seizures with adequate atropinization and correction of hypoxia. In rare cases diazepam or lorazepam may be necessary ... Watch for signs of fluid overload ... Use proparacaine hydrochloride to assist eye irrigation ... /Organophosphates and related compounds/

/SIGNS AND SYMPTOMS/ Methanesulfonyl chloride is corrosive to eyes, skin, and mucous membranes.

/LABORATORY ANIMALS: Acute Exposure/ The 1-hr and 4-hr inhalation LC50 values in rats were approximately 200 ppm and 25 ppm, respectively. Clinical signs during exposure included salivation and marked eye and respiratory tract irritation. Effects noted postexposure included lethargy, persistent disturbances in respiratory pattern, decreases in body weight and food and water intake, lung congestion, and damage to the corneal surface of the eyes.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 7:747]

/LABORATORY ANIMALS: Acute Exposure/ In rabbits, irrigation of the eye 20 to 30 sec after instillation reduced the response, but corneal opacity and congestion of the iris with no pupillary light reaction were still noted.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 7:747]

/LABORATORY ANIMALS: Acute Exposure/ A single dermal application of 2000 mg/kg to rabbits killed all animals within 24 hr. No deaths occurred following a dermal application of 200 mg/kg.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 7:747]

/LABORATORY ANIMALS: Acute Exposure/ The oral LD50 in rats was 255 mg/kg and there were clinical signs of hypertonia, general distress, and stomach irritation.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 7:747]

For more Non-Human Toxicity Excerpts (Complete) data for METHANESULFONYL CHLORIDE (6 total), please visit the HSDB record page.

LC50 Menidia beryllina (inland silverside, length 40-100 mm) 15 mg/L/96 hr; static, 20 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3

LC50 Menidia beryllina (inland silverside) 15 mg/L/96 hr; static bioassay in synthetic seawater at 23 °C, mild aeration applied after 24 hr.

LC50 Lepomis macrochirus (bluegill sunfish) 11 mg/L/96 hr; static bioassay in freshwater at 23 °C, mild aeration applied after 24 hr

LC50 Lepomis macrochirus (bluegill, length 33-75 mm) 11 mg/L/96 hr; static, 23 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3

The substance is harmful to aquatic organisms.

Methylsulfonyl chloride's production and use in flame-resistant products, as a stabilizer for liquid sulfur trioxide, as a biological chemical, a chemical intermediate in the photographic, fiber dye, agricultural, and pharmaceutical industries, a catalyst, curing agent, and chlorinating agent may result in its release to the environment through various waste streams . If released to air, an estimated vapor pressure of 3.1 mm Hg at 25 °C indicates methanesulfonyl chloride will exist solely as a vapor in the atmosphere. Vapor-phase methanesulfonyl chloride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 150 days. Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, methanesulfonyl chloride is expected to have very high mobility based upon an estimated Koc of 6.1. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole. Methanesulfonyl chloride may volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not available. If released into water, methanesulfonyl chloride is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 15 hours and 11 days, respectively. An estimated BCF of 1.9 suggests the potential for bioconcentration in aquatic organisms is low. Methanesulfonyl chloride hydrolyzes slowly in water. Occupational exposure to methanesulfonyl chloride may occur through inhalation and dermal contact with this compound at workplaces where methanesulfonyl chloride is produced or used. Monitoring data indicate that the general population may be exposed to methanesulfonyl chloride via ingestion of drinking water where it was used as a chlorinating agent and dermal contact with this compound via consumer products containing this compound. (SRC)

Methanesulfonyl chloride's production and use in flame-resistant products, as a stabilizer for liquid sulfur trioxide, as a biological chemical, as a chemical intermediate(1) in the photographic, fiber dye, agricultural, and pharmaceutical industries, a catalyst, curing agent, and chlorinating agent(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 6.1(SRC), determined from a structure estimation method(2), indicates that methanesulfonyl chloride is expected to have very high mobility in soil(SRC). Volatilization of methanesulfonyl chloride from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Methanesulfonyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.1 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2007).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 6.1(SRC), determined from a structure estimation method(2), indicates that methanesulfonyl chloride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 15 hours and 11 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 1.9(SRC), from an estimated log Kow of 1.3(SRC) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Methanesulfonyl chloride hydrolyzes slowly in water(7). Biodegradation data were not available(SRC, 2007).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methanesulfonyl chloride, which has an estimated vapor pressure of 3.1 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methanesulfonyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 150 days(SRC), calculated from its rate constant of 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of methanesulfonyl chloride with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 150 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Methanesulfonyl chloride hydrolyzes slowly in water(2). Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(3).

An estimated BCF of 1.9 was calculated for methanesulfonyl chloride(SRC), using an estimated log Kow of 1.3(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of methanesulfonyl chloride can be estimated to be 6.1(SRC). According to a classification scheme(2), this estimated Koc value suggests that methanesulfonyl chloride is expected to have very high mobility in soil.

The Henry's Law constant for methanesulfonyl chloride is estimated as 4.4X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that methanesulfonyl chloride is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 15 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 11 days(SRC). Methanesulfonyl chloride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Methanesulfonyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.1 mm Hg(SRC), determined from a fragment constant method(3).

DRINKING WATER: Methanesulfonyl chloride was detected and identified as an ozonation byproduct in ozone treated water that was collected from Jefferson Parish, LA in January 1994, August 1994, May 1995, and September 1996(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 851 workers (187 of these are female) are potentially exposed to methanesulfonyl chloride in the US(1). Occupational exposure to methanesulfonyl chloride may occur through inhalation and dermal contact with this compound at workplaces where methanesulfonyl chloride is produced or used(SRC). Monitoring data indicate that the general population may be exposed to methanesulfonyl chloride via ingestion of drinking water where it was used as a chlorinating agent and dermal contact with this compound via consumer products containing this compound(SRC).

