dipropylamine

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H301 (14.5%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (85.5%): Harmful if swallowed [Warning Acute toxicity, oral]

H311+H331 (23.9%): Toxic in contact with skin or if inhaled. [Danger Acute toxicity, dermal; acute toxicity, inhalation]

H311 (80.4%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H312 (19.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (54.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (80.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (19.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (25.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 255 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P321, P330, P361+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

FOAM; DRY CHEMICAL; CARBON DIOXIDE. ... WATER MAY BE INEFFECTIVE.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of confined spaces, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

1. REMOVE ALL IGNITION SOURCES; 2. VENTILATE AREA OF SPILL OR LEAK; 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Environmental considerations-water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors.

[40 CFR 240-280, 300-306, 702-799 (7/1/2006)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U110, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U110, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds.

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.

Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Before entering a confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. Store in Tightly closed containers in a cool, well-ventilated area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and open flames are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.

Storage temp: ambient

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

2.9 [mg/m3]

32 [mg/m3]

190 [mg/m3]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Self-contained breathing apparatus; butyl rubber gloves; butyl rubber apron; face shield (USCG, 1999)

SRP: When working with strong solutions of acids or bases or other caustic or corrosive materials, always wear a full face mask. When working with caustic or corrosive gases or vapors, a full face mask will not protect the eyes or prevent inhaling the material. A full face respirator is required.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. Teflon and Polycarbonate are among the recommended protective materials. Contact lenses should not be worn when working with this chemical. Wear splash-proof chemical goggles and face shield unless full face-piece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.

SELF-CONTAINED BREATHING APPARATUS; BUTYL RUBBER GLOVES; BUTYL RUBBER APRON; FACE SHIELD.

Dipropylamine appears as a clear colorless liquid with an ammonia-like odor. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Colorless liquid with an odor of ammonia; [Merck Index]

Colorless liquid

Water-white liquid

Ammonia odor

228.9 °F at 760 mmHg (NTP, 1992)

109.3 °C

109.3 °C @760 [mm Hg]

-39.3 °F (NTP, 1992)

45 °F (USCG, 1999)

63 °F (17 °C) (open cup)

7 °C (closed cup)

Soluble (>=10 mg/ml) (NTP, 1992)

Miscible in ether, very soluble in acetone, soluble in ethanol

In water, 3.51X10+4 mg/L at 25 °C

0.738 at 68 °F (USCG, 1999) - Less dense than water; will float

0.738 at 20 °C/4 °C

Bulk density = 6.1 lb/gal

Saturated liquid density= 46.010 lb/cu ft @ 70 °C

Saturated vapor density= 0.00771 lb/cu ft @ 70 °C

0.7400 @ 20°C

3.5 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

3.49 (air= 1)

20.1 [mmHg]

20.1 mm Hg at 25 °C

7.5 [mm Hg] @6 °C

log Kow = 1.67

Henry's Law constant = 5.1X10-5 atm-cu m/mole at 25 °C

570 deg F (299 °C)

When heated to decomposition it emits toxic fumes of nitroxides.

0.517 mPa.s at 25 °C

-18,750 BTU/LB= -10,420 CAL/G= -436.0X10+5 J/KG

44.04 kJ/mol at 25 °C

6.58 DYNES/CM= 0.00658 NEWTONS/M @ 20 °C

Odor Threshold Low: 0.1 [ppm]

Odor Threshold High: 0.2 [ppm]

Odor low= 0.4140 mg/ cu m; Odor high= 0.8280 mg/ cu m

Index of refraction: 1.40455 at 20 °C/D

pKb = 3; pKa = 11 (conjugate acid)

Forms a hydrate with water

Highly flammable. Soluble in water.

Amines, Phosphines, and Pyridines

Highly Flammable

DIPROPYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Incompatible with acids, organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks aluminum, copper, lead, tin, zinc, and their alloys.

Can react with oxidizers.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 4,400 mg/m3/4hr

LD50 Rat oral 460 mg/kg

LC50 Rat inhalation >8.22 mg/cu m/1 hr

LC50 Rat inhalation 4400 mg/cu m/4 hr

LC50 Mouse inhalation 3070 mg/cu m/2 hr

For more Non-Human Toxicity Values (Complete) data for DIPROPYLAMINE (9 total), please visit the HSDB record page.

