Sodium Cacodylate

H301 (96.3%): Toxic if swallowed [Danger Acute toxicity, oral]

H331 (92.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H400 (87%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (94.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 54 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Warning: Effects usually appear within 30 to 60 minutes but may be delayed for several hours. Caution is advised.

Signs and Symptoms of Acute Sodium Cacodylate Exposure: Acute exposure to sodium cacodylate may be fatal. Headache, red-stained eyes, and a garlicky odor of the breath may be the first effects noticed. Other signs and symptoms include generalized weakness, intense thirst, muscle cramping, seizures, toxic delirium, and shock. Nausea, vomiting, anorexia, abdominal pain, and diarrhea may occur. Hypotension (low blood pressure), tachycardia (rapid heart rate), pulmonary edema, ventricular fibrillation, and other cardiac abnormalities are usually found following severe exposure. Sodium cacodylate is corrosive to the skin, eyes, and mucous membranes.

Emergency Life-Support Procedures: Acute exposure to sodium cacodylate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to sodium cacodylate.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. RUSH to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to sodium cacodylate.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas for at least 15 minutes with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. RUSH to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.

4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. RUSH to a health care facility. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

(Non-Specific -- Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard area. Stay upwind; keep out of low areas. Wear self-contained breathing apparatus and full protective clothing. Move container from fire area, if you can do so without risk.

(Non-Specific -- Pesticide, Solid, n.o.s.) Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam. (EPA, 1998)

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical or carbon dioxide. Keep runoff water out of sewers and water sources.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Cover with plastic sheet to prevent spreading.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Storage: To convert the gas-cleaning residues obtained during the metallurgical processing of arsenic-containing ores into a portable and less water-soluble form, the metals are precipitated as hydroxides by using an excess of lime water and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal.

Keep out of reach of children. ... Avoid inhalation of spray mist. Avoid spray drift to desirable plants.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.

Personnel protection: ... Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment.

ELECTRON MICROSCOPISTS SHOULD SEE THAT EXTREME CARE IS EXCERCISED DURING PREPN OF CACODYLATE BUFFERS.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Do not store near fertilizers, seeds, insecticide, or fungicides.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

3.2 [mg/m3]

86 [mg/m3]

510 [mg/m3]

0.5 [mg/m3], as As

Acute Oral: 0.005 mg/kg/day (L134)

Chronic Oral: 0.0003 mg/kg/day (L134)

Chronic Inhalation: 0.01 mg/m3 (L134)

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu m; Romania and Switzerland, 0.2 mg/cu m; Sweden 0.05 mg/cu m; and Italy 0.25 mg/cu m. /Arsenic and sol cmpd/

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Rubber gloves, goggles or face shield for eye protection, rubber apron.

Personnel protection: ... Avoid bodily contact with the material. ... Wear appropriate chemical protective clothing.

Sodium cacodylate appears as a white crystalline or granular solid with a slight odor. Toxic by ingestion, inhalation, and skin absorption. Used as a herbicide.

Trihydrate: White deliquescent solid; [Hawley] Colorless to light yellow odorless solid; [HSDB] White to yellowish odorless solid; [MSDSonline]

Colorless to light yellow

Crystalline solid

140 °F 140 °F for trihydrate. Liquifies in water of hydration at 140 °F and becomes anhydrous at 284 °F (EPA, 1998)

MP: APPROX 60 °C; 200 G/100 CC OF WATER @ 15-20 °C; 40 G/100 CC OF ALCOHOL@ 25 °C; 100 G/100 CC OF 90% ALCOHOL @ 15-20 °C /SODIUM CACODYLATE TRIHYDRATE/

Soluble in short chain alcohols; insoluble in diethyl ether.

In water, 2X10+6 mg/l @ 25 °C.

greater than 1 at 68 °F (est) (USCG, 1999)

0.00000003 [mmHg]

When heated to decomposition it emits toxic fumes of /arsenic & sodium oxide/.

