Aldrinaldrite

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P318, P319, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement)

H300 (54.5%): Fatal if swallowed [Danger Acute toxicity, oral]

H301+H311 (18.2%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]

H301 (45.5%): Toxic if swallowed [Danger Acute toxicity, oral]

H310 (72.7%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H311 (27.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 11 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H350: May cause cancer [Danger Carcinogenicity]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P261, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P308+P316, P316, P318, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting. Rest. Refer for medical attention .

Excerpt from NIOSH Pocket Guide for Aldrin:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: SOAP WASH IMMEDIATELY - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

Signs and Symptoms of Acute Aldrin Exposure: Signs and symptoms of acute exposure to aldrin may be severe and include headache, dizziness, agitation, nervousness, tremor, seizures, and coma. Convulsive episodes may alternate with periods of severe central nervous system depression. Nausea, vomiting, and diarrhea are common. Hypertension (high blood pressure), tachycardia (rapid heart rate), and cardiac arrhythmias (abnormal heart beating) may be noted. Respiratory depression may lead to respiratory arrest. Contact with the skin, eyes, and mucous membranes may result in redness and irritation. Victims often have an elevated temperature.

Emergency Life-Support Procedures: Acute exposure to aldrin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to aldrin.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. Transport to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to aldrin.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas three times. Wash initially with soap and water, follow with an alcohol wash, then again with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. Transport to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of aldrin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step

4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of aldrin may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step

4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.

4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. Transport to a health care facility. (EPA, 1998)

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Wear full protective clothing, including positive pressure breathing apparatus. Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.

Not Flammable. Extinguish by using water spray, dry chemical, foam, or carbon dioxide. Use water to keep fire-exposed containers cool. Use water spray to disperse the vapors. (EPA, 1998)

In case of fire in the surroundings, use appropriate extinguishing media.

Fire Fighting: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. /Endrin/

Cool fire-exposed containers with water.

Fire extinguishing agents: Water spray, dry chemical, foam, or carbon dioxide for fires involving solutions of aldrin in hydrocarbon solvents.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

A PROCESS FOR REMOVING POLLUTANTS FROM DU PONT'S CHAMBERS WORKS PLANT IN DEEPWATER, NJ IS DESCRIBED. PROCESS CALLS FOR TREATMENT OF WASTES FROM ORG CHEM MFR PROCESSES BY NEUTRALIZATION & SETTLING, FOLLOWED BY A COMBINED POWDERED CARBON-BIOLOGICAL PROCESS.

Survey reports six case histories employing EPA's hazardous materials spills treatment trailer are reviewed. The trailer's ... treatment system has three mixed-media filters and three activated carbon columns to remove suspended, precipitated, and organic soluble materials. Spills of PCB, pentachlorophenol, kepone, termide (chlordane), heptachlor, aldrin, and dieldrin, toxaphene, and dinitrobutylphenol were treated by the EPA trailer, which was generally successful in mitigating environmental effects by filtering and carbon-adsorption. 90% removal was achieved for 21 of 23 compounds.

The effectiveness of reverse osmosis for removing toxic substances from municipal effluents was investigated. Laboratory and pilot plant studies on the removal of such substances as arsenic, cyanide, nitrilotriacetic acid, phenols, aldrin, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, chlordane, malathion, and parathion are described. Reverse osmosis system permeation rates, variations in permeation rates with time, and removal efficiencies for various substances are presented. Chlorinated hydrocarbon and organic phosphate pesticides were almost completely removed by reverse osmosis, while heavy metal removal was consistently greater than 95%. Removal rates for other substances varied from 43-90%, depending on the substance and on the type of membrane used.

The applicability of carbon to remove toxicants on EPA's published list and fish kill due to influent and effluent from five industrial plants currently using adsorption as a treatment method are examined. In the laboratory, activated carbon can achieve levels of less than 1 mg/l of aldrin, dieldrin, endrin, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethene, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane, toxaphene, and aroclors 1254. In operating plants, the toxicity of wastes to fish due to unknown constituents is significantly reduced or totally removed by activated carbon treatment.

For more Cleanup Methods (Complete) data for ALDRIN (7 total), please visit the HSDB record page.

Potential candidate for rotary kiln incineration with a temperature of 820-1600 °C with residence times for liquids and gases: seconds; solids: hours. Also, a potential candidate for fluidized bed incineration with a temperature range of 450-980 °C with residence times for liquids and gases: seconds; Solids, longer.

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

For more Disposal Methods (Complete) data for ALDRIN (9 total), please visit the HSDB record page.