Nitrite ... is used as a food additive in meats and smoked fish. Some fish, vegetables, and fruit juices contain secondary amines. The acidic environment of the stomach facilitates a chemical reaction between nitrite and secondary amines, leading to the formation of carcinogenic nitrosamines. /Secondary amines/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

/SIGNS AND SYMPTOMS/ Inhalation causes severe coughing and chest pain due to irritation of air passages; can cause lung edema; may also cause headache, nausea, faintness, and anxiety. Ingestion causes irritation and burning of mouth and stomach. Contact with eyes causes severe irritation and edema of the cornea. Contact with skin causes severe irritation.

/OTHER TOXICITY INFORMATION/ Moderately toxic by skin contact and inhalation.

/OTHER TOXICITY INFORMATION/ Since the amines are bases and may form strongly alkaline solutions, they can be damaging if splashed in the eye or if allowed to contaminate the skin. Otherwise they have no specific toxic properties, and the lower aliphatic amines are normal constituents of body tissues, so that they occur in a large number of foods, particularly fish, to which they impart a characteristic odor. One area of concern at present is the possibility that some aliphatic amines may react with nitrate or nitrite in vivo to form nitroso compounds, many of which are known to be potent carcinogens in animals ... . /Aliphatic amines/

/LABORATORY ANIMALS: Acute Exposure/ When administered ip to rats, dipropylamine was a moderate inhibitor of liver monoamine oxidase activity. ...

/LABORATORY ANIMALS: Acute Exposure/ N-Propylamine ... and di-n-propylamine show approximately same degree of acute toxicity in animals. Approximate oral LD50 for each is 0.2 g/kg in rats and 0.8 to 1.6 g/kg in mice (10% solution of base). Both cause severe injury to rabbit eye and guinea pig skin.

/LABORATORY ANIMALS: Acute Exposure/ Rabbit and guinea pig; corrosive when applied to skin; necrosis, causes severe burns

/LABORATORY ANIMALS: Acute Exposure/ Rabbit eye irritation test: risk of serious damage to eyes. A 5% solution caused severe damage to the cornea; 1% solution caused minor damage. In another rabbit eye irritation test 1 drop caused corneal damage

For more Non-Human Toxicity Excerpts (Complete) data for DIPROPYLAMINE (8 total), please visit the HSDB record page.

An acute inhalation toxicity study was conducted with 4 Sprague-Dawley rats (sex not reported) receiving whole body exposure to a saturated atmosphere of di-n-propylamine in a gas environment chamber for 15 minutes. The saturated atmosphere was generated by passing air at 1 liter/minute through a bubbler containing the test material, resulting in an average concentration of 110 mg/l. The exposure was run at room temperature. Ten to twelve minutes into the exposure, all rats were observed with labored breathing to the point of gasping, loss of equilibrium, and forced movements. After 15 minutes of exposure, some of the animals became prostrate and the exposure was terminated. All animals survived the exposure and subsequent 14 day observation period. Necropsy did not revealed any gross alterations.

An acute oral toxicity was conducted with groups of fasted female Sprague-Dawley rats (4/group) receiving di-n-propylamine (vehicle use not reported) once orally by gavage. Groups of animals were administered the test material at doses of 0.125, 0.25, 0.50, 1, or 2 g/kg, resulting in the following mortality data (no. animals dead/no. animals tested): 0/4, 0/4, 2/4, 4/4 and 4/4, respectively. Time of deaths were not reported. The acute oral LD50 of di-n-propylamine was calculated to be 0.5 g/kg (95% confidence limits of 0.335 - 0.746 g/kg).

An acute oral toxicity study was conducted with non-fasted male albino Carworth Farm-Nelson rats (5/group) receiving di-n-propylamine, undiluted and as a 5% dilution in corn oil, once orally by gavage. Animals were observed for 14 days post dosing. The administration of the undiluted test material was lethal to all rats at a dose level of 0.125 ml/kg. However, groups of animals receiving the test material, diluted in corn oil, at doses of 0.25, 0.5, 1 or 2 g/kg, resulted in the following mortality data (no. animals dead/no. animals treated): 0/5, 0/5, 3/5 and 5/5, respectively. Deaths occurred within 1 day of dosing. Necropsy of animals found dead revealed congestion in all internal organs. The oral LD50 was calculated by the moving average method to be 0.933 g/kg (0.669 - 1.30 g/kg).

An acute dermal toxicity study was conducted in 3 groups of male albino New Zealand strain rabbits (4/group) administered 24-hour occluded dermal exposure upon clipped skin of the trunk to undiluted di-n-propylamine (CAS # 142-84-7) at doses of 0.625, 1.25, and 2.50 ml/kg respectively. A dermal LD50 calculated by moving average method was 1.25 ml/kg. Following 14-day post-treatment observation necrosis characterized sites of application. Gross necropsy revealed pale or opaque internal organs which study reviewers attributed speculatively to corrosive action of the test material. Among the 6 decedent rabbits, one exhibited a single hemorrhagic lung.

For more TSCA Test Submissions (Complete) data for DIPROPYLAMINE (10 total), please visit the HSDB record page.

EC50 Daphnia magna straus /water flea/ 73 mg/L for 48 hr. /conditions of bioassay not specified/

EC50 Daphnia magna straus 76 mg/L for 24 hr. /conditions of bioassay not specified/

EC50 Scenedesmus subspicatus (Green algae) 5.4 mg/L/72 hr; Effect: cell multiplication inhibition /Conditions of bioassay not specified in source examined/

EC50 Scenedesmus subspicatus (Green algae) 2 mg/L/96 hr; Effect: cell multiplication inhibition /Conditions of bioassay not specified in source examined/

Dipropylamine's production and use as a chemical intermediate, principally in the production of certain herbicides, may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 20.1 mm Hg at 25 °C indicates dipropylamine will exist solely as a vapor in the atmosphere. Vapor-phase dipropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. Dipropylamine does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, dipropylamine is expected to have moderate mobility based upon an estimated Koc of 190. The pKa of dipropylamine is 11 indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon its cationic state. Dipropylamine may volatilize from dry soil surfaces based upon its vapor pressure. Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol. If released into water, dipropylamine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 11.00 indicates dipropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to dipropylamine may occur through inhalation and dermal contact with this compound at workplaces where dipropylamine is produced or used. Monitoring data indicate that the general population may be exposed to dipropylamine via ingestion of food and the use of tobacco products containing dipropylamine. (SRC)

... amines from decomposing fish ... /Amines/

Dipropylamine has been found in tobacco(1,2).

Dipropylamine's production and use as a chemical intermediate(1), principally in the production of certain herbicides(2), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 190(SRC), determined from a log Kow of 1.67(2) and a regression-derived equation(3), indicates that dipropylamine is expected to have moderate mobility in soil(SRC). The pKa of dipropylamine is 11(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of dipropylamine from moist soil surfaces is not expected to be an important fate process given its cationic state(SRC). Dipropylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 20.1 mm Hg(6). Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol(7), suggesting biodegradation may be an important fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 190(SRC), determined from a log Kow of 1.67(2) and a regression-derived equation(3), indicates that dipropylamine is expected to adsorb to suspended solids and sediment(SRC). A pKa of 11(4) indicates dipropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 4(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol(8), suggesting biodegradation may be an important fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dipropylamine, which has a vapor pressure of 20.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dipropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), from its rate constant of 8.7X10-11 cu cm/molecule-sec at 25 °C that was derived using a structure estimation method(3). Dipropylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol(1).

The rate constant for the vapor-phase reaction of dipropylamine with photochemically-produced hydroxyl radicals has been estimated as 8.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Dipropylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Dipropylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 4 was calculated in fish for dipropylamine(SRC), using a log Kow of 1.67(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of dipropylamine was estimated as 190(SRC), using a log Kow of 1.67(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dipropylamine is expected to have moderate mobility in soil(SRC). The pKa of dipropylamine is 11(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 11(1) indicates dipropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces and moist soil surfaces is not expected to be an important fate process(2). The potential for volatilization of dipropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 20.1 mm Hg(3).

EC50 Daphnia magna straus /water flea/ 73 mg/L for 48 hr. /conditions of bioassay not specified/

EC50 Daphnia magna straus 76 mg/L for 24 hr. /conditions of bioassay not specified/

EC50 Scenedesmus subspicatus (Green algae) 5.4 mg/L/72 hr; Effect: cell multiplication inhibition /Conditions of bioassay not specified in source examined/

EC50 Scenedesmus subspicatus (Green algae) 2 mg/L/96 hr; Effect: cell multiplication inhibition /Conditions of bioassay not specified in source examined/

Dipropylamine's production and use as a chemical intermediate, principally in the production of certain herbicides, may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 20.1 mm Hg at 25 °C indicates dipropylamine will exist solely as a vapor in the atmosphere. Vapor-phase dipropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. Dipropylamine does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, dipropylamine is expected to have moderate mobility based upon an estimated Koc of 190. The pKa of dipropylamine is 11 indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon its cationic state. Dipropylamine may volatilize from dry soil surfaces based upon its vapor pressure. Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol. If released into water, dipropylamine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 11.00 indicates dipropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to dipropylamine may occur through inhalation and dermal contact with this compound at workplaces where dipropylamine is produced or used. Monitoring data indicate that the general population may be exposed to dipropylamine via ingestion of food and the use of tobacco products containing dipropylamine. (SRC)

... amines from decomposing fish ... /Amines/

Dipropylamine has been found in tobacco(1,2).

Dipropylamine's production and use as a chemical intermediate(1), principally in the production of certain herbicides(2), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 190(SRC), determined from a log Kow of 1.67(2) and a regression-derived equation(3), indicates that dipropylamine is expected to have moderate mobility in soil(SRC). The pKa of dipropylamine is 11(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of dipropylamine from moist soil surfaces is not expected to be an important fate process given its cationic state(SRC). Dipropylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 20.1 mm Hg(6). Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol(7), suggesting biodegradation may be an important fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 190(SRC), determined from a log Kow of 1.67(2) and a regression-derived equation(3), indicates that dipropylamine is expected to adsorb to suspended solids and sediment(SRC). A pKa of 11(4) indicates dipropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 4(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol(8), suggesting biodegradation may be an important fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dipropylamine, which has a vapor pressure of 20.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dipropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), from its rate constant of 8.7X10-11 cu cm/molecule-sec at 25 °C that was derived using a structure estimation method(3). Dipropylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Dipropylamine was determined to be biodegradable using the Japanese MITI test protocol(1).

The rate constant for the vapor-phase reaction of dipropylamine with photochemically-produced hydroxyl radicals has been estimated as 8.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Dipropylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Dipropylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 4 was calculated in fish for dipropylamine(SRC), using a log Kow of 1.67(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of dipropylamine was estimated as 190(SRC), using a log Kow of 1.67(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dipropylamine is expected to have moderate mobility in soil(SRC). The pKa of dipropylamine is 11(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 11(1) indicates dipropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces and moist soil surfaces is not expected to be an important fate process(2). The potential for volatilization of dipropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 20.1 mm Hg(3).

SURFACE WATER: Dipropylamine was detected at levels ranging from 0.3-3 ppb in various river waters from W Germany(1).

Dipropylamine was qualitatively identified in soil samples taken from Moscow(1).

The following concns (in mg/kg) of dipropylamine were detected in various food products from W Germany: preserved broken beans, 1.0; preserved shelled peas, 0.1; preserved red cabbage, 0.1; paprika, 0.3; paprika brine, 2.0; cucumber, 0.1-1.4; pickled onions, 1.1; celery, 0.9; cheese, 8.4; brown bread, 0.4(1). Trace levels (<0.1 ppm) were detected in baked ham(2). Dipropylamine was identified, not quantified, in boiled beef(3). Dipropylamine was detected in baked ham at a concn of 0.007 ppm(4).

Latakia tobacco leaf has been found to contain dipropylamine(1). Dipropylamine was identified as a naturally occurring compound (concn <0.1 ppm) in samples of American tobacco(2).

Dipropylamine concns of 0.2-0.4 ppm have been detected in whole samples of spotted trout and small mouth bass(1).

Dipropylamine is a constituent of tobacco smoke(1).

Occupational exposure to dipropylamine may occur through inhalation and dermal contact with this compound at workplaces where dipropylamine is produced or used. Monitoring data indicate that the general population may be exposed to dipropylamine via ingestion of food and the use of tobacco products products containing dipropylamine. (SRC)

[40 CFR 240-280, 300-306, 702-799 (7/1/2006)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U110, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U110, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds.

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for DIPROPYLAMINE (8 total), please visit the HSDB record page.

UN 2383; Dipropylamine

IMO 3.2; Dipropylamine

Label: "Flammable Liquid, Corrosive." Hazard Class 3. Packing Group II.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid Corrosive