Mercuric acetate

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 71 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P203, P260, P261, P262, P264, P264+P265, P270, P272, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P321, P330, P333+P317, P361+P364, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Warning: Effects may be delayed. Caution is advised.

Signs and Symptoms of Acute Mercuric Acetate Exposure: Signs and symptoms of acute exposure to mercuric acetate may be severe and include increased salivation, foul breath, inflammation and ulceration of the mucous membranes, abdominal pain, and bloody diarrhea. Oliguria (scanty urination), anuria (suppression of urine formation), and acute renal failure may be noted. Weak pulse, seizures, psychic disturbances, dyspnea (shortness of breath), chest pain, and circulatory collapse may be observed. Dermal exposure may result in dermatitis (red inflamed skin).

Emergency Life-Support Procedures: Acute exposure to mercuric acetate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to mercuric acetate.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. RUSH to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to mercuric acetate.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas for at least 15 minutes with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. RUSH to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.

4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. RUSH to a health care facility. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear boots, protective gloves, and goggles. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear self-contained breathing apparatus when fighting fires involving this material. If contact with the material is anticipated, wear full protective clothing.

Not flammable. Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Use water in flooding quantities as fog. Use foam, carbon dioxide or dry chemical to extinguish fires. (EPA, 1998)

In case of fire in the surroundings, use appropriate extinguishing media.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical, or carbon dioxide.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Cover with plastic sheet to prevent spreading.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

· For solids, prevent dust cloud and avoid inhalation of dust.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Consult an expert! Personal protection: chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not involved in fire: Keep material out of water sources and sewers.

Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

Separated from food and feedstuffs. Keep in the dark. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Well closed.

KEEP WELL CLOSED AND PROTECTED FROM LIGHT

Store at ambient temperature

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

0.02 [mg/m3], as Hg, inhalable fraction[German Research Foundation (DFG)]

0.0037 [ppm]

0.25 [ppm]

0.50 [ppm]

0.1 [mg/m3], as Hg

10 mg Hg/m3 (NIOSH, 2024)

10.0 [mg/m3], as Hg

2 mg/cu m (as Hg) /Mercury (organo) alkyl compounds (as Hg)/

0.02 [mg/m3], as Hg

8 hr Time Weighted Avg (TWA): 0.01 mg/cu m; 15 min Short Term Exposure Limit (STEL) 0.03 mg/cu m; skin /Mercury, alkyl cmpds, as Hg/

Chronic Inhalation: 0.0002 mg/m3 (L134)

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the kidneys. Medical observation is indicated.

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the central nervous system, peripheral nervous system and kidneys. This may result in ataxia, sensory and memory disturbances, tremors, muscle weakness and kidney impairment. The substance may have effects on male fertility. May cause heritable genetic damage to human germ cells.

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. ... Wear appropriate chemical protective gloves, boots, and goggles.

AVOID ALL CONTACT!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work. Wash hands before eating.

Mercury acetate is a white crystalline solid with an odor of vinegar. Sensitive to light. Density 3.25 g / cm3. Toxic by inhalation (dust, etc.) and by ingestion.

Water soluble white crystals with vinegar odor; [CAMEO]

WHITE CRYSTALS OR WHITE CRYSTALLINE POWDER.

White-yellow crystals or powder

Fine white powder or colorless shiny crystal flakes

Solid at 15 °C and 1 atm

Mild vinegar-like odor

Slight acetic odor

Decomposes (EPA, 1998)

352 to 356 °F (EPA, 1998)

179 °C (decomposes)

Soluble in diethyl ether and ethanol

One g dissolves in 2.5 ml cold, 1 ml boiling water; sol in alcohol.

In water, 2.50X10+5 mg/l @ 10 °C

100 G/100 ML WATER AT 100 °C

Solubility in water, g/100ml at 20 °C: 40 (good)

3.27 (EPA, 1998) - Denser than water; will sink

3.28 g/cm³

3.28 @25 °C

0.17 [mmHg]

Vapor pressure, Pa at 25 °C: 0.24 (calculated)

SENSITIVE TO LIGHT; AQ SOLN DECOMP ON STANDING, YIELDING A YELLOW PRECIPITATE

Aqueous solutions decompose on standing, yielding /unidentified/ yellow precipitate.