Corrodes common metals, but reaction is not hazardous.

pKa = 6.29

Granules; slight odor; liquefies in its water of hydration at about 60 °C; becomes anhydrous at 120 °C; burns with a bluish flame, emitting a garlic-like odor; pH about 8-9 /Sodium cacodylate trihydrate/

Deliquescent; white, amorphous crystals or powder; loses water at 120 °C /Sodium cacodylate trihydrate/

Metals -> Arsenic Compounds, Organic

Carcinogens

Reactive agents - 1st degree

Rodenticides

Active substance -> EU Pesticides database: Not approved

Soluble in water.

Salts, Basic

SODIUM CACODYLATE gives basic solutions in water. Corrodes common metals, but reaction is not hazardous. (USCG, 1999). Liquefies in its own water of crystallization when heated to 60 °C; becomes anhydrous at 120 °C [Merck]. Burns with a bluish flame, emitting a garlic-like odor [Merck].

... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS /IRON, ALUMINUM, OR ZINC, HIGHLY TOXIC FUMES OF ARSENIC ARE EMITTED. /ARSENIC CMPD/

Arsenic and its metabolites disrupt ATP production through different mechanisms. At the level of the citric acid cycle, arsenic inhibits the pyruvate dehydrogenase and uncouples the oxidative phosphorylation by competing with phosphate. This leads to inhibition of energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is increased, leading to oxidative stress due to the formation of reactive oxygen species. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carcinogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: No human data and inadequate data in animals. HUMAN CARCINOGENICITY DATA: None. /cacodylic acid/

2B, possibly carcinogenic to humans. (L135)

3, not classifiable as to its carcinogenicity to humans. (L135)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, especially in skin, liver, bladder and lung cancers. (T1, L20)

Hypovolemia from capillary leakage (third-spacing of fluids) is a common, serious, early effect. Muscle cramps, facial edema, bronchitis, dyspnea, chest pain, dehydration, intense thirst, and fluid-electrolyte disturbances are also common following significant exposures. A garlic-like odor of the breath and feces may also occur. After absorption, arsenic may cause multi-organ failure by inhibiting sulfhydryl-containing enzymes. Encephalopathy, with headache, lethargy, mental confusion, hallucinations, emotional lability, memory loss and delirium may occur; seizures, stupor, convulsions, coma, and death may follow within 24 hours of a severe acute exposure. Dysrhythmias (particularly QTc prolongation and torsade de pointes), cardiomyopathy, ARDS, hepatitis, rhabdomyolysis, hemolysis, and renal failure may develop over several days. The sequence of chronic poisoning involves hyperpigmentation, and eczematoid and allergic dermatitis. muscle fasciculations; gross tremors; ataxia; incoordination; and mental confusion. Muscular weakness, limb tenderness and difficulty walking may follow. The final phase consists of peripheral sensory neuropathy of the hands and feet. That may be associated with a motor neuropathy as well (T36).

Oral (L2) ; inhalation (L2); dermal (L2)

Oral (L2) ; inhalation (L2); dermal (L2)

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of “pins and needles” in hands and feet. Breathing high levels of inorganic arsenic can provoque sore throat or irritated lungs. Arsenic also affects the brain, causing neurological disturbances such as headaches, confusion, and drowsiness. (A1)

Initial signs and symptoms of arsenic ingestion include burning lips, throat constriction and dysphagia, followed by excruciating abdominal pain, hemorrhagic gastritis, gastroenteritis, severe nausea, projectile voting, profuse "rice water-like" diarrhea, with hypovolemia that may result in hypotension and an irregular pulse. The sequence of chronic poisoning involves weakness, anorexia, hepatomegaly, jaundice, and gastrointestinal complaints, followed by conjunctivitis, irritation of the throat and respiratory tract. ther effects of chronic exposure include conjunctivitis with irritation and lacrimation; hair, skin and nail changes; hyperkeratosis of feet and hands; and melanosis, with pigment spots in corneal and conjunctival epithelium. Peripheral nervous system symptoms may include numbness, burning, and tingling of the hands and feet; pain; paresthesias; tenderness (T36).

