Chromium Trioxide

H271 (100%): May cause fire or explosion; strong Oxidizer [Danger Oxidizing liquids; Oxidizing solids]

H301 (91.2%): Toxic if swallowed [Danger Acute toxicity, oral]

H310 (45.5%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H311 (46.4%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (26.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330 (91.2%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H334 (97.5%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H340 (99.4%): May cause genetic defects [Danger Germ cell mutagenicity]

H350 (100%): May cause cancer [Danger Carcinogenicity]

H361 (80.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361f (19.9%): Suspected of damaging fertility [Warning Reproductive toxicity]

H372 (99.8%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400 (90.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (91.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P210, P220, P233, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P283, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P317, P318, P319, P320, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P371+P380+P375, P391, P403, P403+P233, P405, P420, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 638 reports by companies from 40 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H290 (100%): May be corrosive to metals [Warning Corrosive to Metals]

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H340 (100%): May cause genetic defects [Danger Germ cell mutagenicity]

H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P210, P220, P233, P234, P260, P261, P264, P270, P271, P272, P273, P280, P283, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P317, P318, P319, P320, P321, P330, P333+P317, P342+P316, P362+P364, P363, P370+P378, P371+P380+P375, P390, P391, P403, P403+P233, P405, P406, P420, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H340: May cause genetic defects [Danger Germ cell mutagenicity]

H350: May cause cancer [Danger Carcinogenicity]

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Contaminated clothing may be a fire risk when dry.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

SMALL FIRE: Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.

LARGE FIRE: Flood fire area with water from a distance. Do not move cargo or vehicle if cargo has been exposed to heat. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

NO water. In case of fire in the surroundings, use appropriate extinguishing media.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Small fire: Use water. Do not use dry chemicals or foams. CO2 or Halon may provide limited control. Large fire: Flood fire area with water from a distance. Do not move cargo or vehicle if cargo has been exposed to heat. Move containers from fire area if you can do it without risk. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

/When fire fighting wear/ self-contained breathing apparatus, with a full facepiece, operated in pressure-demand or other positive pressure mode. /Chromic acid & chromates/

... If involved in a fire decomposes to produce chromium fumes.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

Small Dry Spill

· With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.

Large Spill

· Dike far ahead of spill for later disposal.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· Consider initial downwind evacuation for at least 100 meters (330 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided; Methods and materials for containment and cleaning up: Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wetbrushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

Isolation and Evacuation: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Large spill: Consider initial downwind evacuation for at least 100 meters (330 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Cr(VI) cmpd in waste sludge are completely removed by redn by carbon at 600 °C. /Chromium VI/

Persons not wearing protective equipment and clothing should be restricted from areas of spills until cleanup has been completed. If chromic acid or chromates are spilled, the following steps should be taken: 1. Ventilate area of spill. 2. Collect spilled material in the most convenient and safe manner and deposit in sealed containers for reclamation or for disposal in a secured sanitary landfill. Liquid containing chromic acid or chromates should be absorbed in vermiculite, dry sand, earth, or a similar material. /Chromic acid and chromates/

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D007, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Chromium/

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.

Chemical reduction of concentrated materials to Cr (III) and precipitation by pH adjustment. Precipitates are normally disposed in a chemical waste landfill. Recovery and recycle is a viable alternative to disposal for chromium in plating wastes, tannery wastes, cooling tower blowdown and chemical plant wastes. Recommendable methods: Reduction and precipitation. Not recommendable method: Landfill. Peer-review: Cr (VI) can be removed from solution of low acidity by ion exchange. This can allow recovery of Cr (VI), or the resin can be solidified and disposed of to a landfill. Do not landfill chromium trioxide. Contact with combustible material may cause fire. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Wastewater treatment sludge from the production of chrome green pigments is a poor candidate for incineration. /Chrome green pigments/

For more Disposal Methods (Complete) data for CHROMIC TRIOXIDE (12 total), please visit the HSDB record page.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed. Keep away from sources of ignition - No smoking.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

For more Preventive Measures (Complete) data for CHROMIC TRIOXIDE (12 total), please visit the HSDB record page.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk.

SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.

LARGE SPILL: Dike far ahead of spill for later disposal. (ERG, 2024)

Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents, bases and food and feedstuffs. Well closed. Store in an area without drain or sewer access.

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Heat sensitive. Storage class (TRGS 510): Strongly oxidizing hazardous materials

Storage recommendations: Store in a cool, dry, well-ventilated location. Separate from combustible materials, halogens, sulfides, metals.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

0.0005 [mg/m3]

0.10 [mg/m3]

30 [mg/m3]

(as Cr): Ca TWA 0.0002 mg/m3 (8-hours) See Appendix ASee Appendix C

0.005 [mg/m3], as Cr(VI)

(as CrO3): TWA 0.005 mg/m3 See Appendix C

15 mg Cr(VI)/m3 ; A potential occupational carcinogen. (NIOSH, 2024)

250 mg/cu m (as Cr(II)). /Chromium(II) compounds (as Cr)/

25 mg/cu m (as Cr(III)). /Chromium(III) compounds (as Cr)/

15 mg/cu m (as Cr(VI)). /Chromic acid and chromates/

NIOSH considers chromic acid and chromates to be potential occupational carcinogens. /Chromic acid and chromates/

Ca [15 mg/m3 {as Cr(VI)}]

See: 1333820

0.0002 [mg/m3], as Cr(VI), inhalable particulate matter

0.0005 [mg/m3], as Cr(VI), inhalable particulate matter

8 hr Time Weighted Avg (TWA): 0.5 mg/cu m. /Chromium and Cr(III) inorganic compounds, as Cr/

A4; Not classifiable as a human carcinogen. /Chromium and Cr(III) inorganic compounds, as Cr/

Peak Exposure Recommendation: Transient increases in workers' exposure levels may exceed 3 times the value of the TLV-TWA level for no more than 15 minutes at a time, on no more than 4 occasions spaced 1 hour apart during a workday, and under no circumstances should they exceed 5 times the value of the TLV-TWA level. In addition, the 8-hour TWA is not to be exceeded for an 8-hour work period. /Chromium and Cr(III) inorganic compounds, as Cr/

8 Hr Time Weighted Avg (TWA): 0.05 mg/cu m. /Water-soluble Cr(VI) inorganic compounds, as Cr/

For more Threshold Limit Values (TLV) (Complete) data for CHROMIC TRIOXIDE (11 total), please visit the HSDB record page.

(as Cr(VI), inhalable fraction): 0.0002 mg/m

(as Cr): 0.005 mg/m

(inhalable fraction): skin absorption (H); sensitization of skin (SH); carcinogen category: 1; germ cell mutagen group: 2

Intermediate Oral: 0.005 mg/kg/day (L134)

Chronic Oral: 0.001 mg/kg/day (L134)

Small Fire

· Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.

Large Fire

· Flood fire area with water from a distance.

· Do not move cargo or vehicle if cargo has been exposed to heat.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful concentration of airborne particles can be reached quickly when dispersed.

Chromium trioxide, anhydrous appears as a dark purplish red solid. Under prolonged exposure to fire or heat the containers may explode. Highly toxic. A confirmed human carcinogen.

Liquid; Other Solid; Liquid; Other Solid; Dry Powder; Large Crystals

Dark red to brown crystals, flakes, or powder; [HSDB] Soluble in water; [ACGIH]

ODOURLESS DARK RED DELIQUESCENT CRYSTALS, FLAKES OR GRANULAR POWDER.

CrO3: Dark-red, odorless flakes or powder. [Note: Often used in an aqueous solution (H2CrO4).]

Dark red, bipyramidal prismatic crystals, flakes or granular powder

Brown solid

Flake, ground powder form

Dark-red ... flakes or powder [Note: Often used in an aqueous solution (H2CrO4)]

Odorless

482 °F at 760 mmHg (decomposes) (NTP, 1992)

Approximately 250 °C decomposes

482 °F (Decomposes)

385 °F (NTP, 1992)

387 °F (Decomposes)

Very soluble (NTP, 1992)

Solubility in water, 61.7 g/100 cc solution at 0 °C; 67.45 g/100 cc solution at 100 °C

In water, 169 g/100 g water at 25 °C

In water, 1667 g/L (EU Method A.6 (Water Solubility))

In water, 167.299 lb/100 lb water at 70 °F

Soluble in ethyl alcohol, ethyl ether, sulfuric and nitric acids

For more Solubility (Complete) data for CHROMIC TRIOXIDE (6 total), please visit the HSDB record page.

