sec-butylamine

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P391, P403+P235, P405, and P501 (click each P-code to see the statement)

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H301+H311+H331 (64%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H301 (94.5%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (64.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (67.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (65.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (34.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (64%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H400 (99.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (23.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 164 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting. Thus, the risk of increasing the medical problems by inducing vomiting of a volatile corrosive chemical is very high. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fire Extinguishing Agents Not to Be Used: Water may be ineffective.

Fire Extinguishing Agents: "Alcohol" foam, dry chemical, carbon dioxide (USCG, 1999)

Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Alcohol foam, dry chemical, or carbon dioxide

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.

Vapor is heavier than air and may travel to a source of ignition and flash back.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Small spill: Use absorbent paper to pick up spilled material. Follow by washing surfaces well with soap and water. Seal all wastes in vapor-tight plastic bags for eventual disposal.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Environmental considerations-water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Controlled incineration; incinerator is equipped with a scrubber or thermal unit to reduce NOx emissions. /Butyl Amines/

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. /N-BUTYLAMINE/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Wash thoroughly following contact.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. Do not use water on material itself. Neutralize spilled material with crushed limestone, soda ash, or lime.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

Neutralizing Agents for Acids and Caustics: Flush with water (USCG, 1999)

Fireproof. Separated from strong oxidants and strong acids. Cool. Dry. Keep in a well-ventilated room.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable. /Butyl Amines/

Store in refrigerator. Keep under an inert atmosphere for long-term storage. /Butyl Amines/

Ventilation required during use and storage.

Storage temp: ambient; Venting: Open (flame arrester).

2.0 [ppm]

12.2 [ppm]

15 [ppm]

93 [ppm]

6.1 mg/m

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract.

Repeated or prolonged contact with skin may cause dermatitis.

Chemical safety goggles; rubber gloves and apron; respiratory protective equipment; non-sparking shoes (USCG, 1999)

SRP: When working with strong solutions of acids or bases or other caustic or corrosive materials, always wear a full face mask. When working with caustic or corrosive gases or vapors, a full face mask will not protect the eyes or prevent inhaling the material. A full face respirator is required.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Teflon is recommended by safety equipment suppliers/manufacturers for n-Butylamine and Chlorinated polyethylene (CPE) and VITON/chlorobutylene for Isobutylamine. Contact lenses should not be worn when working with this chemical. Wear dust-proof chemical goggles and face shield unless full face-piece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash. /Butyl Amines/

Chemical safety goggles, rubber gloves and apron; Respiratory protective equipment; Non-sparking shoes.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting.

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety spectacles, face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Sec-butylamine is a white liquid with an odor of ammonia. (USCG, 1999)

Colorless liquid with an ammonia-like odor; [HSDB]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colourless to yellow liquid; Fishy ammonia aroma

Colorless liquid

Amine odor

Ammoniacal

146.3 °F at 760 mmHg (NTP, 1992)

63 °C @760 [mm Hg]

-155 °F (NTP, 1992)

15 °F (NTP, 1992)

-3 °F (-19 °C) (Closed cup)

-9 °C c.c.

Soluble (>=10 mg/ml) (NTP, 1992)

Soluble in water, alcohol, ether, acetone /2-Aminobutane (d) and (l)/; Sol in alcohol, ether, acetone /2-Aminobutane (dl)/

Miscible with most organic solvents

Miscible with ethanol, ether; very soluble in acetone

In water, 1.12X10+5 mg/L at 20 °C

112 mg/mL at 20 °C

Solubility in water: miscible

Soluble in water

Soluble (in ethanol)

0.721 at 68 °F (USCG, 1999) - Less dense than water; will float

0.724 at 20 °C/4 °C

Relative density (water = 1): 0.7

0.715-0.721

0.724 @ 20°C

2.52 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

2.52 (Air=1)

Relative vapor density (air = 1): 2.52

315.37 mmHg (USCG, 1999)

178.0 [mmHg]

178 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 18

178 [mm Hg] @25 °C

log Kow = 0.74

712 °F (USCG, 1999)

When heated to decomposition it emits toxic fumes of nitroxides.

Corrosive to tin, aluminum, and some steels

-3008.6 kJ/mole @ 25 °C

May be sensitive to air. (NTP, 1992). Water soluble.

Amines, Phosphines, and Pyridines

SEC-BUTYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Forms explosive mixture with air. May accumulate static electrical charges, and may cause ignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids causing fire and explosion hazard. Incompatible with organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moitsure. /Butyl Amines/

Incompatible with oxidizing materials.

IDENTIFICATION: sec-Butylamine is a colorless liquid with an ammoniacal odor. It is miscible with water and most organic solvents. Formulated products include phosphate and carbonate salts. Mixed solutions are not stable beyond three days and concentrates or mixed solutions require protection from direct ight or extremes in temperatures. sec-Butylamine is a fungicide particularly effective for the control of fruit rotting fungi. ANIMAL STUDIES: Groups of dogs were administered this compound as the carbonate or acetate salt and data were recorded for heart rate, respiration, blood pressure and EEG apparatus. IV administration of either the acetate or carbonate resulted in elevated blood pressure, heart rate and respiration. Intragastric administration of larger doses resulted in similar responses. Groups of rats 20 males and 20 females were utilized in a two litter generation, four generation. The Fo parents were allowed to bear six additional litters. The F1b, 2b and3b litters were used as parents for the following generation and maintained for varying periods (162-202 days after weaning their respective litters). Reproduction indices, fertility index, sestation index, viability index and lactation index were normal. A reduction of growth was noted throughout the study at the high dietary level. Reproduction was unimpaired for any of the eight litters produced by the Fo generation. Groups of rabbits were fed sec-butylamine phosphate in the diet and subjected to a two generation, one litter per generation reproduction study. Mortality of several animals was evident at the high dose. Animals switched from the high dose to a lower dose had no effect on fertility, duration of gestation, delivery of live progeny or lactation indices in both generations examined. Growth of the progeny in the F1 generation was normal, while it was slightly depressed in the F2. There was no effect of butylamine acetate noted on survival of offspring in either generation. Groups of Dutch Belted does (19 rabbits per group) were administered sec-butylamine daily from Day 8 through 18 of gestation. Mean fetal weights were lower than controls and a decreased viability of live fetuses was noted at the high dose level. There were no differences from controls with respect for reproduction, sex distribution of fetuses or the number of malformations found. Groups of 10 male and 10 female rats were fed sec-butylamine acetate in the diet for 3 months. At the high dose level a significant growth reduction was noted. A dose related leukopenia in both males and females was recorded. Gross and microscopic examination of tissues and organs showed no adverse effects of dietary sec-butylamine. Six male and six female rabbits were treated dermally for 20 days. A surfactant was present in the aqueous solution. The skin of half the animals was abraded prior to the initiation of the study. There was no mortality and only one animal of the abraded group showed adverse reactions (diarrhea) during the study. Growth, clinical chemistry, hematology and gross and microscopic examination of the tissues and organs were normal. The carcinogenic potential of sec-butylamine was judged to be low based on long term studies. In a feeding study using cows, residues of sec-butylamine were found in muscle, liver, fat and kidney. Data on the presence in urine and feces suggest it is easily absorbed in to the blood and excreted in the urine. Urinary samples from two dogs treated with sec-butylamine were acidified and distilled. A diphenylhydrazone was formed which corresponded to the product formed from a reaction with methyl ethyl ketone.[

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Cough. Laboured breathing. Sore throat. Shortness of breath.

Redness. Skin burns. Pain. Blisters.

Redness. Pain. Blurred vision. Severe deep burns.

Diarrhoea. Sore throat. Vomiting. Abdominal pain. Burning sensation. Shock or collapse.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LD50 Hen oral 250 mg/kg

LD50 Rat oral 157.5 mg/kg (male); 146.8 mg/kg (female)

LD50 Dog oral 225 mg/kg

LD50 Rabbit dermal 2500 mg/kg

LD50 Rat oral (female, male) 152 mg/kg

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

/SIGNS AND SYMPTOMS/ Inhalation causes irritation or burns of the respiratory system; Exposure to concentrated vapors can cause asphyxiation. Ingestion causes burns of mouth and stomach. Contact with eyes causes lacrimation, conjunctivitis, burns, corneal edema. Contact with skin causes irritation or burns, dermatitis.

/SIGNS AND SYMPTOMS/ Severe skin irritant. Causes second- and third-degree burns on short contact and is very injurious to the eyes.

/OTHER TOXICITY INFORMATION/ Since the amines are bases and may form strongly alkaline solutions, they can be damaging if splashed in the eye or if allowed to contaminate the skin. ... The lower aliphatic amines are normal constituents of body tissues, so that they occur in a large number of foods, particularly fish, to which they impart a characteristic odor. One area of concern at present is the possibility that some aliphatic amines may react with nitrate or nitrite in vivo to form nitroso compounds, many of which are known to be potent carcinogens in animals ... . /Aliphatic amines/

/LABORATORY ANIMALS: Acute Exposure/ It is a severe dermal irritant although the dermal LD50 in rabbits is 2500 mg/kg.

/LABORATORY ANIMALS: Acute Exposure/ The acute oral LD50 values of /monobutylamines, including sec-butylamine/, were determined in Sprague-Dawley CD rats. Signs of toxicity observed after single oral doses of the monobutylamines included sedation, ataxia, nasal discharge, gasping and salivation followed by convulsions and death at the higher dose levels. Gross pathological examination of animals that died after treatment revealed pulmonary edema. The 14-day, oral single-dose LD50 values (mg/kg) for sec-butylamine were 157.5 for males and 146.8 for females.

/LABORATORY ANIMALS: Acute Exposure/ Seven male rats exposed to saturated vapor (280 mg/L) for 5 hr exhibited intense eye and nose irritation, respiratory difficulty, and convulsions; all died. Cornea lesions were opaque and white, and all other organs appeared normal.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ No effect was noted in a two year feeding study with rats and dogs fed 2500 ppm in diet.

For more Non-Human Toxicity Excerpts (Complete) data for SEC-BUTYLAMINE (8 total), please visit the HSDB record page.

... Employees /with chronic respiratory, skin, or eye disease are/ at increased risk from butylamine exposure. /n-Butylamine/

LC50 Leuciscus idus /Freshwater fish, Ide or Orfe/ 46-68 mg/L for 96 hr. /conditions of bioassay not specified/

EC50; Species: Tetrahymena pyriformis (Ciliate, Log growth phase); Conditions: static, 23 °C; Concentration: 25000 ug/L for 12 hr; Effect: general growth

EC50; Species: Tetrahymena pyriformis (Ciliate, Stationary Growth Phase); Conditions: static, 23 °C; Concentration: 25000 ug/L for 36 hr; Effect: general growth

sec-Butylamine's production may result in its release to the environment through various waste streams; its former use in the US as a fungicide resulted in its direct release to the environment. If released to air, a vapor pressure of 178 mm Hg at 25 °C indicates sec-butylamine will exist solely as a vapor in the atmosphere. Vapor-phase sec-butylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 9 hours. sec-Butylamine does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, sec-butylamine is expected to have high mobility based upon an estimated Koc of 60. The pKa of sec-butylamine is 10.56 indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon its cationic state. sec-Butylamine may volatilize from dry soil surfaces based upon its vapor pressure. In an aerobic screening study, sec-butylamine reached 70 percent of its theoretical BOD after 28 days and in a separate study was identified as being amenable to anaerobic biodegradation. If released into water, sec-butylamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 10.56 indicates sec-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to sec-butylamine may occur through inhalation and dermal contact with this compound at workplaces where sec-butylamine is produced or used. Monitoring and use data indicate that the general population may be exposed to sec-butylamine via ingestion of imported food. (SRC)

