English Safety Data Sheet Database 中文版 MSDS

2-fluoroaniline

CAS No. 348-54-9 | PubChem CID 9584
Section 1. Identification
Chemical Name2-fluoroaniline CAS No.348-54-9
Synonymso-fluoroaniline Chinese Name2-氟苯胺
Molecular FormulaC6H6FN Molecular Weight111.1169
UN No.2941 Data SourcePubChem (NIH/NLM)
GHS Hazard Classification
Signal Word DANGER
Pictograms GHS02 · Flammable GHS05 · Corrosive GHS06 · Acute Toxic GHS07 · Irritant GHS08 · Health Hazard GHS09 · Environmental Hazard
Hazard Statements H226H301H311H331H302H315H317H318H319H335H341H351H372H400
Precautionary Statements P203P210P233P240P241P242P243P260P261P262P264P264+P265P270P271P272P273P280P301+P316P301+P317P302+P352P303+P361+P353P304+P340P305+P351+P338P305+P354+P338P316P317P318P319P321P330P332+P317P333+P317P337+P317P361+P364P362+P364P370+P378P391P403+P233P403+P235P405P501

Section 2. Hazards Identification

H226 (46%): Flammable liquid and vapor [Warning Flammable liquids]

H301+H311+H331 (51.6%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H301 (53.2%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (46.8%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (53.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H315 (46%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (52.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (88.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (11.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331 (53.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H335 (35.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H341 (52.4%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H351 (52.4%): Suspected of causing cancer [Warning Carcinogenicity]

H372 (52.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400 (53.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 126 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Section 4. First-Aid Measures

INHALATION: Remove victim from exposure immediately; if needed, administer oxygen; refer to physician.

EYES: Flush with water for at least 15 min.

SKIN: Remove victim from exposure immediately; remove contaminated clothing; wash contacted area with copious amounts of water and soap; if needed, administer oxygen; refer to physician.

INGESTION: Induce vomiting; get medical attention. (USCG, 1999)

Section 5. Fire-Fighting Measures

Fire Extinguishing Agents: Water, dry chemical, foam or carbon dioxide (USCG, 1999)

Section 6. Accidental Release Measures

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Section 7. Handling and Storage

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Section 8. Exposure Controls / Personal Protection

Rubber gloves; chemical goggles; protective clothing; approved respirator. (USCG, 1999)

Section 9. Physical and Chemical Properties

2-fluoroaniline is a clear liquid with a mild sweet odor. Sinks in and mixes slowly with water. (USCG, 1999)

Clear to pale yellow liquid with a mild sweet odor; [CHRIS]

347 °F at 760 mmHg (USCG, 1999)

-19.3 °F (USCG, 1999)

140 °F (USCG, 1999)

1.1513 at 69.8 °F (USCG, 1999) - Denser than water; will sink

1.0 [mmHg]

3.2 (at 25 °C)

13C nuclear magnetic resonance spectrum

15N nuclear magnetic resonance spectrum

Coriolis coupling

Schoenflies notation

Centrifugal distortion

Chemical bond

Chemical shift

Diamagnetic susceptibility

Equilibrium structure

Internuclear distance

Magnetic susceptibility

Molecular structure

Optical coefficient

Point group

Refractive index

Rotation-vibration spectrum

Rotational excitation cross section

Spin-spin coupling constant

Vibrational mode frequency

Viscosity

Nitrogen Compounds -> Amines, Aromatic

Pharmaceuticals -> Listed in ZINC15

Section 10. Stability and Reactivity

Water soluble.

Aryl Halides

Amines, Aromatic

2-FLUOROANILINE is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Section 11. Toxicological Information

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Source: PubChem CID 9584 (NIH/NLM, public domain). Retrieved from PubChem, a public-domain chemistry database maintained by the U.S. National Library of Medicine. Last updated: 2026-08-02 09:41:11.
Disclaimer: This information is compiled for reference only and does not replace the manufacturer's official Safety Data Sheet. Always consult the supplier's SDS before handling any chemical.