| Section 1. Identification | |||
|---|---|---|---|
| Chemical Name | 2-fluoroaniline | CAS No. | 348-54-9 |
| Synonyms | o-fluoroaniline | Chinese Name | 2-氟苯胺 |
| Molecular Formula | C6H6FN | Molecular Weight | 111.1169 |
| UN No. | 2941 | Data Source | PubChem (NIH/NLM) |
| GHS Hazard Classification | |
|---|---|
| Signal Word | DANGER |
| Pictograms | GHS02 · Flammable GHS05 · Corrosive GHS06 · Acute Toxic GHS07 · Irritant GHS08 · Health Hazard GHS09 · Environmental Hazard |
| Hazard Statements | H226H301H311H331H302H315H317H318H319H335H341H351H372H400 |
| Precautionary Statements | P203P210P233P240P241P242P243P260P261P262P264P264+P265P270P271P272P273P280P301+P316P301+P317P302+P352P303+P361+P353P304+P340P305+P351+P338P305+P354+P338P316P317P318P319P321P330P332+P317P333+P317P337+P317P361+P364P362+P364P370+P378P391P403+P233P403+P235P405P501 |
| Contents | |||
|---|---|---|---|
| Section 2 | Hazards Identification | Section 4 | First-Aid Measures |
| Section 5 | Fire-Fighting Measures | Section 6 | Accidental Release Measures |
| Section 7 | Handling and Storage | Section 8 | Exposure Controls / Personal Protection |
| Section 9 | Physical and Chemical Properties | Section 10 | Stability and Reactivity |
| Section 11 | Toxicological Information | ||
H226 (46%): Flammable liquid and vapor [Warning Flammable liquids]
H301+H311+H331 (51.6%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
H301 (53.2%): Toxic if swallowed [Danger Acute toxicity, oral]
H302 (46.8%): Harmful if swallowed [Warning Acute toxicity, oral]
H311 (53.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H315 (46%): Causes skin irritation [Warning Skin corrosion/irritation]
H317 (52.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H318 (88.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (11.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H331 (53.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]
H335 (35.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H341 (52.4%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H351 (52.4%): Suspected of causing cancer [Warning Carcinogenicity]
H372 (52.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (53.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 126 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
INHALATION: Remove victim from exposure immediately; if needed, administer oxygen; refer to physician.
EYES: Flush with water for at least 15 min.
SKIN: Remove victim from exposure immediately; remove contaminated clothing; wash contacted area with copious amounts of water and soap; if needed, administer oxygen; refer to physician.
INGESTION: Induce vomiting; get medical attention. (USCG, 1999)
Fire Extinguishing Agents: Water, dry chemical, foam or carbon dioxide (USCG, 1999)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)
Rubber gloves; chemical goggles; protective clothing; approved respirator. (USCG, 1999)
2-fluoroaniline is a clear liquid with a mild sweet odor. Sinks in and mixes slowly with water. (USCG, 1999)
Clear to pale yellow liquid with a mild sweet odor; [CHRIS]
347 °F at 760 mmHg (USCG, 1999)
-19.3 °F (USCG, 1999)
140 °F (USCG, 1999)
1.1513 at 69.8 °F (USCG, 1999) - Denser than water; will sink
1.0 [mmHg]
3.2 (at 25 °C)
13C nuclear magnetic resonance spectrum
15N nuclear magnetic resonance spectrum
Coriolis coupling
Schoenflies notation
Centrifugal distortion
Chemical bond
Chemical shift
Diamagnetic susceptibility
Equilibrium structure
Internuclear distance
Magnetic susceptibility
Molecular structure
Optical coefficient
Point group
Refractive index
Rotation-vibration spectrum
Rotational excitation cross section
Spin-spin coupling constant
Vibrational mode frequency
Viscosity
Nitrogen Compounds -> Amines, Aromatic
Pharmaceuticals -> Listed in ZINC15
Water soluble.
Aryl Halides
Amines, Aromatic
2-FLUOROANILINE is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect