Ethanolamine

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (2 of 4786) of reports.

H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (> 99.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (> 99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (13.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332 (99.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (15.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H412 (13.1%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 4786 reports by companies from 90 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 2 of 4786 reports by companies.

There are 89 notifications provided by 4784 of 4786 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H228 (100%): Flammable solid [Danger Flammable solids]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P240, P241, P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P370+P378, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 59 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H227: Combustible liquid [Warning Flammable liquids]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P210, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P333+P317, P362+P364, P363, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P210, P233, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P403, P405, and P501 (click each P-code to see the statement)

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· Removal of solidified molten material from skin requires medical assistance.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Use water spray, dry chemical "alcohol resistant" foam, or carbon dioxide. Use water to keep fire-exposed containers cool.

Wear special protective clothing and positive pressure self-contained breathing apparatus.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for ammonia and organic ammonia derivatives adapted to the airborne concentration of the substance. Collect leaking liquid in sealable plastic containers. Absorb remaining liquid in inert absorbent. Then wash away with plenty of water. Do NOT let this chemical enter the environment.

Accidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations ... Keep in suitable, closed containers for disposal.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in liquid form, for small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. 4. If in solid form, allow to melt and follow (3) above.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

For more Preventive Measures (Complete) data for 2-AMINOETHANOL (9 total), please visit the HSDB record page.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Separated from strong oxidants, strong acids, aluminium and food and feedstuffs. Dry. Ventilation along the floor. Store in an area without drain or sewer access.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Hygroscopic. Handle and store under inert gas.

Separate from oxidizing materials, acids, and halogens. Store in a cool, dry, well-ventilated location.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

0.2 [ppm]

6.0 [ppm]

50 [ppm]

140 [ppm]

3 ppm (8 mg/m³)

6 ppm (15 mg/m³)

TWA 3 ppm (8 mg/m3) ST 6 ppm (15 mg/m3)

3.0 [ppm]

3 ppm (6 mg/m³)

TWA 3 ppm (6 mg/m3) See Appendix G

30 ppm (NIOSH, 2024)

30.0 [ppm]

Excerpts from Documentation for IDLHs: Other animal data: Cats exposed for 2 hours to vapors of ethanolamine at concentrations reaching 970 ppm displayed vomiting tendencies; mice had no adverse effects from the same exposures [Sidorov et al. 1968]. A single 8­hour exposure to concentrated vapors did not kill any of six rats [UCC 1970]. Guinea pigs survived a 15­minute exposure to ethanolamine at 193 ppm [Treon et al. 1957].

See: 141435

8 hr Time Weighted Avg (TWA): 3 ppm; 15 min Short Term Exposure Limit (STEL): 6 ppm.

3 ppm as TWA; 6 ppm as STEL.

2.5 mg/m

0.51 mg/m

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.

The substance is corrosive to the skin and eyes. Corrosive on ingestion. The vapour is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.

Excerpt from NIOSH Pocket Guide for Ethanolamine:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Ethanolamine appears as a clear colorless liquid with an odor resembling that of ammonia. Flash point 185 °F. May attack copper, brass, and rubber. Corrosive to tissue. Moderately toxic. Produces toxic oxides of nitrogen during combustion.

Liquid; Other Solid; Liquid; CBI; Large Crystals

Colorless, viscous liquid or solid (below 51 degrees F) with an unpleasant, ammonia-like odor; [NIOSH]

COLOURLESS VISCOUS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR.

Colorless, viscous liquid or solid (below 51 °F) with an unpleasant, ammonia-like odor.

Colorless, viscous liquid or solid (below 51 °F)

Unpleasant, ammonia-like

338 °F at 760 mmHg (NTP, 1992)

170.3 °C

171 °C @760 [mm Hg]

50.5 °F (NTP, 1992)

Deliquescent crystals from alcohol, mp: 75-77 °C /Hydrochloride/

200 °F (NTP, 1992)

86 °C (187 °F)

185 °F (85 °C) (closed cup)

85 °C c.c.

greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

In water, 1X10+6 mg/L at 25 °C (miscible)

