Ethyl Acetate

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (3 of 5233) of reports.

H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H319 (91.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H336 (99.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

Aggregated GHS information provided per 5233 reports by companies from 95 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 3 of 5233 reports by companies.

There are 94 notifications provided by 5230 of 5233 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P319, P321, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Rinse contaminated clothes (fire hazard) with plenty of water. Remove contaminated clothes. Rinse skin with plenty of water or shower.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Rinse mouth. Seek medical attention if you feel unwell.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use alcohol-resistant foam, foam, powder, carbon dioxide, fine water spray. In case of fire: keep drums, etc., cool by spraying with water.

Cool exposed containers with water.

Use carbon dioxide, dry chemical, or alcohol foam.

Wear self contained breathing apparatus for fire fighting if necessary.

Flashback along vapor trail may occur.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber. Ethyl acetate should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.

1. By absorbing it in vermiculite, dry sand, earth, or a similar material.

The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Biological treatment.

The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Activated carbon.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U112 and F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Incineration: Burn waste material in an approved waste disposal incinerator.

1. By absorbing it in vermiculite, dry sand, earth, or a similar material. 2. By atomizing in a suitable combustion chamber.

For more Disposal Methods (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.

The worker should immediately wash the skin when it becomes contaminated.

For more Preventive Measures (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids.

Keep tightly closed in cool place.

During transport: stable during transport. Storage temperature: ambient. Venting: open (flame arrester) or pressure-vacuum.

... Containers which are opened must be carefully resealed and kept upright to prevent leakage.

On storage, it is slowly decomposed by water.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

614.0 [ppm]

200.0 [ppm]

1200 [ppm]

1700 [ppm]

10000 [ppm]

400 ppm (1400 mg/m³)

TWA 400 ppm (1400 mg/m3)

400.0 [ppm]

2000 ppm ; Based on 10% of the lower explosive limit. (NIOSH, 2024)

2000.0 [ppm]

Excerpts from Documentation for IDLHs: Workers regularly exposed to concentrations from 375 to 1,500 ppm for several months showed no unusual signs or symptoms [Patty 1963]. Concentrations in the range of 8,000 to 20,000 ppm have been considered dangerous for short exposures [Henderson and Haggard 1943].

2000 ppm (Based on 10% of the lower explosive limit for safety considerations even though the relevant toxicological data indicated that irreversible health effects or impairment of escape existed only at higher concentrations.)

2000 ppm

2000 ppm [10%LEL]

See: 141786

8 hr Time Weighted Avg (TWA): 400 ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

400 ppm as TWA.

400 ppm [1979]

734 mg/m

750 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

· Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

Ethyl acetate appears as a clear colorless liquid with a fruity odor. Flash point 24 °F. Less dense than water. Vapors heavier than air.

Liquid; CBI; Other Solid

A clear colorless liquid with a fruity odor; [CAMEO]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colourless liquid, volatile at low temperatures with a fragrant, acetic, ethereal odour

Colorless liquid with an ether-like, fruity odor.

Clear, volatile

Colorless liquid

CHARACTERISTIC ETHER-LIKE ODOR REMINISCENT OF PINEAPPLE.

Fragrant odor

Ether-like, fruity odor

Fruity with a brandy note

Pleasant taste when diluted

BITTERSWEET, WINE-LIKE BURNING TASTE.

Ethyl acetate ... contributes a fruity flavor to beer.

171 °F at 760 mmHg (NTP, 1992)

Azeotropic mixture with water (6.1% wt/wt), bp: 70.4 °C; azeotropic mixture with water (7.8% wt/wt) and alcohol (9.0% wt/wt), bp: 70.3 °C; Slowly decomposed by moisture, then acquires acid reaction; absorbs water (up to 3.3% wt/wt)

76.50 to 77.50 °C. @ 760.00 mm Hg

77.11 °C @760 [mm Hg]

-118.5 °F (NTP, 1992)

-83.8 °C

-83.6 °C

24 °F (NTP, 1992)

-4 °C c.c.

50 to 100 mg/mL at 70 °F (NTP, 1992)

In water, 8.0X10+4 mg/L at 25 °C

Very soluble in water (64 g/L at 25 °C)

Miscible with ethanol, ethyl ether; very soluble in acetone, benzene

Miscible with chloroform

For more Solubility (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.

80 mg/mL at 25 °C

Solubility in water, g/100ml at 20 °C: 8.7 (poor)

Slightly soluble in ethanol, ether, glycerol, fixed and volatile oils, soluble in water (1ml in 10ml)

(in ethanol)

(77 °F): 10%

0.902 at 68 °F (USCG, 1999) - Less dense than water; will float

0.9003 g/cu cm at 20 °C

DENSITY OF SATURATED AIR (AIR= 1) 1.02; CONVERSION FACTORS: 1 MG/L= 278 PPM; 1 PPM= 3.60 MG/CU M

Relative density (water = 1): 0.9

0.894-0.898

Highly flammable. Slightly soluble in water. This chemical is slowly hydrolyzed by moisture.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

Peroxidizable Compound

CSL00036

THIONYL CHLORIDE + ETHYL ACETATE + IRON

Galvanised drums burst when used for storing thionyl chloride in ethyl acetate

Gas Under Pressure

Bretherick's

CSL00124

PERACETIC ACID + ETHYL ACETATE

Peroxides in ethyl acetate

Corrosive,Explosive,Flammable,Oxidizer

CSL00002 oxidation

peroxides in various batches of ACS-grade ethyl acetate. The level of peroxide in ethyl acetate is not required by ACS.

http://pubs.acs.org/cen/safety/20001218.html

ETHYL ACETATE is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. This chemical may ignite or explode with lithium aluminum hydride. It may also ignite with potassium tert-butoxide. It is incompatible with nitrates, strong alkalis and strong acids. It will attack some forms of plastics, rubber and coatings. It is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. (NTP, 1992). SOCl2 reacts with esters, such as ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).

... can react vigorously with oxidizing materials ... Potentially explosive reaction with lithium tetrahydroaluminate. Ignites on contact with potassium teri-butoxide. Violent reaction with chlorosulfonic acid, (LiAIH2 + 2-chloromethyl furan), oleum.

Incompatible with strong acids; strong alkalies; nitrates, strong oxidizers; chlorosulfonic acid; lithium aluminium hydride ...

Nitrates, strong oxidizers, alkalis & acids.