Provide an eyewash station. Where there is any possibility of exposure of an employee's body to endrin or liquids containing endrin, facilities for quick drenching of the body should be provided within the immediate work area for emergency use. /Endrin/

Eating and smoking should not be permitted in areas where endrin or liquids containing endrin are handled, processed, or stored. Wash hands with soap and water before eating, smoking, or using toilet facilities. /Endrin/

Good industrial hygiene practices recommend that engineering controls be used to reduce environmental concentrations to the permissible exposure levels. However, there are some exceptions where respirators may be used to control exposure. Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. In addition to respirator selection, a complete respirator protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation. /Endrin/

Clothing which has had any possibility of being contaminated ... should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of /material/ from the clothing. ... If clothing has had any possibility of being contaminated ... employees should change into uncontaminated clothing before leaving the work premises. If the clothing is to be laundered or otherwise cleaned to remove the endrin, the person performing the operation should be informed of its hazardous properties. /Endrin/

For more Preventive Measures (Complete) data for ALDRIN (24 total), please visit the HSDB record page.

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors.

SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

Protect containers against physical damage. Store in well-ventilated, cool, dark place separated from sources of ignition. Outdoor or detached storage is preferred.

For liquids and solids: glass bottles, packed with inert cushioning material, or plastic bottles, together in a wooden box (15 l receptacle net, 75 kg package gross) or fiberboard box (5 l net, 40 kg package gross); cans, packed together in a wooden box of 75 kg gross or fiberboard box of 20 l receptacle net, 40 kg package gross; in metal drums of 450 kg gross. For solids only: paper or plastic bags packed together in a wooden box (5 kg receptacle, 75 kg package gross) or in a fiberboard box (5 kg receptacle, 40 kg package gross); wooden barrel, fiber or plywood drum of 200 kg package gross; waterproof multi-ply paper bag of 50 kg package gross.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

0.25 [mg/m3], inhalable fraction[German Research Foundation (DFG)]

0.15 [mg/m3]

10 [mg/m3]

100 [mg/m3]

Ca TWA 0.25 mg/m3 [skin] See Appendix A

0.25 [mg/m3]

0.25 mg/m³

TWA 0.25 mg/m3 [skin]

25 mg/m3 ; A potential occupational carcinogen. [From NPG: Aldrin] (NIOSH, 2024)

25 mg/m3 ; A potential occupational carcinogen. (NIOSH, 2024)

25.0 [mg/m3]

NIOSH considers aldrin to be a potential occupational carcinogen. 25 mg/cu m.

25 mg/m³

Ca [25 mg/m3]

See: 309002

0.05 [mg/m3], inhalable fraction and vapor

8 hr Time Weighted Avg (TWA): 0.05 mg/cu m (inhalable fraction and vapor), skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

A3: Confirmed animal carcinogen with unknown relevance to humans.

0.05 mg/m

(inhalable fraction): 0.25 mg/m

Acute Oral: 0.002 mg/kg/day (L134)

Chronic Oral: 0.00003 mg/kg/day (L134)

FAO/WHO Residue tolerance limit: 0.03-0.3 mg/kg/day

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.

The substance may cause effects on the central nervous system. This may result in convulsions. The effects may be delayed. Medical observation is indicated.

Cumulative effects are possible. See Acute Hazards/Symptoms.

Excerpt from NIOSH Pocket Guide for Aldrin:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin:

• WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

• DAILY - The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Provide:

• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.

• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)

WHEN OPENING CONTAINERS, MIXING, OR APPLYING PRODUCT, WEAR PROTECTIVE RUBBER OR PVC GLOVES, RUBBER BOOTS, & CLEAN OVERALLS. WEAR /NIOSH APPROVED/ DUST MASK WHEN HANDLING DUST CONCENTRATES.

Particulate Concentration: 1 mg/cu m or less: Any chemical cartridge respirator with an organic vapor cartridge(s) dust and mist filter(s) including pesticide respirators which meet the requirements of this class, or any supplied-air respirator, or any self contained breathing apparatus. 5 mg/cu m or less: A chemical cartridge respirator with a full facepiece, organic vapor cartridge(s), and dust and mist filter(s), including pesticide respirators which meet the requirements of this class, or a gas mask with a chin style or a front or back mounted organic vapor canister and dust and mist filter, including pesticide respirators which meet the requirements of this class, or any supplied air respirator with a full facepiece, helmet, or hood, or any self contained breathing apparatus with a full facepiece. 100 mg/cu m or less: A powered air purifying respirator with an organic vapor cartridge and high efficiency particulate filter, including pesticide respirators which meet the requirements of this class, or a type C supplied-air respirator operated in pressure demand or other positive pressure or continous flow mode. 200 mg/cu m or less: a type C supplied air respirator with a full facepiece operated in pressure demand or other positive pressure mode or with a full facepiece, helmet, or hood operated in continuous flow mode. Greater than 200 mg/cu m or entry and escape from unknown concentrations: Self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode, or a combination respirator which includes a type C supplied air respirator with a full facepiece operated in pressure demand or other positive pressure or continuous flow mode and an auxiliary self contained breathing apparatus operated in pressure demand or other positive pressure mode. Escape: Any gas mask providing protection against organic vapors and particulates, including pesticide respirators which meet the requirements of this class, or any escape self contained breathing apparatus. /Endrin/