Miscible with methanol, acetone, glycerin; solubility at 25 °C: in benzene: 1.4%, in ether: 2.1%, in carbon tetrachloride: 0.2%, in n-heptane: less than 0.1%. Immiscible with ether, solvent hexane, fixed oils, although it dissolves many essential oils

Miscible with ethanol, glycerol; soluble in chloroform; slightly soluble in ether, ligroin

1000.0 mg/mL

Solubility in water: freely soluble

Miscible

1.016 at 68 °F (USCG, 1999) - Denser than water; will sink

1.0180 g/cu cm at 20 °C

Relative density (water = 1): 1.02

1.0180 @ 20°C

2.1 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

2.1 (Air = 1)

Relative vapor density (air = 1): 2.1

0.4 mmHg at 68 °F ; 6 mmHg at 140 °F (NTP, 1992)

0.4 [mmHg]

VP: 6 mm Hg at 60 °C

0.404 mm Hg at 25 °C

Vapor pressure, Pa at 20 °C: 53

0.4 mmHg

0.75 [mm Hg] @35 °C

log Kow = -1.31

-1.31 (estimated)

Chemical stability: Absorbs carbon dioxide (CO2) from air. Stable under recommended storage conditions.

Water soluble with evolution of heat.

Alcohols and Polyols

Amines, Phosphines, and Pyridines

ETHANOLAMINE is a base. Reacts with organic acids (acetic acid, acrylic acid), inorganic acids (hydrochloric acid, hydrofluoric acid, nitric acid, sulfuric acid, chlorosulfonic acid), acetic anhydride, acrolein, acrylonitrile, cellulose, epichlorohydrin, mesityl oxide, beta-propiolactone, vinyl acetate. Emits toxic fumes of nitrogen oxides when heated to decomposition [Sax, 9th ed., 1996, p. 1498].

Incompatible materials: Strong acids and oxidizing agents, iron, copper, brass, rubber.

Strong oxidizers, strong acids, iron [Note: May attack copper, brass, and rubber].

Strong alkali. Reacts with oxidizing materials, acids, halogenated hydrocarbons to produce heat. Reacts with iron producing an unstable and pyrophoric complex trisethanolaminoiron.

Mixing acetic acid and 2-aminoethanol in a closed container caused the temperature and pressure to increase. (It was observed when equimolar quantities of 2 chemicals were mixed in a closed container. In some cases the changes were solely vapor pressure effects due to heat of solution.)

For more Hazardous Reactivities and Incompatibilities (Complete) data for 2-AMINOETHANOL (18 total), please visit the HSDB record page.

Strong oxidizers, strong acids, iron [Note: May attack copper, brass, and rubber.]

The CIR Expert Panel concluded that ethanolamine and the 12 related ethanolamine salts, listed below, are safe in the present practices of use and concentration described in this safety assessment (rinse-off products only) when formulated to be non-irritating. The Panel cautioned that ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Ethanolamine...

Safe for use in cosmetics, with qualifications

The CIR Expert Panel concluded that ethanolamine and the 12 related ethanolamine salts, listed below, are safe in the present practices of use and concentration described in this safety assessment (rinse-off products only) when formulated to be non-irritating. The Panel cautioned that ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Monoethanolamine...