Nitrates; strong oxidizers, alkalis & acids

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

IDENTIFICATION AND USE: Ethyl Acetate is a colorless liquid with a smell similar to glue or nail polish that is used as an industrial solvent. Ethyl Acetate is used as a solvent for chemical reactions. Because of its odor it is often used in cosmetics and its smell is associated with nail polishes. Additionally, it is used in confectionery, perfumes, and fruits because it evaporates at a fast rate, leaving but the scent of the perfume on the skin. Ethyl acetate is an effective poison for use in insect collector as its vapors are a respiratory tract irritant whose vapors can kill the insect quickly without destroying it, leaving it intact for study. HUMAN EXPOSURE AND TOXICITY: Short-term exposure to high levels of ethyl acetate results first in irritation of the eyes, nose and throat, followed by headache, nausea, vomiting, sleepiness, and unconsciousness. High concentrations can cause CNS depression and congestion of the liver and kidneys. Chronic poisoning has been described as producing anemia, leucocytosis (transient increase in the white blood cell count), and cloudy swelling, and fatty degeneration. Runners were evaluated after complaining of wheezing coughing, rhinitis, or shortness of breath after practicing in a facility under construction. Investigation revealed levels of ethyl acetate and toluene low enough to meet federal guidelines but apparently sufficient to cause symptoms in the athletes. Its carcinogenic properties are not known. Workers who in earlier years had been exposed to ethyl acetate concentrations of 300 mL/cu m and who were exposed at the time of the investigation to 16 mL/cu m were found to have normal sperm quality. ANIMAL STUDIES: In animals it has a narcotic effect at concentrations of over 5000 ppm. Repeated exposures of rabbits to 4450 ppm for 1 hr daily for 40 days resulted in anemia with leukocytosis, and damage to liver and kidneys. Male rats exposed to a high dose (3600 mg/kg/day) of ethyl acetate by gavage showed significant toxic effects, which resulted in depressed body and organ weights, and depressed food consumption. Female rats exposed to the high dose showed slight but non-significant depression of above parameters compared with controls. Exposure of rats to 750 and 1500 ppm ethyl acetate via inhalation for 6 hr per day, 5 days per week for 13 weeks, diminished behavioral responses to unexpected auditory stimuli during the exposure session and appeared to have an acute sedative effect. There were no signs of acute intoxication 30 min after exposure sessions ended. Rats exposed to 750 and 1500 ppm had reduced body weight, body weight gain, feed consumption, and feed efficiency, which fully or partially recovered within 4 weeks. Reductions in body weight gain and feed efficiency were observed in male rats exposed to 350 ppm. The principal behavioral effect of subchronic exposure was reduced motor activity in the 1500 ppm females, an effect that was not present after the 4-week recovery period. All other functional observation battery and motor activity parameters were unaffected, and no pathology was observed in nervous system tissues. In conclusion, there was no evidence that subchronic exposure up to 1500 ppm ethyl acetate produced any enduring neurotoxic effects in rats. Ethyl acetate is strong inducer of aneuploidy in the yeast Saccaromyces cerevisiae, but was negative for mutagenicity in Salmonella typhimurium assays. The solvent yielded negative result in the micronucleus assay in Chinese hamsters in vivo. In vivo hydrolysis of ethyl acetate to acetic acid and ethanol occurred rapidly. ECOTOXICITY STUDIES: Exposure of the common indian catfish (Heteropneustes fossilus) to 170 ppm of ethyl acetate for 3, 6, 12, 48, and 96 hr induced marked changes in carbohydrate metabolism. Hepatic glycogen levels declined significantly at 3, 48, and 96 hr, but there was no marked alteration in muscle glycogen content at any of the exposure periods. Hyperglycemia occurred at all time intervals. Blood pyruvate levels were elevated at 3, 6, 48, and 96 hr. Hyperlacticemia resulted at 3 and 96 hr, but hypolacticemia occurred at 6 and 12 hr. Impairment of carbohydrate metabolism might be responsible for the toxic action of ethyl acetate.

Ethyl acetate

9 x 10 ^-1 mg/kg-day

Volatile Organic Compound (VOC)

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

The substance can be absorbed into the body by inhalation of its vapour.

inhalation, ingestion, skin and/or eye contact

Sore throat. Cough. Headache. Drowsiness.

Redness. Dry skin.

Redness.

irritation eyes, skin, nose, throat; narcosis; dermatitis

Eyes, skin, respiratory system

Neurotoxin - Acute solvent syndrome

Ethyl Acetate

7 x 10^-1 mg/kg-day

7 x 10^-2 mg/m^3

7 x 10^-1 mg/m^3

PDF Document

Inadequate information to assess carcinogenic potential

PPRTV Current

PPRTV Memo

LC50 (mice) = 45,000 mg/m3/2H

LD50 Rat oral 11.3 mL/kg

LD50 Rabbit oral 4.9 g/kg

LC50 Mouse inhalation 1500 ppm/4hr

LC50 Rabbit inhalation 2500 ppm/4hr

For more Non-Human Toxicity Values (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.

Study of 30 workers exposed chronically to 15-50 mg of ethyl acetate in addition to 20 to 80 mg of amyl acetate/L of air showed no ... abnormalities in cornea, merely hyperemia of bulbar conjunctiva. ... Prolonged inhalation may be damaging to lung, liver, kidney, & heart. ... No effect on eyes ... known from systemic absorption.