Metals -> Mercury Compounds, Inorganic

Water soluble. Decomposed by water to form a yellow insoluble product.

Salts, Basic

High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26)

No indication of carcinogenicity (not listed by IARC). (L135)

Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Oral (L7) ; inhalation (L7); dermal (L7)"

Sore throat. Cough.

MAY BE ABSORBED! Redness.

Redness.

Metallic taste. Burning sensation. Abdominal pain. Vomiting. Diarrhoea.

Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)

Neurotoxin - Sensorimotor

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

LD50: 41 mg/kg (Oral, Rat) (L435)

LD50: 570 mg/kg (Dermal, Rat) (L435)

LD50: 6.5 mg (Intraperitoneal, Mouse) (L435)

LD50: 4.4 mg (Intravenous, Mouse ) (L435)

LD50 OF MERCURIC ACETATE FOR BALANUS EBURNEUS LARVAE WAS 0.78 MG/l.

No growth of culture Scrippsiella faeroense (dinoflagellate) 1,000 ug/l/14 days

55% reduction in growth Gymnodinium spendens (dinoflagellate) 10 ug/l/11 days

45% reduction in growth, morphological variation of Scrippsiello faeroense (dinoflagellate) 10 ug/l/25 days

For more Non-Human Toxicity Values (Complete) data for MERCURIC ACETATE (6 total), please visit the HSDB record page.

Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)

EMBRYONIC EFFECTS OF COMBINATIONS OF MERCURIC ACETATE (2 OR 4 MG/KG) & CADMIUM SULFATE (2 MG/KG) ADMIN TO PREGNANT HAMSTERS ON 8TH DAY OF GESTATION WERE MUCH MORE SEVERE THAN THOSE OF MERCURIC ACETATE COMBINATIONS WITH ZINC SULFATE (2 MG/KG). THE PROTECTIVE VALUE OF ZINC SULFATE AGAINST THE EMBRYOPATHIC EFFECTS OF MERCURIC ACETATE WAS ALSO DETECTED BY THE MANNER OF ADMIN OF THE 2 METALS. THE MERCURIC ACETATE/ZINC SULFATE CONBINATIONS PRODUCED ONLY A FEW MALFORMATIONS.

(14)C-LABELED N-ETHYLMALEIMIDE INCUBATED WITH RABBIT OR HUMAN SERUM CAN COMPETE WITH ORGANOMERCURIALS SUCH AS MERCURIC ACETATE FOR TRANSPORT BY SERUM PROTEINS.

ADDN OF 1000 OR 2000 PPM MERCURIC ACETATE TO DIET OF RATS FOR 15 DAYS STIMULATED THE IN VITRO OXIDATIVE CLEAVAGE OF ETHYL P-NITROPHENYL BENZENETHIOPHOSPHATE (EPN) & THE O-DEMETHYLATION OF P-NITROANISOLE BY LIVER MICROSOMES.

SUBCUTANEOUS INJECTION OF 193 UMOL/KG OF (+)-PENICILLAMINE TWICE A DAY ON 6TH & 7TH DAYS AFTER INTRAMUSCULAR ADMIN OF 100 UG MERCURIC ACETATE INCR THE URINARY EXCRETION OF MERCURY IN RATS MORE THAN AN EQUIMOLAR DOSE OF N-ACETYL-(+)-PENICILLAMINE BUT LESS THAN THAT OF 48.3 UMOL/KG OF 2,3-DIMERCAPTOPROPANOL. ALL THIOL COMPLEXING AGENTS TESTED DECR KIDNEY CONTENT OF MERCURY & INCR LIVER & BLOOD CONCN.

The protective activity of spironolactone (CAS 52-01-7) against mercuric acetate intoxication and the action of a spironolactone-mercuric acetate complex were studied on female Sprague-Dawley rats. Spironolactone was given 30 min after the toxic agent. It was found that spironolactone reversed the toxic effects of mercury, the mercury-spironolactone complex was much less toxic than mercuric acetate and its toxicity disappeared with the administration of spironolactone. A molecular mechanism for the protective action of spironolactone against mercury intoxication is proposed. The presence of both the steroidal skeleton and the thioacetyl group in the same molecule is necessary for the protection against mercury intoxication.