IDENTIFICATION AND USE: 2-Aminoethanol is a colorless, viscous liquid or solid (below 51 °F). It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. The dual function groups, amino and hydroxyl, make it useful in cutting fluids and as intermediates in the production of surfactants, soaps, salts, corrosion control inhibitors, and in pharmaceutical and miscellaneous applications. 2-Aminoethanol and other amines appear to be potentially useful components of topical formulations used to decontaminate and protect the skin against chemical warfare agents. As a pharmaceutical adjuvant, it is used as a solvent for fats and oils, and in combination with fatty acids forms soaps in the formulations of various types of emulsion such as lotions and creams. It is used in hydraulic fracturing. HUMAN EXPOSURE AND TOXICITY: A concentration of 5.9% is irritating to human skin. Symptoms associated with CNS depression in humans include increased blood pressure, diuresis, salivation, and pupillary dilation. Large doses produce sedation, coma, and death following depression of blood pressure and cardiac collapse. 2-Aminoethanol inhalation by humans has been reported to cause immediate allergic responses of dyspnea and asthma and clinical symptoms of acute liver damage and chronic hepatitis. ANIMAL STUDIES: Undiluted liquid causes redness and swelling when applied to the skin of the rabbit. Administration of 2-aminoethanol by the intravenous route in dogs produced increased blood pressure, diuresis, salivation, and pupillary dilation. Rats, mice, rabbits, and guinea pigs exposed to vapor or mist at high concentrations (up to 1250 ppm) developed pulmonary, hepatic, and renal lesions. In a 90-day subacute oral toxicity study of 2-aminoethanol in rats that a maximum daily dose of 0.32 g/kg resulted in no effect; 0.64 g/kg/day resulted in altered liver or kidney wt; and at 1.28 g/kg death occurred. It is considered to be liver toxin. No treatment-related effects were noted in dogs administered as much as 22 mg/kg/d of 2-aminoethanol for 2 yr. In developmental studies in rabbits maternal toxicity was seen at the two higher dose levels (25, 75 mg/kg body weight) as skin irritation and at the highest dose level as reduced weight gain. There was no treatment related effect on the incidence of any fetal variation or malformation or on the number of malformed fetuses. 2-Aminoethanol has been demonstrated to be non-mutagenic in the Ames Salmonella typhimurium assay, with and without S9 metabolic activation, using TA 1535, TA 1537, TA 1538, TA 98, and TA 100; and also negative in the Escherichia coli assay, Saccharomyces gene conversion assay, and rat liver chromosome assay. ECOTOXICITY STUDIES: Aquatic toxicity tests were conducted using zebra fish fry (Brachydanio rerio) and the unicellular algae Isochrysis galbana (a flagellate) and Chaetoceros gracilis (a diatom). Inhibition of cell division, chlorophyll content, and (14)CO2 uptake in the algae were sensitive end points. 2-Aminoethanol had an LC50 /in the zebra fish fry/ higher than 5,000 mg/L.

No indication of carcinogenicity to humans (not listed by IARC).

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, ingestion, skin and/or eye contact

Cough. Sore throat. Headache. Shortness of breath. Drowsiness.

MAY BE ABSORBED! Redness. Pain. Skin burns.

Redness. Pain. Severe burns.

Burning sensation. Abdominal pain. Shortness of breath. Shock or collapse.

irritation eyes, skin, respiratory system; drowsiness

Eyes, skin, respiratory system, central nervous system

Chemical: MONOETHANOLAMINE

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

LC50 (mice) > 2,420mg/m3/2H

LD50 Guinea pig oral 620 mg/kg body weight

LD50 Rats oral 10.2 g/kg

LD50 Rat oral 3.32 g/kg

LD50 Rat oral 2,050 mg/kg

For more Non-Human Toxicity Values (Complete) data for 2-AMINOETHANOL (12 total), please visit the HSDB record page.

... Here we investigated hair dye-induced dermatitis and hair loss using in vivo mouse model to uncover the causative ingredients. Commercially available hair dye products or combination of the ingredients of hair dye product were applied topically for 3 days on the dorsum of the female C57BL/6 mice and, dermatitis and hair loss were examined. The mice treated with hair dye products exhibited unequivocal signs of hair loss and dermatitis. To find out causative ingredients, combinations of the representative components of hair dye including reducing agents, the mixture of dye and monoethanolamine (MEA), ammonia, and hydrogen peroxide (H(2)O(2)) were applied and thereafter, hair loss and dermatitis were evaluated. All the groups treated with the combinations containing H(2)O(2) and neutralized dye mixture manifested hair loss and dermatitis. Subsequent experiments revealed that H(2)O(2) and MEA synergistically induced hair loss and dermatitis. Histological examination showed that oxidative stress may be the mechanism underlying hair-dye induced dermatitis. Consistently, H(2)O(2) and MEA synergistically induced oxidative stress and cytotoxicity in human keratinocytes. These results suggest that H(2)O(2) and MEA may be the key causative ingredients for hair dye-associated dermatitis and hair loss.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously ... . If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

With monoethanolamine, if symptoms develop or overexposure is suspected, the following may be useful: liver and kidney function tests. Evaluation by a qualified allergist, including careful exposure history and special testing, may help diagnose skin allergy.