Aldrin, liquid appears as a solution in oil of aldrin, a noncombustible water-insoluble solid. Used as an insecticide. Mixed with a flammable carrier solvent.

Aldrin, cast solid is a brown to white solid. If the large pieces are broken up or powdered, it is toxic by inhalation and skin absorption. It is insoluble in water and noncombustible. It is used as an insecticide.

Colorless to dark-brown crystalline solid with a mild chemical odor. [Note: Formerly used as an insecticide.] [NIOSH]

COLOURLESS CRYSTALS.

Colorless to dark-brown crystalline solid with a mild chemical odor.

Colorless to dark-brown crystalline solid with a mild chemical odor. [Note: Formerly used as an insecticide.]

Colorless needles

Brown to white, crystalline solid

Colorless to dark brown crystalline solid ...

... Mild chemical odor ...

293 °F at 2 mmHg (decomposes) (EPA, 1998)

145 °C at 2 mm Hg

at 0.27kPa: 145 °C

decomposes

145 °C @760 [mm Hg]

Decomposes

219 °F for pure product; 120 to 140 °F for technical product. (EPA, 1998)

MP: 40-60 °C /TECHNICAL GRADE ALDRIN/

104-105 °C

Approximately 150F or higher (EPA, 1998)

less than 1 mg/mL at 75 °F (NTP, 1992)

0.027 MG/L IN WATER AT 27 °C; > 600 G/L AT 27 °C IN ACETONE, BENZENE, XYLENE

Sol in aromatics, esters, ketones, paraffins and halogenated solvents.

Sol in ethanol, ether, and acetone.

Moderately sol in petroleum oils

In water, 170 mg/l @ 25 °C

Solubility in water: none

1.7 at 68 °F (EPA, 1998) - Denser than water; will sink

1.6 at 20 °C/4 °C (solid)

1.6 g/cm³

1.6 @ 20°C

6e-06 mmHg at 77 °F (EPA, 1998)

0.000012 [mmHg]

1.20X10-4 mm Hg @ 25 °C

Vapor pressure, Pa at 20 °C: 0.009

0.00008 mmHg

0.000006 [mm Hg] @20 °C

Log kow= 6.50

Henry's Law constant = 4.4X10-5 atm-cu m/mole @ 25 °C

STABLE IN PRESENCE OF ORG & INORG BASES & STABLE TO ACTION OF HYDRATED METAL CHLORIDES AND MILD ACIDS

Highly flammable. Insoluble in water.

Insoluble in water.

Halogenated Organic Compounds

Hydrocarbons, Aliphatic Unsaturated

Highly Flammable

ALDRIN, LIQUID is a chlorinated diene. May be sensitive to prolonged exposure to light. Stable to heat and in the presence of inorganic and organic bases. Stable with hydrated metal chlorides and mild acids. Reacts with concentrated acids and phenols in the presence of oxidizing agents. Can react with acid catalysts, acid oxidizing agents and active metals (NTP, 1992).

ALDRIN may be sensitive to prolonged exposure to light. This chemical is stable to heat and in the presence of inorganic and organic bases. It is stable to hydrated metal chlorides and mild acids. This compound is thermally stable up to 392 °F and it is stable between pH 4 and 8. This compound reacts with concentrated acids and phenols in the presence of oxidizing agents. It can be corrosive to metals. It can react with acid catalysts, acid oxidizing agents and active metals. (NTP, 1992)

Concentrated mineral acids, active metals, acid catalysts, acid oxidizing agents, phenol.

Reacts with concentrated acids and phenols in the presence of oxidizing agents to give dieldrin.