Ethyl acetate in combination with toluene appeared to produce a mixture of lower toxicity than that of either compound alone. Mixing of ethyl acetate with propylene oxide, propylene glycol, or formalin appears to decr its LD50 value, but its toxicity increases in combination with morpholine, ethylene glycol, or ethyl alcohol.

In order to determine the lung disease potential of waterproofing sprays, several components of suspected sprays, as well as a commercial spray, were tested on CD-l-mice. Mice placed in inhalation chambers were exposed to aerosols containing one or more of the suspected components, including n-heptane, ethyl-acetate, fluororesin, silicone, and a commercial spray. An intermittent inhalation methods was used to prevent the solvents from causing anesthetic death. Mice were sacrificed 1 hour after the end of exposure. The lungs of both exposed and control mice were isolated and examined microscopically for any changes. The amounts released of the were similar. Mice exposed to the commercial and fluororesin sprays were cyanotic and depressed for 1 hour, while those exposed to the other sprays were cyanotic for only several minutes. In almost all mice exposed to the commercial spray, significant changes relative to the controls included a thickened pulmonary alveolar septa, cellular infiltration, fused and hemorrhaged alveolar walls, and diminished alveoli. Fluororesin particles were found in the alveolar space. Significantly more pronounced pathological changes were discovered in mice exposed to the fluororesin spray, relative to the commercial spray. In mice exposed to the silicone spray, significant differences were observed in alveolar collapse and hemorrhage, compared to the controls. The lungs of mice exposed to the N-heptane, ethyl-acetate, and fluororesin free sprays were similar to control lungs. In mice exposed to the silicon resin free spray, significant changes, relative to the commercial spray group, included alveolar collapse, hyperemia, hemorrhage and increased thickness and cellular infiltration of the septum. /It was/ concluded that ethyl-acetate and n-heptane contained in waterproofing sprays do not cause pulmonary disorders. Instead, fluororesin is implicated in respiratory disorders caused by such sprays.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

Consider the points of attack /eyes, skin, respiratory system/ in placement and periodic physical examinations. Evaluate for brain and nervous system damage.

/HUMAN EXPOSURE STUDIES/ A variety of national occupational exposure limits for ethyl acetate exist based on different studies, mostly relying on subjective evaluations of ethyl acetate as an irritant. Only one study also used physiological methods with inconsistent results in subjective and objective data. The present study was designed to investigate ethyl acetate on three different dimensions: behavioral, physiological and psychological indicators of adverse chemosensory effects were investigated during acute exposures to different concentrations of ethyl acetate. Twenty-four subjects were challenged with ethyl acetate in three exposure patterns (2 ppm, 400 ppm, 400 ppm including peaks of 800 ppm). While the odor intensity is rated "strong", trigeminal perceptions were rated less than "moderate". The absence of substantial trigeminal ratings was supported by physiological data. There was neither an effect of concentration on blinking frequency nor on nasal resistance which both are indicators of irritation. Furthermore, there are no effects of ethyl acetate concentration on behavioral measures indicating no olfactory or trigeminally mediated disturbance of cognitive processing. In conclusion, the results of this multilevel approach revealed no adverse chemosensory effects at ethyl acetate concentrations as recommended by the German MAK-value.

/SIGNS AND SYMPTOMS/ The data present does not indicate that ethyl acetate is acute/ly/ toxic. Eye, nose and throat irritation has been reported after human exposure... Neither skin irritation nor sensitization has been reported after human exposure. In one old review there is a statement of sensitization, resulting in inflammation of the mucous membranes and in eczematous eruptions of the skin which is reported to appear in rare cases. ...The data that supports the neurotoxicological properties of ethyl acetate are scarce and often documented lacking necessary data...

/SIGNS AND SYMPTOMS/ Unacclimated subjects found the odor of ethyl acetate objectionably strong at 200 ppm, and mild eye, nose, and throat irritation was experienced at 400 ppm.