/HUMAN EXPOSURE STUDIES/ Numerous publications address the skin sensitizing potential of the short chain alkanolamines triethanolamine (TEA), diethanolamine (DEA), monoethanolamine (MEA), which are not skin sensitizing according to animal studies ... MEA and DEA were patch tested ... in 9602 and 8791 patients, respectively when prevalence of contact allergy was 3.8% and 1.8%. MEA is the prominent allergen in metalworkers with exposure to water-based metalworking fluids (wbMWFs); DEA is probably used in cutting fluids less frequently nowadays. Chronic damage to the skin barrier resulting from wbMWF, the alkalinity of ethanolamines (increasing from TEA to MEA), and other cofactors may contribute to a notable sensitization risk.

/SIGNS AND SYMPTOMS/ ... When undiluted monoethanolamine is applied to human skin on gauze for 1 1/2 hr, only marked redness and infiltration of the skin result.

/SIGNS AND SYMPTOMS/ ... A concentration of 5.9% ethanolamine is irritating to human skin.

/SIGNS AND SYMPTOMS/ Symptoms associated with /CNS depression/ of the ethanolamines /in humans/ include increased blood pressure, diuresis, salivation, and pupillary dilation. Large doses produce sedation, coma, and death following depression of blood pressure and cardiac collapse. /Ethanolamines/

For more Human Toxicity Excerpts (Complete) data for 2-AMINOETHANOL (6 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ /Ethanolamine/ undiluted liquid causes redness and swelling when applied to the skin of the rabbit ...

/LABORATORY ANIMALS: Acute Exposure/ ... Administration of monoethanolamine by the intravenous route in dogs produced increased blood pressure, diuresis, salivation, and pupillary dilation ...

/LABORATORY ANIMALS: Acute Exposure/ In the eye /of rabbits/, a drop of ethanolamine causes injury slightly less than that /caused/ by ammonia (grade 9, on a 1 to 10 scale).

/LABORATORY ANIMALS: Acute Exposure/ /Investigators/ injected ip approximately 168 mg/kg of MEA into male albino mice every day for 4 days. Mice were sacrificed at 6, 12, 24, 48, and 96 hr. At all times from 12 to 96 hr, the liver ethanol kinase levels of the treated mice were significantly higher than control mouse liver levels.

For more Non-Human Toxicity Excerpts (Complete) data for 2-AMINOETHANOL (34 total), please visit the HSDB record page.

EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays; Click on the "Chemical Explorer" button on the tool bar to see the data./[USEPA; ICSS Dashboard Application; Available from, as of December 8, 2014: http://actor.epa.gov/dashboard/]

EC50; Species: Pseudomonas putida (bacteria); Concentration: 12,200 mg/L for 2 hr; Effect: inhibition of NH3- oxidation /Conditions of bioassay not specified in source examined/

LC50; Species: Carassius auratus (Goldfish); Conditions: static; Concentration: 190 mg/L for 24 hr

LC50; Species: Carassius auratus (Goldfish); Conditions: static; Concentration: 170 mg/L for 96 hr

LC50; Species: Gambusia affinis (Western mosquitofish); Concentration: 375 mg/L for 24 hr /Conditions of bioassay not specified in source examined/

For more Ecotoxicity Values (Complete) data for 2-AMINOETHANOL (20 total), please visit the HSDB record page.

/AQUATIC SPECIES/ Monoethanolamine (MEA), diethanolamine (DEA) and triethanolamine (TEA) are compounds with potential acute, sub-chronic and chronic toxicity effects towards aquatic species. A literature review highlighted the existence of a gap in the knowledge on their toxicity with saltwater testing species. A battery of toxicity tests including the alga Phaeodactylum tricornutum Bohlin, the bivalve molluscs Crassostrea gigas (Thunberg) and Mytilus galloprovincialis (Lmk), and the crustacean Artemia franciscana, was considered to update and improve the existing ecotoxicological information. Data were provided as the Effective Concentration that induces a 50% effect in the observed population (EC50), Lowest Observed Effect Concentration (LOEC) and No Observed Effect Concentration (NOEC). EC50, LOEC and NOEC values were compared with a reviewed database containing the existing ecotoxicological data from saltwater organisms.