... amines from decomposing fish ... /Amines/

sec-Butylamine's production may result in its release to the environment through various waste streams; its former use in the US as a fungicide(1) resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 60(SRC), determined from a log Kow of 0.74(2) and a regression-derived equation(3), indicates that sec-butylamine is expected to have high mobility in soil(SRC). The pKa of sec-butylamine is 10.56(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of sec-butylamine from moist soil surfaces is not expected to be an important fate process given its cationic state(SRC). sec-Butylamine is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). In an aerobic screening study, sec-butylamine reached 70 percent of its theoretical BOD after 28 days(7) and in a separate study was identified as being amenable to anaerobic biodegradation(8).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 60(SRC), determined from a log Kow of 0.74(2) and a regression-derived equation(3), indicates that sec-butylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.56(4) indicates sec-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In an aerobic screening study, sec-butylamine reached 70 percent of its theoretical BOD after 28 days(8) and in a separate study was identified as being amenable to anaerobic biodegradation(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-butylamine, which has a vapor pressure of 178 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-butylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9 hours(SRC), calculated from its rate constant of 4.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). sec-Butylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: sec-Butylamine was readily bio-oxidized in Warburg respirometer studies using aniline-acclimated activated sludge(1). In an aerobic screening test, a 100 ppm sec-butylamine concn, in the presence of activated sludge, reached >60 and 70 percent of its theoretical BOD after 10 and 28 days, respectively(2).

ANAEROBIC: After an acclimation period of 52 days, 66% utilization of sec-butylamine occurred by anaerobic bacteria acclimated to acetate culture(1). sec-Butylamine was identified as being amenable to anaerobic biodegradation(2).

The rate constant for the vapor-phase reaction of sec-butylamine with photochemically-produced hydroxyl radicals has been estimated as 4.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 9 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). sec-Butylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). sec-Butylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for sec-butylamine(SRC), using a log Kow of 0.74(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of sec-butylamine is estimated as 60(SRC), using a log Kow of 0.74(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that sec-butylamine is expected to have high mobility in soil. The pKa of sec-butylamine is 10.56(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 10.56(1) indicates sec-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(2). sec-Butylamine's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of sec-butylamine from dry soil surfaces may exist based upon its vapor pressure of 178 mm Hg(3).

SEDIMENT: A sediment core sample collected from Chesapeake Bay, MD in June 1988, from a depth of 10-15 cm, had a sec-butylamine concentration of 0.05 uM(1).

LC50 Leuciscus idus /Freshwater fish, Ide or Orfe/ 46-68 mg/L for 96 hr. /conditions of bioassay not specified/

EC50; Species: Tetrahymena pyriformis (Ciliate, Log growth phase); Conditions: static, 23 °C; Concentration: 25000 ug/L for 12 hr; Effect: general growth

EC50; Species: Tetrahymena pyriformis (Ciliate, Stationary Growth Phase); Conditions: static, 23 °C; Concentration: 25000 ug/L for 36 hr; Effect: general growth

sec-Butylamine's production may result in its release to the environment through various waste streams; its former use in the US as a fungicide resulted in its direct release to the environment. If released to air, a vapor pressure of 178 mm Hg at 25 °C indicates sec-butylamine will exist solely as a vapor in the atmosphere. Vapor-phase sec-butylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 9 hours. sec-Butylamine does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, sec-butylamine is expected to have high mobility based upon an estimated Koc of 60. The pKa of sec-butylamine is 10.56 indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon its cationic state. sec-Butylamine may volatilize from dry soil surfaces based upon its vapor pressure. In an aerobic screening study, sec-butylamine reached 70 percent of its theoretical BOD after 28 days and in a separate study was identified as being amenable to anaerobic biodegradation. If released into water, sec-butylamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 10.56 indicates sec-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to sec-butylamine may occur through inhalation and dermal contact with this compound at workplaces where sec-butylamine is produced or used. Monitoring and use data indicate that the general population may be exposed to sec-butylamine via ingestion of imported food. (SRC)