Solubility in water, g/100ml: 61.7 (good)

2.7 (NTP, 1992) - Denser than water; will sink

2.7 g/cm³

2.70 @25 °C

2.70 (CrO3)

Very low (NIOSH, 2024)

Very low

Stable under recommended storage conditions.

Trivalent chromium is the most stable oxidation state and hexavalent chromium is the second most stable state. /Trivalent and hexavalent chromium/

May ignite organic materials on contact. (USCG, 1999)

Decomposes when heated to 250 °C, liberating oxygen to support combustion.

Decomposes at 250 °C to chromic oxide and oxygen

Decomposes at 250 °C with release of oxygen

Dissolves in water to form a weak acid

Chromium trioxide, CrO3, contains hexavalent chromium. Its molecular weight is 100.01. It is also known as red oxide of chromium, chromic anhydride, chromic acid anhydride and, erroneously, chromic acid.

Heat of fusion: 37.7 cal/g

Deliquescent

Hexavalent chromium is linked to oxygen and is a powerful oxidizer, but it does not form coordination compounds, and is easily reduced to chromium trioxide. /Hexavalent chromium/

Deliquescent. Water soluble, giving acidic solutions.

Anhydrides

Oxidizing Agents, Strong

Strong Oxidizing Agent

Water-Reactive

CHROMIUM TRIOXIDE is a powerful oxidizing agent. Can react violently upon contact with reducing reagents, including organic matter, leading to ignition or explosion. Dangerously reactive with acetone, alcohols, alkali metals (sodium, potassium), ammonia, arsenic, dimethylformamide, hydrogen sulfide, phosphorus, peroxyformic acid, pyridine, selenium, sulfur, and many other chemicals [Sax, 9th ed., 1996, p. 852]. Noncombustible but can accelerate the burning of combustible materials. Sufficient heat may be generated from the reaction with combustible materials to ignite the mass. Aqueous solutions corrode many metals rapidly. Often mixed with sulfuric acid to make "cleaning solution" for glass. Used cleaning solution in closed bottles may explode due to the build up of gaseous carbon dioxide arising from oxidation of organic impurities [Bryson, W. R., Chem. Brit., 1975, 11, p. 377].

Incompatible materials: Organic materials, Phosphorus, powdered metals.

Water-reactive.

Acetylene is oxidized violently.

Stirring chromium trioxide (added in small portions) with unheated /hexamethylphosphoramide/ leads to the formation of a complex useful for oxidizing alcohols to carbonyl derivatives. The trioxide must not be crushed before being added to the solvent, because violent decomposition may then occur.

For more Hazardous Reactivities and Incompatibilities (Complete) data for CHROMIC TRIOXIDE (28 total), please visit the HSDB record page.

Combustible, organic, or other readily oxidizable materials (paper, wood, sulfur, aluminum, plastics, etc.); corrosive to metals