/AQUATIC SPECIES/ The influence of monoethanolamine (MEA) as a CO(2) absorbent on photoautotrophic culture of CO(2)-fixing microalgae was investigated. When 300 ppm MEA (4.92 mM) was added to blank culture medium, the dissolved inorganic carbon and the molar absorption ratio increased to 51.0 mg/L and 0.34 mol CO2 = mol MEA, respectively, which was an almost 6-fold increase in CO(2) solubility. When free MEA up to 300 mg/L was added to a green alga Scenedesmus sp. culture that was supplied 5% (v/v) CO(2) at 0.1 vvm, both cell growth rate and final cell density were enhanced compared to when no MEA was added. The cell growth rate reached 288.6 mg/L/d, which was equivalent to 539.6 mg CO(2)/L/d as a CO(2)-fixation rate and enhancement of about 63.0% compared to not adding MEA. Chlorophyll-a content and nitrate consumption rate increased correspondingly. MEA doses higher than 400mg/L inhibited cell growth, probably due to toxicity of the carbamate intermediate.

/AQUATIC SPECIES/ ... Aquatic toxicity tests were conducted using zebra fish fry (Brachydanio rerio) and the unicellular algae Isochrysis galbana (a flagellate) and Chaetoceros gracilis (a diatom). Inhibition of cell division, chlorophyll content, and (14)CO2 uptake in the algae were sensitive end points. ... Monoethanolamine had an LC50 /in the zebra fish fry/ higher than 5,000 mg/L.

/PLANTS/ The cowpea aphid Aphis craccivora that infests the black locust Robinia pseudoacacia shows toxicity to its predator, the multicolored Asian ladybird beetle, Harmonia axyridis. In contrast, the same aphid species that infests the common vetch, Vicia angustifolia, is suitable prey for H. axyridis larvae. Previously, it was reported that the toxicity of A. craccivora infesting R. pseudoacacia was due to canavanine and 2-aminoethanol, but there was some doubt about the toxicity of these compounds and their concentrations in the aphids. In the present study, we determined the concentrations of cyanamide, canavanine, and 2-aminoethanol in A. craccivora infesting the two host plants. In the extracts of A. craccivora that infested either of the host plants, canavanine was undetectable, and 2-aminoethanol was detected at the concentration of 3.0-4.0 ug/g fresh weight. Cyanamide was detected in the extract of A. craccivora that infested R. pseudoacacia (7.7 ug/g fresh weight) but not in that infesting V. angustifolia. The toxicity of canavanine, 2-aminoethanol, and cyanamide was evaluated against H. axyridis larvae in a bioassay by using an artificial diet containing these compounds at various concentrations. Cyanamide exhibited 10-100 times stronger toxicity than canavanine and 2-aminoethanol. These results indicate that the toxicity is at least partly due to cyanamide, which is present in the toxic A. craccivora that infests R. pseudoacacia but absent from the non-toxic A. craccivora that infests V. angustifolia.

For more Ecotoxicity Excerpts (Complete) data for 2-AMINOETHANOL (6 total), please visit the HSDB record page.

The substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment in circumstances different to normal use.

2-Aminoethanol's production and use in hydraulic fracturing, as a gas scrubbing agent, as a dispersing agent for agricultural chemicals, as a pharmaceutics aid, as a component in polishes, hair waving solutions, emulsifiers and as a detergent used in dry cleaning and wool treatment may result in its release to the environment through various waste streams. 2-Aminoethanol has been identified as a constituents of mammalian and human urine. If released to air, a vapor pressure of 0.404 mm Hg at 25 °C indicates 2-aminoethanol will exist solely as a vapor in the atmosphere. Vapor-phase 2-aminoethanol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3.6 hours. 2-Aminoethanol does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, 2-aminoethanol is expected to have very high mobility based upon an estimated Koc of 0.59. However, absorption is affected by the acidity of the soil. The pKa of 2-aminoethanol is 9.5, indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. 2-Aminoethanol is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Using standard aerobic biodegradation tests employing activated sludge inoculum, 2-aminoethanol exhibited 64.4 to 91.4% CO2 consumption, suggesting that biodegradation is an important environmental fate process. This compound is considered to be readily biodegradable. If released into water, 2-aminoethanol is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. However, absorption is affected by the acidity of the substrate. A pKa of 9.5 indicates 2-aminoethanol will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to 2-aminoethanol may occur through inhalation and dermal contact with this compound at workplaces where 2-aminoethanol is produced or used. Limited monitoring data indicate that the general population may be exposed to 2-aminoethanol via ingestion of food, use of tobacco products and dermal contact with consumer products containing 2-aminoethanol. (SRC)

A number of aliphatic amines have been identified as normal constituents of mammal and human urine, including ethanolamine(1).

