English Safety Data Sheet Database 中文版 MSDS

trimethyl orthoformate

CAS No. 149-73-5 | PubChem CID 9005
Section 1. Identification
Chemical Nametrimethyl orthoformate CAS No.149-73-5
Synonymsmethyl orthofor-mate Chinese Name三甲氧基甲烷
Molecular FormulaC4H10O3 Molecular Weight106.1204
UN No.2438 Data SourcePubChem (NIH/NLM)
GHS Hazard Classification
Signal Word DANGER
Pictograms GHS02 · Flammable GHS07 · Irritant
Hazard Statements H225H319H335H332
Precautionary Statements P210P233P240P241P242P243P261P264+P265P271P280P303+P361+P353P304+P340P305+P351+P338P319P337+P317P370+P378P403+P233P403+P235P405P501P317

Section 2. Hazards Identification

This chemical does not meet GHS hazard criteria for 0.7% (2 of 294) of reports.

H225 (99.3%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H319 (99.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (33.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 294 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 2 of 294 reports by companies.

There are 12 notifications provided by 292 of 294 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P337+P317, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Section 8. Exposure Controls / Personal Protection

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

Section 9. Physical and Chemical Properties

Colorless liquid with a pungent odor; [HSDB]

COLORLESS LIQUID

PUNGENT ODOR

100.6 °C @ 760 MM HG

100.6 °C @760 [mm Hg]

SOL IN ETHANOL, IN ETHER

0.9676 @ 20 °C/4 °C

0.9676 @ 20°C

3.67 (AIR= 1)

81.4 [mmHg]

INDEX OF REFRACTION: 1.3773 @ 25 °C/D

Schoenflies notation

Boiling point

Chemical bond

Chemical shift

Heat of sublimation

Internuclear distance

Lineshape

Molecular structure

Optical coefficient

Point group

Refractive index

Vapor pressure

Other Classes -> Ethers, Other

Section 11. Toxicological Information

Neurotoxin - Other CNS neurotoxin

LC50 (rat) = 40,000 mg/m3

AN IRRITANT TO SKIN, EYES, & MUCOUS MEMBRANES.

Source: PubChem CID 9005 (NIH/NLM, public domain). Retrieved from PubChem, a public-domain chemistry database maintained by the U.S. National Library of Medicine. Last updated: 2026-08-02 09:55:07.
Disclaimer: This information is compiled for reference only and does not replace the manufacturer's official Safety Data Sheet. Always consult the supplier's SDS before handling any chemical.