Concentrated mineral acids, active metals, acid catalysts, acid oxidizing agents, phenol

IDENTIFICATION: Aldrin is a chlorinated cyclodiene insecticide. Pure aldrin is a white crystalline solid. Technical grade aldrin is tan in color. Aldrin has been used in various formulations which include emulsifiable concentrates, wettable powders, granules, dusts and solutions in hydrocarbon liquids. Aldrin has a mild chemical odor, and is very soluble in most organic solvents (aromatics, esters, ketones, paraffins and halogenated solvents. Impurities of aldrin include octachlorocyclopentene, hexachlorobutadiene, toluene and a mixture of compounds formed by polymerization during the aldrin reaction along with carbonyl compounds. Aldrin is very effective soil insecticide and has been used to treat seeds. It has been used to control termites, corn root worms, seed corn beetle and maggot, wire worms, rice water weevil, grasshoppers and Japanese beetles. HUMAN EXPOSURE: The CNS seems to be the primary site with resultant seizures. Toxic exposures produce tremors, giddiness, hyperexcitability, seizures and comas. Poisoning occurs mainly through absorption through the skin. Epidemiological studies do not show any carcinogenic risk. Absorption can occur by inhalation, dermal and gastrointestinal routes. Clinical toxicity from aldrin actually is due to its rapid metabolism in the body to dieldrin. Symptoms reflect CNS toxicity due to GABA neurotransmission inhibition. Headache, tremors, hyperexcitability, seizures and comas have been noted. Respiratory absorption occurs, expiratory aldrin concentrations are decreased compared to inspired concentrations. Aldrin is rapidly converted to dieldrin primarily in the liver. Consequently little aldrin is found in the blood or tissues. Autopsy cases show dieldrin levels in the brain, liver and adipose tissue. After chronic oral human administration, blood dieldrin concentrations decreases exponentially following first order kinetics with an estimated half life of 369 days. Elimination occurs primarily through the feces via the bile. 9-Hydroxydieldrin seems to be the major metabolite excreted. Dieldrin is also excreted in the breast milk. Small amounts of dieldrin metabolites are excreted in the urine after either topical or iv administration. Dieldrin metabolites may also be found in the urine after ingestion. There have been a few cases of aldrin toxicity in children with resulting signs of CNS stimulation similar to adults. Death has resulted after acute ingestion. The fetus concentrates dieldrin, and the possibility of contaminated breast milk consumption increase the risk of CNS effects in the very young. Increased sister chromatid exchanges and exchange type chromosome aberrations were noted in floriculturists after exposure to several pesticides including aldrin. Cardiovascular complications include blood pressure fluctuations and tachycardia after overdose. Blood urea nitrogen levels, gross hematuria and albuminuria for several days after an acute overdose was noted. No dermatitis was seen in pesticide manufacturing workers. Normal hematological parameters were noted in pesticide manufacturing workers during at least a four years of follow up. ANIMAL/BACTERIAL/VIRAL/CELL STUDIES: Inhalation exposure to aldrin in several species resulted in death. Single dermal applications of aldrin in xylene produced death in test animals. Oral administration of aldrin to rats causes convulsions. Aldrin induced unscheduled DNA synthesis in SV-40 transformed human fibroblast cells (VA-4) both in the presence and absence of rat liver microsomes, The DNA breakage rates in Escherichia coli plasmid after treatment with aldrin or dieldrin did not differ from those in untreated plasma DNA suggesting that, at least in these studies, the compounds did not interact directly with DNA. The effects of aldrin and dieldrin on the uptake of tritiated thymidine by cultured rat thymocytes and human lymphocytes were tested under different experimental conditions. Both compounds appeared to have marginal effects on thymidine uptake, suggesting inhibition of DNA synthesis. Aldrin and dieldrin did not induce unscheduled DNA synthesis in primary cultures of Fischer 344 rat hepatocytes. In the hepatocyte primary culture/DNA repair test using freshly isolated hepatocytes of high metabolic capability to monitor the production of DNA damage by measuring DNA repair synthesis. Aldrin and dieldrin gave equivocal results concerning DNA repair, but there was no damage to DNA. Aldrin induced DNA strand breaks in an alkaline elution rat hepatocyte assay. Both aldrin and dieldrin inhibited gap junctional intercellular communication between 6-thioguanine sensitive and 6-thioguanine resistant human teratocarcinoma cells in culture. No increased incidence of malignant neoplasms have been found in several studies. In animal assays there was an increased incidence of hepatic tumors including hepatocellular adenomas. In animal studies, aldrin did cause an increase in fetal mortality, increased incidence of cleft palate and webbed foot and a decreased postnatal survival have been reported.[

Aldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. Aldrin also inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (T10, L87)

3 x 10 ^-5 mg/kg-day

Pesticide

0.002−0.2

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Inadequate evidence of carcinogenicity in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Cancer Classification: Group B2 Probable Human Carcinogen

CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Orally administered aldrin produced significant increases in tumor responses in three different strains of mice in both males and females. Tumor induction has been observed for structurally related chemicals, including dieldrin, a metabolite. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient.