2-Aminoethanol's production and use as a gas scrubbing agent, as a dispersing agent for agricultural chemicals, as a pharmaceutics aid, as a component in polishes, hair waving solutions, emulsifiers(1) and as a detergent used in dry cleaning and wool treatment(2) may result in its release to the environment through various waste streams(SRC). Its use in hydraulic fracturing(3) will result in its direct release to the environment.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 0.59(SRC), determined from a log Kow of -1.31(2) and a regression-derived equation(3), indicates that 2-aminoethanol is expected to have very high mobility in soil(SRC). However, absorption is affected by the acidity of the soil(SRC). The pKa of 2-aminoethanol is 9.5(4), indicating that this compound will exist almost in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. 2-aminoethanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.404 mm Hg at 25 °C(6). Using the Closed Bottle, CO2 Evolution, and MITI tests, 2-aminoethanol exhibited 64.4, 91.4, and 71.2% CO2 evolution, respectively, after 28 days(7), suggesting that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 0.59(SRC), determined from a log Kow of -1.31(2) and a regression-derived equation(3), indicates that 2-aminoethanol is not expected to adsorb to suspended solids and sediment(SRC). However, adsorption can be affected by the acidity of the substrate(SRC). A pKa of 9.5(4) indicates 2-aminoethanol will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Using the Closed Bottle, CO2 Evolution, and MITI tests, 2-aminoethanol exhibited 64.4, 91.4, and 71.2% CO2 evolution, respectively, after 28 days(6), suggesting that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-aminoethanol, which has a vapor pressure of 0.404 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-aminoethanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.6 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Aminoethanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: 2-Aminoethanol, present at 100 mg/L, reached 49.2% (nitrogen dioxide end product)and 93.6% (ammonia end product) of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 ppm in the Japanese MITI test(1). 2-Aminoethanol achieved 91.8% biodegradation after 28 days in a OECD Guideline 301B Sturm Test and 93.4% after 22 days in a Sealed vessel test(2). 2-Aminoethanol, present at 10 ppm, reached 34% of its theoretical BOD in 5 days and 40% of its theoretical BOD in 20 days using a sewage inoculum(3). Other screening studies using a sewage inoculum gave similar results: 2.5 ppm test concentration, 5 day, 61-84% theoretical BOD(4); test concentration not specified, 10 day, 65% theoretical BOD(5); test concentration not specified, 5 day, 71% theoretical BOD, and 98% COD removal(6); 2.5 ppm test concentration, 5, 10, 20 and 50 days - 0, 58.4, 64, 75% theoretical BOD, respectively(7). In a Modified OECD Screening test, 2-aminoethanol, present at 20 mg/L, achieved 94% after 28 days using fresh inoculum and 99% after 28 days using preconditioned inoculum. In the Modified Sturm tests, 2-aminoethanol reached 97% DOC and 92% of its theoretical CO2 in 28 days using fresh inoculum; the compound also reached 96% DOC and 62% of its theoretical CO2 after 28 days using preconditioned inoculum(8). Using an activated sludge inoculum and the Closed Bottle, CO2 Evolution, and MITI tests, 2-aminoethanol starting concentrations of 7.64, 25.4, 76.4, and 100 mg/L exhibited 64.4, 91.4, and 71.2% O2 consumption, respectively, after 28 days; all tests had a lag time of approximately 5 days(9). Using an activated sludge inoculum and the Manometric Respirometry test, 2-aminoethanol starting concentration of 76.4 mg/L exhibited 83.0% O2 consumption, after 28 days with a lag time of approximately 5 days(9).

