3,5-Di(propan-2-yl)phenyl hydroperoxide

H242 (88.9%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]

H304 (22.2%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]

H314 (88.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (88.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (22.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331 (66.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (22.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H411 (88.9%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P234, P235, P240, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P331, P332+P317, P333+P317, P337+P317, P362+P364, P363, P370+P378, P391, P403, P403+P233, P405, P410, P411, P420, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 9 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

INHALATION: move to fresh air; call a doctor.

EYES: flush with water for 15 minutes, holding eyelids open; call physician.

SKIN: wash several times with soap and water. (USCG, 1999)

Extinguish with dry chemicals, foam or carbon dioxide. Water may be ineffective on fire. Cool exposed containers with water. (USCG, 1999)

Extinguish with dry chemicals, foam or carbon dioxide. Water may be ineffective on fire. Cool exposed containers with water.

If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Dangerously explosive. /Diisopropylbenzene hydroperoxide solution (not over 72% peroxide)/

Evacuation: If the material is on fire or involved in fire consider evacuation of one-half (1/2) mile radius. /Diisopropylbenzene hydroperoxide solution (not over 72% peroxide)/

In case of fire, water should be applied by the sprinkler system or by hose from a safe distance, preferably with a fog nozzle. Foam may be necessary instead if the peroxide is diluted in a low density flammable solvent. Portable extinguishers should not be used except for very small fires. Peroxides threatened by fire should be wetted from a safe distance for cooling. /Peroxides, Organic and Inorganic/

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Spills should be cleaned up promptly using non-sparking tools and an inert, moist diluent such as vermiculite or sand. Sweepings may be placed in open containers or polyethylene bags and the area washed with water and detergent. Spilled, contaminated, waste or questionable peroxides should be destroyed. /Peroxides, Organic and Inorganic/

Most peroxides can be hydrolyzed by adding them slowly with stirring to about ten times their weight of cold 10% sodium hydroxide solution. The reaction may require several hours. /Peroxides, Organic and Inorganic/

Dilute and drain into the sewer with abundant water. /Hydrogen peroxide/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Keep spilled material wet. Wet spilled material before picking it up. /Diisopropylbenzene hydroperoxide solution (not over 72% peroxide)/

Personnel protection: Avoid breathing dusts, and fumes from burning material. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. If contact with the material anticipated, wear appropriate chemical protective clothing. Approach fire with caution. /Diisopropylbenzene hydroperoxide solution (not over 72% peroxide)/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Stop discharge if possible. Keep people away. Avoid contact with liquid and vapor. Isolate and remove discharged material. Notify local health and pollution control agencies. (USCG, 1999)

MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Solvent-resistant gloves; chemical-resistant apron; chem goggles or face shield; self-contained breathing apparatus.

Wear appropriate chemical protective gloves, boots, and goggles. /Diisopropylbenzene hydroperoxide solution (not over 72% peroxide)/

Persons handling peroxides should use safety glasses with side shields, goggles or face shield for eye protection. Emergency eyewash facilities should be provided. Gloves, aprons and other protective clothing as necessary should be used to prevent skin contact. Clothing and equipment that generate static electricity should be avoided. Smoking should be prohibited. /Peroxides, Organic and Inorganic/

Liquid; colorless to pale yellow; sharp, unpleasant odor. May float or sink in water. (USCG, 1999)

Colorless to pale-yellow liquid (52% solution in nonvolatile solvent); [Hawley]

Colorless to pale yellow liquid

SHARP, DISAGREEABLE

less than 15 °F (USCG, 1999)

Freezing Point: < -9 °C

175 °F (USCG, 1999)

175 °F (CLOSED CUP)

0.956 at 59 °F (USCG, 1999) - Less dense than water; will float

0.956 @ 15 °C (liq)

0.00231 [mmHg]

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Plastics & Rubber -> Curing Agents (Aromatic)

No rapid reaction with air. No rapid reaction with water.

Peroxides, Organic

Explosive

Strong Oxidizing Agent

The explosive instability of the lower dialkyl peroxides (e.g., dimethyl peroxide) and 1,1-bis-peroxides decreases rapidly with increasing chain length and degree of branching, the di-tert-alkyl derivatives being amongst the most stable class of peroxides. Though many 1,1-bis-peroxides have been reported, few have been purified because of the higher explosion hazards compared with the monofunctional peroxides. It is unlikely that this derivative would be particularly unstable compared to other peroxides in its class [Bretherick 2nd ed., p 44 1979].

Aluminum, copper, brass, lead, zinc salts, mineral acids, oxidizing or reducing agents all can cause rapid decomp.

Dermatotoxin - Skin burns.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool .... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic peroxides/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic peroxides/

Peroxides should be washed promptly from the skin to prevent irritation. In the case of eye contact, the eyes should be flushed immediately with large amounts of water, and medical attention should be obtained. ... Medical attention should also be obtained in case of accidental ingestion. ... /Peroxides, Organic and Inorganic/

Hydroperoxides ... are extremely irritating and corrosive to the eyes, with risk of blindness, and may cause serious injury or death if ingested in sufficient quantity. /Hydroperoxides/

The main toxic effect of most peroxides is irritation of skin, mucous membranes and eyes. Prolonged or intense skin contact or splashes in the eyes may cause severe injury. ... /Peroxides, Organic and Inorganic/

A 4 day subacute skin irritation test in rabbits was performed with this hydroperoxide in propylene glycol. After four applications of one a day, 1.75% wt./vol. of this chemical caused mild to moderate dermatitis; 3.5, 7.0, and 14.0 percent caused severe dermatitis at the end of 4 days. In fact, for the two highest concentrations the fourth application was discontinued due to necrosis.

An acute inhalation study using rats exposed to the nominal concentrations of 2.18, 4.26, and 5.59 mg/l caused red nasal discharge at even the lowest dose. The animals also showed signs of shortness of breath, reduced activity, and vasodilitation. Fifty percent of the animals exposed to the 5.59 mg/l level died showing similar symptoms.

Individuals with eye, skin, and chronic respiratory diseases /may be/ at an increased risk. /Hydrogen peroxide/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Fire or Explosion: May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated. Runoff may create fire or explosion hazard. /Organic peroxide type D, solid/

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Health: Fire may produce irritating, corrosive and/or toxic gases. Ingestion or contact (skin, eyes) with substance may cause severe injury or burns. Runoff from fire control or dilution water may cause pollution. /Organic peroxide type D, solid/

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Organic peroxide type D, solid/

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection. /Organic peroxide type D, solid/

For more DOT Emergency Guidelines (Complete) data for DIISOPROPYLBENZENE HYDROPEROXIDE (8 total), please visit the HSDB record page.

UN 3106; Organic peroxide type D, solid

UN 3106; Organic peroxide type D, solid, temperature controlled.

IMO 5.2; Organic peroxide type D, solid; Organic peroxide type D, solid, temperature controlled.

49 191 30; Diisopropylbenzene hydroperoxide solution (not over 70% peroxide)

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

Organic Peroxide