Chemical: CACODYLIC ACID

Cacodylic acid + sodium salt

Children

General Population

Human Health Benchmarks for Pesticides - 2021 Update

LD50: 644 mg/kg (Oral, Rat) (T14)

LD50: 720 mg/kg (Intraperitoneal, Rat) (T32)

LD50: 2600 mg/kg (Oral, Rat)

LD50 Rat oral 2600 mg/kg

LD50 Mouse oral 4 mg/kg

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Aggressive decontamination with gastric lavage is recommended if the patient has consumed a potentially life-threatening dose and if the patient is not vomiting. Administer charcoal as a slurry (T36).

Muscarinic receptorsare altered by sulfhydryl reagents. Arsenic cmpd, which have been used as insecticides, exert their toxic effects by combining with sulfhydryl groups. The action of arsenicals on the muscarinic receptor from invertebrate and vertebrate species (locust and rat) was compared. Disulfide reducing reagents dithiothreitol and British Anti-Lewisite, but not arsenicals, inhibited (3)H quinuclidinyl benzilate binding. However, after disulfide reduction, arsenicals caused a further inhibition of muscarinic binding. The effect of dithiothreitol + arsenicals was largely irreversible. The locust receptors were more sensitive to the action of both disulfide reagents either in the absence or presence of arsenicals than the rat receptors. The sulfhydryl reagent p-chloromercuric benzoate was more effective at inhibiting the locust receptors than the rat receptors, but addition of arsenicals did not cause further inhibition in either the locust or rat receptors. In locust, dithiothreitol + cacodylate and dithiothreitol + arsenite caused a reduction in the number of sites without modifying the affinity of (3)H quinuclidinyl benzilate binding. In rat, dithiothreitol + arsenite caused a decrease in the affinity, while dithiothreitol + cacodylate caused a decrease in the affinity of (3)H quinuclidinyl benzilate binding and its number of sites. Competition experiments after dithiothreitol + cacodylate showed that the IC50 remained unchanged in the locust. In the rat, the IC50 for atropine was increased and increased for carbachol. These results are explained assuming that the binding site of the locust receptor has a disulfide group similar to that of the mammalian receptor, but that th hydrophobic interactions within the binding site are weaker in the locust receptor.

STRONG GARLIC ODOR IS IMPARTED TO BREATH, SWEAT, & URINE.

Ingestion or excessive inhalation causes irritation of stomach and intestines with nausea, vomiting, diarrhea, shock, rapid pulse, coma.

Irritating to skin and eyes.

APPROX 100 & 1000 UG/L (AS ARSENIC) DID NOT SIGNIFICANTLY AFFECT SURVIVAL OF OTHER TEST SPECIES AFTER 28 DAYS OR REDUCE YOUNG PRODUCTION IN DAPHNIA AFTER 14 DAYS OF EXPOSURE.

EFFECTIVE CONCN CAUSING 50% INHIBITION OF MICROBIAL DEHYDROGENASE ACTIVITY (IC50) WAS CALCULATED. IC50 VALUE FOR SODIUM CACODYLATE WAS 2000 PPM.

The effect of pure sodium cacodylate on dividing cells was studied. The root meristematic cells of Allium cepa leguminosae (the roots were squashed in acetoorcein) and endosperm cells of Haemanthus katherinae Bak. (in vitro observations) were used. Serious disturbances in karyokinesis and cytokinesis were found that led most often to the formation of polyploid or multinucleate (Allium cepa) cells. These results point to damage of the mitotic spindle and phragmoplast.