Within the framework of EPA's Proposed Guidelines for Carcinogen Risk Assessment, it is proposed that the most appropriate cancer risk descriptor for aldrin/dieldrin, relating to the mouse liver tumor response, is 'not likely a human carcinogen', a descriptor consistent with the example of phenobarbital cited by EPA.

A3: Confirmed animal carcinogen with unknown relevance to humans.

TR-021: Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) (1978 )

09/26/77

Equivocal Evidence

Clear Evidence

No Evidence

It is concluded that under the conditions of these bioassays, none of the tumors occurring in Osborne-Mendel rats treated with aldrin or dieldrin could clearly be associated treatment.

3, not classifiable as to its carcinogenicity to humans. (L135)

Aldrin is a neurotoxin and works by overstimulating the central nervous system. Ingestion of large amounts of aldrin causes convulsions and death. However, chronic exposure to lower amounts of aldrin also has adverse affects because it is oxidized to dieldrin, which accumulates in the body. Dieldrin is known to damage the nervous system, liver, and immune system. (L87)

The substance can be absorbed into the body through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Oral (L87) ; inhalation (L87) ; dermal (L87)

See Ingestion.

MAY BE ABSORBED! See Ingestion.

Convulsions. Dizziness. Headache. Nausea. Vomiting. Muscle twitching.

headache, dizziness; nausea, vomiting, malaise (vague feeling of discomfort); myoclonic jerks of limbs; clonic, tonic convulsions; coma; hematuria (blood in the urine), azotemia; [potential occupational carcinogen]

Exposure to aldrin results in headaches, dizziness, irritability, nausea and vomiting, cardiac arrhythmias, muscular weakness, uncontrolled muscle movements, hyperexcitability, seizures and coma. (L87)

central nervous system, liver, kidneys, skin

[in animals: tumors of the lungs, liver, thyroid & adrenal glands]

Chemical: ALDRIN

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Other Poison - Organochlorine

IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens.

ACGIH Carcinogen - Confirmed Animal.

FAO/WHO ADI: 0.0001 mg/kg /Aldrin, dieldrin/

4 x 10^-5 mg/kg-day

PDF Document

See the IRIS entry for Aldrin

IRIS Current

ATSDR Final

LD50 ANAS PLATYRHYNCHOS (MALLARD) ORAL FEMALE 520 MG/KG (95% CONFIDENCE LIMIT 229-1210 MG/KG) 3-4 MO OLD

LD50 PHASIANUS COLCHICUS (PHEASANT) FEMALE ORAL 16.8 MG/KG (95% CONFIDENCE LIMIT) 3-4 MO OLD

LD50 COLINIS VIRGINIANUS (BOBWHITE) FEMALE ORAL 6.59 MG/KG (95% CONFIDENCE LIMIT) 3-4 MO OLD

LD50 DENDROCYGNA BICOLOR (FULVOUS WHISTLING DUCK) MALE ORAL 29.2 MG/KG (95% CONFIDENCE LIMIT) 3-6 MO OLD

For more Ecotoxicity Values (Complete) data for ALDRIN (26 total), please visit the HSDB record page.

3.90e-02

1.80e-01

5.70e-04

2.50e-03

9.20e-04

4.00e+00

1.50e-04

1.70e+01

4.90e-03

Volatile

3.90e+00

1.80e+01

5.70e-02

2.50e-01

9.20e-02

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment because it is persistent. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment in circumstances different to normal use.

Aldrin's former use as a pesticide resulted in its direct release to the environment. If released to air, a vapor pressure of 1.2X10-4 mm Hg at 25 °C indicates aldrin will exist solely in the vapor-phase in the ambient atmosphere. Vapor-phase aldrin will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 6 hrs. Aldrin has a UV absorption max of 227 nm and photodegradative half-life of 113 hrs and dieldrin is the primary photoproduct. If released to soil, aldrin is expected to have moderate to no mobility based upon a range of Koc values of 400-28,000. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 4.4X10-5 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. A loss of 50% of surface applied aldrin to soil was estimated to occur within 1-2 weeks after application compared to 10-15 weeks for soil-incorporated aldrin. Aldrin was classified as moderately persistent with a half-life in soil ranging from 20-100 days. In soil, aldrin is converted to dieldrin by epoxidation, which occurs in aerobic and biologically-active soils. If released into water, aldrin is expected to adsorb to suspended solids and sediment based upon the range of Koc values. A river die-away test was conducted in capped bottles with aldrin in raw water from the Little Miami River in Ohio. After 2, 4, and 8 weeks, 20, 60, and 80% of the initial amount of aldrin had degraded. Aldrin may be degraded rapidly under anaerobic conditions based on an anaerobic wastewater study. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. In a laboratory study using distilled water, the volatilization half-life of aldrin was 5.8 days at 30 °C and a depth of approximately 1 cm. Experimental BCF values ranging from 735 to 20,000 suggest that bioconcentration in aquatic organisms is high to very high. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Monitoring data indicate that the general population may be exposed to aldrin via ingestion of food and drinking water containing aldrin. (SRC)

Aldrin's former use as a pesticide(1) has resulted in its direct release to the environment(SRC). Aldrin is an insecticide formerly used against termites and soil-dwelling pests such as ants(1), wireworms, whitegrubs, etc(2). The manufacture and use of aldrin has been discontinued in the United States(3).