ANAEROBIC: 2-Aminoethanol, present at 100 mg/L total organic carbon, was shown to be readily biodegradable in 50 days using a digester sludge inoculum at 300 mg/L total COD, obtained from a wastewater treatment plant in Beijing, China(1). 2-Aminoethanol achieved 100% anaerobic biodegradation after 22 days; the initial concentration was unknown(2).

Biological Oxygen Demand (BOD): 78%, 5 days; (theor) 0%, 5 days; 64%, 20 days

Monoethanolamine contained in wastewater from the ethylene manufacturing process is not toxic to aquatic microorganisms participating in biological wastewater treatment, and self-purification of reservoirs when in concn of 200, 300, 50, and 20 mg/L for protozoans, saprophyte bacteria, first phase nitrification bacteria, and second phase nitrification bacteria, respectively.

The rate constant for the vapor-phase reaction of 2-aminoethanol with photochemically-produced hydroxyl radicals has been estimated as 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3.6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Aminoethanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 2-Aminoethanol does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3.2 was calculated in fish for 2-aminoethanol(SRC), using a log Kow of -1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). [

The Koc of 2-aminoethanol is estimated as 0.59(SRC), using a log Kow of -1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-aminoethanol is expected to have very high mobility in soil. Adsorption can be affected by the acidity of the soil(SRC). The pKa of 2-aminoethanol is 9.5(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 9.5(1) indicates 2-aminoethanol will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces and moist soil surfaces is not expected to be an important fate process(2). 2-Aminoethanol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 0.404 mm Hg(3).

2-Aminoethanol was detected, not quantified in 24 Italian Cheeses(1). 2-Aminoethanol was detected in prune, plum, peach and nectarine juices at 1-6, 4, and 1 mg/L(2). 2-Aminoethanol has been identified as a meat volatile of chicken(3).

2-Aminoethanol has been identified in marine and freshwater algae(1).

2-Aminoethanol was detected in the cabin atmosphere of nuclear submarines at < 1 ppm(1). 2-Aminoethanol is present in smoke resulting from charring/burning of chitin, the exoskeleton of crustaceans and insects, at an abundance (percent relative to major compound) of 1.4%(2). 2-Aminoethanol is present in bulk machining fluids used in the automotive parts manufacturing industry at 2-11% by weight(3). The compound was detected in one of five samples (0.10 ppm) in an aircraft maintenance degreasing facility(4). 2-Aminoethenol was detected, not quantified in a formulation for an all purpose cleaner(5).

2-Aminoethanol is a component of tobacco(1,2).

According to the 2012 TSCA Inventory Update Reporting data, 10 reporting facilities estimate the number of persons reasonably likely to be exposed manufacturing, processing, or use of 2-aminoethanol in the United States may be as low as 10 workers and upwards to 499 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,163,087 workers (328,648 of these were female) were potentially exposed to 2-aminoethanol in the US(1). Occupational exposure to 2-aminoethanol may occur through inhalation and dermal contact with this compound at workplaces where 2-aminoethanol is produced or used. Limited monitoring data indicate that the general population may be exposed to 2-aminoethanol via ingestion of food, use of tobacco products and dermal contact with consumer products containing 2-aminoethanol(SRC).

A number of aliphatic amines have been identified as normal constituents of mammalian and human urine, including ethanolamine(1). Average excretion rate: men - 0.162 mg/kg per day; women - 0.492 mg/kg per day; cats 0.47 mg/kg per day; rats - 01.46 mg/kg per day; and rabbits - 1.0 mg/kg per day(1).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Ethanolamine; Ethanolamine, solution; Monoethanolamine/

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Health: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Ethanolamine; Ethanolamine, solution; Monoethanolamine/

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Ethanolamine; Ethanolamine, solution; Monoethanolamine/

/GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Ethanolamine; Ethanolamine, solution; Monoethanolamine/

For more DOT Emergency Guidelines (Complete) data for 2-AMINOETHANOL (8 total), please visit the HSDB record page.

UN 2491; Ethanolamine or ethanolamine solutions

IMO 8; Ethanolamine or ethanolamine solutions

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive

Do not transport with food and feedstuffs.

UN Hazard Class: 8; UN Pack Group: III