The induction of hepatic zinc-thionein by various chemical forms of arsenic and modulation by selenium were investigated in mice. The four representative forms of arsenic tested were the organic cmpd methylarsonate and dimethylarsinate, and the inorganic cmpd m-arsenite and arsenate. Male ICR mice were administered doses of respective arsenic cmpd either orally or ip. Twenty-four hours later, livers were assayed for zinc concn by atomic absorption spectrophotometry. Metallothionein determination was made by HPLC/atomic absorption spectrophotometry by cadmium displacement of zinc. The mortality rate of the mice within 24 hr of ip injection as a function of dose indicated that the inorganic arsenic cmpd were much more toxic than the organic arsenic cmpd. The inorganic cmpd also induced hepatic zinc-thionein at doses one order of magnitude lower than the organic cmpd. There were no significant differences in results between oral and ip administration. The coadministration of selenite and m-arsenite ip induced approximately one fifth as much hepatic zinc-thionein as selenite alone but a comparable amount to that of m-arsenite alone. It was concluded that hepatic zinc-thionein induction by the arsenic cmpd examined parallels their respective toxicities. Inhibition of selenite induction of zinc-thionein by m-arsenite could relate to the ability of arsenic and selenium to reduce each other's toxicity.

LC50 Gammarus fasciatus more than 100 mg/l/96 hr at 15 °C, mature, static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l as calcium carbonate and alkalinity of 30-35 mg/l. /Technical material, 100%/

LC50 Palaeminetes 28 mg/l/96 hr at 21 °C, mature (95% confidence limit 14-58 mg/l) Static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l ascalcium carbonate and alkalinity of 30-35 mg/l. /Technical material, 100%; tested in hard water, 272 ppm calcium carbonate/

LC50 Lepomis macrochirus (Bluegill) 17 mg/l/96 hr at 18 °C, wt 0.8 g (95% confidence limit 15-19 mg/l) static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l as calcium carbonate and alkalinity of 30-35 mg/l. /Technical material, 100%/

ORGANOARSENICALS, SUCH AS DIMETHYLARSINIC ACID ... & SODIUM CACODYLATE ARE ADSORBED BY CLAY SOILS. ... DOWNWARD LEACHING OF METHANEARSONIC ACID SALTS HAS ALSO BEEN REPORTED. THE METHANEARSONIC ACID SALTS & DIMETHYLARSINIC ACID ARE FIXED BY IRON & ALUMINUM IN SOIL, ALTHOUGH NOT AS STRONGLY AS INORGANIC ARSENATE.

LC50 Gammarus fasciatus more than 100 mg/l/96 hr at 15 °C, mature, static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l as calcium carbonate and alkalinity of 30-35 mg/l. /Technical material, 100%/

LC50 Palaeminetes 28 mg/l/96 hr at 21 °C, mature (95% confidence limit 14-58 mg/l) Static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l ascalcium carbonate and alkalinity of 30-35 mg/l. /Technical material, 100%; tested in hard water, 272 ppm calcium carbonate/

LC50 Lepomis macrochirus (Bluegill) 17 mg/l/96 hr at 18 °C, wt 0.8 g (95% confidence limit 15-19 mg/l) static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l as calcium carbonate and alkalinity of 30-35 mg/l. /Technical material, 100%/

ORGANOARSENICALS, SUCH AS DIMETHYLARSINIC ACID ... & SODIUM CACODYLATE ARE ADSORBED BY CLAY SOILS. ... DOWNWARD LEACHING OF METHANEARSONIC ACID SALTS HAS ALSO BEEN REPORTED. THE METHANEARSONIC ACID SALTS & DIMETHYLARSINIC ACID ARE FIXED BY IRON & ALUMINUM IN SOIL, ALTHOUGH NOT AS STRONGLY AS INORGANIC ARSENATE.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Storage: To convert the gas-cleaning residues obtained during the metallurgical processing of arsenic-containing ores into a portable and less water-soluble form, the metals are precipitated as hydroxides by using an excess of lime water and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal.

/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.

/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for SODIUM CACODYLATE (8 total), please visit the HSDB record page.

UN 1688; Sodium cacodylate

IMO 6.1; Sodium cacodylate

49 239 85; Sodium cacodylate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.