TERRESTRIAL FATE: APPLICATION OF ALDRIN AT 3, 9, & 15 KG AI/HA IN CLAY LOAM & SANDY LOAM SOIL EVERY YEAR FROM 1972-1974 SHOWED RESIDUES REMAINED LONGER IN CLAY LOAM THAN IN SANDY LOAM SOIL. RATE OF CONVERSION TO DIELDRIN WAS HIGHER IN SANDY LOAM THAN IN CLAY LOAM SOIL. ALDRIN RESIDUES LEACHED INTO SOIL WITH RAIN WATER. NEITHER ALDRIN NOR DIELDRIN TRANSLOCATED IN MAIZE, PEARL MILLET PLANTS & GRAINS.

TERRESTRIAL FATE: Based on a classification scheme(1), a range of experimental Koc values of 400-28,000(2), indicates that aldrin is expected to be moderately mobile to immobile in soil(SRC). Volatilization of aldrin from moist soil surfaces is expected to be an important fate process(SRC) given an experimental Henry's Law constant of 4.4X10-5 atm-cu m/mole(3). Volatilization of aldrin from soil is more rapid when it is applied to the soil surface rather than incorporated into the soil(5). A loss of 50% from a surface application was estimated to occur within 1-2 weeks after application compared to 10-15 weeks for soil-incorporated aldrin(5). Aldrin is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.2X10-4 mm Hg(4).

TERRESTRIAL FATE: Aldrin was applied at 1.5 kg ai/ha to flooded soil. After 30, 90, 120, 240, and 270 days, 44.2%, 55.4%, 74.13%, 88.07%, and 100% of the aldrin had dissipated from the soil(1). Aldrin applied at 20 lb/acre (incorporated into first 6 inches) to muck and loam had respective half-lives of 3.75 and 2.40 months for the first half-year and 13.0 and 9.7 months for the following three years(2). Three and one-half years following the application to a Miami silt loam of 20 and 200 lb aldrin incorporated 6 inches per acre, 1.12% and 2.55%, respectively, of the calculated initial amount of aldrin remained(2). Aldrin was applied 20 lb incorporated 6 inches per acre to Miami silt loam and at 100 lb incorporated 6 inches per acre to Plainfield sand(2). After incubation for 56 days at 6, 26, and 46 °C, 83.8%, 55.7% and 13.7% of the initial amount of recoverable aldrin remained on the Miami silt loam and 63%, 38%, and 10.2% remained on the Plainfield sand, respectively(2). After 2 months incubation at 30 °C, 44%, 58%, and 33% of about 15 ppm of aldrin applied remained in the Maahas, Louisiana, and Casiguran soils under upland (80% water saturated), respectively, and under flooded conditions, 65%, 81%, 74%, and 64% remained in the Pila, Maahas, Louisiana and Casiguran soils, respectively(3). Soils were treated with aldrin at 5 lb/acre from 1958-62(4). Dieldrin was formed from aldrin in the soil and constituted 50 and 90% of the aldrin plus dieldrin residues recovered in 1959 and 1963, respectively(4). Soils from AR, FL, HI, MD, MT, OR, and SC were treated with 10 ml of 0.5% aqueous aldrin emulsion/10 g soil(5). The preparations were placed randomly around a test site in the Harrison Experimental Forest in southern Mississippi. In all preparations except the Hawaiian soil, the percent degradation in the upper 0.5 inch layer (36-72%) was greater than in the lower layer (unspecified depth) (11-33%). In the Hawaiian soil samples, degradation in the lower layer was 63% and in the upper layer was 49%(5). Aldrin was converted into dieldrin in these studies(5). When aldrin was applied to agricultural soils in Germany, Spain, England and the United States, significant amounts of dieldrin derived from the applied aldrin were detected in the soils within 6 months of aldrin application(6). Aldrin was classified as moderately persistent meaning its half-life in soil ranged from 20-100 days(7).

AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 400 to 28,000(2), indicate that aldrin is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 4.4X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 27 hrs and 19 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). The estimated volatilization half-life from a model pond is 52 yrs if adsorption is considered(5). According to a classification scheme(6), BCFs ranging from 735 to 20,000(7-11), suggest the potential for bioconcentration in aquatic organisms is high to very high(SRC). A river die-away test was conducted in capped bottles with aldrin in raw water from the Little Miami River in Ohio. The river receives domestic and industrial wastes and farm runoff(12). After 2, 4, and 8 weeks, 20, 60, and 80% of the initial amount of aldrin had degraded(12).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), aldrin, which has a vapor pressure of 1.2X10-4 mm Hg at 25 °C(2), is expected to exist solely in the vapor-phase in the ambient atmosphere(SRC). Vapor-phase aldrin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 hrs(SRC), calculated from its rate constant of 6.5X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Slow photolysis of aldrin vapor (60% in one week vs 16% in a dark control) was observed(4). This is expected due to the weak absorption of aldrin above 290 nm(5).

ABILITY OF FUNGI ISOLATED FROM SOILS TO DEGRADE (14)C ALDRIN & ITS METABOLITES WAS ASSAYED IN CULTURE GROWTH MEDIUM. PENICILLIUM METABOLIZED PARENT CMPD OR ONE OF ITS METABOLITES. FIELD STUDIES PERFORMED WITH SOILS PACKED INTO PVC TUBES SHOWED THAT ADDED (14)C ALDRIN LEACHED FASTEST IN SOIL POOR IN ORGANIC MATTER.

AEROBIC: Aldrin, present at 100 mg/l, reached 0% of its theoretical BOD in 14 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1). In soil, aldrin is converted to dieldrin by epoxidation, which occurs in all aerobic and biologically-active soils, with 50-75% of end-season residues detected as dieldrin(2). No biodegradation of aldrin at 5 and 10 mg/l was observed through the third subculture of a mixed culture inoculum from sewage(3). Activated sludge biodegraded 1.5% of the initial aldrin in an unspecified amount of time(4). Aldrin incubated for 30 days in a water surface film collected off of Hawaii was degraded by 8.1% to the diol(5). A pure culture of the marine alga, Dunaliella sp, degraded 23.3% of the initial aldrin to dieldrin and 5.2% to the diol(5). A pure culture of Aerobacter aerogenes degraded 36-46% of the initial amount of aldrin in 24 hours(6).

ANAEROBIC: Aldrin was degraded under anaerobic conditions in biologically active waste water sludge (pH 7-8, 35 °C) with a half-life of < 1 week(1).

INSECTIDES SUCH AS ALDRIN MINERALIZE DURING IRRADIATION WITH PYREX FILTERED UV LIGHT; AMT OF MINERALIZATION INCR WITH USE OF SHORT WAVE UV LIGHT.

NO REACTION OF OZONE WITH CHLORINATED DOUBLE BOND OF ALDRIN HAS BEEN FOUND. IT IS BELIEVED THAT SHIELDING OF CHLORINATED DOUBLE BOND BY BULKY CHLORINE SUBSTITUENTS & ENDO-SUBSTITUENTS PREVENTS SUCH AN ATTACK.

Aqueous reactions: persistence in river water in a sealed glass jar under sunlight and artificial fluorescent light-initial concn of 10 ug/l: after 1 hr: 100%; 1 wk: 100%; 2 wk: 80%; 4 wk: 40%; 8 wk: 20%.

The rate constant for the vapor-phase reaction of aldrin with photochemically-produced hydroxyl radicals has been estimated as 6.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of approximately 6 hrs at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). Aldrin has a UV absorbance max of 227 nm; and photodegradative half-life of 113 hours(2). Studies indicate that aldrin will also react with nitrogen dioxide in the ambient atmosphere to produce dieldrin(2). After 3 hours of exposure to nitrogen dioxide and UV radiation >290 nm, 32% of vapor-phase aldrin was converted to dieldrin(2). Aldrin, irradiated with ultraviolet light in an oxygenated aqueous solution, underwent little change except in the presence of amino acids and humic acids in natural waters(2). Aldrin is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3). An extrapolated hydrolysis rate constant of 3.8X10-5/hr at pH 7 and 25 °C has been determined for aldrin based on a measured value at 75 °C; the half-life for this reaction is 760 days(2).

