Zinc hexafluorosilicate

H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (72.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (72.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H400 (78.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (96%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 149 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P304+P340, P305+P351+P338, P319, P321, P330, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)

INHALATION: move to fresh air.

INGESTION: cause vomiting by giving soapy water or mustard water; have patient drink large quantities of lime water, if necessary, give stimulant such as strong coffee.

EYES: flush with water; call physician as necessary.

SKIN: wash with soap and water. (USCG, 1999)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Cover with plastic sheet to prevent spreading.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

· For solids, prevent dust cloud and avoid inhalation of dust.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Environmental considerations: Water spill: Neutralize with agricultural lime (slaked lime), crushed limestone, or sodium bicarbonate. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates or greater concentration.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not on fire and not involved in fire: Keep upwind. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

1.0 [mg/m3], inhalable fraction, as F[German Research Foundation (DFG)]

2.5 [mg/m3], as F

8 hr Time Weighted Avg (TWA): 2.5 mg/cu m. /Fluorides, as F/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Fluorides, as F/

A4; Not classifiable as a human carcinogen. /Fluorides, as F/

Biological Exposure Index (BEI): Determinant: fluorides in urine; Sampling Time: prior to shift; BEI: 3 mg/g creatinine. Determinant: fluorides in urine; Sampling Time: end of shift; BEI: 10 mg/g creatinine. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. The determinant is nonspecific, since it is also observed after exposure to other chemicals. /Fluorides/

Intermediate Oral: 0.3 mg/kg/day (L134)

Chronic Oral: 0.3 mg/kg/day (L134)

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Dust respirator; chemical goggles or face shield; protective gloves (USCG, 1999)

/NIOSH certified/ respirator; chemical goggles or face shield; protective gloves /Hexahydrate/

/NIOSH CERTIFIED RESPIRATOR/; GOGGLES OR FACE SHIELD; PROTECTIVE GLOVES. /HEXAHYDRATE/

Zinc fluorosilicate appears as a solid material, or the solid mixed with water. Insoluble in water and denser than water. Contact with the material may cause irritation to skin, eyes, and mucous membranes. It may be toxic by ingestion.

Hexahydrate: White solid; [Merck Index] Grey odorless solid; [MSDSonline]

White crystalline powder

122 to 158 °F at 760 mmHg (decomposes) (USCG, 1999)

Solubility: 77 g/100 g water at 10 °C; 93 g/100 g water at 60 °C /Hexahydrate/

54.371 lb/100 lb water at 70 °F

2.1 at 68 °F (USCG, 1999) - Denser than water; will sink

Density: 2.104 g/cu cm

When heated to decomp it emits toxic fumes of /hydrogen fluoride and zinc oxide/.

Soln of zinc fluosilicate is mildly acidic

INDEX OF REFRACTION: 1.3824, 1.3956 /HEXAHYDRATE/

PH OF 1% AQUEOUS SOLN 3.2; WHITE CRYSTALS /HEXAHYDRATE/

COLORLESS HEXAGONAL PRISMS; DECOMP @ 100 °C /HEXAHYDRATE/

HYDROLYZED BY ALKALI TO FLUORIDE ION /FLUOSILICATE SALTS/

Metals -> Metals, Inorganic Compounds

Insoluble in water.

Salts, Basic

Halogenating Agents

ZINC FLUOROSILICATE has weak oxidizing or reducing powers. Redox reactions can however still occur. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive.

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

A4; Not classifiable as a human carcinogen. /Fluorides, as F/

No indication of carcinogenicity to humans (not listed by IARC).

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

Inhalation (L49) ; oral (L49) ; dermal (L49)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Neurotoxin - Other CNS neurotoxin

Dermatotoxin - Skin burns.