/SIGNS AND SYMPTOMS/ SYMPTOMATOLOGY (acute intoxication): 1. Early emotional lability: exhilaration, boastfulness, talkativeness, remorse, and belligerency. 2. Impaired motor coordination: slowed reaction time, slurred speech, ataxia. 3. Sensory disturbances: diplopia, vertigo. 4. Flushing of face, rapid pulse, sweating. 5. Nausea and vomiting. Eventual incontinence of urine and feces. 6. Drowsiness, stupor, and finally coma, with impaired or absent tendon reflexes. Convulsive episodes may indicate hypoglycemia. 7. Pupils dilated or normal. 8. Peripheral vascular collapse (shock); hypotension, tachycardia, cold pale skin, hypothermia. 9. Slow stentorous respiration. 10. Death from respiratory or circulatory failure or from aspiration pneumonitis. 11. During convalescence: postalcoholic headache and gastritis; infections, alcoholic psychoses. /Ethyl alcohol/

For more Human Toxicity Excerpts (Complete) data for ETHYL ACETATE (14 total), please visit the HSDB record page.

LC50; Species: Heteropneustes fossilis (Common Indian catfish); Conditions: /freshwater, static/; Concentration: 212.5 ppm for 96 hr

EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 4300000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation/

EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static, 24 °C, pH 8.0-9.3; Concentration: 3300000 ug/L for 48 hr; Effect: population, decreased biomass /formulation/

EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static, 24 °C, pH 8.0-9.3; Concentration: 5600000 ug/L for 48 hr; Effect: decreased population, general population changes /formulation/

For more Ecotoxicity Values (Complete) data for ETHYL ACETATE (13 total), please visit the HSDB record page.

/AQUATIC SPECIES/ Exposure of the fish /common Indian catfish, Heteropneustes fossilus/ to 170 ppm of ethyl acetate for 3, 6, 12, 48, and 96 hr induced marked changes in carbohydrate metabolism. Hepatic glycogen levels declined significantly at 3, 48, and 96 hr, but there was no marked alteration in muscle glycogen content at any of the exposure periods. Hyperglycemia occurred at all time intervals. Blood pyruvate levels were elevated at 3, 6, 48, and 96 hr. Hyperlacticemia resulted at 3 and 96 hr, but hypolacticemia occurred at 6 and 12 hr. Impairment of carbohydrate metabolism might be responsible for the toxic action of ethyl acetate.

6.20e+02

2.60e+03

7.30e+01

3.10e+02

1.40e+02

2.00e+00

3.10e-02

7.00e-01

7.00e-02

Volatile

1.08e+04

1.90e+03

7.90e+03

2.20e+02

9.20e+02

4.30e+02

Ethyl acetate's production and use in artificial flavoring, as a solvent, in the manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes and in cleaning textiles may result in its release to the environment through various waste streams. Ethyl acetate is a natural product of fermentation. Natural sources of ethyl acetate include animal waste, plant volatiles, and microbes. Ethyl acetate occurs naturally in yeast and sugarcane, where it is photosynthetically produced. It is also released by molds. If released to air, a vapor pressure of 93.2 mm Hg at 25 °C indicates ethyl acetate will exist solely as a vapor in the atmosphere. Vapor-phase ethyl acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 9 days. Ethyl acetate does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, ethyl acetate is expected to have very high mobility based upon an estimated Koc of 18. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 1.34X10-4 atm-cu m/mole. Ethyl acetate may volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 95% of the Theoretical BOD was reached in 2 weeks indicating that biodegradation is an important environmental fate process in soil and water. If released into water, ethyl acetate is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 9 hrs and 6 days, respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Ethyl acetate's hydrolysis half-life at 25 °C and pH 7 is 2 years, indicating that hydrlosys is not an important environmental fate process. Occupational exposure to ethyl acetate may occur through inhalation and dermal contact with this compound at workplaces where ethyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to ethyl acetate via inhalation of ambient air, ingestion of food, and dermal contact with this consumer products containing ethyl acetate. (SRC)

Ethyl acetate is a natural product of fermentation(1,2). Natural sources of ethyl acetate include animal waste, plant volatiles, and microbes(1). Ethyl acetate occurs naturally in yeast and sugarcane, where it is photosynthetically produced. It is also released by molds(3).

Ethyl acetate's production and use as a pharmaceutic aid (flavor); in artificial fruit essences; as a solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacturing smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 18(SRC), determined from a log Kow of 0.73(2) and a regression-derived equation(3), indicates that ethyl acetate is expected to have very high mobility in soil(SRC). Volatilization of ethyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.34X10-4 atm-cu m/mole(4). Ethyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 93.2 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 95% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 18(SRC), determined from a log Kow of 0.73(2) and a regression-derived equation(3), indicates that ethyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 1.34X10-4 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 9 hrs and 6 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 95% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethyl acetate, which has a vapor pressure of 93.2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9 days(SRC), calculated from its rate constant of 1.6X10-12 cu cm/molecule-sec at 25 °C(3). Ethyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Ethyl acetate, present at 100 mg/L, reached 95% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A review concluded that ethyl acetate is easily removed by biological treatment(2). Reported 5 day BOD values using a sewage inoculum range from 36-68% of theoretical(3-6) with the value being somewhat reduced in salt water(3). One investigator reported that ethyl acetate was completely degraded in 20 hr using activated sludge(7). In a bench-scale continuous-flow activated sludge reactor with an 8 hour retention time, 99.9% removal including 17% volatilization loss) was obtained, with 80% of the theoretical BOD(8). Ethyl acetate was 90% biooxidized in a 20-day BOD test using a filtered raw sewage seed; it was biooxidized 77% in a 28-day OECD closed-bottle test(9). A screening procedure that was systematically applied to a large number of organic chemicals ranked ethyl acetate as being completely biodegraded in a short time by general microorganisms(10). After a 5 hr lag, 43 to 53% of theoretical BOD was obtained in 50 to 70 hr(10). In screening tests, ethyl acetate, present at a concentration of 5 ppm, reached 26.6 and 57.1% of its theoretical BOD in 5 days using the standard dilution method and seawater dilution method, respectively(11). 99.9% removal of ethyl acetate was observed in a complete mix continuous-flow activated sludge system; 93% of this removal was attributed to biodegradation(12).

ANAEROBIC: Ethyl acetate has been demonstrated to be amenable to anaerobic biodegradation(1). It was mineralized (>75% of theoretical methane production) in 10% sludge from a secondary digester within 8 weeks(2). 96% utilization occurred in an anaerobic reactor with a 20 day retention time(3). Ethyl acetate, at a concentration of 1000 mg/L, was readily degraded in batch reactors containing anaerobic solids from an industrial anaerobic digester with some exposure to ethyl acetate(4). 100% loss of ethyl acetate was observed in aquifer slurries amended with sulfate and nitrate following 244 days and 85 days incubation, respectively(5). 94% of theoretical methane production was observed after incubation in sediment and groundwater collected from the methanogenic portion of an anoxic aquifer polluted by municipal landfill leachate(6).

The rate constant for the vapor-phase reaction of ethyl acetate with photochemically-produced hydroxyl radicals is 1.60X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 9 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). A base-catalyzed second-order hydrolysis rate constant of 0.12 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 1.8 years and 66 days at pH values of 7 and 8, respectively(3). The observed rate constant for the vapor-phase reaction of ethyl acetate with nitrate radicals is 1.4X1017 cu cm/molecule-sec(3,4). This corresponds to an atmospheric half-life of about 16 years(SRC) at an average night-time nitrate radical concentration of 2X10+8 molecules/cu cm (nitrate radicals are unstable in sunlight)(2). The rate constant for the reaction of ethyl acetate with hydroxyl radicals in aqueous solution is 4.0X10+8 L/mol sec(5). This corresponds to a half-life of about 5.5 years(SRC) at an average aqueous hydroxyl radical concentration of 1X1017 mol/L(6). Simple esters are resistant to hydrolysis; ethyl acetate's hydrolysis half-life at 25 °C and pH 7 is 2.0 years(7). Ethyl acetate does not contain chromophores that absorb at wavelengths >290 nm(8) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated for ethyl acetate(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of ethyl acetate is estimated as 18(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethyl acetate is expected to have very high mobility in soil(SRC). A log Ki (snow surface/air (cu m/sq m)) of -3.69 has been reported for sorption to snow(4).

The Henry's Law constant for ethyl acetate is 1.34X10-4 atm-cu m/mole(1). This Henry's Law constant indicates that ethyl acetate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 9 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 6 days(SRC). Ethyl acetate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Ethyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 93.2 mm Hg(3).

GROUNDWATER: Ethyl acetate was not detected in an aquifer polluted by a paint factory even though ethyl acetate was stored in buried tanks that leaked(1).

DRINKING WATER: Ethyl acetate was detected, not quantified in 3 New Orleans drinking water plants(1). It was detected in drinking water, no levels given(2). Ethyl acetate was identified in commercially bottled Artesian water(3).

SURFACE WATER: Of 14 heavily industrialized river basins in USA (204 sites), only 1 site (Delaware River Basin) tested positive for ethyl acetate, at 1 ppb(1). The concentration in the Hayashida River in Tatsumo City, Japan (site of leather industry) was reported at 585 ppb(2). Ethyl acetate was identified in water samples from the brook, Rickenbach East, Switzerland, which receives discharges from a paint factory(3).

Effluent gas from the metal painting factory and from the lumber painting factory contained ethyl acetate(1). Ethyl acetate emission rate was determined to be 0.10 mg/km following analysis of 205 air samples from the Gubrist highway tunnel, Zurich Switzerland, sampled in 2004(2).

Ethyl acetate was detected, not quantified in oil refinery final effluent(1) and effluent from sewage treatment plants(2). Ethyl acetate has been detected in U.S. municipal landfill leachate at concentrations ranging from 42 to 290 g/L(3). Ethyl acetate was identified, but not quantified, in hazardous waste samples from a Midwest remedial action site(4). Ethyl acetate was detected, but not quantified, in a grab sample of oil refinery final effluent from a refinery in Lockport, IL(5). Ethyl acetate was identified as a volatile organic compound in a composite waste sample obtained from a barge which dumped its waste on Feb 9, 1978 at the Puerto Rico dumpsite(6). Ethyl acetate was identified in flue gas from a waste incineration plant in Germany(7).

URBAN/SUBURBAN: Ethyl acetate was detected, not quantified in Leningrad, USSR(1). Average concentrations of ethyl acetate in urban air samples collected from four different sites in Stockholm ranged from 0.27 to 2.64 ppb; the average concentration at a site 12 km outside Stockholm was 0.23 ppb(2). It was identified in ambient air from Pasadena, TX, Houston, TX, and Glendora, CA(3). Ethyl acetate was detected at an arithmetic mean of 2.6 ug/cu m using 37 outdoor samples from 27 sites in Melbourne, Australia, sampled in summer/early autumn(4).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U112 and F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Incineration: Burn waste material in an approved waste disposal incinerator.

1. By absorbing it in vermiculite, dry sand, earth, or a similar material. 2. By atomizing in a suitable combustion chamber.

For more Disposal Methods (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for ETHYL ACETATE (8 total), please visit the HSDB record page.

UN 1173; Ethyl acetate

IMO 3; Ethyl acetate

49 091 60; Ethyl acetate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: F, Xi; R: 11-36-66-67; S: (2)-16-26-33

UN Hazard Class: 3; UN Pack Group: II