Treatment of saturated aldrin vapor (5000 ug) with a sunlamp for 45 hours resulted in 14-34% degradation (based on the amount aldrin recoverable from the reactor walls)(1). Dieldrin (50-60 ug) and photoaldrin (20-30 ug) were the photo-products. Irradiation of 1 ug of aldrin vapor with the sunlamp for 168 hours resulted in 60% degradation compared to 16% degradation in a dark control(1). Dieldrin (0.63 ug) was the primary photo-product and photoaldrin (0.02 ug) and photodieldrin (0.02 ug) were also detected(1). A photolysis half-life of 1.1 day was determined for 0.33 ppb aldrin in San Francisco Bay water exposed to sunlight, although insufficient detail concerning the experimental conditions is available to conclude that this result was due solely to direct photolysis(2). Exposure of an aldrin film to sunlight for 1 month resulted in a solution containing 2.6% unchanged aldrin and 9.6% photoaldrin, 4.1% dieldrin, 24.1% photodieldrin and 59.7% of an unidentified product(3). Photolysis half-lives of thin films of aldrin irradiated at >300 nm were 4.7, 8.3, and 11 days, respectively(4). Solid aldrin adsorbed on silica gel, and irradiated at >290 nm for 6 days, was 11% mineralized(5). A 0.07 M aqueous solution of aldrin was 25% photooxidized by constituents of natural waters(6). Irradiation of aldrin in 0.05 M hydrogen peroxide for 12 hr at >290 nm reduced the aldrin concn by 79.5% compared to a dark control in which the aldrin concn decreased by 32.9%(7).

SUSCEPTIBLE MOSQUITOFISH, GAMBUSIA AFFINIS, EXPERIENCED GREATER ACCUM OF ALDRIN IN TISSUES THAN RESISTANT MOSQUITOFISH. PROBABLE CAUSES FOR RESISTANCE IN DECR ORDERS OF IMPORTANCE: IMPLIED SITE INSENSITIVITY; BARRIERS TO PENETRATION; & BIOTRANSFORMATION.

BLUE MUSSELS (MYTILUS SPECIES) USED AS INDICATORS FOR MONITORING POLLUTION OF LAGOON WATERS SHOWED ALDRIN TO BE PRESENT UP TO 0.4 UG/KG IN WET TISSUE.

The bioconcentration factor of aldrin in molluscs is 4571(1), in the golden orfe is 3,890(2), in an unspecified fish is 10,715(3) and in the alga, Chlorella fusca, is 12,260(4). The BCF values for aldrin in carp (Cyprinus carpio) range from 735-20,000(5). According to a classification scheme(6), this range of BCF values suggests the potential for bioconcentration in aquatic organisms is high to very high(SRC).

According to a classification scheme(1), a range of Koc values of 400-28,000(2), suggests that aldrin is expected to be moderately mobile to immobile in soil(SRC).

Potential candidate for rotary kiln incineration with a temperature of 820-1600 °C with residence times for liquids and gases: seconds; solids: hours. Also, a potential candidate for fluidized bed incineration with a temperature range of 450-980 °C with residence times for liquids and gases: seconds; Solids, longer.

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

For more Disposal Methods (Complete) data for ALDRIN (9 total), please visit the HSDB record page.

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

For more DOT Emergency Guidelines (Complete) data for ALDRIN (16 total), please visit the HSDB record page.

UN 2762; Organochlorine pesticides, liquid, flammable, toxic, flashpoint less than 23 °C

UN 2761; Organochlorine pesticides, solid, toxic

IMO 3.0; Organochlorine pesticide, liquid, flammable, toxic, flashpoint less than 23 °C

UN 2995; Organochlorine pesticides, liquid, toxic, flammable, flashpoint not less than 23 °C

For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for ALDRIN (7 total), please visit the HSDB record page.

49 214 03; Aldrin

49 214 06; Aldrin mixture, liquid (with more than 60% aldrin)

49 214 07; Aldrin mixture, dry (with more than 65% aldrin)

49 411 07; Aldrin, cast solid

49 411 08; Aldrin mixture, liquid, with 60% or less aldrin

49 411 09; Aldrin mixture, dry, with 65% or less aldrin

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Organochlorine pesticide, liquid, flammable, toxic, flash point less than 23 °C; organochlorine pesticide, liquid, toxic; organochlorine pesticide, liquid, toxic, flammable, flash point 23 °C or more; and organochlorine pesticide, solid, toxic are included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Organochlorine pesticide, solid, toxic; organochlorine pesticide, liquid, flammable, toxic, flash point less than 23 °C; organochlorine pesticide, liquid, toxic, flammable, flash point not less than 23 °C; and organochlorine pesticide, liquid, toxic are included on the dangerous goods list.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Flammable Liquid Poison

Do not transport with food and feedstuffs. Severe marine pollutant.

Symbol: T, N; R: 24/25-40-48/24/25-50/53; S: (1/2)-22-36/37-45-60-61

UN Hazard Class: 6.1; UN Pack Group: II