Basic Treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and neat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with available water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Mercury and related compounds/

Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient with severe pulmonary edema or respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Mercury and related compounds/

Organic mercury exposure is best monitored by the measurement of total mercury (or the specific derivative) in whole blood. It has been recommended that the blood mercury level not be allowed to exceed 0.10 mg/l in workers exposed to organomercury compounds. /Organomercury compounds/

1-40 ppm in diet of broilers for 7 wk produced hyperkeratosis of gizzard. Egg shell quality decr in laying hen fed 0.5-2.0 ppm for 280 days. Blood samples were collected before and at various times up to 2.5 months after the last injection and assayed for divalent mercury. Electroretinograms were recorded after the last injection and 2 weeks or 3 months later to allow for recovery. A dose related increase in symptoms such as scratching of head skin, minute hemorrhaging in the iris, mouth bleedings, and loss of appetite was observed. One of five cats given 0.25 mg/kg mercury acetate, one of five cats given 0.075 mg/kg, and two of five cats given 0.050 mg/kg died. Dose related increases in blood Hg+2 concentration occurred, ranging from 11.3 to 51.2 ug per 100 ml. These tended to decrease after exposure ended; however, cats given 0.050 to 0.075 mg/kg mercury acetate still had blood Hg+2 concentrations of 5.8 to 16.6 ug/100 ml 2.5 months after the last dose. The b-wave of the electroretinograms was consistently higher in treated cats than in the controls. This change persisted into the recovery period. Most of the treated cats (87.5 percent) had higher b-wave amplitudes than the controls. b-Wave latencies tended to be reduced in cats given 0.025 and 0.050 mg/kg mercury acetate. The authors suggest that mercury acetate induces a persistent increase in the excitability of the retina in cats. The photoreceptors and glial cell layer appear to be the sites most affected.

SINGLE DOSE OF 15 MG/KG ADMIN SC TO HAMSTERS ON MORNING OF 8TH DAY OF GESTATION PRODUCED RESORPTIONS & ABNORMALITIES INCL EDEMA, RETARDATION, VENTRAL WALL DEFECTS, PERICARDIAL CAVITY DISTENTION, CLEFT PALATE, HYDROCEPHALUS & HEART DEFECTS WHEN OBSERVED ON 12TH OR 15TH DAY.

12 OR 14 DAY OLD HAMSTER FETUSES REMOVED FROM FEMALES PRETREATED IV ON 8TH DAY OF GESTATION SHOWED RESORPTIONS, DELAYED GROWTH RATE & VARYING DEGREES OF DORSALLY LOCALIZED SC EDEMA. WT LOSS, KIDNEY LESIONS, DIARRHEA, TREMOR & SOMNOLENCE WERE OBSERVED IN MATERNAL ANIMALS.

HEMODYNAMIC EFFECTS OF MERCURIC ACETATE WERE EVALUATED IN SYSTEMIC ARTERIAL CIRCULATION, RENAL CIRCULATION, & CIRCULATION OF ONE LOWER LIMB OF ANESTHETIZED RABBIT. IV INJECTION OF 0.5 MG, 1 MG & 2 MG PRODUCED SIGNIFICANT VASOSPASTIC EFFECT WHICH WAS SLIGHT IN SYSTEMIC CIRCULATION, CLEARLY EVIDENT IN CIRCULATORY DISTRICT OF FEMORAL ARTERY, & VERY MARKED IN RENAL DISTRICT.

For more Non-Human Toxicity Excerpts (Complete) data for MERCURIC ACETATE (13 total), please visit the HSDB record page.

LC50 Pimephales promelas (fathead minnows) 0.42 mg/l/48 hr, 0.53 mg/l/24 hr, 0.19 mg/l/96 hr /Conditions of bioassay not specified/

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment because it is persistent.

