Sodium hydrogen difluoride

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (75.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P260, P264, P264+P265, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 238 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P260, P264, P270, P308+P316, P319, P321, P405, and P501 (click each P-code to see the statement)

Call a doctor.

INGESTION: Gastric lavage with lime water or a 1% solution of calcium chloride. Aluminum hydroxide gel should be exceptionally effective for binding flouride.

EYES: Wash with running water or weak boric acid solution followed by water.

SKIN: Wash with soap and water. (USCG, 1999)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. (ERG, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

1.0 [mg/m3], inhalable fraction, as F[German Research Foundation (DFG)]

1.2 [mg/m3]

13 [mg/m3]

79 [mg/m3]

2.5 [mg/m3], as F

500 mg/cu m /Fluorides (as F)/

8 hr Time Weighted Avg (TWA): 2.5 mg/cu m. /Fluorides, as F/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Fluorides, as F/

A4; Not classifiable as a human carcinogen. /Fluorides, as F/

Biological Exposure Index (BEI): Determinant: fluorides in urine; Sampling Time: prior to shift; BEI: 3 mg/g creatinine. Determinant: fluorides in urine; Sampling Time: end of shift; BEI: 10 mg/g creatinine. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. The determinant is nonspecific, since it is also observed after exposure to other chemicals. /Fluorides/

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

USSR & Czechoslovakia: 1 mg/cu m; West Germany & Sweden: 2.5 mg/cu m.

Rubber gloves, safety glasses, self-contained breathing apparatus. (USCG, 1999)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Sodium bifluoride is a white crystalline solid. It is soluble in water. It is corrosive to tissue. It is used as a preservative for anatomical and zoological specimens, in metal plating and for many other uses.

Sodium bifluoride, solution is a white crystalline powder, as an aqueous solution, corrosive irritant to tissues.

Dry Powder; Liquid; Other Solid; Dry Powder; Liquid

White solid; [Merck Index] White odorless pellets; [MSDSonline]

COLORLESS, OR WHITE CRYSTALLINE POWDER, RHOMBOHEDRAL

Decomposes in melting (USCG, 1999)

SOL IN COLD & HOT WATER

2.08 at 68 °F (USCG, 1999) - Denser than water; will sink

2.08 @25 °C

Not flammable (USCG, 1999)

Decomp on heating.

Other Classes -> Fluorides, Inorganic

Corrosives

Reactive agents - 1st degree

Water soluble. Reacts with water liberating heat and forming a corrosive solution. The reaction is not violent.

Reacts with water liberating heat and forming a corrosive solution. The reaction is not violent.

Salts, Acidic

Fluoride Salts, Soluble

Water and Aqueous Solutions

Acidic salts, such as SODIUM BIFLUORIDE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Solutions of sodium bifluoride may contain some hydrofluoric acid, which can cause severe chemical burns and is one of the few materials that can etch glass. Unlike other halide ions, fluoride is quite reactive, acting as a weak base and participating in some unique reactions. In particular, fluorides react strongly with compounds containing calcium, magnesium, or silicon ions, which means that solutions containing soluble fluorides are corrosive to both living tissue and glass.

A4; Not classifiable as a human carcinogen. /Fluorides, as F/

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

From a study of these cases one concludes that a single dose of 5 to 10 g (70 to 140 mg/kg) of sodium fluoride by mouth is almost certain to be lethal in an untreated adult. /Sodium fluoride/

LD50 Rat oral 80 mg/kg /Sodium fluoride/

... Extensive experimental evaluation of possible treatments of hydrofluoric acids burns of rabbit eyes, which, to the extent that rabbit and human eyes are comparable, appears to provide a sound scientific basis for a choice. Fluoride ion is toxic when it gains access to the corneal stroma through damage of the corneal epithelium by low acid pH. ... Compared the results of irrigating burned eyes for 30 minutes with one liter each of a series of substances designed to inactivate fluoride ion, and separately evaluated the toxicity of these substances themselves. ... Subconjunctival injections ... concluded that subconjunctival 10% calcium gluconate or irrigation with 0.2% benzethionum chloride or 0.05% benzalkonium chloride were themselves too injurious to normal rabbit eyes to recommend for clinical use. ... Found the only non-toxic treatment with therapeutic value was a single irrigation with isotonic sodium chloride or magnesium chloride. ... Found that repeated irrigation was inadvisable because it strikingly increased the frequency of corneal ulceration in burned eyes. ... The simplest and most effective first-aid treatment was copious irrigation with water or saline. /Hydrofluoric acid/