... amines from decomposing fish ... /Amines/

sec-Butylamine's production may result in its release to the environment through various waste streams; its former use in the US as a fungicide(1) resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 60(SRC), determined from a log Kow of 0.74(2) and a regression-derived equation(3), indicates that sec-butylamine is expected to have high mobility in soil(SRC). The pKa of sec-butylamine is 10.56(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of sec-butylamine from moist soil surfaces is not expected to be an important fate process given its cationic state(SRC). sec-Butylamine is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). In an aerobic screening study, sec-butylamine reached 70 percent of its theoretical BOD after 28 days(7) and in a separate study was identified as being amenable to anaerobic biodegradation(8).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 60(SRC), determined from a log Kow of 0.74(2) and a regression-derived equation(3), indicates that sec-butylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.56(4) indicates sec-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In an aerobic screening study, sec-butylamine reached 70 percent of its theoretical BOD after 28 days(8) and in a separate study was identified as being amenable to anaerobic biodegradation(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-butylamine, which has a vapor pressure of 178 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-butylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9 hours(SRC), calculated from its rate constant of 4.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). sec-Butylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: sec-Butylamine was readily bio-oxidized in Warburg respirometer studies using aniline-acclimated activated sludge(1). In an aerobic screening test, a 100 ppm sec-butylamine concn, in the presence of activated sludge, reached >60 and 70 percent of its theoretical BOD after 10 and 28 days, respectively(2).

ANAEROBIC: After an acclimation period of 52 days, 66% utilization of sec-butylamine occurred by anaerobic bacteria acclimated to acetate culture(1). sec-Butylamine was identified as being amenable to anaerobic biodegradation(2).

The rate constant for the vapor-phase reaction of sec-butylamine with photochemically-produced hydroxyl radicals has been estimated as 4.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 9 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). sec-Butylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). sec-Butylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for sec-butylamine(SRC), using a log Kow of 0.74(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of sec-butylamine is estimated as 60(SRC), using a log Kow of 0.74(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that sec-butylamine is expected to have high mobility in soil. The pKa of sec-butylamine is 10.56(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 10.56(1) indicates sec-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(2). sec-Butylamine's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of sec-butylamine from dry soil surfaces may exist based upon its vapor pressure of 178 mm Hg(3).

SEDIMENT: A sediment core sample collected from Chesapeake Bay, MD in June 1988, from a depth of 10-15 cm, had a sec-butylamine concentration of 0.05 uM(1).

SOIL: sec-Butylamine was found in the soil (loam) of the Moscow (USSR) region at an unspecified concentration(1).

... Residues /of sec-butylamine from post-harvest treatments/ in citrus fruit (orange, tangarine, mandarin, grapefruit and lemon) ranged from 0.88-7.65 ug/g ... Pome fruit residues ranged from 2.75-11.6 ug/g, with pears (11.2-11.6 ug/g) having 3-4 times higher residues than apples (2.75-3.61 ug/g). Whole green or ripened Cavendish bananas contained residues ranging from 15.1-27.6 ug/g, with 2% or less of the residue being found in the pulp.

sec-Butylamine has been determined to be a volatile component of cattle feed lots, probably from the decomposition of manure(1).

Occupational exposure to sec-butylamine may occur through inhalation and dermal contact with this compound at workplaces where sec-butylamine is produced or used. Monitoring and use data indicate that the general population may be exposed to sec-butylamine via ingestion of food, and dermal contact with this compound and other products containing sec-butylamine. (SRC)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Controlled incineration; incinerator is equipped with a scrubber or thermal unit to reduce NOx emissions. /Butyl Amines/

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. /N-BUTYLAMINE/

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible materials. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Alkylamines, NOS/

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Alkylamines, NOS/

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Alkylamines, NOS/

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing is recommended for fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Alkylamines, NOS/

For more DOT Emergency Guidelines (Complete) data for SEC-BUTYLAMINE (16 total), please visit the HSDB record page.

UN 1125; n-Butylamine

IMO 3.2; n-Butylamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive

Symbol: F, C, N; R: 11-20/22-35-50; S: (1/2)-9-16-26-28-36/37/39-45-61; Note: C

UN Hazard Class: 3; UN Subsidiary Risks: 6.1; UN Pack Group: II