LD50: 100 mg/kg (Oral, Guinea pig) (T18)

LD50 Oral Guinea pig 100 mg/kg

Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Fluorine and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's to support vital signs if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Fluorine and related compounds/

Fluoride levels in urine should be checked periodically and all workers should be subjected to periodical skeletal X-ray exam particularly of the pelvis. /Fluorine and cmpd/

A suicide served to show that poisoning by zinc hexafluorosilicate is typical of poisoning by the fluoride ion. A 35 year old man drank half a glassful of a 5 to 10% solution of a commercial formulation. Following ingestion, emesis and tetanic convulsions occurred in 3.4 hr and death in 4.5 hr. Pathology was typical of fluoride poisoning.

Inhalation of dust irritates nose and throat; excessive inhalation may cause severe pulmonary inflammation. Ingestion cause nausea, cramps, vomiting, shock, convulsions, cyanosis, and other symptoms of fluoride poisoning. Contact with eyes or skin causes irritation; skin ulcers may develop.

SYMPTOMATOLOGY: 1. Severe gastritis or gastroenteritis with abdominal pain, retching, and prolonged vomiting, beginning 10-60 min after ingestion. Vomitus may become bloody. Diarrhea is sometimes violent; the feces are watery and later tarry. Dehydration becomes intense. 2. Shock, pallor, cyanosis and coldness. Rapid, weak or imperceptible pulse, low blood pressure, rapid and shallow respirations. 3. Sometimes breathing is deep and rapid, reflecting an accompanying metabolic acidosis. 4. Drowsiness, hyporeflexia, dilated pupils, coma. Vasomotor instability, shock or coma and a serum iron level in great excess of the total iron-binding capacity are poor prognostic signs. /Fluoride/

SYMPTOMATOLOGY: 5. Liver injury, consisting of hemorrhagic necrosis which is usually reversible. 6. Death from shock, usually in 4-5 hr. Sometimes following apparent recovery, pneumonia with fever or secondary shock may cause death 1-3 days later. 7. Among survivors pyloric stenosis and mild hepatic cirrhosis may be encountered as persistent sequelae, but recovery is usually complete. /Fluoride/

For more Human Toxicity Excerpts (Complete) data for ZINC SILICOFLUORIDE (11 total), please visit the HSDB record page.

IN EXPERIMENTAL ANIMALS FLUOSILICATES APPEAR TO BE AS TOXIC AS CORRESPONDING FLUORIDES. /FLUOSILICATES/

/Acute poisoning/ If sufficient fluoride is absorbed ... fluoride ion increases capillary permeability and also produces a coagulation defect. These actions lead to hemorrhagic gastroenteritis and hemorrhages, congestion, and edema in various organs including the brain. Clinical manifestations ... include excitability, muscle tremors, weakness, urination, defecation, salivation, emesis, sudden collapse, clonic convulsions, coma, and death due to respiratory and cardiac failure. Cyanosis and early rigor mortis ... /Fluoride/

Signs of acute systemic fluoride intoxication are increased salivation, lacrimation, vomiting, diarrhea, muscular fibrillation, and respiratory, cardiac, and general depression. ... /Fluorides/

Chronic manifestations of excess fluoride in cattle are ... dental fluorosis and osteofluorosis. Animals with moderate to severe osteofluorosis sometimes exhibit an intermittent, non-specific, a typical lameness or stiffness that may be associated with calcification of periarticular structures and tendon insertions. This lameness or stiffness is often transitory in nature; and limits feeding or grazing time, thereby impairing animal performance. Other general non-specific signs or symptoms sometimes associated with chronic fluoride toxicosis include thickened, dry unpliable skin and poor performance. /Fluoride/

The visible effects of toxic concn of fluoride on plants ... may include chlorosis, peripheral necrosis, leaf distortion, and malformation or abnormal fruit development. /Fluoride/

Patients with kidney dysfunction may be particularly susceptible to fluoride toxicity. /Fluoride/

Populations that appear to be at increased risk from the effects of fluoride are individuals that suffer from diabetes insipidus or some forms of renal impairment. /Fluoride/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for ZINC SILICOFLUORIDE (8 total), please visit the HSDB record page.

UN 2855; Zinc fluorosilicate

IMO 6.1; Zinc silicofluoride

49 663 92; Zinc silicofluoride, hazardous substance, solid, not otherwise specified

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.