IDENTIFICATION AND USE: Chromic trioxide is a brown solid. It is used Chromium plating, copper stripping, aluminum anodizing, corrosion inhibitor, photography, purifying oil and acetylene, hardening microscopical preparations, oxidizing agent in organic chemistry. It is also has been used as a veterinary medication. HUMAN EXPOSURE AND TOXICITY: Chronic industrial exposures have led to severe liver damage, CNS involvement and perhaps lung cancer. Allergic reactions are common. If ingested, is characterized by fulminant gastroenteritis, shock, and toxic nephritis. Chromium trioxide causes local burns. Levels of Cr VI in the form of chromium trioxide were capable of giving rise to nasal irritation at concentrations as low as 0.06 mg/cu m. In an otorhinolaryngological examination survey of 77 workers from 8 chromium-plating factories ... workers were exposed to a hexavalent chromium trioxide aerosol at levels ranging from 23-681 ug/cu m. Sixteen papillomas of the upper respiratory tract were found in 14 of the 77 workers. The authors compared this prevalence of papillomas of the oral cavity with that of other workers surveyed (10/208) and with that of clinical patients (1/40). Ulcers in 4 of 9 workers exposed to chromic trioxide mist varying from 0.18 to 1.4 mg/cu m in breathing zone have been described. In one of the cases, perforation occurred after one month of exposure. Chromosome aberration rate was significantly increased in cultured human leukocytes treated with (2 & 4 ug/mL) of chromium trioxide hexahydrate (400 & 600 ug/mL). ANIMAL STUDIES: Sarcomas (spindle-cell sarcomas and fibrosarcomas) at the implantation site were seen after 1 year in 15/35 rats implanted im with pellets of 25 mg sintered chromium trioxide. No implantation site tumors were obtained in 35 controls. A group of 43 female mice was exposed by inhalation to chromium trioxide mist (85% of particles > 5 um) generated by a miniaturized electroplating system at a chromium concentration of 1.81 mg/cu m for 120 min twice a week for 12 months, at which time 23 mice were killed. The remaining 20 were killed six months after the last exposure. Nasal perforation was seen in 3/23 and 3/20 mice killed at 12 and 18 months, respectively; 0/23 and 6/20 nasal papillomas occurred in these groups. A single lung adenoma was reported in the group killed at 18 months. No nasal inflammatory change or lung tumor was seen in a group of 20 untreated control mice. Golden hamsters received chromium(VI) trioxide iv on day 8 of pregnancy as either 5, 7.5, 10, or 15 mg/kg body weight. The dose of 15 mg/kg body weight proved to be lethal to 3/4 mother animals. The rate of resorptions increased with the higher doses (29% with 7.5 mg/kg body weight; 41% with 10 mg/kg body weight; 2% in controls), as did the rate of malformations (cleft palate, 85% at 7.5 and 10 mg/kg body weight). With the higher doses, 31% (7.5 mg/kg body weight) and 49% (10 mg/kg body weight) of the fetuses were retarded. Chromic trioxide induced high levels of chromosomal aberrations in mammalian cells. ECOTOXICITY STUDIES: Chromic trioxide inhibited kiwifruit growth and development.

Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produced during reoxidation of pentavalent chromium by hydrogen peroxide molecules present in the cell. Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, chromium-DNA adducts, chromosomal aberrations and alterations in cellular signaling pathways. It has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. It can also cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (A12, L16, A34, A35, A36)

WEIGHT OF EVIDENCE CHARACTERIZATION: Under the current guidelines (1986), Cr(VI) is classified as Group A - known human carcinogen by the inhalation route of exposure. Carcinogenicity by the oral route of exposure cannot be determined and is classified as Group D. Under the proposed guidelines (1996), Cr(VI) would be characterized as a known human carcinogen by the inhalation route of exposure on the following basis. Hexavalent chromium is known to be carcinogenic in humans by the inhalation route of exposure. Results of occupational epidemiological studies of chromium-exposed workers are consistent across investigators and study populations. Dose-response relationships have been established for chromium exposure and lung cancer. Chromium-exposed workers are exposed to both Cr(III) and Cr(VI) compounds. Because only Cr(VI) has been found to be carcinogenic in animal studies, however, it was concluded that only Cr(VI) should be classified as a human carcinogen. Animal data are consistent with the human carcinogenicity data on hexavalent chromium. Hexavalent chromium compounds are carcinogenic in animal bioassays, producing the following tumor types: intramuscular injection site tumors in rats and mice, intrapleural implant site tumors for various Cr(VI) compounds in rats, intrabronchial implantation site tumors for various Cr(VI) compounds in rats and subcutaneous injection site sarcomas in rats. In vitro data are suggestive of a potential mode of action for hexavalent chromium carcinogenesis. Hexavalent chromium carcinogenesis may result from the formation of mutagenic oxidatitive DNA lesions following intracellular reduction to the trivalent form. Cr(VI) readily passes through cell membranes and is rapidly reduced intracellularly to generate reactive Cr(V) and Cr(IV) intermediates and reactive oxygen species. A number of potentially mutagenic DNA lesions are formed during the reduction of Cr(VI). Hexavalent chromium is mutagenic in bacterial assays, yeasts and V79 cells, and Cr(VI) compounds decrease the fidelity of DNA synthesis in vitro and produce unscheduled DNA synthesis as a consequence of DNA damage. Chromate has been shown to transform both primary cells and cell lines. HUMAN CARCINOGENICITY DATA: Occupational exposure to chromium compounds has been studied in the chromate production, chromeplating and chrome pigment, ferrochromium production, gold mining, leather tanning and chrome alloy production industries. Workers in the chromate industry are exposed to both trivalent and hexavalent compounds of chromium. Epidemiological studies of chromate production plants in Japan, Great Britain, West Germany, and the United States have revealed a correlation between occupational exposure to chromium and lung cancer, but the specific form of chromium responsible for the induction of cancer was not identified ... Studies of chrome pigment workers have consistently demonstrated an association between occupational chromium exposure (primarily Cr(VI)) and lung cancer. Several studies of the chromeplating industry have demonstrated a positive relationship between cancer and exposure to chromium compounds. ANIMAL CARCINOGENICITY DATA: Animal data are consistent with the findings of human epidemiological studies of hexavalent chromium ... /Chromium (VI)/