Burns of the eye by hydrofluoric acid can be devastating. Anhydrous hydrogen fluoride has been known to destroy the eye and to require enucleation ... . The danger of hydrofluoric acid solutions depends upon the concentration. /Anhydrous hydrogen fluoride/

Industrial experience in chemical manufacturing where a mixture of fluorine, fluorides, and hydrogen fluoride may be present in the air indicates that conjunctival hyperemia in the palpebral tissue occurs commonly, irritation of the eyelids occurs occasionally, but corneal disturbance is rare. /Hydrogen fluoride/

Less than 1 g by mouth, however, has caused dangerous poisoning; whereas 120 g has been survived, probably because of prompt vomiting. Six grams have been administered intravenously to a teenager without signs of systemic toxicity, but the dosage was given intermittently over a period of 9 days. The systemic toxicity of sodium fluosilicate is about equal to that of sodium fluoride, whereas the less soluble cyrolite is much less toxic. /Sodium fluoride/

A remarkable mass of poisoning, involving 263 victims of whom 47 died, occurred at the Oregon State Hospital when sodium fluoride roach powder mistaken for powdered milk was added scrambled eggs. The prepared dish was rejected by some because of a salty or soapy taste and produced numbness of the mouth in others. Toxic signs and symptoms consisted of abrupt and severe nausea, vomiting and diarrhea, followed promptly by abdominal burning and cramps. In many cases blood was noted in the vomitus and feces. General collapse was evidenced by pallor, weakness, shallow pulse and respirations, weak heart sounds, wet cold skin, cyanosis, mydriasis and coma. Some victims also experienced a thick, mucoid discharge from the mouth and nose, paralysis of the muscles of deglutution, painful carpopedalspasms of the extremities and localized or generalized urticaria. /Sodium fluoride/

For more Human Toxicity Excerpts (Complete) data for SODIUM HYDROGEN DIFLUORIDE (6 total), please visit the HSDB record page.

The clastogenic potential of sodium fluoride was determined both in vitro (using cultured human lymphocytes) and in vivo (using the rat bone-marrow micronucleus test). The incidence of chromosome aberrations in human lymphocyte cultures exposed to 20 or 40 ug/ml sodium fluoride (3 and 9% respectively) was significantly increased compared it control cultures (0.5%). However, the incidence of micronucleated polychromatic erythrocytes in male AP rats dosed 1000 mg/kg sodium fluoride (the maximum tolerated dose over 24 hr) or 500 mg/kg sodium fluoride was similar to that in the animals dosed distilled water (vehicle control). Thus, sodium fluoride is clastogenic in vitro but not in vivo.

OCCURS ARTIFICIALLY FROM TIN PLATE PRODUCTION; NEUTRALIZER IN LAUNDRY RINSING OPERATIONS; PRESERVATIVE FOR ZOOLOGICAL & ANATOMICAL SPECIMENS; ETCHING GLASS; ANTISEPTIC.

LEATHER BLEACH

CLEANER FOR STONE & BRICK BUILDING FACES.

OCCURS ARTIFICIALLY FROM TIN PLATE PRODUCTION; NEUTRALIZER IN LAUNDRY RINSING OPERATIONS; PRESERVATIVE FOR ZOOLOGICAL & ANATOMICAL SPECIMENS; ETCHING GLASS; ANTISEPTIC.

LEATHER BLEACH

CLEANER FOR STONE & BRICK BUILDING FACES.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for SODIUM HYDROGEN DIFLUORIDE (8 total), please visit the HSDB record page.

UN 2439; Sodium bifluoride, solid or solution.

IMO 8.0; Sodium bifluoride, solid or solution.

49 323 56; Sodium bifluoride, solution.

49 323 55; Sodium bifluoride, solid

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive