Hydroxylammonium nitrate

H201: (Deleted) Explosive; mass explosion hazard [Danger Explosives]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P203, P210, P230, P240, P250, P260, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P380, P372, P373, P391, P401, P405, and P501 (click each P-code to see the statement)

H201 (100%): (Deleted) Explosive; mass explosion hazard [Danger Explosives]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (99%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Aggregated GHS information provided per 96 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

0.16 [ppm]

24 [ppm]

92 [ppm]

Aqueous solution; [Sigma-Aldrich MSDS]

1.156 @25 °C

Other Uses -> Explosives

Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)

Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137)

Oral (L1137) ; inhalation (L1137)

Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)