INSECTICIDAL ACTION OF MERCURIC ACETATE APPLIED TO SOIL IS DUE TO METALLIC MERCURY IN THE GASEOUS STATE. FACTORS AFFECTING THE REDUCTION OF MERCURY SALTS TO METALLIC MERCURY ARE SOIL ORGANIC MATTER, MOISTURE, SOIL PH, & TEMPERATURE.

METHYLMERCURY WAS FORMED AT VARIOUS INTERVALS, WHEN SOLN OF 1 NMOL OF MERCURIC ACETATE IN 100 ML WATER WAS IRRADIATE WITH BLACKLIGHT HAVING A SPECTRAL DISTRIBUTION SIMILAR TO SUNLIGHT.

AVERAGE TISSUE CONCN OF MERCURY IN OYSTERS (CRASSOSTREA VIRGINICA) HELD IN SEAWATER CONTAINING 10 OR 100 PPB MERCURIC ACETATE FOR 45 DAYS WAS 28,000 AND 140,000 PPB. TISSUE CONCN OF OYSTERS-TREATED WITH 100 PPB MERCURY ACETATE DECLINED FROM 115,000 TO 65,000 PPB AFTER 30 DAYS IN ESTUARINE WATER WITH NO ADDED MERCURY, AND TISSUE CONCN OF OYSTERS TREATED WITH 10 PPB DECLINED FROM 18000 TO 15,000 PPB IN 18 DAYS. OYSTERS ACCUM MERCURY 1,400 TIMES AND 2,800 TIMES ABOVE THE 100 AND 10 PPB ENVIRONMENTAL CONCN.

LC50 Pimephales promelas (fathead minnows) 0.42 mg/l/48 hr, 0.53 mg/l/24 hr, 0.19 mg/l/96 hr /Conditions of bioassay not specified/

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment because it is persistent.

INSECTICIDAL ACTION OF MERCURIC ACETATE APPLIED TO SOIL IS DUE TO METALLIC MERCURY IN THE GASEOUS STATE. FACTORS AFFECTING THE REDUCTION OF MERCURY SALTS TO METALLIC MERCURY ARE SOIL ORGANIC MATTER, MOISTURE, SOIL PH, & TEMPERATURE.

METHYLMERCURY WAS FORMED AT VARIOUS INTERVALS, WHEN SOLN OF 1 NMOL OF MERCURIC ACETATE IN 100 ML WATER WAS IRRADIATE WITH BLACKLIGHT HAVING A SPECTRAL DISTRIBUTION SIMILAR TO SUNLIGHT.

AVERAGE TISSUE CONCN OF MERCURY IN OYSTERS (CRASSOSTREA VIRGINICA) HELD IN SEAWATER CONTAINING 10 OR 100 PPB MERCURIC ACETATE FOR 45 DAYS WAS 28,000 AND 140,000 PPB. TISSUE CONCN OF OYSTERS-TREATED WITH 100 PPB MERCURY ACETATE DECLINED FROM 115,000 TO 65,000 PPB AFTER 30 DAYS IN ESTUARINE WATER WITH NO ADDED MERCURY, AND TISSUE CONCN OF OYSTERS TREATED WITH 10 PPB DECLINED FROM 18000 TO 15,000 PPB IN 18 DAYS. OYSTERS ACCUM MERCURY 1,400 TIMES AND 2,800 TIMES ABOVE THE 100 AND 10 PPB ENVIRONMENTAL CONCN.

Bioconcentration Factors for Mercury: Marine Plants 1,000; Marine Invertebrates 100,000; Marine Fish 1,670; Freshwater Plants 1,000; Freshwater Invertebrates 100,000; Freshwater Fish 1,000.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for MERCURIC ACETATE (8 total), please visit the HSDB record page.

IMO 6.1; Mercury acetate

UN 1629; Mercury acetate

49 232 41; Mercuric acetate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Severe marine pollutant.

Symbol: T+, N; R: 26/27/28-33-50/53; S: (1/2)-13-28-36-45-60-61; Note: A, 1

UN Hazard Class: 6.1; UN Pack Group: II