Methylsulfonyl chloride was detected in workplace air samples at a softwood and hardwood kraft pulp mill which utilized chlorine-containing bleaching agents. Six samples were positive with concentrations ranging from 2-20 ug/cu m, median was 6 ug/cu m(1) in the softwood bleaching plant. 34 samples were positive with concentrations ranging from 0.9 to 4.5 ug/cu m, median was 2.2 ug/cu m(1) in the hardwood bleaching plant.

LC50 Menidia beryllina (inland silverside, length 40-100 mm) 15 mg/L/96 hr; static, 20 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3

LC50 Menidia beryllina (inland silverside) 15 mg/L/96 hr; static bioassay in synthetic seawater at 23 °C, mild aeration applied after 24 hr.

LC50 Lepomis macrochirus (bluegill sunfish) 11 mg/L/96 hr; static bioassay in freshwater at 23 °C, mild aeration applied after 24 hr

LC50 Lepomis macrochirus (bluegill, length 33-75 mm) 11 mg/L/96 hr; static, 23 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3

The substance is harmful to aquatic organisms.

Methylsulfonyl chloride's production and use in flame-resistant products, as a stabilizer for liquid sulfur trioxide, as a biological chemical, a chemical intermediate in the photographic, fiber dye, agricultural, and pharmaceutical industries, a catalyst, curing agent, and chlorinating agent may result in its release to the environment through various waste streams . If released to air, an estimated vapor pressure of 3.1 mm Hg at 25 °C indicates methanesulfonyl chloride will exist solely as a vapor in the atmosphere. Vapor-phase methanesulfonyl chloride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 150 days. Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, methanesulfonyl chloride is expected to have very high mobility based upon an estimated Koc of 6.1. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole. Methanesulfonyl chloride may volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not available. If released into water, methanesulfonyl chloride is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 15 hours and 11 days, respectively. An estimated BCF of 1.9 suggests the potential for bioconcentration in aquatic organisms is low. Methanesulfonyl chloride hydrolyzes slowly in water. Occupational exposure to methanesulfonyl chloride may occur through inhalation and dermal contact with this compound at workplaces where methanesulfonyl chloride is produced or used. Monitoring data indicate that the general population may be exposed to methanesulfonyl chloride via ingestion of drinking water where it was used as a chlorinating agent and dermal contact with this compound via consumer products containing this compound. (SRC)

Methanesulfonyl chloride's production and use in flame-resistant products, as a stabilizer for liquid sulfur trioxide, as a biological chemical, as a chemical intermediate(1) in the photographic, fiber dye, agricultural, and pharmaceutical industries, a catalyst, curing agent, and chlorinating agent(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 6.1(SRC), determined from a structure estimation method(2), indicates that methanesulfonyl chloride is expected to have very high mobility in soil(SRC). Volatilization of methanesulfonyl chloride from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Methanesulfonyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.1 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2007).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 6.1(SRC), determined from a structure estimation method(2), indicates that methanesulfonyl chloride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 15 hours and 11 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 1.9(SRC), from an estimated log Kow of 1.3(SRC) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Methanesulfonyl chloride hydrolyzes slowly in water(7). Biodegradation data were not available(SRC, 2007).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methanesulfonyl chloride, which has an estimated vapor pressure of 3.1 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methanesulfonyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 150 days(SRC), calculated from its rate constant of 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of methanesulfonyl chloride with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 150 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Methanesulfonyl chloride hydrolyzes slowly in water(2). Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(3).

An estimated BCF of 1.9 was calculated for methanesulfonyl chloride(SRC), using an estimated log Kow of 1.3(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of methanesulfonyl chloride can be estimated to be 6.1(SRC). According to a classification scheme(2), this estimated Koc value suggests that methanesulfonyl chloride is expected to have very high mobility in soil.

The Henry's Law constant for methanesulfonyl chloride is estimated as 4.4X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that methanesulfonyl chloride is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 15 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 11 days(SRC). Methanesulfonyl chloride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Methanesulfonyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.1 mm Hg(SRC), determined from a fragment constant method(3).

DRINKING WATER: Methanesulfonyl chloride was detected and identified as an ozonation byproduct in ozone treated water that was collected from Jefferson Parish, LA in January 1994, August 1994, May 1995, and September 1996(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 851 workers (187 of these are female) are potentially exposed to methanesulfonyl chloride in the US(1). Occupational exposure to methanesulfonyl chloride may occur through inhalation and dermal contact with this compound at workplaces where methanesulfonyl chloride is produced or used(SRC). Monitoring data indicate that the general population may be exposed to methanesulfonyl chloride via ingestion of drinking water where it was used as a chlorinating agent and dermal contact with this compound via consumer products containing this compound(SRC).

Methylsulfonyl chloride was detected in workplace air samples at a softwood and hardwood kraft pulp mill which utilized chlorine-containing bleaching agents. Six samples were positive with concentrations ranging from 2-20 ug/cu m, median was 6 ug/cu m(1) in the softwood bleaching plant. 34 samples were positive with concentrations ranging from 0.9 to 4.5 ug/cu m, median was 2.2 ug/cu m(1) in the hardwood bleaching plant.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Isolation and Protective Action Distances for Methanesulfonyl chloride [Table#5455]

/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

For more DOT Emergency Guidelines (Complete) data for METHANESULFONYL CHLORIDE (9 total), please visit the HSDB record page.

UN 3246; Methanesulfonyl chloride

IMO 6.1; Methanesulfonyl chloride

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Poison Inhalation Hazard Corrosive

Airtight. Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

UN Hazard Class: 6.1; UN Subsidiary Risks: 8; UN Pack Group: I