Evaluation: There is sufficient evidence in humans for the carcinogenicity of chromium(VI) compounds. Chromium(VI) compounds cause cancer of the lung. Also positive associations have been observed between exposure to Chromium(IV) compounds and cancer of the nose and nasal sinuses. There is sufficient evidence in experimental animals for the carcinogenicity of chromium(VI) compounds. Chromium(VI) compounds are carcinogenic to humans (Group 1). /Chromium(VI) compounds/

Chromium Hexavalent Compounds: known to be human carcinogens. /Chromium hexavalent compound/

A1; Confirmed human carcinogen. /Water-soluble Cr(VI) inorganic compounds/

A1; Confirmed human carcinogen. /Insoluble Cr(VI) inorganic compounds/

1, carcinogenic to humans. (L135)

Hexavalent chromium is a known carcinogen. Chronic inhalation especially has been linked to lung cancer. Hexavalent chromium has also been known to cause reproductive and developmental defects. (A12)

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, ingestion, skin and/or eye contact

Oral (L16) ; inhalation (L16) ; dermal (L16)

Burning sensation. Sore throat. Cough. Wheezing. Laboured breathing.

Redness. Pain. Skin burns.

Redness. Pain. Blurred vision. Severe burns.

Nausea. Vomiting. Abdominal pain. Burning sensation. Diarrhoea. Shock or collapse.

irritation respiratory system; nasal septum perforation; liver, kidney damage; leukocytosis (increased blood leukocytes), leukopenia (reduced blood leukocytes), eosinophilia; eye injury, conjunctivitis; skin ulcer, sensitization dermatitis; [potential occupational carcinogen]

Breathing hexavalent chromium can cause irritation to the lining of the nose, nose ulcers, runny nose, and breathing problems, such as asthma, cough, shortness of breath, or wheezing. Ingestion of hexavalent chromium causes irritation and ulcers in the stomach and small intestine, as well as anemia. Skin contact can cause skin ulcers. (L16)

Blood, respiratory system, liver, kidneys, eyes, skin

[lung cancer]

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.

NTP Carcinogen - Known to be a human carcinogen.

ACGIH Carcinogen - Confirmed Human.

SURROGATE. Based on Total Chromium -- use 1:6 ratio (x7)

IRIS Current

LC50 (rat) = 167 mg/m3/4 H; [CHEMINFO]

LD50: 80 mg/kg (Oral, Rat) (T14)

LD50: 14 mg/kg (Intraperitoneal, Mouse) (T14)

LD50 Rat oral 135-177 mg chromic trioxide/kg.

LD50 mouse oral 80-114 mg chromic trioxide/kg.

LD50 Rat oral 80 mg/kg

LD50 Mouse oral 127 mg/kg

LD50 Mouse ip 14 mg/kg

There is no known antidote for chromium poisoning. Exposure is usually handled with symptomatic treatment. (L16)

Renal structural and functional alterations following an exposure to a heterogeneous chemical mixture (HCM) of phthalic acid di butyl ester, 1, 2-dichlorobenzene, cadmium chloride and chromium trioxide, administered /to rats/ through oral gavage in low doses (1/100 and 1/1000 of LD50 value of individual chemical) for 60 days, followed by withdrawal /until/ 120 days resulted in significant rise in kidney lipid peroxidation and fall in the activities of enzymatic antioxidants. However, withdrawal of HCM treatment restored most of these altered parameters. Degenerative changes in the kidney included proximal convoluted tubules devoid of brush boarder with cytoplasmic blebbing, dissolution and sloughing of nuclei. Cortical glomeruli were also affected with epithelial disintegration, pyknosis of podocyte nuclei and mesengial cell hyperplasia. The morphological alterations recovered fully in the low dose compared to the high dose treatment group.

This study was conducted to investigate the modulating effects of (-)-epigallocatechin-3-gallate (EGCG), quercetin, and rutin on the genotoxic damage induced by Cr(VI) in polychromatic erythrocytes of CD-1 mice. The animals were divided into the following groups: (i) vehicle only; (ii) flavonoids (10 mg/kg EGCG, 100 mg/kg quercetin, 625 mg/kg rutin, or 100-625 mg/kg quercetin-rutin); (iii) Cr(VI) (20 mg/kg of CrO3); and (iv) flavonoids concomitantly with Cr(VI). All of the treatments were administered intraperitoneally (i.p.). The genotoxic damage was evaluated based on the number of micronucleated polychromatic erythrocytes (MN-PCE) obtained from the caudal vein 0, 24, 48, and 72 hr after treatment. Groups treated with EGCG and quercetin exhibited no significant statistical changes in induction of MN-PCE. However, CrO3 treatment significantly increased MN-PCE induction 24 and 48 hr after injection. Treatment with flavonoids prior to CrO3 exposure decreased MN-PCE induction compared with CrO3 only. The magnitudes of the potency of flavonoids were in the following order: rutin (82%) > quercetin (64%) > quercetin-rutin (59%) and EGCG (44%). The group treated with rutin significantly reduced genotoxic damage in mice treated with Cr(VI) (antioxidant effect). However rutin exerted a marginal genotoxic effect when administered alone (pro-oxidant effect). Our findings suggest protective effects of EGCG, quercetin, and rutin against genotoxic damage induced by Cr(VI).

EC50; Species: /Oncorhynchus mykiss/ (rainbow trout) embryo larva; Concentration: 190 ug/L as chromium for 28 days, with a water hardness of 101 mg/L as calcium carbonate; Effect: death and deformity /Conditions of bioassay not specified/

EC50; Species: Carassius auratus (goldfish) embryo larva; Concentration: 660 ug/L as chromium for 7 days, with a water hardness of 195 mg/L as calcium carbonate; Effect: death and deformity /Conditions of bioassay not specified/

LC50; Species: Ophryotrocha diadema (polychaete worm); Conditions: static; Concentration: 7,500 ug/L as chromium and Ctendrilus seratus (polychaete worm) 4,300 ug/L as chromium.

LC50; Species: Capitella captata (polychaete worm); Conditions: static; Concentration: 8,000 ug/L as chromium (larval) and 5,000 ug/L as chromium (adult); unmeasured method

For more Ecotoxicity Values (Complete) data for CHROMIC TRIOXIDE (34 total), please visit the HSDB record page.

/PLANTS/ Due to its widespread industrial use, chromium is considered a dangerous environmental pollutant. It is known to inhibit plant growth and development. The present study provides ...evidence of the toxicity of this metal on the male haploid generation of a higher plant. Both Cr(III) and Cr(VI) species, supplied as CrCl(3) and CrO(3), respectively, exerted a strong dose-dependent inhibitory effect on kiwifruit pollen tube emergence and growth. Cr(III) resulted more effective than Cr(VI) in the 16-75 uM interval; moreover, complete inhibition of germination was attained at much lower doses than Cr(VI). Also tube morphology was affected. While the plasma membrane was still undamaged in the large majority of the treated pollen grains, dramatic ultrastructural alterations were induced by chromium including chromatin condensation, swelling of mitochondria, cytoplasmic vacuolization, and perturbed arrangement of endoplasmic reticulum cisternae. Thus, it seems that the impact of the two chromium species on kiwifruit pollen may result in severe compromission of both essential structures and functions of the male gametophyte.

The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.

Biological oxygen demand (BOD): none

Using carp (Cyprinus carpio) which were exposed over a 6-week period to chromic trioxide concentrations of 1, 5, 20 and 100 ppb (measured as chromium), the chromium BCF ranged from 4.6 to 72(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC).

According to the 2012 TSCA Inventory Update Reporting data, 4 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of chromium oxide (CrO3) (1333-82-0) in the United States may be as low as <100 workers and as high as 100-499 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 68,271 workers (11,533 of these are female) were potentially exposed to chromic trioxide in the US(1).

Chrome platers are exposed to chromium trioxide (CrO3) and its aqueous solution, chromic acid (H2CrO4). There is no convincing evidence that these highly corrosive soluble chromates pose a lung cancer risk among chrome plater, although the suggestion of an increased risk has been reported. Today, however, there are additives that reduce the escape of mist by reducing bubbling at electrodes, and newer plating methods, including electrolysis plating, and other control measures have greatly reduced exposures to these chromates.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D007, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Chromium/

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.

Chemical reduction of concentrated materials to Cr (III) and precipitation by pH adjustment. Precipitates are normally disposed in a chemical waste landfill. Recovery and recycle is a viable alternative to disposal for chromium in plating wastes, tannery wastes, cooling tower blowdown and chemical plant wastes. Recommendable methods: Reduction and precipitation. Not recommendable method: Landfill. Peer-review: Cr (VI) can be removed from solution of low acidity by ion exchange. This can allow recovery of Cr (VI), or the resin can be solidified and disposed of to a landfill. Do not landfill chromium trioxide. Contact with combustible material may cause fire. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Wastewater treatment sludge from the production of chrome green pigments is a poor candidate for incineration. /Chrome green pigments/

For more Disposal Methods (Complete) data for CHROMIC TRIOXIDE (12 total), please visit the HSDB record page.

/GUIDE 141 OXIDIZERS - TOXIC/ Fire or Explosion: These substances will accelerate burning when involved in a fire. May explode from heat or contamination. Some may burn rapidly. Some will react explosively with hydrocarbons (fuels). May ignite combustibles (wood, paper, oil, clothing, etc.). Containers may explode when heated. Runoff may create fire or explosion hazard. /Chromium trioxide, anhydrous/

/GUIDE 141 OXIDIZERS - TOXIC/ Health: Toxic by ingestion. Inhalation of dust is toxic. Fire may produce irritating, corrosive and/or toxic gases. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution. /Chromium trioxide, anhydrous/

/GUIDE 141 OXIDIZERS - TOXIC/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Chromium trioxide, anhydrous/

/GUIDE 141 OXIDIZERS - TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection. /Chromium trioxide, anhydrous/

For more DOT Emergency Guidelines (Complete) data for CHROMIC TRIOXIDE (8 total), please visit the HSDB record page.

1755 154(acid solution)

1463 141(acid, solid)

UN 1463; Chromium trioxide, anhydrous.

IMO 5.1; Chromic trioxide, anhydrous.

49 185 10; Chromic trioxide

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Chromium trioxide, anhydrous is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Chromium trioxide, anhydrous is included on the dangerous goods list.

Oxidizer Poison Corrosive

Do not transport with food and feedstuffs.

Symbol: O, T+, N; R: 45-46-9-24/25-26-35-42/43-48/23-62-50/53; S: 53-45-60-61; Note: E

UN Hazard Class: 5.1; UN Subsidiary Risks: 6.1 and 8; UN Pack Group: II